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The map label for this gene is rnc [H]

Identifier: 158334880

GI number: 158334880

Start: 1701744

End: 1702487

Strand: Direct

Name: rnc [H]

Synonym: AM1_1717

Alternate gene names: 158334880

Gene position: 1701744-1702487 (Clockwise)

Preceding gene: 158334874

Following gene: 158334881

Centisome position: 26.17

GC content: 53.9

Gene sequence:

>744_bases
ATGGCTAGTTGCCCCCCTCAACGACAACGACAGCTCGAAAAATTGATCCAGCGACTGGGGCTACCAGGGAATGCCCCCAT
TCGTTGGGACCTACTCGATCTGGCTCTGACCCATCCGTCTGCCTCTGGGCGGGCCAATTATGAACAATTAGAATTTGTGG
GCGACTCCGTTGTCCGTCTCTTAGCCGCCGTCCTTTTACAGGCAGAGAATGCTCAAGGATCCGTGGGAGAATGGTCGGCG
ATTCGTTCCGTATTGGTCAGCGATCGTCACCTGGCGACCCTAGCCGCTAACTATGGTCTGGATCGATTTCTACTGCTAGG
TCCCAGTACCCTGAAAGATCGCCGAGGTCAAGACTCTCGATTAGCCGATGCTTTTGAAGCCGTCTTGGGGGCCCTTTATC
TCAGCACCGGTGACCTCTCGCTAATTCAGCCCTGGCTCCAAGATCCTTTGCGAAACAAGGCAGAGCAGGTCAGGATCGAT
CCCGCGTATCAGAACTATAAAGCTGCCCTCCAGCAATGGACTCAGGCCGTTTATCAACAATTACCCGAATATCGAGTCCA
AGAGACTTCACCTCCATCCCAGGATCCTAGTGACGTGATGGCTGACCGCTTTACTGCCGAAGTCTGGCTCCAAGAGGAAC
TACTGGGGGTGGGCAAAGGGCACTCTATCAAAGCCGCAGAGAAAGCCGCAGCCCAAATAGCCTTTTTAAAAGTCCAGTCG
CCGTTGGCCGAGACTGAGTTTTAG

Upstream 100 bases:

>100_bases
GGTGGAGAAAGAGAACAGAACCCGGCTTACCGCCTGCTCTTCCCTCTATCTTTAGGGGATACTCCCCTAGCTTTAAACGT
CATCTTTACTTCCCTCATCA

Downstream 100 bases:

>100_bases
GTTTCAACAGTCCCTTTTCCATCATTCGATAGGATAATGGATATATATCTACGGCTCAAAGATTCATAGAAAAGGATAAA
AATGATGGATCTGGTCCTAC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III 2; RNase III 2 [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MASCPPQRQRQLEKLIQRLGLPGNAPIRWDLLDLALTHPSASGRANYEQLEFVGDSVVRLLAAVLLQAENAQGSVGEWSA
IRSVLVSDRHLATLAANYGLDRFLLLGPSTLKDRRGQDSRLADAFEAVLGALYLSTGDLSLIQPWLQDPLRNKAEQVRID
PAYQNYKAALQQWTQAVYQQLPEYRVQETSPPSQDPSDVMADRFTAEVWLQEELLGVGKGHSIKAAEKAAAQIAFLKVQS
PLAETEF

Sequences:

>Translated_247_residues
MASCPPQRQRQLEKLIQRLGLPGNAPIRWDLLDLALTHPSASGRANYEQLEFVGDSVVRLLAAVLLQAENAQGSVGEWSA
IRSVLVSDRHLATLAANYGLDRFLLLGPSTLKDRRGQDSRLADAFEAVLGALYLSTGDLSLIQPWLQDPLRNKAEQVRID
PAYQNYKAALQQWTQAVYQQLPEYRVQETSPPSQDPSDVMADRFTAEVWLQEELLGVGKGHSIKAAEKAAAQIAFLKVQS
PLAETEF
>Mature_246_residues
ASCPPQRQRQLEKLIQRLGLPGNAPIRWDLLDLALTHPSASGRANYEQLEFVGDSVVRLLAAVLLQAENAQGSVGEWSAI
RSVLVSDRHLATLAANYGLDRFLLLGPSTLKDRRGQDSRLADAFEAVLGALYLSTGDLSLIQPWLQDPLRNKAEQVRIDP
AYQNYKAALQQWTQAVYQQLPEYRVQETSPPSQDPSDVMADRFTAEVWLQEELLGVGKGHSIKAAEKAAAQIAFLKVQSP
LAETEF

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=199, Percent_Identity=27.1356783919598, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI155030236, Length=199, Percent_Identity=27.1356783919598, Blast_Score=71, Evalue=9e-13,
Organism=Escherichia coli, GI1788920, Length=210, Percent_Identity=30, Blast_Score=75, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27331; Mature: 27200

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASCPPQRQRQLEKLIQRLGLPGNAPIRWDLLDLALTHPSASGRANYEQLEFVGDSVVRL
CCCCCHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LAAVLLQAENAQGSVGEWSAIRSVLVSDRHLATLAANYGLDRFLLLGPSTLKDRRGQDSR
HHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCHHHHHCCCCCHH
LADAFEAVLGALYLSTGDLSLIQPWLQDPLRNKAEQVRIDPAYQNYKAALQQWTQAVYQQ
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHEECCHHHHHHHHHHHHHHHHHHHH
LPEYRVQETSPPSQDPSDVMADRFTAEVWLQEELLGVGKGHSIKAAEKAAAQIAFLKVQS
CHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHC
PLAETEF
CHHCCCC
>Mature Secondary Structure 
ASCPPQRQRQLEKLIQRLGLPGNAPIRWDLLDLALTHPSASGRANYEQLEFVGDSVVRL
CCCCHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LAAVLLQAENAQGSVGEWSAIRSVLVSDRHLATLAANYGLDRFLLLGPSTLKDRRGQDSR
HHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCHHHHHCCCCCHH
LADAFEAVLGALYLSTGDLSLIQPWLQDPLRNKAEQVRIDPAYQNYKAALQQWTQAVYQQ
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHEECCHHHHHHHHHHHHHHHHHHHH
LPEYRVQETSPPSQDPSDVMADRFTAEVWLQEELLGVGKGHSIKAAEKAAAQIAFLKVQS
CHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHC
PLAETEF
CHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]