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The map label for this gene is livH [H]

Identifier: 158334049

GI number: 158334049

Start: 840952

End: 842112

Strand: Reverse

Name: livH [H]

Synonym: AM1_0863

Alternate gene names: 158334049

Gene position: 842112-840952 (Counterclockwise)

Preceding gene: 158334050

Following gene: 158334048

Centisome position: 12.95

GC content: 50.04

Gene sequence:

>1161_bases
TTGCTCACTTCGTTATTGGACGGTTTGTTTGATGGCATCAGCATAGGCTCAGTGTTGCTGTTAGCAGCATTGGGCCTTGC
CATTGTTTTTGGCCTAATGGGTGTGATCAACATGGCCCATGGGGAGTTGATGATGATTGGTGCCTATACAACCTTCGTGG
TCCAGAATGCCTTTAAATCCTTCGGTCAACCCTGGTTCGGTGCCTACATTTTTGTGGCATTGATCTGCGCTTTTTTCGTC
ACCGCGTTGTTGGGGCTCATTCTTGAAAAAGGAGTGATTCGCCATCTCTATGGCAGGCCCCTAGAGACACTCCTAGCGAC
CTGGGGCGTCAGCTTAATTCTGCGACAGTTTGTGCGGAGTGTGAGCTGGGTGATGGTGCTAGGGATAGGTGTGTTTTGCA
TCCTTTACTTTGGGGCAATGACCCTTATTTCCCGAATGCCAAATGTTGAGAAAATTAAGGGTTGGGCACGGACTGTTTTA
ATCCCTCTTTCTGCGGGGATCGCCTGGACAGCCGGTAGCATGTTGGGACAAACCTATCAGCTAGCAGCCACCAAACCTTG
GTTTGGTGCCCAAAATGTCGATGTCACTGCGCCAGGTTGGCTACGAAAGGGGATCAAGCTAGGCACCTATCAATTGCCTT
ATGTTCGCCTGTTTATCCTGGTGTTGACGATTGTTTGCATCATTGGCATGTATATGTTTTTACAACGCTCGGCTTGGGGA
TTGCGGATTCGAGCAGTGACCCAAAATCGGAGTATGAGCGCTTGTTTAGGCATTCCCACCAAGCGAGTGGACGCCCTCAC
TTTTGCATTGGGGTCAGGCTTAGCAGGGGTTGCGGGCTGTGCCGTGAGTTTATTAGGCTCCGTTGGCCCTAATACCGGTC
AGAATTATATTGTGGACACCTTTATGGTTGTCGTTGTTGGAGGGGTAGGCAAGCTGGTCGGCAGCATTGTCGCGGCAATG
GCGATTGGCATCGCCAATTATATGATTGGTGCTAATGCCCTCAGTCCGCTAGTAGCCTGGTTTCCTCAGCTGGCTAGTGT
TTTTGAGTTCTTCGCCAACGCTAGTATGGCGAAAGTGCTGGTCTTTGCACTGATTGTCACGTTCTTGCAATTCCGACCTG
CTGGCATATTCCCTCAAAAAGGACGCATGGTAGATGCTTAA

Upstream 100 bases:

>100_bases
GGATATGCCTGTGATTGGTCTGATCCCAATAAAGGCGAGAAATACAAGATCTAAACCTCGCCTAACGTTATCAACAACCC
TGTCACCATAAGGAGATGCT

Downstream 100 bases:

>100_bases
AAGCAGCATATGATTACAGATTCTTCTCCCGTCAAGTCCTCATTTGCCATGCGCCGACGCTCTTTATTGATCGAAGGGGT
GATCGTGGTTGCGATCGCGC

Product: urea/ branched-chain amino acid ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MLTSLLDGLFDGISIGSVLLLAALGLAIVFGLMGVINMAHGELMMIGAYTTFVVQNAFKSFGQPWFGAYIFVALICAFFV
TALLGLILEKGVIRHLYGRPLETLLATWGVSLILRQFVRSVSWVMVLGIGVFCILYFGAMTLISRMPNVEKIKGWARTVL
IPLSAGIAWTAGSMLGQTYQLAATKPWFGAQNVDVTAPGWLRKGIKLGTYQLPYVRLFILVLTIVCIIGMYMFLQRSAWG
LRIRAVTQNRSMSACLGIPTKRVDALTFALGSGLAGVAGCAVSLLGSVGPNTGQNYIVDTFMVVVVGGVGKLVGSIVAAM
AIGIANYMIGANALSPLVAWFPQLASVFEFFANASMAKVLVFALIVTFLQFRPAGIFPQKGRMVDA

