Click here to switch to the map view.

The map label for this gene is murC

Identifier: 158334963

GI number: 158334963

Start: 1789801

End: 1791264

Strand: Reverse

Name: murC

Synonym: AM1_1800

Alternate gene names: 158334963

Gene position: 1791264-1789801 (Counterclockwise)

Preceding gene: 158334965

Following gene: 158334962

Centisome position: 27.54

GC content: 47.2

Gene sequence:

>1464_bases
ATGCAAAGTGCAGTCGATTTAGGTGGTCGTCCCATTCACTTCATTGGTGTTGGTGGTATCGGCATGTCTGCACTAGCCCA
TATCCTCCTCAAACGACAATTGCCTATTTCGGGCTCAGATGCTCGCGCTAACCATATCACCCAAAAATTAGAATCCCAGG
GTGCCCAGATCTTCTCCCGGCAAGAGGCGACTAACATCAAGCAGCTTTGCCAGGGGTCTTCTGCTCCCCCTCAAGTGATT
TGTTCAACGGCCATTCATGAGGACAATCCTGAGTACCAGGCCGCTGTTCAAGCAGGATGCCCTATCTTTCACCGTTCTGA
TGTGCTGGCAGCGCTCATGCAAGAGTTCCCGCAAAGCATTGCAATTGCTGGAACCCATGGTAAAACAACCACGAGTAGTT
TGGTGGGCTATTTATTGTTGCAAGCGAGTTTAGATCCCACCATCATTGTGGGCGGAGAAGTTGCTGCATGGGGTGGGAAT
GCCCGCACGGGTGAAAGCCCCTATCTAGTCGCTGAGGCTGATGAATCTGATGGGTCCCTCGTAAAGTTTTTCCCTCACAT
TGGTGTTATTACAAATATTGAACTTGATCACCCTGATCACTACACCTCACTGGATCAAGTGGTGAGCATCTTTCAAGAGT
TTGTCGATCATTGCCATACTTTGATTGTCTCGGTAGACTGCCCCACCATCGCTGATCGTTTTCTCGCATTGGCTACCGAT
CAGTCCATGATTACTTACAGTTTGAGTAGTAAAGTATCGGCAGATTATACGGTTCAAAATATTGACTATTCAGGCCAAGG
AACAATCGTAGAGGTCCTAGAACGTGGAGAGAGCTTAGGACAGTTAGAGCTTCCTCTGCTGGGAGAACATAATCTTAGTA
ATGCCCTAGCTGCCGTTGCAGTTGGCCGTTACGTCGGTTTAGAATTCCCTGCCATTGCTAAAGCATTACGGACTTTCTCA
GGAGCGAAGCGTCGTTTCGAAATTTATGGAGAAGCTCAAGGGATTTGTTTGATCGACGATTATGCACATCATCCTAGTGA
AATCCAAGTGACCTTGGCATCAGCGAAGCTCCAAGCTCAAGCAGCAGCTGCAACCTATTCTCAATCACGAGTGGTGGCCG
TCTTCCAACCCCATCGCTACAGCCGCGCAGCCACCTTCTTTCAAGAGTTTAGCCAATCTTTTCAAGATGCCGATTTAGTG
GTTGTGACTGATATCTATAGTGCTGGAGAAGCAAATCCAGGCACCATTAATGGTAAAAAGTTGGCAGATGCAATTGCCGC
TAACCATTCTGTCGTGACGTTTCAACCGACTTTGACCAATGTTATCGATTTTTTGCAAGGACATTTGCAATCGGGTGATG
TAGTCCTATTCTTGGGAGCAGGAGATTTGAACCGCATCATTCCAGATTTGCTTACCCATTTTCAGGTCTCATCAAAACCT
TCTCCTGAGGTTGTTTTGAAATGA

Upstream 100 bases:

>100_bases
AGATGTGTGGGAAGCAAGGAAAAGAACTCGAATTTTTTAGAGTTCCTGCTATGATGTCGCGTGTAACTAGGTGTGGGCCG
AGAAGGAGCGAAATATAGTA

Downstream 100 bases:

>100_bases
CTCAGTCTTTACCCTCCATCTTTATTGACAATGGCAACTGCGAAATTCAGCCTTATGTGAGTTTGGCCGATATGACGACA
TTCCGCGTAGGGGGAGCAGC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MQSAVDLGGRPIHFIGVGGIGMSALAHILLKRQLPISGSDARANHITQKLESQGAQIFSRQEATNIKQLCQGSSAPPQVI
CSTAIHEDNPEYQAAVQAGCPIFHRSDVLAALMQEFPQSIAIAGTHGKTTTSSLVGYLLLQASLDPTIIVGGEVAAWGGN
ARTGESPYLVAEADESDGSLVKFFPHIGVITNIELDHPDHYTSLDQVVSIFQEFVDHCHTLIVSVDCPTIADRFLALATD
QSMITYSLSSKVSADYTVQNIDYSGQGTIVEVLERGESLGQLELPLLGEHNLSNALAAVAVGRYVGLEFPAIAKALRTFS
GAKRRFEIYGEAQGICLIDDYAHHPSEIQVTLASAKLQAQAAAATYSQSRVVAVFQPHRYSRAATFFQEFSQSFQDADLV
VVTDIYSAGEANPGTINGKKLADAIAANHSVVTFQPTLTNVIDFLQGHLQSGDVVLFLGAGDLNRIIPDLLTHFQVSSKP
SPEVVLK

Sequences:

