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The map label for this gene is sasA [H]

Identifier: 158334638

GI number: 158334638

Start: 1456104

End: 1457594

Strand: Direct

Name: sasA [H]

Synonym: AM1_1468

Alternate gene names: 158334638

Gene position: 1456104-1457594 (Clockwise)

Preceding gene: 158334631

Following gene: 158334639

Centisome position: 22.39

GC content: 47.35

Gene sequence:

>1491_bases
ATGGTTTCCTTTTTAAAAAAGCGATTATTTGCACCGTTATACGTCAGTTTGACGGTGCTTATTTTGCTGTTACTAACCCA
AGAAGGGTTAAGCTTAGTCGTCAATATTCAGAAGCAACGCAACGTCAACCGTATCACCCAAACCTTCAAAATTAAGCGAG
AAAGTGAGCGTTTACTTAGAGCCGCTCTAGAAGAAAAAGTGGCCCTTCGTGGATACTTGCTCAACAAAGATAAAGAATTT
CTCCAACAGTATCGAGATGGTCGAACTGCTTTTAGCACCAGCCTAGATCGCTTATCCAATCTCCTCCAAGATGATCCGTC
TCTCAAGGATAATTTAGGCGACATTTACACCTTCCATTCCCAATGGGAAGATCAATTTGTGCAGCCCGTCTTGTCCGGCT
CCTTTGAACTTGAGGACTTATCCCAGCTGGGGTCATTGGATACGTTACGAGGCACGATTGATGGCATTTTGCTGTACGAA
AAGGGACTTTTAAACGCACAAAATAGGCGGCTAGCCCACTTGGAATGGCTCAATCAGCTGAGTTTCGTATTGAGTGGTCT
CAGCATTGGCGTGATTACGATTGGCAGTGTTGGCAACTTTGGACTCCTGCGCCGTCGAATGGTTTCTCCGATTCAACACC
TGATGAAAGTCGGTCAAGCCTGGAAAACAGGTCAACTCGAGGTCCAAATCACCCATACCTCAGAAGATGAAATGGGCCAA
CTCGCCATCATTCTCAATGATATGGCCCAAGATATTCGCAATCGACAAGAAAAGATTCAGCAACGAAACCAACAGCTTGA
AGATTTAATCCGCACCTTCTCCCATGATTTACGTACCCCATTACTCGCCAATCGCAGTACCTTACATGCCATGGTCGGCG
GGGCTTTTGGCGACGTTAGTGACTCCTTCAAAGAGATATTGGGGGAATCTCAAGACGCCAATGACAACCTGATTAAGCTG
GTGGAAACCCTGCTCGATATTAGTCGCTACGAAGCCGAGGGAAGTCGTATCCTCAATCGAGAGCGGTTGAATTGGCATAA
GATTTGCGATCGCGTCACCCTTTGGATTCAGCAAAGCACCCAAGACAGATGTCACTTAAAAACTGATATTAAATCCAACT
TGCCTGATGCGATTGGGGATGCCATTGAAATTCAACGGGTTCTCCTTAATTTGGTCGAAAATGCCGTACGCTTAAGCGAC
CAGGGCAAAACCATTCGGATCGAGGTCCTGTCATCCCAACCTAGCCAGGTTCAAGTTGCCGTCCGTGATCACGGGCCGGG
GCTGAAGGAGAAAGATGCGAAACACTTATTTCGACGATTTTCTCAAGGAACCGGTCGCCAAGGTCGAGCGGGGTTGGGAC
TGTACCTTTGTCGTCAAATTATTGAAGCTCATGGAGGGAAGATTTGGGTAGAAAGCACCATCGGTCAGGGCGCGACGTTC
TGGTTCTCGCTGCCTATCGAGGCTTCACCATCACTCAACGGTACGGCCTAA

Upstream 100 bases:

