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The map label for this gene is gcvT [H]

Identifier: 158334699

GI number: 158334699

Start: 1514456

End: 1515580

Strand: Reverse

Name: gcvT [H]

Synonym: AM1_1532

Alternate gene names: 158334699

Gene position: 1515580-1514456 (Counterclockwise)

Preceding gene: 158334700

Following gene: 158334698

Centisome position: 23.3

GC content: 50.22

Gene sequence:

>1125_bases
GTGCAAACGTGGATTACCATGGCAGACTCCTTGAAACCGACTCCTTTACTAGAGCAACATCAGCAGCTCAATGCTCGGAT
GATGGGCTTTGGGGGTTGGAATATGCCTGTTCAATATGAAGGCATCACCGTTGAGCATCAAAGCGTCCGTCAAAAAGTGG
GCATGTTTGATATCTCTCATATGGGTAAGTTCTTGCTCAAGGGAGATAACTTACGGCAGAAACTGCAGCCCTTAGTCCCC
TCTGATCTCAGTCAGCTTGAACCGGGGCAAGCAAAGTACTCTGTCTTTTTGAATGAGCAAGCTGGGATTATTGATGATCT
AATCTTTTACTTTGAGGGGATCTCAGACTCAGGAGCAGAAATTGGCAAGCTGATTGTCAATGCCTCGACTACGGCTAAGG
ACAAAGCCTGGTTATTAGAGAATGTTTCCGCTGAAGCGATTGGGTTTGAGGATGTTTCCGACTCCCATGTGCTAATTGCC
GTGCAAGGACCCGATGCGATCTCAACTCTGCAGCGCTTTACCCCCACCGATCTCTCGGCCATTCGCAACTATCGCCATCA
GTCTGGCACCATCCTGGAGCAACCCGCCTGGTTTGCCCGCACTGGGTACACTGGCGAAGACGGGTTTGAAGTCATGGTCG
ATCCAGAGACGGGTAAGAAACTCTGGCAGACCCTTTTGGAGGCTGGTGTTGCTCCCTGCGGTTTGGGAGCCCGCGATACC
TTAAGACTAGAAGCCGCCATGGCTCTGTATGGTCAAGATATAAATGACACTACAACCCCCTACGAAGCTGGGTTGGGATG
GTTGGTTAATCTAGATCAAGGTGAGTTTATTGGCCAAGACACCCTCAAGAAGCAGCAAGCAGAGGGACCGCCCCGTAAGT
TAGTGGCTTTGGAAATGCAGGGGCGTCATATTGCTCGTCATGATTATCCCGTTTGGGTCAATGACCAAGAAGTGGGCATT
GTCACCAGCGGCAGTTTTTCACCCACTTTGGGTAAATCGATTGCCCTCGCCTATGTCCCAACGGCTTATGCCAAATCCGG
TACGGAAGTAGCGGTATTAATCCGCAAGAAGCCCCAACTGGCAACGGTTGTTAAAAAGCCCTTTTATCGACGACCTAAAG
CGTGA

Upstream 100 bases:

>100_bases
GTCATATCGCAACAACACTGATCTGAACACTAGGTTCATGATATAAATGCGAGGGCTGGTTCGCAGATGGTGTGTTACAT
CGAGCCCAGCCAGAAGCTTA

Downstream 100 bases:

>100_bases
GATTTAAGGCAAAATATGGTTTGGATGATTCTCCTGAAATCCTACTCAACTTCCTTATTGACTGAGGCACCCCATTATGA
GTTTTGAATATCCCGACAAT

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MQTWITMADSLKPTPLLEQHQQLNARMMGFGGWNMPVQYEGITVEHQSVRQKVGMFDISHMGKFLLKGDNLRQKLQPLVP
SDLSQLEPGQAKYSVFLNEQAGIIDDLIFYFEGISDSGAEIGKLIVNASTTAKDKAWLLENVSAEAIGFEDVSDSHVLIA
VQGPDAISTLQRFTPTDLSAIRNYRHQSGTILEQPAWFARTGYTGEDGFEVMVDPETGKKLWQTLLEAGVAPCGLGARDT
LRLEAAMALYGQDINDTTTPYEAGLGWLVNLDQGEFIGQDTLKKQQAEGPPRKLVALEMQGRHIARHDYPVWVNDQEVGI
VTSGSFSPTLGKSIALAYVPTAYAKSGTEVAVLIRKKPQLATVVKKPFYRRPKA

Sequences:

