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The map label for this gene is pdhC [H]

Identifier: 158318986

GI number: 158318986

Start: 8873275

End: 8875032

Strand: Direct

Name: pdhC [H]

Synonym: Franean1_7269

Alternate gene names: 158318986

Gene position: 8873275-8875032 (Clockwise)

Preceding gene: 158318985

Following gene: 158318987

Centisome position: 98.79

GC content: 75.09

Gene sequence:

>1758_bases
GTGACCCATCGACAGTTCCGCCTCCCCGATCTCGGCGAGGGGCTGACCGAGGCGGAGATCGTCCGGTGGCTGGTGGAGGT
CGGCGAGACCGTGACGGTCAACCAGCCGCTGGTCGAGGTCGAGACGGCCAAGGCGGTCGTCGAGATCCCGTCCCCGTTCG
CGGGTGTGCTCGTCGAACGGCACGGCGAGGCCGGCACCGAGCTCGCCGTGGGCACGCCGCTGCTGACCATCGACGAGCCG
GGCGACGAGCCCGCGACCGGCCCGACGACCGGGTCAGTCACCGGAGCTACCGAAGCCACCGGCCAGGAGACCACGCCGGG
GGACGCCACTCGCAACGGCGCGGCATCCCTGCCCGTGTCCCGGACCGGAGAGGCCGCGGACGTCCCAGGGGGGGCCGGCA
CGGCCGACCTGTCACCGATGGCCGCCGGGCGCACCCCGATGCTGGTGGGGTACGGCCCGCGCAGCGACTCCGGCCCGCGC
CGCCGGCGGCGCCCCCGCAACCCGGACGGCCCCCTGCCCGGCTCGACGACGCCCGCGGCGACCATCGCCGCCCCCGCGCC
CGCCCCCGGCACAGCGCCCACTGCCAGCTCAGCGCCCAGGGCCATGGCACCCGTCGTGTCGTCGGTGCCGGCCTCGGCGC
CAGCCACATCCCCGGCGTCGGCCGCGGCCGGTGCGCCGGACCGATCAGCCGTAGTGCCGATCGGGGCAGCCCCGCGGCAT
GGGCGCGTCGCGGCGAAGCCACCCGTCCGCAAGCTCGCGCGTGATCTGGGTGTGGACCTCTCCACGCTCGCGGGCACCGG
TCCCGCGGGCACCATCAGCCGCGCCGACGTCGAAACCGCGGCGCGTCAGGCCACGCCCCCCGAGCCCGCGCCCGTCCCCA
CCACCGCCACTCCGACGACCCGCACTGGGCCGGTCCGTGTCCCTGGCGTTGTCCCTTCGTCCAACGGAATCGACGGCCCG
CGCCAGCCGGAACTGAACGGACACGCGGCGACCACACGGCGGGTGCCCGGAGCCATCCCACCCGACGCCGGATTCAACGA
CACCGACCGGATCTGGCGGATCCCCGTCACGGGCGTGCGGCGCACCATGGCACGGGCGATGGTGGCCAGCGTGTTCTCGG
CCCCGCACGCCACCGAGTTCCTCAGCGTGGACGTCACCGAGACGATGGCGGCCCGCGAGCGGATCGCCGCCCTGCCGGAC
TTCGCCGGCATCCGGGTCACGCCGCTGCTGCTCGTGGCGAAGGCGCTCCTCACCGCCGTCCGGCGCCACCCAATGATCAA
CTCGACCTGGGTGGGCGACACGTCCGGGGAGAACGCCGAGATCCAGGTGCACGAGCGGATCAACCTCGGCATCGCCGTGG
CCGGGCCGCGTGGCCTGGTCGTCCCGAACATCCCGGACGCCGGATCGCGCGGCCTGGTCGACCTCGCCCGCAGCCTGCAC
TCCCTCACCGAGGCCGCGCGCGCCGACCGGCTGCGCCCGGCCGACCTCTCCGGCGGGACCATCACCATCACCAACGTCGG
AGTTCTCGGGGTGGACACCGGGGCACCGGTCCTCAATCCCGGTGAGGCCGCGATCCTCGCCCTCGGCGCGATCCGCCCGG
CTCCCTGGGTGCACGAAGGCGAGCTGGCGGTACGGACGGTGGCCCACCTCGCGCTGTCCTTCGACCACCGCGTCGTGGAC
GGCGAGCTCGGCTCGGCGGTCCTGGCCGACGTCGCGGCCGTCCTCGCCGACCCCGTCATCGCGCTCGCCTGGAGCTGA

Upstream 100 bases:

>100_bases
CCCCGTACCCCCCGGCCCGGCTGGAAGACCACTACCTCCCCGACGTCGACCGGATCCTCGACGCCGTCGACCGATCGTTC
GGCTACTGAGGAGATCTCCG

Downstream 100 bases:

>100_bases
CCCCGTGGGGCGGCCGGCGACCCGGGAAGCCCGCCTACAGCGGAGGATCCGGGCGAACCGGGCCGCGCCAGCCACCCCAC
GGCCCGGTCACACGACGCAC

Product: dehydrogenase catalytic domain-containing protein

Products: NA

Alternate protein names: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2 [H]

Number of amino acids: Translated: 585; Mature: 584

Protein sequence:

>585_residues
MTHRQFRLPDLGEGLTEAEIVRWLVEVGETVTVNQPLVEVETAKAVVEIPSPFAGVLVERHGEAGTELAVGTPLLTIDEP
GDEPATGPTTGSVTGATEATGQETTPGDATRNGAASLPVSRTGEAADVPGGAGTADLSPMAAGRTPMLVGYGPRSDSGPR
RRRRPRNPDGPLPGSTTPAATIAAPAPAPGTAPTASSAPRAMAPVVSSVPASAPATSPASAAAGAPDRSAVVPIGAAPRH
GRVAAKPPVRKLARDLGVDLSTLAGTGPAGTISRADVETAARQATPPEPAPVPTTATPTTRTGPVRVPGVVPSSNGIDGP
RQPELNGHAATTRRVPGAIPPDAGFNDTDRIWRIPVTGVRRTMARAMVASVFSAPHATEFLSVDVTETMAARERIAALPD
FAGIRVTPLLLVAKALLTAVRRHPMINSTWVGDTSGENAEIQVHERINLGIAVAGPRGLVVPNIPDAGSRGLVDLARSLH
SLTEAARADRLRPADLSGGTITITNVGVLGVDTGAPVLNPGEAAILALGAIRPAPWVHEGELAVRTVAHLALSFDHRVVD
GELGSAVLADVAAVLADPVIALAWS

Sequences:

>Translated_585_residues
MTHRQFRLPDLGEGLTEAEIVRWLVEVGETVTVNQPLVEVETAKAVVEIPSPFAGVLVERHGEAGTELAVGTPLLTIDEP
GDEPATGPTTGSVTGATEATGQETTPGDATRNGAASLPVSRTGEAADVPGGAGTADLSPMAAGRTPMLVGYGPRSDSGPR
RRRRPRNPDGPLPGSTTPAATIAAPAPAPGTAPTASSAPRAMAPVVSSVPASAPATSPASAAAGAPDRSAVVPIGAAPRH
GRVAAKPPVRKLARDLGVDLSTLAGTGPAGTISRADVETAARQATPPEPAPVPTTATPTTRTGPVRVPGVVPSSNGIDGP
RQPELNGHAATTRRVPGAIPPDAGFNDTDRIWRIPVTGVRRTMARAMVASVFSAPHATEFLSVDVTETMAARERIAALPD
FAGIRVTPLLLVAKALLTAVRRHPMINSTWVGDTSGENAEIQVHERINLGIAVAGPRGLVVPNIPDAGSRGLVDLARSLH
SLTEAARADRLRPADLSGGTITITNVGVLGVDTGAPVLNPGEAAILALGAIRPAPWVHEGELAVRTVAHLALSFDHRVVD
GELGSAVLADVAAVLADPVIALAWS
>Mature_584_residues
THRQFRLPDLGEGLTEAEIVRWLVEVGETVTVNQPLVEVETAKAVVEIPSPFAGVLVERHGEAGTELAVGTPLLTIDEPG
DEPATGPTTGSVTGATEATGQETTPGDATRNGAASLPVSRTGEAADVPGGAGTADLSPMAAGRTPMLVGYGPRSDSGPRR
RRRPRNPDGPLPGSTTPAATIAAPAPAPGTAPTASSAPRAMAPVVSSVPASAPATSPASAAAGAPDRSAVVPIGAAPRHG
RVAAKPPVRKLARDLGVDLSTLAGTGPAGTISRADVETAARQATPPEPAPVPTTATPTTRTGPVRVPGVVPSSNGIDGPR
QPELNGHAATTRRVPGAIPPDAGFNDTDRIWRIPVTGVRRTMARAMVASVFSAPHATEFLSVDVTETMAARERIAALPDF
AGIRVTPLLLVAKALLTAVRRHPMINSTWVGDTSGENAEIQVHERINLGIAVAGPRGLVVPNIPDAGSRGLVDLARSLHS
LTEAARADRLRPADLSGGTITITNVGVLGVDTGAPVLNPGEAAILALGAIRPAPWVHEGELAVRTVAHLALSFDHRVVDG
ELGSAVLADVAAVLADPVIALAWS