>100_bases
TGGGGGGAAACCTAAGAGGATTAACCCCTGTTTCAGATCACAGCAAAGCCCTGTAAATTGTCTGTAAGTCACGGGTTGGG
CAGTTGCTAAGACGATTGAA

Downstream 100 bases:

>100_bases
ACCCAAGAGGTTATCATGTCTGAGCAACCGATTCACTTACTCCTCGTAGAAGACCATGCCCTGATGCGGATGGGGCTAAA
AGGGCAATTTAGTTTAGAGT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MVSFLKKRLFAPLYVSLTVLILLLLTQEGLSLVVNIQKQRNVNRITQTFKIKRESERLLRAALEEKVALRGYLLNKDKEF
LQQYRDGRTAFSTSLDRLSNLLQDDPSLKDNLGDIYTFHSQWEDQFVQPVLSGSFELEDLSQLGSLDTLRGTIDGILLYE
KGLLNAQNRRLAHLEWLNQLSFVLSGLSIGVITIGSVGNFGLLRRRMVSPIQHLMKVGQAWKTGQLEVQITHTSEDEMGQ
LAIILNDMAQDIRNRQEKIQQRNQQLEDLIRTFSHDLRTPLLANRSTLHAMVGGAFGDVSDSFKEILGESQDANDNLIKL
VETLLDISRYEAEGSRILNRERLNWHKICDRVTLWIQQSTQDRCHLKTDIKSNLPDAIGDAIEIQRVLLNLVENAVRLSD
QGKTIRIEVLSSQPSQVQVAVRDHGPGLKEKDAKHLFRRFSQGTGRQGRAGLGLYLCRQIIEAHGGKIWVESTIGQGATF
WFSLPIEASPSLNGTA

Sequences:

>Translated_496_residues
MVSFLKKRLFAPLYVSLTVLILLLLTQEGLSLVVNIQKQRNVNRITQTFKIKRESERLLRAALEEKVALRGYLLNKDKEF
LQQYRDGRTAFSTSLDRLSNLLQDDPSLKDNLGDIYTFHSQWEDQFVQPVLSGSFELEDLSQLGSLDTLRGTIDGILLYE
KGLLNAQNRRLAHLEWLNQLSFVLSGLSIGVITIGSVGNFGLLRRRMVSPIQHLMKVGQAWKTGQLEVQITHTSEDEMGQ
LAIILNDMAQDIRNRQEKIQQRNQQLEDLIRTFSHDLRTPLLANRSTLHAMVGGAFGDVSDSFKEILGESQDANDNLIKL
VETLLDISRYEAEGSRILNRERLNWHKICDRVTLWIQQSTQDRCHLKTDIKSNLPDAIGDAIEIQRVLLNLVENAVRLSD
QGKTIRIEVLSSQPSQVQVAVRDHGPGLKEKDAKHLFRRFSQGTGRQGRAGLGLYLCRQIIEAHGGKIWVESTIGQGATF
WFSLPIEASPSLNGTA
>Mature_496_residues
MVSFLKKRLFAPLYVSLTVLILLLLTQEGLSLVVNIQKQRNVNRITQTFKIKRESERLLRAALEEKVALRGYLLNKDKEF
LQQYRDGRTAFSTSLDRLSNLLQDDPSLKDNLGDIYTFHSQWEDQFVQPVLSGSFELEDLSQLGSLDTLRGTIDGILLYE
KGLLNAQNRRLAHLEWLNQLSFVLSGLSIGVITIGSVGNFGLLRRRMVSPIQHLMKVGQAWKTGQLEVQITHTSEDEMGQ
LAIILNDMAQDIRNRQEKIQQRNQQLEDLIRTFSHDLRTPLLANRSTLHAMVGGAFGDVSDSFKEILGESQDANDNLIKL
VETLLDISRYEAEGSRILNRERLNWHKICDRVTLWIQQSTQDRCHLKTDIKSNLPDAIGDAIEIQRVLLNLVENAVRLSD
QGKTIRIEVLSSQPSQVQVAVRDHGPGLKEKDAKHLFRRFSQGTGRQGRAGLGLYLCRQIIEAHGGKIWVESTIGQGATF
WFSLPIEASPSLNGTA