>Translated_487_residues
MQSAVDLGGRPIHFIGVGGIGMSALAHILLKRQLPISGSDARANHITQKLESQGAQIFSRQEATNIKQLCQGSSAPPQVI
CSTAIHEDNPEYQAAVQAGCPIFHRSDVLAALMQEFPQSIAIAGTHGKTTTSSLVGYLLLQASLDPTIIVGGEVAAWGGN
ARTGESPYLVAEADESDGSLVKFFPHIGVITNIELDHPDHYTSLDQVVSIFQEFVDHCHTLIVSVDCPTIADRFLALATD
QSMITYSLSSKVSADYTVQNIDYSGQGTIVEVLERGESLGQLELPLLGEHNLSNALAAVAVGRYVGLEFPAIAKALRTFS
GAKRRFEIYGEAQGICLIDDYAHHPSEIQVTLASAKLQAQAAAATYSQSRVVAVFQPHRYSRAATFFQEFSQSFQDADLV
VVTDIYSAGEANPGTINGKKLADAIAANHSVVTFQPTLTNVIDFLQGHLQSGDVVLFLGAGDLNRIIPDLLTHFQVSSKP
SPEVVLK
>Mature_487_residues
MQSAVDLGGRPIHFIGVGGIGMSALAHILLKRQLPISGSDARANHITQKLESQGAQIFSRQEATNIKQLCQGSSAPPQVI
CSTAIHEDNPEYQAAVQAGCPIFHRSDVLAALMQEFPQSIAIAGTHGKTTTSSLVGYLLLQASLDPTIIVGGEVAAWGGN
ARTGESPYLVAEADESDGSLVKFFPHIGVITNIELDHPDHYTSLDQVVSIFQEFVDHCHTLIVSVDCPTIADRFLALATD
QSMITYSLSSKVSADYTVQNIDYSGQGTIVEVLERGESLGQLELPLLGEHNLSNALAAVAVGRYVGLEFPAIAKALRTFS
GAKRRFEIYGEAQGICLIDDYAHHPSEIQVTLASAKLQAQAAAATYSQSRVVAVFQPHRYSRAATFFQEFSQSFQDADLV
VVTDIYSAGEANPGTINGKKLADAIAANHSVVTFQPTLTNVIDFLQGHLQSGDVVLFLGAGDLNRIIPDLLTHFQVSSKP
SPEVVLK

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=499, Percent_Identity=35.0701402805611, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1790680, Length=376, Percent_Identity=30.3191489361702, Blast_Score=165, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_ACAM1 (B0CCD6)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001516135.1
- ProteinModelPortal:   B0CCD6
- SMR:   B0CCD6
- GeneID:   5680616
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_1800
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   AMAR329726:AM1_1800-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 52176; Mature: 52176

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSAVDLGGRPIHFIGVGGIGMSALAHILLKRQLPISGSDARANHITQKLESQGAQIFSR
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QEATNIKQLCQGSSAPPQVICSTAIHEDNPEYQAAVQAGCPIFHRSDVLAALMQEFPQSI
HHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHCCHHE
AIAGTHGKTTTSSLVGYLLLQASLDPTIIVGGEVAAWGGNARTGESPYLVAEADESDGSL
EEECCCCCCHHHHHHHHHHHHCCCCCEEEECCEEEECCCCCCCCCCCEEEEECCCCCCCE
VKFFPHIGVITNIELDHPDHYTSLDQVVSIFQEFVDHCHTLIVSVDCPTIADRFLALATD
EEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCCC
QSMITYSLSSKVSADYTVQNIDYSGQGTIVEVLERGESLGQLELPLLGEHNLSNALAAVA
CCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHH
VGRYVGLEFPAIAKALRTFSGAKRRFEIYGEAQGICLIDDYAHHPSEIQVTLASAKLQAQ
HHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCCCCCEEEEEEEHHHHHHH
AAAATYSQSRVVAVFQPHRYSRAATFFQEFSQSFQDADLVVVTDIYSAGEANPGTINGKK
HHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCCCCCHHH
LADAIAANHSVVTFQPTLTNVIDFLQGHLQSGDVVLFLGAGDLNRIIPDLLTHFQVSSKP
HHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCC
SPEVVLK
CCCEEEC
>Mature Secondary Structure
MQSAVDLGGRPIHFIGVGGIGMSALAHILLKRQLPISGSDARANHITQKLESQGAQIFSR
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QEATNIKQLCQGSSAPPQVICSTAIHEDNPEYQAAVQAGCPIFHRSDVLAALMQEFPQSI
HHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHCCHHE
AIAGTHGKTTTSSLVGYLLLQASLDPTIIVGGEVAAWGGNARTGESPYLVAEADESDGSL
EEECCCCCCHHHHHHHHHHHHCCCCCEEEECCEEEECCCCCCCCCCCEEEEECCCCCCCE
VKFFPHIGVITNIELDHPDHYTSLDQVVSIFQEFVDHCHTLIVSVDCPTIADRFLALATD
EEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCCC
QSMITYSLSSKVSADYTVQNIDYSGQGTIVEVLERGESLGQLELPLLGEHNLSNALAAVA
CCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHH
VGRYVGLEFPAIAKALRTFSGAKRRFEIYGEAQGICLIDDYAHHPSEIQVTLASAKLQAQ
HHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCCCCCEEEEEEEHHHHHHH
AAAATYSQSRVVAVFQPHRYSRAATFFQEFSQSFQDADLVVVTDIYSAGEANPGTINGKK
HHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCCCCCHHH
LADAIAANHSVVTFQPTLTNVIDFLQGHLQSGDVVLFLGAGDLNRIIPDLLTHFQVSSKP
HHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCC
SPEVVLK
CCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA