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The map label for this gene is serA [H]

Identifier: 158334453

GI number: 158334453

Start: 1263985

End: 1265568

Strand: Direct

Name: serA [H]

Synonym: AM1_1274

Alternate gene names: 158334453

Gene position: 1263985-1265568 (Clockwise)

Preceding gene: 158334452

Following gene: 158334454

Centisome position: 19.43

GC content: 50.25

Gene sequence:

>1584_bases
ATGCCCAAGGTTCTCGTCTCAGATCCAATTGACCCCTCTGGTATTGACCTTTTAGGTCAAGTTGCCCAGGTCGATGTAAA
GACCAAGCTTTCTCCTGAAGAATTAATCCAAATTATTCCTGAGTACGATGCCCTGATGATTCGGTCGGGCACTCAAGTTA
CAGAAGCAGTGATTGAAGCCGCCACCCAGCTCAAAATTATTGGTCGAGCTGGTGTGGGTGTCGATAATGTGGATGTGCCC
ACAGCCACCAAAAAAGGGATTGTAGTGGTTAACTCTCCAGAGGGTAACACCATCGCCGCCGCAGAACATGCTTTAGCCTT
AATGCTGTCCCTCTCTCGCCATATTCCCGATGCCAACCAGTCCGTTAAAGCGGGCAAATGGGAACGCAAAAAGTTTACCG
GCGTAGAAGTCTATAAAAAGACCCTGGGTGTTGTTGGACTGGGCAAAATCGGTTCCCATGTGGCCACCGTTGCCCGGGCA
ATGGGAATGAAGCTGCTAGCCTACGACCCTTTCTTATCCCAAGAACGGGCAGAGCAGTTAGGCTGCAGACTAGTGGAGTT
AGATTTTTTATTCCAAGAATCGGACTACATCACCTTACATCTCCCCAAAACACCAGAAACCCAGAACTTAGTCAATGCTG
AGACCCTCGGCAAAATGAAGTCCACCGCCCGCATTATCAACTGCGCTCGTGGCGGCATCATTGATGAAGACGCCCTAGGC
AAAGCCCTAGAATCCGGGCAAATCGCTGCTGCAGCCTTGGATGTCTATGCCAGCGAACCCCTAGGAGACTCTCCTCTATG
TCATCTAGAGCAAGACATCATCTTGACCCCCCACCTAGGAGCCTCAACAGAAGAAGCTCAAACTAACGTAGCAGTTGACG
TCGCCGAGCAAATTCGCGATGTGCTTTTAGGACTACCAGCCCGGTCAGCTGTAAACATTCCTGGCTTACGTCCCGACGTA
CTGGAAAAACTCAAGCCATACATGCTCCTAGCCGAGACCTTGGGCAATCTAGTCGGTCAATTAGCGGGGGGCCGGATAGA
ATCCCTAGATGTCCGTCTCCAAGGAGAACTGGCCTCCAACGATAGTCAACCGATTGTTGTCGCAGCCCTCAAAGGACTGT
TATCCCCAGCATTGCGAGAGCGTGTGAACTATGTGAATGCCGGCATTGAAGCCAAAGATCGTGGGATTCGCGTCGTGGAG
ACTCGTGATGCTTCGGTTCGGGATTATTCCGGGTCTATTCAACTTTCTGCCAAAGGCCCCTCTGAAACTCGCTCAGTAAC
GGGTGCCATTCTAGGGGAGGACGAGCTGCGCATTACCAATATTGATGACTTTCCAATCAATGTGGTCCCTACCCGGCACA
TGTTGTTGACAGTACACCGAGATATGCCCGGTATTATTGGCCAAATTGGCTCCCAGTTAGGTAGCTTTAACGTCAATATC
GCCAGTATGCAAGTAGGCCGCAAGATGGTTCGAGGCTCGGCTGTGATGGTTCTTAGCCTAGATGATCCCTTACCCGAAGG
AGTACTGTCTGAAATCACGAATGTAGAAGGCATTCGTGATGCCTATATTGTGAATTTACAATAA

Upstream 100 bases:

>100_bases
TTCTTCCCTCGGGGTTCTTGTAGAATGGCGAACTGAGGTGTCAGAAACTGATTAATTCCGTTCTGCTCATCGCTGTGAAC
TTTCATTCTCCTTTCCTGTT

Downstream 100 bases:

