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The map label for this gene is degU [H]

Identifier: 158334639

GI number: 158334639

Start: 1457610

End: 1458278

Strand: Direct

Name: degU [H]

Synonym: AM1_1469

Alternate gene names: 158334639

Gene position: 1457610-1458278 (Clockwise)

Preceding gene: 158334638

Following gene: 158334640

Centisome position: 22.41

GC content: 48.73

Gene sequence:

>669_bases
ATGTCTGAGCAACCGATTCACTTACTCCTCGTAGAAGACCATGCCCTGATGCGGATGGGGCTAAAAGGGCAATTTAGTTT
AGAGTCCGATTTTGAAGTGATCGGCGAGGCCGAAAATGGTCAACAGGCGATTGACTTAGCGGCACAGCTTCAACCCAATA
TCGTCCTGATGGATATTGAACTGCCTATTTTGGATGGCATCTCTGCCACCCAAAAAATTAAAGCGACCTGCCCAGATATC
CGAGTTCTGGCCCTAAGCGCCTTTGGTAAAGACAATCAAGTGGTCGGCATGCTCGCCGCTGGGGCTGATGGGTACTGCTT
AAAAAGTATTGATTGGCAGCAATTACTAGCCGTCATTCGCTTAATTCAAGGGGGAGGGACCTACTTAGATCCTCAAATCG
CCCATAAGCTAGCCTCCATGCTAAAGTCTGCAAACACCCCCACAACCGCACCTGCCCATCGACAAACTGCTCCGGCAACC
GTACTTAGTGATCGAGAGCGAGAAGTTCTGCAGTTAATCAGTGAAGGCTGCTCCAATCAAGAAATTGCCAACCAGCTGTA
TCTATCCCTCGGAACCATCAAGTCCTATGTACGGATGATTTTGAATAAGTTAAGCGTGGATGACCGGGTTCAAGCTGCAG
CAAAAGCCGTTCGAGAAGGGTTGATCTAA

Upstream 100 bases:

>100_bases
GGTAGAAAGCACCATCGGTCAGGGCGCGACGTTCTGGTTCTCGCTGCCTATCGAGGCTTCACCATCACTCAACGGTACGG
CCTAAACCCAAGAGGTTATC

Downstream 100 bases:

>100_bases
CTTCATCCAATTAGGCGGATATCCAGGTGGATACTACTGGTCTAGGTGCAAAACTAGTCAGTAGATAGTAGGCGAAAAAA
TCAGCGTTCGGCAAACTGTA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MSEQPIHLLLVEDHALMRMGLKGQFSLESDFEVIGEAENGQQAIDLAAQLQPNIVLMDIELPILDGISATQKIKATCPDI
RVLALSAFGKDNQVVGMLAAGADGYCLKSIDWQQLLAVIRLIQGGGTYLDPQIAHKLASMLKSANTPTTAPAHRQTAPAT
VLSDREREVLQLISEGCSNQEIANQLYLSLGTIKSYVRMILNKLSVDDRVQAAAKAVREGLI

Sequences:

>Translated_222_residues
MSEQPIHLLLVEDHALMRMGLKGQFSLESDFEVIGEAENGQQAIDLAAQLQPNIVLMDIELPILDGISATQKIKATCPDI
RVLALSAFGKDNQVVGMLAAGADGYCLKSIDWQQLLAVIRLIQGGGTYLDPQIAHKLASMLKSANTPTTAPAHRQTAPAT
VLSDREREVLQLISEGCSNQEIANQLYLSLGTIKSYVRMILNKLSVDDRVQAAAKAVREGLI
>Mature_221_residues
SEQPIHLLLVEDHALMRMGLKGQFSLESDFEVIGEAENGQQAIDLAAQLQPNIVLMDIELPILDGISATQKIKATCPDIR
VLALSAFGKDNQVVGMLAAGADGYCLKSIDWQQLLAVIRLIQGGGTYLDPQIAHKLASMLKSANTPTTAPAHRQTAPATV
LSDREREVLQLISEGCSNQEIANQLYLSLGTIKSYVRMILNKLSVDDRVQAAAKAVREGLI

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=217, Percent_Identity=30.4147465437788, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1787473, Length=212, Percent_Identity=33.9622641509434, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788521, Length=210, Percent_Identity=30.952380952381, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1786747, Length=208, Percent_Identity=25.9615384615385, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790102, Length=210, Percent_Identity=28.0952380952381, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788712, Length=198, Percent_Identity=23.2323232323232, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24044; Mature: 23913

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQPIHLLLVEDHALMRMGLKGQFSLESDFEVIGEAENGQQAIDLAAQLQPNIVLMDIE
CCCCCEEEEEECCHHHHHHCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHCCCCEEEEEEC
LPILDGISATQKIKATCPDIRVLALSAFGKDNQVVGMLAAGADGYCLKSIDWQQLLAVIR
CCHHCCCCHHHHHHCCCCCEEEEEEECCCCCCCEEEEEECCCCCCEECCCCHHHHHHHHH
LIQGGGTYLDPQIAHKLASMLKSANTPTTAPAHRQTAPATVLSDREREVLQLISEGCSNQ
HHHCCCCEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCH
EIANQLYLSLGTIKSYVRMILNKLSVDDRVQAAAKAVREGLI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEQPIHLLLVEDHALMRMGLKGQFSLESDFEVIGEAENGQQAIDLAAQLQPNIVLMDIE
CCCCEEEEEECCHHHHHHCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHCCCCEEEEEEC
LPILDGISATQKIKATCPDIRVLALSAFGKDNQVVGMLAAGADGYCLKSIDWQQLLAVIR
CCHHCCCCHHHHHHCCCCCEEEEEEECCCCCCCEEEEEECCCCCCEECCCCHHHHHHHHH
LIQGGGTYLDPQIAHKLASMLKSANTPTTAPAHRQTAPATVLSDREREVLQLISEGCSNQ
HHHCCCCEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCH
EIANQLYLSLGTIKSYVRMILNKLSVDDRVQAAAKAVREGLI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]