Sequences:

>Translated_386_residues
MLTSLLDGLFDGISIGSVLLLAALGLAIVFGLMGVINMAHGELMMIGAYTTFVVQNAFKSFGQPWFGAYIFVALICAFFV
TALLGLILEKGVIRHLYGRPLETLLATWGVSLILRQFVRSVSWVMVLGIGVFCILYFGAMTLISRMPNVEKIKGWARTVL
IPLSAGIAWTAGSMLGQTYQLAATKPWFGAQNVDVTAPGWLRKGIKLGTYQLPYVRLFILVLTIVCIIGMYMFLQRSAWG
LRIRAVTQNRSMSACLGIPTKRVDALTFALGSGLAGVAGCAVSLLGSVGPNTGQNYIVDTFMVVVVGGVGKLVGSIVAAM
AIGIANYMIGANALSPLVAWFPQLASVFEFFANASMAKVLVFALIVTFLQFRPAGIFPQKGRMVDA
>Mature_386_residues
MLTSLLDGLFDGISIGSVLLLAALGLAIVFGLMGVINMAHGELMMIGAYTTFVVQNAFKSFGQPWFGAYIFVALICAFFV
TALLGLILEKGVIRHLYGRPLETLLATWGVSLILRQFVRSVSWVMVLGIGVFCILYFGAMTLISRMPNVEKIKGWARTVL
IPLSAGIAWTAGSMLGQTYQLAATKPWFGAQNVDVTAPGWLRKGIKLGTYQLPYVRLFILVLTIVCIIGMYMFLQRSAWG
LRIRAVTQNRSMSACLGIPTKRVDALTFALGSGLAGVAGCAVSLLGSVGPNTGQNYIVDTFMVVVVGGVGKLVGSIVAAM
AIGIANYMIGANALSPLVAWFPQLASVFEFFANASMAKVLVFALIVTFLQFRPAGIFPQKGRMVDA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=374, Percent_Identity=24.5989304812834, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 41404; Mature: 41404

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSLLDGLFDGISIGSVLLLAALGLAIVFGLMGVINMAHGELMMIGAYTTFVVQNAFKS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHH
FGQPWFGAYIFVALICAFFVTALLGLILEKGVIRHLYGRPLETLLATWGVSLILRQFVRS
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
VSWVMVLGIGVFCILYFGAMTLISRMPNVEKIKGWARTVLIPLSAGIAWTAGSMLGQTYQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEECCCCHHHHHHHHHCCHHE
LAATKPWFGAQNVDVTAPGWLRKGIKLGTYQLPYVRLFILVLTIVCIIGMYMFLQRSAWG
ECCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LRIRAVTQNRSMSACLGIPTKRVDALTFALGSGLAGVAGCAVSLLGSVGPNTGQNYIVDT
EEEEEEECCCCCHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
FMVVVVGGVGKLVGSIVAAMAIGIANYMIGANALSPLVAWFPQLASVFEFFANASMAKVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
VFALIVTFLQFRPAGIFPQKGRMVDA
HHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLTSLLDGLFDGISIGSVLLLAALGLAIVFGLMGVINMAHGELMMIGAYTTFVVQNAFKS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHH
FGQPWFGAYIFVALICAFFVTALLGLILEKGVIRHLYGRPLETLLATWGVSLILRQFVRS
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
VSWVMVLGIGVFCILYFGAMTLISRMPNVEKIKGWARTVLIPLSAGIAWTAGSMLGQTYQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEECCCCHHHHHHHHHCCHHE
LAATKPWFGAQNVDVTAPGWLRKGIKLGTYQLPYVRLFILVLTIVCIIGMYMFLQRSAWG
ECCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LRIRAVTQNRSMSACLGIPTKRVDALTFALGSGLAGVAGCAVSLLGSVGPNTGQNYIVDT
EEEEEEECCCCCHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
FMVVVVGGVGKLVGSIVAAMAIGIANYMIGANALSPLVAWFPQLASVFEFFANASMAKVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
VFALIVTFLQFRPAGIFPQKGRMVDA
HHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]