>Translated_374_residues
MQTWITMADSLKPTPLLEQHQQLNARMMGFGGWNMPVQYEGITVEHQSVRQKVGMFDISHMGKFLLKGDNLRQKLQPLVP
SDLSQLEPGQAKYSVFLNEQAGIIDDLIFYFEGISDSGAEIGKLIVNASTTAKDKAWLLENVSAEAIGFEDVSDSHVLIA
VQGPDAISTLQRFTPTDLSAIRNYRHQSGTILEQPAWFARTGYTGEDGFEVMVDPETGKKLWQTLLEAGVAPCGLGARDT
LRLEAAMALYGQDINDTTTPYEAGLGWLVNLDQGEFIGQDTLKKQQAEGPPRKLVALEMQGRHIARHDYPVWVNDQEVGI
VTSGSFSPTLGKSIALAYVPTAYAKSGTEVAVLIRKKPQLATVVKKPFYRRPKA
>Mature_374_residues
MQTWITMADSLKPTPLLEQHQQLNARMMGFGGWNMPVQYEGITVEHQSVRQKVGMFDISHMGKFLLKGDNLRQKLQPLVP
SDLSQLEPGQAKYSVFLNEQAGIIDDLIFYFEGISDSGAEIGKLIVNASTTAKDKAWLLENVSAEAIGFEDVSDSHVLIA
VQGPDAISTLQRFTPTDLSAIRNYRHQSGTILEQPAWFARTGYTGEDGFEVMVDPETGKKLWQTLLEAGVAPCGLGARDT
LRLEAAMALYGQDINDTTTPYEAGLGWLVNLDQGEFIGQDTLKKQQAEGPPRKLVALEMQGRHIARHDYPVWVNDQEVGI
VTSGSFSPTLGKSIALAYVPTAYAKSGTEVAVLIRKKPQLATVVKKPFYRRPKA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=374, Percent_Identity=33.6898395721925, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI257796258, Length=362, Percent_Identity=32.8729281767956, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI257796254, Length=369, Percent_Identity=30.8943089430894, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI257796256, Length=314, Percent_Identity=33.1210191082803, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI24797151, Length=340, Percent_Identity=28.8235294117647, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI197927446, Length=331, Percent_Identity=25.0755287009063, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI21361378, Length=331, Percent_Identity=25.0755287009063, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI194306651, Length=335, Percent_Identity=24.7761194029851, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1789272, Length=372, Percent_Identity=41.6666666666667, Blast_Score=249, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17560118, Length=379, Percent_Identity=36.9393139841689, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71994045, Length=358, Percent_Identity=23.7430167597765, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71994052, Length=358, Percent_Identity=23.7430167597765, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI32563613, Length=321, Percent_Identity=23.98753894081, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320222, Length=383, Percent_Identity=32.3759791122715, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI20129441, Length=382, Percent_Identity=35.6020942408377, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI20130091, Length=359, Percent_Identity=22.5626740947075, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571104, Length=340, Percent_Identity=23.5294117647059, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 41238; Mature: 41238

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTWITMADSLKPTPLLEQHQQLNARMMGFGGWNMPVQYEGITVEHQSVRQKVGMFDISH
CCCEEEHHCCCCCCHHHHHHHHCCCEEEECCCCCCCEEECCEEECHHHHHHHHCCEEHHH
MGKFLLKGDNLRQKLQPLVPSDLSQLEPGQAKYSVFLNEQAGIIDDLIFYFEGISDSGAE
HHHHHCCCCCHHHHHHCCCCCCHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCHH
IGKLIVNASTTAKDKAWLLENVSAEAIGFEDVSDSHVLIAVQGPDAISTLQRFTPTDLSA
HEEEEEECCCCCCCHHHHHHCCCCCEECCCCCCCCEEEEEEECCHHHHHHHHCCCCHHHH
IRNYRHQSGTILEQPAWFARTGYTGEDGFEVMVDPETGKKLWQTLLEAGVAPCGLGARDT
HHHHHHCCCCEEECCCCEEECCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCHH
LRLEAAMALYGQDINDTTTPYEAGLGWLVNLDQGEFIGQDTLKKQQAEGPPRKLVALEMQ
HHHHHHHHHHCCCCCCCCCCHHCCCEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEEEC
GRHIARHDYPVWVNDQEVGIVTSGSFSPTLGKSIALAYVPTAYAKSGTEVAVLIRKKPQL
CCEEECCCCCEEECCCCEEEEECCCCCCCCCCCEEEEEECHHHHCCCCEEEEEEECCCHH
ATVVKKPFYRRPKA
HHHHHCCCCCCCCC
>Mature Secondary Structure
MQTWITMADSLKPTPLLEQHQQLNARMMGFGGWNMPVQYEGITVEHQSVRQKVGMFDISH
CCCEEEHHCCCCCCHHHHHHHHCCCEEEECCCCCCCEEECCEEECHHHHHHHHCCEEHHH
MGKFLLKGDNLRQKLQPLVPSDLSQLEPGQAKYSVFLNEQAGIIDDLIFYFEGISDSGAE
HHHHHCCCCCHHHHHHCCCCCCHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCHH
IGKLIVNASTTAKDKAWLLENVSAEAIGFEDVSDSHVLIAVQGPDAISTLQRFTPTDLSA
HEEEEEECCCCCCCHHHHHHCCCCCEECCCCCCCCEEEEEEECCHHHHHHHHCCCCHHHH
IRNYRHQSGTILEQPAWFARTGYTGEDGFEVMVDPETGKKLWQTLLEAGVAPCGLGARDT
HHHHHHCCCCEEECCCCEEECCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCHH
LRLEAAMALYGQDINDTTTPYEAGLGWLVNLDQGEFIGQDTLKKQQAEGPPRKLVALEMQ
HHHHHHHHHHCCCCCCCCCCHHCCCEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEEEC
GRHIARHDYPVWVNDQEVGIVTSGSFSPTLGKSIALAYVPTAYAKSGTEVAVLIRKKPQL
CCEEECCCCCEEECCCCEEEEECCCCCCCCCCCEEEEEECHHHHCCCCEEEEEEECCCHH
ATVVKKPFYRRPKA
HHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA