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The map label for this gene is alr [H]

Identifier: 158334044

GI number: 158334044

Start: 836312

End: 837472

Strand: Direct

Name: alr [H]

Synonym: AM1_0858

Alternate gene names: 158334044

Gene position: 836312-837472 (Clockwise)

Preceding gene: 158334043

Following gene: 158334051

Centisome position: 12.86

GC content: 51.85

Gene sequence:

>1161_bases
ATGGTAAAGCATGCATCCCCTGGGACATTGGCTTGTGAACGCGCTTGGGTCAATATCGATCTTAAAGCGCTCGAAAACAA
TGTTCGCCAAATCAAGCAACAATTGTTGCCCCAAACCGCACTTATGGCTGTGGTCAAAGCCGATGGCTATGGCCATGGTG
CCGTTACGGTTGCCCAAACCGCCTTGGCGAATGGAGCGACTTGGCTGGGGGTTGCCACCATCCTGGAAGGGATTGAACTC
CGCCAAGCCGATATCAATGCGCCGATATTAATCCTCGGGGCCACCCATACTGTTCAAGAAATTGAGGCGATTGTTCGCTG
GCAACTGCAGCCTACCCTCTGTAGTCCAGAACAAGCCCTCATCTTTTCTCGCCATTTACAACATCCATTACCCATTCACC
TCAAAGTGGATACGGGCATGTCTCGATTGGGGCCCATTTGGCAGCAGGGAGCCACCTTCATTGAATTTGTCTCCCGCCTA
CCGAACCTTAAAATTGCCAGTATCTATTCCCATCTCGCCACGGCCGATGATGCAGACTCTAGCTTTATGCTGCAGCAGCA
AAGTCGGTTGCAGGATGTTTTAAGCCGCATCCAAGCTCAAGATATCCCTTTACCTAAACTGCACCTAGCCAACTCAGCCG
GAACCTTAGTCGGCCCTCAATTTCATTACGACTTAGTTCGAGTGGGGCTAGCACTTTACGGACTTTATCCGGCTCCCCAC
TTCCAGCAAGCAATTGCCCTGCAGCCAGTAATGCAAGTGAAGGCTCGAATCACCCAAATCAAAACCCTACCCGCAGGATC
GGGGGTGAGCTATAACCATACCTTCACGACTGAGCAGCCCCTCACTGTCGCAGTCGTTGGCATCGGCTATGCAGATGGGG
TCCCCCGGTCCTTGTCTAACCAGATGAATGTGATTATTCGAGGACGGTTGGCCCCTCAAATCGGTGCTATTACCATGGAC
CAACTGATGGTGGATGTCAGCGATGTTCCCAACTTGCAGGTGGGAGAAGTGGTCACCATCTTAGGCCAGGATGGTAAGGC
TTCAATCTCAGCAGAAACCTGGGCAGACGCTCTGGGTACCATTTCTTACGAGATTGTCTGCGGGTTCAAGCATCGGCTTC
CTCGCATCTTAGTCAATAGCGATGTTCCTCAGCGACTTTGA

Upstream 100 bases:

>100_bases
ACAGGAACAATTAGCGACGGTCGGTTATCAACAATACCTCAAGGACTATCAAGCTGCCTCCTCTGCAGGCTAAGATTCGA
ACAGTGTGCCGGATTCAGGA

Downstream 100 bases:

>100_bases
ACACTAGCTGATAGTCAACCTGGAATACCCTGGGCTTCTAATCTAAGGTGCAAACTGATCCATCGTCACATGTTTAGGAT
GTTGGGAAACACGCCGTAAC

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MVKHASPGTLACERAWVNIDLKALENNVRQIKQQLLPQTALMAVVKADGYGHGAVTVAQTALANGATWLGVATILEGIEL
RQADINAPILILGATHTVQEIEAIVRWQLQPTLCSPEQALIFSRHLQHPLPIHLKVDTGMSRLGPIWQQGATFIEFVSRL
PNLKIASIYSHLATADDADSSFMLQQQSRLQDVLSRIQAQDIPLPKLHLANSAGTLVGPQFHYDLVRVGLALYGLYPAPH
FQQAIALQPVMQVKARITQIKTLPAGSGVSYNHTFTTEQPLTVAVVGIGYADGVPRSLSNQMNVIIRGRLAPQIGAITMD
QLMVDVSDVPNLQVGEVVTILGQDGKASISAETWADALGTISYEIVCGFKHRLPRILVNSDVPQRL

Sequences:

>Translated_386_residues
MVKHASPGTLACERAWVNIDLKALENNVRQIKQQLLPQTALMAVVKADGYGHGAVTVAQTALANGATWLGVATILEGIEL
RQADINAPILILGATHTVQEIEAIVRWQLQPTLCSPEQALIFSRHLQHPLPIHLKVDTGMSRLGPIWQQGATFIEFVSRL
PNLKIASIYSHLATADDADSSFMLQQQSRLQDVLSRIQAQDIPLPKLHLANSAGTLVGPQFHYDLVRVGLALYGLYPAPH
FQQAIALQPVMQVKARITQIKTLPAGSGVSYNHTFTTEQPLTVAVVGIGYADGVPRSLSNQMNVIIRGRLAPQIGAITMD
QLMVDVSDVPNLQVGEVVTILGQDGKASISAETWADALGTISYEIVCGFKHRLPRILVNSDVPQRL
>Mature_386_residues
MVKHASPGTLACERAWVNIDLKALENNVRQIKQQLLPQTALMAVVKADGYGHGAVTVAQTALANGATWLGVATILEGIEL
RQADINAPILILGATHTVQEIEAIVRWQLQPTLCSPEQALIFSRHLQHPLPIHLKVDTGMSRLGPIWQQGATFIEFVSRL
PNLKIASIYSHLATADDADSSFMLQQQSRLQDVLSRIQAQDIPLPKLHLANSAGTLVGPQFHYDLVRVGLALYGLYPAPH
FQQAIALQPVMQVKARITQIKTLPAGSGVSYNHTFTTEQPLTVAVVGIGYADGVPRSLSNQMNVIIRGRLAPQIGAITMD
QLMVDVSDVPNLQVGEVVTILGQDGKASISAETWADALGTISYEIVCGFKHRLPRILVNSDVPQRL

Specific function: Provides the D-alanine required for cell wall biosynthesis [H]

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:
GO:0003824: Alanine racemase
GO:0006522: Alanine racemase
GO:0007047: Alanine racemase
GO:0008360: Alanine racemase
GO:0008784: Alanine racemase
GO:0009252: Alanine racemase
GO:0016853: Alanine racemase
GO:0030170: Alanine racemase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family [H]

Homologues:

Organism=Escherichia coli, GI1787439, Length=374, Percent_Identity=31.8181818181818, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1790487, Length=363, Percent_Identity=28.9256198347107, Blast_Score=153, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622 [H]

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N [H]

EC number: =5.1.1.1 [H]

Molecular weight: Translated: 41910; Mature: 41910

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKHASPGTLACERAWVNIDLKALENNVRQIKQQLLPQTALMAVVKADGYGHGAVTVAQT
CCCCCCCCCEEEEEEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHH
ALANGATWLGVATILEGIELRQADINAPILILGATHTVQEIEAIVRWQLQPTLCSPEQAL
HHHCCCHHHHHHHHHHCHHHEECCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHH
IFSRHLQHPLPIHLKVDTGMSRLGPIWQQGATFIEFVSRLPNLKIASIYSHLATADDADS
HHHHHCCCCCCEEEEECCCHHHHCHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCC
SFMLQQQSRLQDVLSRIQAQDIPLPKLHLANSAGTLVGPQFHYDLVRVGLALYGLYPAPH
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCH
FQQAIALQPVMQVKARITQIKTLPAGSGVSYNHTFTTEQPLTVAVVGIGYADGVPRSLSN
HHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEECCCCCEEEEEEEECCCCCCCHHHCC
QMNVIIRGRLAPQIGAITMDQLMVDVSDVPNLQVGEVVTILGQDGKASISAETWADALGT
CCEEEEEECCCCCCCCEEHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHC
ISYEIVCGFKHRLPRILVNSDVPQRL
EEEEEEECHHHCCCEEEECCCCCCCC
>Mature Secondary Structure
MVKHASPGTLACERAWVNIDLKALENNVRQIKQQLLPQTALMAVVKADGYGHGAVTVAQT
CCCCCCCCCEEEEEEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHH
ALANGATWLGVATILEGIELRQADINAPILILGATHTVQEIEAIVRWQLQPTLCSPEQAL
HHHCCCHHHHHHHHHHCHHHEECCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHH
IFSRHLQHPLPIHLKVDTGMSRLGPIWQQGATFIEFVSRLPNLKIASIYSHLATADDADS
HHHHHCCCCCCEEEEECCCHHHHCHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCC
SFMLQQQSRLQDVLSRIQAQDIPLPKLHLANSAGTLVGPQFHYDLVRVGLALYGLYPAPH
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCH
FQQAIALQPVMQVKARITQIKTLPAGSGVSYNHTFTTEQPLTVAVVGIGYADGVPRSLSN
HHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEECCCCCEEEEEEEECCCCCCCHHHCC
QMNVIIRGRLAPQIGAITMDQLMVDVSDVPNLQVGEVVTILGQDGKASISAETWADALGT
CCEEEEEECCCCCCCCEEHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHC
ISYEIVCGFKHRLPRILVNSDVPQRL
EEEEEEECHHHCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]