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI31711992, Length=364, Percent_Identity=29.6703296703297, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI203098816, Length=232, Percent_Identity=30.1724137931034, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI203098753, Length=231, Percent_Identity=30.3030303030303, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI19923748, Length=232, Percent_Identity=31.0344827586207, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI110671329, Length=344, Percent_Identity=26.1627906976744, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI260898739, Length=169, Percent_Identity=33.1360946745562, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1786305, Length=345, Percent_Identity=28.695652173913, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1786946, Length=227, Percent_Identity=31.7180616740088, Blast_Score=131, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17560088, Length=404, Percent_Identity=27.7227722772277, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17537937, Length=354, Percent_Identity=27.4011299435028, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17538894, Length=231, Percent_Identity=26.8398268398268, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI25146366, Length=251, Percent_Identity=26.2948207171315, Blast_Score=95, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6320352, Length=233, Percent_Identity=29.6137339055794, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324258, Length=234, Percent_Identity=24.3589743589744, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI18859875, Length=332, Percent_Identity=28.6144578313253, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24645909, Length=232, Percent_Identity=30.6034482758621, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20129315, Length=231, Percent_Identity=29.4372294372294, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24582497, Length=229, Percent_Identity=29.2576419213974, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 912 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 4,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001078
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 59491; Mature: 59360

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHRQFRLPDLGEGLTEAEIVRWLVEVGETVTVNQPLVEVETAKAVVEIPSPFAGVLVER
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEECCEEEEECCCCHHHHHHHH
HGEAGTELAVGTPLLTIDEPGDEPATGPTTGSVTGATEATGQETTPGDATRNGAASLPVS
CCCCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RTGEAADVPGGAGTADLSPMAAGRTPMLVGYGPRSDSGPRRRRRPRNPDGPLPGSTTPAA
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCE
TIAAPAPAPGTAPTASSAPRAMAPVVSSVPASAPATSPASAAAGAPDRSAVVPIGAAPRH
EEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCEEEECCCCCCC
GRVAAKPPVRKLARDLGVDLSTLAGTGPAGTISRADVETAARQATPPEPAPVPTTATPTT
CCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
RTGPVRVPGVVPSSNGIDGPRQPELNGHAATTRRVPGAIPPDAGFNDTDRIWRIPVTGVR
CCCCEECCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCEEECCHHHHH
RTMARAMVASVFSAPHATEFLSVDVTETMAARERIAALPDFAGIRVTPLLLVAKALLTAV
HHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
RRHPMINSTWVGDTSGENAEIQVHERINLGIAVAGPRGLVVPNIPDAGSRGLVDLARSLH
HHCCCCCCEECCCCCCCCCEEEEEEEECEEEEEECCCCEEECCCCCCCCCCHHHHHHHHH
SLTEAARADRLRPADLSGGTITITNVGVLGVDTGAPVLNPGEAAILALGAIRPAPWVHEG
HHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCC
ELAVRTVAHLALSFDHRVVDGELGSAVLADVAAVLADPVIALAWS
HHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure 
THRQFRLPDLGEGLTEAEIVRWLVEVGETVTVNQPLVEVETAKAVVEIPSPFAGVLVER
CCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEECCEEEEECCCCHHHHHHHH
HGEAGTELAVGTPLLTIDEPGDEPATGPTTGSVTGATEATGQETTPGDATRNGAASLPVS
CCCCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RTGEAADVPGGAGTADLSPMAAGRTPMLVGYGPRSDSGPRRRRRPRNPDGPLPGSTTPAA
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCE
TIAAPAPAPGTAPTASSAPRAMAPVVSSVPASAPATSPASAAAGAPDRSAVVPIGAAPRH
EEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCEEEECCCCCCC
GRVAAKPPVRKLARDLGVDLSTLAGTGPAGTISRADVETAARQATPPEPAPVPTTATPTT
CCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
RTGPVRVPGVVPSSNGIDGPRQPELNGHAATTRRVPGAIPPDAGFNDTDRIWRIPVTGVR
CCCCEECCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCEEECCHHHHH
RTMARAMVASVFSAPHATEFLSVDVTETMAARERIAALPDFAGIRVTPLLLVAKALLTAV
HHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
RRHPMINSTWVGDTSGENAEIQVHERINLGIAVAGPRGLVVPNIPDAGSRGLVDLARSLH
HHCCCCCCEECCCCCCCCCEEEEEEEECEEEEEECCCCEEECCCCCCCCCCHHHHHHHHH
SLTEAARADRLRPADLSGGTITITNVGVLGVDTGAPVLNPGEAAILALGAIRPAPWVHEG
HHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCC
ELAVRTVAHLALSFDHRVVDGELGSAVLADVAAVLADPVIALAWS
HHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA