Click here to switch to the map view.

The map label for this gene is coaBC [H]

Identifier: 158333340

GI number: 158333340

Start: 117593

End: 118798

Strand: Direct

Name: coaBC [H]

Synonym: AM1_0110

Alternate gene names: 158333340

Gene position: 117593-118798 (Clockwise)

Preceding gene: 158333339

Following gene: 158333341

Centisome position: 1.81

GC content: 50.08

Gene sequence:

>1206_bases
GTGTCTTCCCGCATCCTAATTGGTATCGGTGGCGGTATCGCTGCCTACAAAGTCTGTGAAGTCATCTCAGCATTGGTGAA
ATCTGGTGCAAAAGTGAGGGCAATCCTCACTTCTGCCGCCCAAGAGTTCATTACGCCCTTAACCATCACCACCCTCTGCC
GACAGCCAGCCTATGAGGACACCAGTCTTTGGCAGCCCCACCATACTCGCCCATTACATATTGAGTTGGGAGAATGGGCT
GACTTATTGGTCCTAGCCCCTTTAACCGCAAATACCTTAGCCAAACTAAACGCGGGATTGGCTGACAATCTATTGACCAA
TACTGTTTTGGCTTCAACTGCTCCTATCCTCGTTACCCCTGCAATGAATACCACCATGTGGCAACAGGCAGTTGTTCAAC
GTAATTGGCATCAACTACTTGAAGATCAGCGGTATCATGCGTTAGGCCCTGGGTCTGGCATGCTAGCCTGTGACACCGTG
GGAGAAGGGCGGATGGCAGAACCTGCCGATCTCTTGACCTACATCAATTCCCTGTTAGTGACCAAGGGCGAACGGGACCT
TAAGGGCAAACGGCTTCTGATCAGTGCTGGCGGAACTCGTGAGCACCTCGATCCAGTCCGGTTTATTGGCAATCCATCAT
CAGGGAAAATGGGACTGGCTTTGGCTTTGGCAGCTTGGTATAGAGGGGCAGACGTTCAGTTGGTGCATGGTCCCTTAGCA
TCCCCATTGCCAACAACGCCCCAATTAGAAACGGTTGCCGTGACCAGTTCGGCAGAAATGCGTGCTGCAATGTTAGCCGC
ATATCCTCAAGCTGATTGGACCATTATGGCTGCGGCCGTTGGCGACGTGCAGCCAGCCCACTATTTTCCTGAGAAGCTAC
CGAAAAAATCCCTACCTTCGGATCTGCTCCTCAAACCTATTCCCGATATCCTGGCAGAACTTGGTCAACAAAAACAGTCC
CATCAGAAACTGATTGGTTTTGCTGCTCAAACGGGAGATATCATCGCTCCTGCACAAGAGAAGCTAGAACGAAAAAGGTT
AGATGCTATCGTTGCCAACCCCATTGATCAACCCCAAAGTGGATTTGGTTCTGAGCATAATCAAGCTGTATTTCTAGATT
CGGCAGGGCATCAGGTGGCTATTCCCATATGCAGCAAATTACTGATGGCGCATCAAGTCCTGAATCTCATTAATGGATTA
GCCTAA

Upstream 100 bases:

>100_bases
CCAACGTCCAGAACTAACTGAATCTTATCTATACCTATTAGATCTAGAAGCATTCGACGAATCCTAATCTCCATCGTACG
TGTGAGTTTATAGCGACCTT

Downstream 100 bases:

>100_bases
ACGCAGACATATCCATTCCCTAATCCTCGCGCGAGGTCTCCACTAGAAATGACGTGTTTAACTCAATCTTCCTTACATGA
AGTGCTTAAAGGCAAAACTG

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSSRILIGIGGGIAAYKVCEVISALVKSGAKVRAILTSAAQEFITPLTITTLCRQPAYEDTSLWQPHHTRPLHIELGEWA
DLLVLAPLTANTLAKLNAGLADNLLTNTVLASTAPILVTPAMNTTMWQQAVVQRNWHQLLEDQRYHALGPGSGMLACDTV
GEGRMAEPADLLTYINSLLVTKGERDLKGKRLLISAGGTREHLDPVRFIGNPSSGKMGLALALAAWYRGADVQLVHGPLA
SPLPTTPQLETVAVTSSAEMRAAMLAAYPQADWTIMAAAVGDVQPAHYFPEKLPKKSLPSDLLLKPIPDILAELGQQKQS
HQKLIGFAAQTGDIIAPAQEKLERKRLDAIVANPIDQPQSGFGSEHNQAVFLDSAGHQVAIPICSKLLMAHQVLNLINGL
A

Sequences:

>Translated_401_residues
MSSRILIGIGGGIAAYKVCEVISALVKSGAKVRAILTSAAQEFITPLTITTLCRQPAYEDTSLWQPHHTRPLHIELGEWA
DLLVLAPLTANTLAKLNAGLADNLLTNTVLASTAPILVTPAMNTTMWQQAVVQRNWHQLLEDQRYHALGPGSGMLACDTV
GEGRMAEPADLLTYINSLLVTKGERDLKGKRLLISAGGTREHLDPVRFIGNPSSGKMGLALALAAWYRGADVQLVHGPLA
SPLPTTPQLETVAVTSSAEMRAAMLAAYPQADWTIMAAAVGDVQPAHYFPEKLPKKSLPSDLLLKPIPDILAELGQQKQS
HQKLIGFAAQTGDIIAPAQEKLERKRLDAIVANPIDQPQSGFGSEHNQAVFLDSAGHQVAIPICSKLLMAHQVLNLINGL
A
>Mature_400_residues
SSRILIGIGGGIAAYKVCEVISALVKSGAKVRAILTSAAQEFITPLTITTLCRQPAYEDTSLWQPHHTRPLHIELGEWAD
LLVLAPLTANTLAKLNAGLADNLLTNTVLASTAPILVTPAMNTTMWQQAVVQRNWHQLLEDQRYHALGPGSGMLACDTVG
EGRMAEPADLLTYINSLLVTKGERDLKGKRLLISAGGTREHLDPVRFIGNPSSGKMGLALALAAWYRGADVQLVHGPLAS
PLPTTPQLETVAVTSSAEMRAAMLAAYPQADWTIMAAAVGDVQPAHYFPEKLPKKSLPSDLLLKPIPDILAELGQQKQSH
QKLIGFAAQTGDIIAPAQEKLERKRLDAIVANPIDQPQSGFGSEHNQAVFLDSAGHQVAIPICSKLLMAHQVLNLINGLA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:
GO:0003824: Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase
GO:0004632: Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase
GO:0004633: Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase
GO:0010181: Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase
GO:0015937: Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase
GO:0015941: Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase
GO:0016874: Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=182, Percent_Identity=35.7142857142857, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI87082301, Length=399, Percent_Identity=41.1027568922306, Blast_Score=246, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17560194, Length=187, Percent_Identity=31.5508021390374, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322762, Length=186, Percent_Identity=32.258064516129, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324629, Length=82, Percent_Identity=42.6829268292683, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322925, Length=116, Percent_Identity=33.6206896551724, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24657262, Length=172, Percent_Identity=32.5581395348837, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42960; Mature: 42829

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRILIGIGGGIAAYKVCEVISALVKSGAKVRAILTSAAQEFITPLTITTLCRQPAYED
CCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TSLWQPHHTRPLHIELGEWADLLVLAPLTANTLAKLNAGLADNLLTNTVLASTAPILVTP
CCCCCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEC
AMNTTMWQQAVVQRNWHQLLEDQRYHALGPGSGMLACDTVGEGRMAEPADLLTYINSLLV
CCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
TKGERDLKGKRLLISAGGTREHLDPVRFIGNPSSGKMGLALALAAWYRGADVQLVHGPLA
CCCCCCCCCCEEEEECCCCHHHCCHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCC
SPLPTTPQLETVAVTSSAEMRAAMLAAYPQADWTIMAAAVGDVQPAHYFPEKLPKKSLPS
CCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCHHHCCHHCCCH
DLLLKPIPDILAELGQQKQSHQKLIGFAAQTGDIIAPAQEKLERKRLDAIVANPIDQPQS
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHCCCCCCCCC
GFGSEHNQAVFLDSAGHQVAIPICSKLLMAHQVLNLINGLA
CCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSRILIGIGGGIAAYKVCEVISALVKSGAKVRAILTSAAQEFITPLTITTLCRQPAYED
CCCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TSLWQPHHTRPLHIELGEWADLLVLAPLTANTLAKLNAGLADNLLTNTVLASTAPILVTP
CCCCCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEC
AMNTTMWQQAVVQRNWHQLLEDQRYHALGPGSGMLACDTVGEGRMAEPADLLTYINSLLV
CCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
TKGERDLKGKRLLISAGGTREHLDPVRFIGNPSSGKMGLALALAAWYRGADVQLVHGPLA
CCCCCCCCCCEEEEECCCCHHHCCHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCC
SPLPTTPQLETVAVTSSAEMRAAMLAAYPQADWTIMAAAVGDVQPAHYFPEKLPKKSLPS
CCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCHHHCCHHCCCH
DLLLKPIPDILAELGQQKQSHQKLIGFAAQTGDIIAPAQEKLERKRLDAIVANPIDQPQS
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHCCCCCCCCC
GFGSEHNQAVFLDSAGHQVAIPICSKLLMAHQVLNLINGLA
CCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]