>100_bases
TGGCCGATCCAGGCATCCACACTCCGTCGGACACTCCTACGGCTTTACCCCCTAGCCAATGGTGGGAAATTAAAGTTGTG
GGAGTGCCACTGCTAGATGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MPKVLVSDPIDPSGIDLLGQVAQVDVKTKLSPEELIQIIPEYDALMIRSGTQVTEAVIEAATQLKIIGRAGVGVDNVDVP
TATKKGIVVVNSPEGNTIAAAEHALALMLSLSRHIPDANQSVKAGKWERKKFTGVEVYKKTLGVVGLGKIGSHVATVARA
MGMKLLAYDPFLSQERAEQLGCRLVELDFLFQESDYITLHLPKTPETQNLVNAETLGKMKSTARIINCARGGIIDEDALG
KALESGQIAAAALDVYASEPLGDSPLCHLEQDIILTPHLGASTEEAQTNVAVDVAEQIRDVLLGLPARSAVNIPGLRPDV
LEKLKPYMLLAETLGNLVGQLAGGRIESLDVRLQGELASNDSQPIVVAALKGLLSPALRERVNYVNAGIEAKDRGIRVVE
TRDASVRDYSGSIQLSAKGPSETRSVTGAILGEDELRITNIDDFPINVVPTRHMLLTVHRDMPGIIGQIGSQLGSFNVNI
ASMQVGRKMVRGSAVMVLSLDDPLPEGVLSEITNVEGIRDAYIVNLQ

Sequences:

>Translated_527_residues
MPKVLVSDPIDPSGIDLLGQVAQVDVKTKLSPEELIQIIPEYDALMIRSGTQVTEAVIEAATQLKIIGRAGVGVDNVDVP
TATKKGIVVVNSPEGNTIAAAEHALALMLSLSRHIPDANQSVKAGKWERKKFTGVEVYKKTLGVVGLGKIGSHVATVARA
MGMKLLAYDPFLSQERAEQLGCRLVELDFLFQESDYITLHLPKTPETQNLVNAETLGKMKSTARIINCARGGIIDEDALG
KALESGQIAAAALDVYASEPLGDSPLCHLEQDIILTPHLGASTEEAQTNVAVDVAEQIRDVLLGLPARSAVNIPGLRPDV
LEKLKPYMLLAETLGNLVGQLAGGRIESLDVRLQGELASNDSQPIVVAALKGLLSPALRERVNYVNAGIEAKDRGIRVVE
TRDASVRDYSGSIQLSAKGPSETRSVTGAILGEDELRITNIDDFPINVVPTRHMLLTVHRDMPGIIGQIGSQLGSFNVNI
ASMQVGRKMVRGSAVMVLSLDDPLPEGVLSEITNVEGIRDAYIVNLQ
>Mature_526_residues
PKVLVSDPIDPSGIDLLGQVAQVDVKTKLSPEELIQIIPEYDALMIRSGTQVTEAVIEAATQLKIIGRAGVGVDNVDVPT
ATKKGIVVVNSPEGNTIAAAEHALALMLSLSRHIPDANQSVKAGKWERKKFTGVEVYKKTLGVVGLGKIGSHVATVARAM
GMKLLAYDPFLSQERAEQLGCRLVELDFLFQESDYITLHLPKTPETQNLVNAETLGKMKSTARIINCARGGIIDEDALGK
ALESGQIAAAALDVYASEPLGDSPLCHLEQDIILTPHLGASTEEAQTNVAVDVAEQIRDVLLGLPARSAVNIPGLRPDVL
EKLKPYMLLAETLGNLVGQLAGGRIESLDVRLQGELASNDSQPIVVAALKGLLSPALRERVNYVNAGIEAKDRGIRVVET
RDASVRDYSGSIQLSAKGPSETRSVTGAILGEDELRITNIDDFPINVVPTRHMLLTVHRDMPGIIGQIGSQLGSFNVNIA
SMQVGRKMVRGSAVMVLSLDDPLPEGVLSEITNVEGIRDAYIVNLQ