Specific function: May be involved in signal transduction. Participates in the kaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with kaiC. Required for robustness of the circadian rhythm of gene expression an

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=359, Percent_Identity=27.0194986072423, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1788393, Length=291, Percent_Identity=28.8659793814433, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI145693157, Length=245, Percent_Identity=27.3469387755102, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786912, Length=311, Percent_Identity=27.6527331189711, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI87081816, Length=251, Percent_Identity=26.2948207171315, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790300, Length=261, Percent_Identity=29.1187739463602, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788549, Length=259, Percent_Identity=28.957528957529, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788713, Length=239, Percent_Identity=25.5230125523013, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=454, Percent_Identity=23.7885462555066, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787894, Length=331, Percent_Identity=26.8882175226586, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=277, Percent_Identity=25.2707581227437, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790436, Length=242, Percent_Identity=26.4462809917355, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011649
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF07689 KaiB [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56081; Mature: 56081

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSFLKKRLFAPLYVSLTVLILLLLTQEGLSLVVNIQKQRNVNRITQTFKIKRESERLLR
CHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHH
AALEEKVALRGYLLNKDKEFLQQYRDGRTAFSTSLDRLSNLLQDDPSLKDNLGDIYTFHS
HHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHCCCHHEEHHH
QWEDQFVQPVLSGSFELEDLSQLGSLDTLRGTIDGILLYEKGLLNAQNRRLAHLEWLNQL
HHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHH
SFVLSGLSIGVITIGSVGNFGLLRRRMVSPIQHLMKVGQAWKTGQLEVQITHTSEDEMGQ
HHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHH
LAIILNDMAQDIRNRQEKIQQRNQQLEDLIRTFSHDLRTPLLANRSTLHAMVGGAFGDVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHCCCCCCHH
DSFKEILGESQDANDNLIKLVETLLDISRYEAEGSRILNRERLNWHKICDRVTLWIQQST
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHCC
QDRCHLKTDIKSNLPDAIGDAIEIQRVLLNLVENAVRLSDQGKTIRIEVLSSQPSQVQVA
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEE
VRDHGPGLKEKDAKHLFRRFSQGTGRQGRAGLGLYLCRQIIEAHGGKIWVESTIGQGATF
EECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEE
WFSLPIEASPSLNGTA
EEEECCCCCCCCCCCC
>Mature Secondary Structure
MVSFLKKRLFAPLYVSLTVLILLLLTQEGLSLVVNIQKQRNVNRITQTFKIKRESERLLR
CHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHH
AALEEKVALRGYLLNKDKEFLQQYRDGRTAFSTSLDRLSNLLQDDPSLKDNLGDIYTFHS
HHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHCCCHHEEHHH
QWEDQFVQPVLSGSFELEDLSQLGSLDTLRGTIDGILLYEKGLLNAQNRRLAHLEWLNQL
HHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHH
SFVLSGLSIGVITIGSVGNFGLLRRRMVSPIQHLMKVGQAWKTGQLEVQITHTSEDEMGQ
HHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHH
LAIILNDMAQDIRNRQEKIQQRNQQLEDLIRTFSHDLRTPLLANRSTLHAMVGGAFGDVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHCCCCCCHH
DSFKEILGESQDANDNLIKLVETLLDISRYEAEGSRILNRERLNWHKICDRVTLWIQQST
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHCC
QDRCHLKTDIKSNLPDAIGDAIEIQRVLLNLVENAVRLSDQGKTIRIEVLSSQPSQVQVA
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEE
VRDHGPGLKEKDAKHLFRRFSQGTGRQGRAGLGLYLCRQIIEAHGGKIWVESTIGQGATF
EECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEE
WFSLPIEASPSLNGTA
EEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12917486 [H]