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The map label for this gene is garR [H]

Identifier: 158318870

GI number: 158318870

Start: 8733265

End: 8734074

Strand: Reverse

Name: garR [H]

Synonym: Franean1_7151

Alternate gene names: 158318870

Gene position: 8734074-8733265 (Counterclockwise)

Preceding gene: 158318871

Following gene: 158318869

Centisome position: 97.24

GC content: 69.26

Gene sequence:

>810_bases
GTGAAGACTGGATTCATCGGGCTCGGCAGCATGGGGCTGCCGATGGCACAGCGGCTTCAGTCGCAGGGCCACGACCTCAC
GCTCTACGCCCGGCGGCCGGCCTCGCTGGAACCGTTCGCCGGCACCAGCGCCACCATCGCGGCCACCCCTGCGGAGATGG
GCGCGTCGGTCGACGCCGTCGGCATCTGTGTCTTTGACGCGGCCGGTGTGGAAGAGGTCATGTTCGGACCGGACGGCCTG
GCCGGCACCCTCAACCCTGGCGCGGTCGTGCTCGTCCACAGCACGGTGGCACCCGCGCAGATCCGCAGGATCGCCGGGCG
GGCGGCGACGCACGGCCTACGTGTCCTGGACGCGCCGGTGAGCGGCGGGCAACCGAGGGCGCTGGCCGGCGAGCTGACGA
TCATGATCGGCGGTGACGCTGACACGCTCGCCGATGTCGCCGAGCTGCTCTCGGCGCTGTCGAACCATGTCGTGCACCTG
GGCGCGGTCGGGGCGGGGTCGTACGCGAAGCTCATCAACAACACGATGTTCGCCGCGCAGATCGCACTCGCGGACGACGC
GATGAAAGCCGGGGAATCGCTCGGCATCGATCCCGCGGGTCTCGCGGCGGTCCTGGCGACCAGCAGCTCGGCCTGTATAG
CCTCGGGCGTACGGTTGCGTGCCGGTTCCCTCGCCGGTCTCGCGGACTCGCCCGCGAATCTGACGCTCACCAAAGACGCC
ACGCTGATGGCCGAAATTCTCGGCGACGCTCCGGGAAACGGGCTGGTCGAGGTCGCACAGCGTTTCGTCACCGCCATGAA
GTCCAACTGA

Upstream 100 bases:

>100_bases
GCCTCCGACGCCGTCGAGACGAAAGTGCTCCGCCAGACCGGTGCACCCGCCCGGACGTCATGACCACCAGTACGCCGAGA
GCTACCACGACGAGGACACC

Downstream 100 bases:

>100_bases
ATGCGAACGGACACCCGGATGTCGACGACCGCAGGACAGCTGGGTATCGAGCACCAGACCGTCTTCGGGTTGCCGCCGGT
GGAGTTCGTGCATCTTGCCG

Product: NAD-binding 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MKTGFIGLGSMGLPMAQRLQSQGHDLTLYARRPASLEPFAGTSATIAATPAEMGASVDAVGICVFDAAGVEEVMFGPDGL
AGTLNPGAVVLVHSTVAPAQIRRIAGRAATHGLRVLDAPVSGGQPRALAGELTIMIGGDADTLADVAELLSALSNHVVHL
GAVGAGSYAKLINNTMFAAQIALADDAMKAGESLGIDPAGLAAVLATSSSACIASGVRLRAGSLAGLADSPANLTLTKDA
TLMAEILGDAPGNGLVEVAQRFVTAMKSN

Sequences:

>Translated_269_residues
MKTGFIGLGSMGLPMAQRLQSQGHDLTLYARRPASLEPFAGTSATIAATPAEMGASVDAVGICVFDAAGVEEVMFGPDGL
AGTLNPGAVVLVHSTVAPAQIRRIAGRAATHGLRVLDAPVSGGQPRALAGELTIMIGGDADTLADVAELLSALSNHVVHL
GAVGAGSYAKLINNTMFAAQIALADDAMKAGESLGIDPAGLAAVLATSSSACIASGVRLRAGSLAGLADSPANLTLTKDA
TLMAEILGDAPGNGLVEVAQRFVTAMKSN
>Mature_269_residues
MKTGFIGLGSMGLPMAQRLQSQGHDLTLYARRPASLEPFAGTSATIAATPAEMGASVDAVGICVFDAAGVEEVMFGPDGL
AGTLNPGAVVLVHSTVAPAQIRRIAGRAATHGLRVLDAPVSGGQPRALAGELTIMIGGDADTLADVAELLSALSNHVVHL
GAVGAGSYAKLINNTMFAAQIALADDAMKAGESLGIDPAGLAAVLATSSSACIASGVRLRAGSLAGLADSPANLTLTKDA
TLMAEILGDAPGNGLVEVAQRFVTAMKSN

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=212, Percent_Identity=35.377358490566, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI40556376, Length=184, Percent_Identity=32.0652173913043, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI145693186, Length=198, Percent_Identity=34.8484848484849, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786719, Length=198, Percent_Identity=34.3434343434343, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1790315, Length=192, Percent_Identity=31.25, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789092, Length=187, Percent_Identity=37.4331550802139, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17557316, Length=214, Percent_Identity=34.5794392523364, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24655230, Length=214, Percent_Identity=29.9065420560748, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19922568, Length=214, Percent_Identity=29.9065420560748, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574115, Length=191, Percent_Identity=28.7958115183246, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 26838; Mature: 26838

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTGFIGLGSMGLPMAQRLQSQGHDLTLYARRPASLEPFAGTSATIAATPAEMGASVDAV
CCCCEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEECHHHHCCCCCEE
GICVFDAAGVEEVMFGPDGLAGTLNPGAVVLVHSTVAPAQIRRIAGRAATHGLRVLDAPV
EEEEECCCCCHHEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCC
SGGQPRALAGELTIMIGGDADTLADVAELLSALSNHVVHLGAVGAGSYAKLINNTMFAAQ
CCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHCHHHHHH
IALADDAMKAGESLGIDPAGLAAVLATSSSACIASGVRLRAGSLAGLADSPANLTLTKDA
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHCCCEEECCCCCCCCCCCCCEEEECCH
TLMAEILGDAPGNGLVEVAQRFVTAMKSN
HHHHHHHCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTGFIGLGSMGLPMAQRLQSQGHDLTLYARRPASLEPFAGTSATIAATPAEMGASVDAV
CCCCEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEECHHHHCCCCCEE
GICVFDAAGVEEVMFGPDGLAGTLNPGAVVLVHSTVAPAQIRRIAGRAATHGLRVLDAPV
EEEEECCCCCHHEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCC
SGGQPRALAGELTIMIGGDADTLADVAELLSALSNHVVHLGAVGAGSYAKLINNTMFAAQ
CCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHCHHHHHH
IALADDAMKAGESLGIDPAGLAAVLATSSSACIASGVRLRAGSLAGLADSPANLTLTKDA
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHCCCEEECCCCCCCCCCCCCEEEECCH
TLMAEILGDAPGNGLVEVAQRFVTAMKSN
HHHHHHHCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]