Click here to switch to the map view.

The map label for this gene is purE [H]

Identifier: 158334043

GI number: 158334043

Start: 835745

End: 836284

Strand: Direct

Name: purE [H]

Synonym: AM1_0857

Alternate gene names: 158334043

Gene position: 835745-836284 (Clockwise)

Preceding gene: 158334039

Following gene: 158334044

Centisome position: 12.85

GC content: 52.96

Gene sequence:

>540_bases
TTGAGCCATCCTGAAGTTGCCATCATTATGGGCAGTGATTCTGATTTACCGACGATGCAAGCTGCGATCGCAGTCTGCGA
AGACTTCAAAGTCACGCCCCATGTGGAAATCATTTCCGCCCATCGAACCCCTCAACGGATGGTGGAATTTGCCCAACAGG
CCCACCAACAGGGCATAAAAGTGATCATTGCCGGTGCCGGAGGAGCGGCTCATCTACCGGGGATGGTGGCAGCCCTATCT
CCATTACCCGTGATTGGTGTCCCCGTGGCCAGTCGCCACTTAAAAGGATTGGATTCCCTATACTCCATTGTCCAAATGCC
GGGGGGCATTCCCGTGGCCACCGTTGCCATTGGCAATGCCAAAAATGCGGGTCTCTTGGCCATTCAAATATTGGCTGCTC
AGCGCCCAGAACTCCAAGAGCAGGTCATTGCCTATCGTCGCTCCCTCTCAGAAATGGTTCAAGACAAACAGGAACAATTA
GCGACGGTCGGTTATCAACAATACCTCAAGGACTATCAAGCTGCCTCCTCTGCAGGCTAA

Upstream 100 bases:

>100_bases
AAATCCAGATCAAACGTGAGGTTTTTAATTAAAAAACAAGACTTGCTGTTCGTCTTCTCATTTTAACGTTGTCCCTGTTT
TGCAAAGGAAAGAAGATCCC

Downstream 100 bases:

>100_bases
GATTCGAACAGTGTGCCGGATTCAGGAATGGTAAAGCATGCATCCCCTGGGACATTGGCTTGTGAACGCGCTTGGGTCAA
TATCGATCTTAAAGCGCTCG

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MSHPEVAIIMGSDSDLPTMQAAIAVCEDFKVTPHVEIISAHRTPQRMVEFAQQAHQQGIKVIIAGAGGAAHLPGMVAALS
PLPVIGVPVASRHLKGLDSLYSIVQMPGGIPVATVAIGNAKNAGLLAIQILAAQRPELQEQVIAYRRSLSEMVQDKQEQL
ATVGYQQYLKDYQAASSAG

Sequences:

>Translated_179_residues
MSHPEVAIIMGSDSDLPTMQAAIAVCEDFKVTPHVEIISAHRTPQRMVEFAQQAHQQGIKVIIAGAGGAAHLPGMVAALS
PLPVIGVPVASRHLKGLDSLYSIVQMPGGIPVATVAIGNAKNAGLLAIQILAAQRPELQEQVIAYRRSLSEMVQDKQEQL
ATVGYQQYLKDYQAASSAG
>Mature_178_residues
SHPEVAIIMGSDSDLPTMQAAIAVCEDFKVTPHVEIISAHRTPQRMVEFAQQAHQQGIKVIIAGAGGAAHLPGMVAALSP
LPVIGVPVASRHLKGLDSLYSIVQMPGGIPVATVAIGNAKNAGLLAIQILAAQRPELQEQVIAYRRSLSEMVQDKQEQLA
TVGYQQYLKDYQAASSAG

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:
GO:0004638: Phosphoribosylaminoimidazole carboxylase, catalytic subunit
GO:0006189: Phosphoribosylaminoimidazole carboxylase, catalytic subunit

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=111, Percent_Identity=61.2612612612613, Blast_Score=137, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324702, Length=171, Percent_Identity=57.8947368421053, Blast_Score=189, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18942; Mature: 18811

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHPEVAIIMGSDSDLPTMQAAIAVCEDFKVTPHVEIISAHRTPQRMVEFAQQAHQQGIK
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCE
VIIAGAGGAAHLPGMVAALSPLPVIGVPVASRHLKGLDSLYSIVQMPGGIPVATVAIGNA
EEEECCCCCHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
KNAGLLAIQILAAQRPELQEQVIAYRRSLSEMVQDKQEQLATVGYQQYLKDYQAASSAG
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SHPEVAIIMGSDSDLPTMQAAIAVCEDFKVTPHVEIISAHRTPQRMVEFAQQAHQQGIK
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCE
VIIAGAGGAAHLPGMVAALSPLPVIGVPVASRHLKGLDSLYSIVQMPGGIPVATVAIGNA
EEEECCCCCHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
KNAGLLAIQILAAQRPELQEQVIAYRRSLSEMVQDKQEQLATVGYQQYLKDYQAASSAG
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]