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The map label for this gene is upp [H]

Identifier: 158334659

GI number: 158334659

Start: 1476090

End: 1476743

Strand: Reverse

Name: upp [H]

Synonym: AM1_1490

Alternate gene names: 158334659

Gene position: 1476743-1476090 (Counterclockwise)

Preceding gene: 158334663

Following gene: 158334658

Centisome position: 22.71

GC content: 51.07

Gene sequence:

>654_bases
ATGGCGCTTCAACTTCGGGTATATGTTCCTCCTCATCCTTTAATTAAGCATTGGTTGGCGGTGGCCCGCGATCGGAATAC
ACCAGGGGTAATGTTTCGGACGGCGATGACGGAGCTAGGTCGATGGCTGACTTACGAAGCCATGCGGGAATGGTTCCCTT
TAGTAGAAACAACAGTTGAGACACCTTTAGGTCCTGCTGCCGCTGCTGTGATCAATCCTGAACTACCCGTTGCAGTGGTA
CCGATTCTCAGAGCTGGACTGACCTTGCTAGAAGGCGCACAAAGTGTCATCCCTAGAGCCGCCACCTACCACTTGGGTTT
AGCGCGCGATGAAGAAACCCTGCAACCTCACTGTTATTTGAATAAACTTCCAGATCAGTTTCTGCCCCAAACTCGCATCT
TGATCACAGAACCGATGCTAGCCACGGGCGGGTCGATTATGACCACCATGCAGGAACTTACCCAACGCCAAGCCAATCCA
GAGTTGGTTCGGATTATCTCAGTCGTGGCAGCGCCCCCAGCGCTGAAGGAATTGGGTGAAAACTACCCGAGTTTACAAAT
CTATACTGCGACGATTGATGAAGGCTTGAATGAACAAGGGTTCATTGTTCCTGGGTTAGGAGATGCGGGCGATCGCGCTT
TTGAAACTGTTTAG

Upstream 100 bases:

>100_bases
GGTGTCTGTGTTTCGACACCGATGGCAAGGGATTAAACGGCGTATGATAGGTCAGGTTCAAGAACGAACTGCTTTGCTCC
TAACCTGCTTCAGTAACCAT

Downstream 100 bases:

>100_bases
GTGAATTTAGATGATGTCGGCTATCCCCATGGTGGTGGATTGCCGATCCTCTTGAACGGCAATCTCACAATCTCACCGTA
TACCCTGACTACAAAACATC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MALQLRVYVPPHPLIKHWLAVARDRNTPGVMFRTAMTELGRWLTYEAMREWFPLVETTVETPLGPAAAAVINPELPVAVV
PILRAGLTLLEGAQSVIPRAATYHLGLARDEETLQPHCYLNKLPDQFLPQTRILITEPMLATGGSIMTTMQELTQRQANP
ELVRIISVVAAPPALKELGENYPSLQIYTATIDEGLNEQGFIVPGLGDAGDRAFETV

Sequences:

>Translated_217_residues
MALQLRVYVPPHPLIKHWLAVARDRNTPGVMFRTAMTELGRWLTYEAMREWFPLVETTVETPLGPAAAAVINPELPVAVV
PILRAGLTLLEGAQSVIPRAATYHLGLARDEETLQPHCYLNKLPDQFLPQTRILITEPMLATGGSIMTTMQELTQRQANP
ELVRIISVVAAPPALKELGENYPSLQIYTATIDEGLNEQGFIVPGLGDAGDRAFETV
>Mature_216_residues
ALQLRVYVPPHPLIKHWLAVARDRNTPGVMFRTAMTELGRWLTYEAMREWFPLVETTVETPLGPAAAAVINPELPVAVVP
ILRAGLTLLEGAQSVIPRAATYHLGLARDEETLQPHCYLNKLPDQFLPQTRILITEPMLATGGSIMTTMQELTQRQANPE
LVRIISVVAAPPALKELGENYPSLQIYTATIDEGLNEQGFIVPGLGDAGDRAFETV

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=204, Percent_Identity=23.0392156862745, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI57863312, Length=204, Percent_Identity=23.0392156862745, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87082118, Length=212, Percent_Identity=39.1509433962264, Blast_Score=152, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17539892, Length=204, Percent_Identity=21.5686274509804, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17539894, Length=204, Percent_Identity=21.5686274509804, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321920, Length=194, Percent_Identity=28.3505154639175, Blast_Score=93, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45550449, Length=206, Percent_Identity=26.6990291262136, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573516, Length=206, Percent_Identity=26.6990291262136, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573514, Length=206, Percent_Identity=26.6990291262136, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573512, Length=206, Percent_Identity=26.6990291262136, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23886; Mature: 23755

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALQLRVYVPPHPLIKHWLAVARDRNTPGVMFRTAMTELGRWLTYEAMREWFPLVETTVE
CEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPLGPAAAAVINPELPVAVVPILRAGLTLLEGAQSVIPRAATYHLGLARDEETLQPHCYL
CCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCCHHHCCCHHHH
NKLPDQFLPQTRILITEPMLATGGSIMTTMQELTQRQANPELVRIISVVAAPPALKELGE
HCCCHHHCCCCEEEEECCHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHCC
NYPSLQIYTATIDEGLNEQGFIVPGLGDAGDRAFETV
CCCCEEEEEEEHHCCCCCCCEEECCCCCCCCHHHCCC
>Mature Secondary Structure 
ALQLRVYVPPHPLIKHWLAVARDRNTPGVMFRTAMTELGRWLTYEAMREWFPLVETTVE
EEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPLGPAAAAVINPELPVAVVPILRAGLTLLEGAQSVIPRAATYHLGLARDEETLQPHCYL
CCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCCHHHCCCHHHH
NKLPDQFLPQTRILITEPMLATGGSIMTTMQELTQRQANPELVRIISVVAAPPALKELGE
HCCCHHHCCCCEEEEECCHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHCC
NYPSLQIYTATIDEGLNEQGFIVPGLGDAGDRAFETV
CCCCEEEEEEEHHCCCCCCCEEECCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]