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:
GO:0004617: D-3-phosphoglycerate dehydrogenase
GO:0005488: D-3-phosphoglycerate dehydrogenase
GO:0006564: D-3-phosphoglycerate dehydrogenase
GO:0008152: D-3-phosphoglycerate dehydrogenase
GO:0016616: D-3-phosphoglycerate dehydrogenase
GO:0048037: D-3-phosphoglycerate dehydrogenase
GO:0051287: D-3-phosphoglycerate dehydrogenase
GO:0055114: D-3-phosphoglycerate dehydrogenase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=403, Percent_Identity=43.1761786600496, Blast_Score=311, Evalue=7e-85,
Organism=Homo sapiens, GI4557497, Length=277, Percent_Identity=35.3790613718412, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI61743967, Length=277, Percent_Identity=35.3790613718412, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI6912396, Length=300, Percent_Identity=32, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI145580578, Length=313, Percent_Identity=31.629392971246, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4557499, Length=313, Percent_Identity=31.629392971246, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI145580575, Length=302, Percent_Identity=31.4569536423841, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI1789279, Length=295, Percent_Identity=36.271186440678, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI87082289, Length=319, Percent_Identity=34.7962382445141, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1787645, Length=244, Percent_Identity=35.2459016393443, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1788660, Length=299, Percent_Identity=29.7658862876254, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87081824, Length=191, Percent_Identity=30.3664921465969, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=46.2732919254658, Blast_Score=277, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI25147481, Length=300, Percent_Identity=30.3333333333333, Blast_Score=135, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6320925, Length=329, Percent_Identity=36.4741641337386, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6322116, Length=328, Percent_Identity=35.6707317073171, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324055, Length=284, Percent_Identity=29.2253521126761, Blast_Score=123, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6324964, Length=294, Percent_Identity=27.891156462585, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=113, Percent_Identity=32.7433628318584, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=47, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24646446, Length=291, Percent_Identity=35.0515463917526, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646448, Length=291, Percent_Identity=35.0515463917526, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646452, Length=291, Percent_Identity=35.0515463917526, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646450, Length=291, Percent_Identity=35.0515463917526, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI62472511, Length=291, Percent_Identity=35.0515463917526, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI28571528, Length=314, Percent_Identity=35.3503184713376, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI28574286, Length=315, Percent_Identity=31.1111111111111, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45551003, Length=317, Percent_Identity=29.9684542586751, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI28574284, Length=317, Percent_Identity=29.9684542586751, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24585514, Length=317, Percent_Identity=29.9684542586751, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI28574282, Length=317, Percent_Identity=29.9684542586751, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI45552429, Length=317, Percent_Identity=29.9684542586751, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24585516, Length=313, Percent_Identity=28.4345047923323, Blast_Score=130, Evalue=3e-30,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56354; Mature: 56222

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3 ; PS00287 CYSTATIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVLVSDPIDPSGIDLLGQVAQVDVKTKLSPEELIQIIPEYDALMIRSGTQVTEAVIEA
CCCCEECCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHH
ATQLKIIGRAGVGVDNVDVPTATKKGIVVVNSPEGNTIAAAEHALALMLSLSRHIPDANQ
HHHEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCC
SVKAGKWERKKFTGVEVYKKTLGVVGLGKIGSHVATVARAMGMKLLAYDPFLSQERAEQL
CCCCCCCCCHHCCHHHHHHHHHCEEECCHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
GCRLVELDFLFQESDYITLHLPKTPETQNLVNAETLGKMKSTARIINCARGGIIDEDALG
CCEEEEEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KALESGQIAAAALDVYASEPLGDSPLCHLEQDIILTPHLGASTEEAQTNVAVDVAEQIRD
HHHHCCCEEEEEEHHHHCCCCCCCCCEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
VLLGLPARSAVNIPGLRPDVLEKLKPYMLLAETLGNLVGQLAGGRIESLDVRLQGELASN
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCC
DSQPIVVAALKGLLSPALRERVNYVNAGIEAKDRGIRVVETRDASVRDYSGSIQLSAKGP
CCCCCHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEECCCEEEEEECCC
SETRSVTGAILGEDELRITNIDDFPINVVPTRHMLLTVHRDMPGIIGQIGSQLGSFNVNI
CCHHHHEEEEECCCCEEEEECCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHCCCCEEE
ASMQVGRKMVRGSAVMVLSLDDPLPEGVLSEITNVEGIRDAYIVNLQ
HHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure 
PKVLVSDPIDPSGIDLLGQVAQVDVKTKLSPEELIQIIPEYDALMIRSGTQVTEAVIEA
CCCEECCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHH
ATQLKIIGRAGVGVDNVDVPTATKKGIVVVNSPEGNTIAAAEHALALMLSLSRHIPDANQ
HHHEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCC
SVKAGKWERKKFTGVEVYKKTLGVVGLGKIGSHVATVARAMGMKLLAYDPFLSQERAEQL
CCCCCCCCCHHCCHHHHHHHHHCEEECCHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
GCRLVELDFLFQESDYITLHLPKTPETQNLVNAETLGKMKSTARIINCARGGIIDEDALG
CCEEEEEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KALESGQIAAAALDVYASEPLGDSPLCHLEQDIILTPHLGASTEEAQTNVAVDVAEQIRD
HHHHCCCEEEEEEHHHHCCCCCCCCCEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
VLLGLPARSAVNIPGLRPDVLEKLKPYMLLAETLGNLVGQLAGGRIESLDVRLQGELASN
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCC
DSQPIVVAALKGLLSPALRERVNYVNAGIEAKDRGIRVVETRDASVRDYSGSIQLSAKGP
CCCCCHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEECCCEEEEEECCC
SETRSVTGAILGEDELRITNIDDFPINVVPTRHMLLTVHRDMPGIIGQIGSQLGSFNVNI
CCHHHHEEEEECCCCEEEEECCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHCCCCEEE
ASMQVGRKMVRGSAVMVLSLDDPLPEGVLSEITNVEGIRDAYIVNLQ
HHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]