Click here to switch to the map view.

The map label for this gene is loxA [H]

Identifier: 158334003

GI number: 158334003

Start: 795165

End: 797183

Strand: Reverse

Name: loxA [H]

Synonym: AM1_0817

Alternate gene names: 158334003

Gene position: 797183-795165 (Counterclockwise)

Preceding gene: 158334004

Following gene: 158334002

Centisome position: 12.26

GC content: 47.5

Gene sequence:

>2019_bases
ATGAATATCTCTCTACCTCAAAATGATTCCAATCCTGTTCAACGGCAAACGGCTTTAGTGGCTGCTCGTCGAGACTATCG
CTATAACTACACTTACCTCCCTAATGGCGGGGCAATGGCCGAGAAAGTGCCCCCACAAGATCAATCCCTTGGCAAATTTC
CTTGGCTTCAAGATGCCTTATCTCTGCTGCTGAGAATAGATGCTAACCAAGCTTTACAAGACGTTAATGAAACAGGTTCT
GTCCGAAAACTCCGCCGATTTGCCTGGCTTACCCGTGTCACCCGTTTCTTGAATAACCCTAAACGTGCTGGCTTTTTGAA
GTTTTTGTTAGCCAAAGTTCTGCCAATTATTCGGTTGGTTCAACGCTTGCAAGATGGCAAACCACCCTCCATTGAGCAAA
ACAGTTCCCAAACCCCCTCGGCCAAAGTGAACGATATCCACCAGCCGTTACTGGAAACATTAATCTCTGAGGTCAAAGAT
CCCCGAGACCATGCTCAAGAGCAGCAGAAGCTCGACCATCAAGCTTTAGCTATGCAGGCTAAGCAAGCCCAAGACAGTTT
GTCAGACTACAGCCAACTCTTTCAAGCCTATAACGATCTGTTTCAGATTATTTATTTGCCTTGTATTAGCCAACAGTTCT
GGACAGATCGAGCCTTTGTCGCCCAGCGAGTTGCGGGAGCGAACCCTTTAGTTCTAGAACAATGCAAGAGATTACCAGAC
CACTTCCCTGTCACTAACGATCAATATCAGGCCGTGATGGGAACTGCTGATTCTCTCCAAAAGGCTGGAGCAGAGGGGCG
ACTTTATATCACTGATTATGCAGTGTTGAACCTATTAGAACCGGGCACTTTTCCGGATGCTCAAAAATATGTCTATGCTC
CCCTCGCCCTGTTTGCAGTACCTGCGGAAGGAAGCGGCTCCCTCACAGCCGTAGCCATTCAGTGCCAGCAGCAGCCAGGC
TCTGATAATCCTATTTTCACTCCACCCCCTGAGGGTAGCCCCCAGTCCGAGCAATGGGCTTGGCTGATGGCAAAAACCAT
CGTTCAAATCGCTGATGGCAATTACCATGAGCTCATTTCTCATCTCGGTCGGACCCACTTATTGATCGAGCCCATTGTAG
TGGCTACCTATCGTCAACTGGCCCCTAATCATCCCCTCAGCGCCTTATTGCGTCCTCATTTTGAAGGAACATTGTTTATT
AATAATGCAGCCATTTCTGGCCTTGTTAATGATGGAGGTACCGTGGATTCAGTGATGTCTGGCACTATTGAATCTTCTAA
AGAGCTCAGCGTTAAAGCCGTACAAGGGTTCCCCTACGGTTTTAATGATTCGATGCTACCCGCCACACTCTCCAGACGGG
GGGTCGATAATGTGGATCAGCTTCCTGACTATCCCTATCGAGATGATGCACTACTCGTTTGGAATGCGATTCACGATTGG
GTTGAGAGCTATCTAGACTTGTATTACCTCAGCGATCAGGATGTGGTAGAGGACACCGAACTCCAAGCTTGGTTAGCAGA
AATGGTCGCTCAAGACGGAGGGCGCATGACAGAAATTGGGGAAACCGCATCGGATCAGGAGCAACCTAGCTTGCGCACTA
AAGCTTACTTGGCAGATATGGTGACGCTCATTATTTTTACAGGGAGTGCCCAACATGCAGCCGTGAACTTCTCCCAATCG
ACTTATATGACCTATATCCCCAACTTGCCTTTAGCGGGATATCGACCCGCGCCAAAGTCAACAAAGGCAACCACTCAAGA
CTATTTCAACCTTCTTCCTTCCCTGAAACAGGCAGAGACCCAGATGGATATGACCTATTTGTTGGGTTCTCTTTACTACA
CCCTATTAGGGGAATATGGAGAAGAGCACTTTACGGATACTAGGGTGCAACCTCTACTCAAAGCATTTCAGCAACAGTTA
GATGCCATTGGCATCATCATTGATGAACGGAACAGTGTTCGCCCAACCTTTTATGATTTCCTACATCCTAATAAAATCCC
TCAGAGTATTAACATCTGA

Upstream 100 bases:

>100_bases
TTTTCGCCATTTTTTTTTAGTTTCTACCTTTTTGAAGTAGCTTTCATCGTTTTCCCCTAAACCTTTTCCCCTCACGCTGT
TGTTAGTCACATTTGGTCTT

Downstream 100 bases:

>100_bases
GTTTGACTTTCTCCAATCAAGGGCTTTGTTCAGATCTGGCCAAAAAAGGGTAACGCCGACCAATCAGGCCATTTCCCAAA
ATGGCTTATCCAGAATTTGT

Product: lipoxygenase

Products: NA

Alternate protein names: 15-LOX [H]

Number of amino acids: Translated: 672; Mature: 672

Protein sequence:

>672_residues
MNISLPQNDSNPVQRQTALVAARRDYRYNYTYLPNGGAMAEKVPPQDQSLGKFPWLQDALSLLLRIDANQALQDVNETGS
VRKLRRFAWLTRVTRFLNNPKRAGFLKFLLAKVLPIIRLVQRLQDGKPPSIEQNSSQTPSAKVNDIHQPLLETLISEVKD
PRDHAQEQQKLDHQALAMQAKQAQDSLSDYSQLFQAYNDLFQIIYLPCISQQFWTDRAFVAQRVAGANPLVLEQCKRLPD
HFPVTNDQYQAVMGTADSLQKAGAEGRLYITDYAVLNLLEPGTFPDAQKYVYAPLALFAVPAEGSGSLTAVAIQCQQQPG
SDNPIFTPPPEGSPQSEQWAWLMAKTIVQIADGNYHELISHLGRTHLLIEPIVVATYRQLAPNHPLSALLRPHFEGTLFI
NNAAISGLVNDGGTVDSVMSGTIESSKELSVKAVQGFPYGFNDSMLPATLSRRGVDNVDQLPDYPYRDDALLVWNAIHDW
VESYLDLYYLSDQDVVEDTELQAWLAEMVAQDGGRMTEIGETASDQEQPSLRTKAYLADMVTLIIFTGSAQHAAVNFSQS
TYMTYIPNLPLAGYRPAPKSTKATTQDYFNLLPSLKQAETQMDMTYLLGSLYYTLLGEYGEEHFTDTRVQPLLKAFQQQL
DAIGIIIDERNSVRPTFYDFLHPNKIPQSINI

Sequences:

>Translated_672_residues
MNISLPQNDSNPVQRQTALVAARRDYRYNYTYLPNGGAMAEKVPPQDQSLGKFPWLQDALSLLLRIDANQALQDVNETGS
VRKLRRFAWLTRVTRFLNNPKRAGFLKFLLAKVLPIIRLVQRLQDGKPPSIEQNSSQTPSAKVNDIHQPLLETLISEVKD
PRDHAQEQQKLDHQALAMQAKQAQDSLSDYSQLFQAYNDLFQIIYLPCISQQFWTDRAFVAQRVAGANPLVLEQCKRLPD
HFPVTNDQYQAVMGTADSLQKAGAEGRLYITDYAVLNLLEPGTFPDAQKYVYAPLALFAVPAEGSGSLTAVAIQCQQQPG
SDNPIFTPPPEGSPQSEQWAWLMAKTIVQIADGNYHELISHLGRTHLLIEPIVVATYRQLAPNHPLSALLRPHFEGTLFI
NNAAISGLVNDGGTVDSVMSGTIESSKELSVKAVQGFPYGFNDSMLPATLSRRGVDNVDQLPDYPYRDDALLVWNAIHDW
VESYLDLYYLSDQDVVEDTELQAWLAEMVAQDGGRMTEIGETASDQEQPSLRTKAYLADMVTLIIFTGSAQHAAVNFSQS
TYMTYIPNLPLAGYRPAPKSTKATTQDYFNLLPSLKQAETQMDMTYLLGSLYYTLLGEYGEEHFTDTRVQPLLKAFQQQL
DAIGIIIDERNSVRPTFYDFLHPNKIPQSINI
>Mature_672_residues
MNISLPQNDSNPVQRQTALVAARRDYRYNYTYLPNGGAMAEKVPPQDQSLGKFPWLQDALSLLLRIDANQALQDVNETGS
VRKLRRFAWLTRVTRFLNNPKRAGFLKFLLAKVLPIIRLVQRLQDGKPPSIEQNSSQTPSAKVNDIHQPLLETLISEVKD
PRDHAQEQQKLDHQALAMQAKQAQDSLSDYSQLFQAYNDLFQIIYLPCISQQFWTDRAFVAQRVAGANPLVLEQCKRLPD
HFPVTNDQYQAVMGTADSLQKAGAEGRLYITDYAVLNLLEPGTFPDAQKYVYAPLALFAVPAEGSGSLTAVAIQCQQQPG
SDNPIFTPPPEGSPQSEQWAWLMAKTIVQIADGNYHELISHLGRTHLLIEPIVVATYRQLAPNHPLSALLRPHFEGTLFI
NNAAISGLVNDGGTVDSVMSGTIESSKELSVKAVQGFPYGFNDSMLPATLSRRGVDNVDQLPDYPYRDDALLVWNAIHDW
VESYLDLYYLSDQDVVEDTELQAWLAEMVAQDGGRMTEIGETASDQEQPSLRTKAYLADMVTLIIFTGSAQHAAVNFSQS
TYMTYIPNLPLAGYRPAPKSTKATTQDYFNLLPSLKQAETQMDMTYLLGSLYYTLLGEYGEEHFTDTRVQPLLKAFQQQL
DAIGIIIDERNSVRPTFYDFLHPNKIPQSINI

Specific function: Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid (HpETE) which is rapidly reduced to hydroxyeicosatetraenoic acid (HETE). Could act on exogenous human-derived substrates to potentially modulate the local inflammatory responses during P.a

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm. Secreted, extracellular space. Note=Periplasmic with some activity further secreted to the extracellular milieu [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoxygenase domain [H]

Homologues:

Organism=Homo sapiens, GI4502053, Length=500, Percent_Identity=33, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI260166612, Length=498, Percent_Identity=33.7349397590361, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI182765464, Length=499, Percent_Identity=34.0681362725451, Blast_Score=238, Evalue=2e-62,
Organism=Homo sapiens, GI4502057, Length=526, Percent_Identity=30.0380228136882, Blast_Score=237, Evalue=3e-62,
Organism=Homo sapiens, GI85067501, Length=508, Percent_Identity=33.4645669291339, Blast_Score=229, Evalue=9e-60,
Organism=Homo sapiens, GI40316937, Length=463, Percent_Identity=33.6933045356371, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI85067499, Length=508, Percent_Identity=31.496062992126, Blast_Score=198, Evalue=2e-50,
Organism=Homo sapiens, GI154426292, Length=542, Percent_Identity=29.7047970479705, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI85067503, Length=508, Percent_Identity=28.3464566929134, Blast_Score=151, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000907
- InterPro:   IPR013819
- InterPro:   IPR020834
- InterPro:   IPR020833 [H]

Pfam domain/function: PF00305 Lipoxygenase [H]

EC number: =1.13.11.33 [H]

Molecular weight: Translated: 75247; Mature: 75247

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCC
>Mature Secondary Structure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CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]