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The map label for this gene is cutS [H]

Identifier: 158318853

GI number: 158318853

Start: 8714670

End: 8715791

Strand: Direct

Name: cutS [H]

Synonym: Franean1_7134

Alternate gene names: 158318853

Gene position: 8714670-8715791 (Clockwise)

Preceding gene: 158318852

Following gene: 158318858

Centisome position: 97.02

GC content: 63.99

Gene sequence:

>1122_bases
GTGGATAGGGCGCCCGGTTTGAGCGTTCGCCTCAAACTCACCCTCAGCTACGCCGGCTTCCTCATGCTTGCGGGTGTCTT
GCTGCTCGCGGTCGTGTGGGTGTTCCTGCTGCGTTACGTACCCGAGACGATCTACACAGCACCTCCCGAAACGGGATCGC
GACCCGGCCCCTTTATGTTCATACCCGACCGCTCCGACCTGCTTCAAGCCTTCGTCCCGAAGGCAGCCGCAATGCTGGCG
TTCCTGCTGATGTTCAGCCTGCTGGGAGGATGGATCCTCGCCGGCAGCATGCTCGCGCCCCTGACCCGCATCACCAACGC
GACCCGCCTGACCGCGAACGGATCGCTCTCCCACCGGATCCAGCTGGAAGGCCGCAAGGATGAATTCCGCGAACTCGCCG
ACGCCTTCGACGCCATGCTCGCGCGGCTCGAAGCACACGACGCCGAACAGCAGAGGTTCGCAGCCAATGCCTCCCACGAA
CTGCGCACCCCGCTGGCGATCACGCAGACCCTGCTCGACGTGGCCCGCAAAGATCTGAACCGCGACGCCGGCGAACTTGT
CGACCGCCTCCATTTGGTCAACACCCGAGCGATCGACCTCACCGAAGCACTGCTTCTGCTCAGCCGTGCCAACCAGCGAT
CCTTCACGCGAGAACGCGTCGATCTGTCCCTGGCGGCGGAAGAAGCGACTGAAACGCTTCTCCCCCTCGCAGAAAAACAT
GGCGTCACCATCGAGACCTCCGGCGACATGGCCGCCACCATCGGCTCACATGCGCTCCTGCTGCAGATGACCACGAACCT
TGCGCACAACGCGATCGTCCACAATCTGCCTGAACAGGGCACCGTGTGGGTCACGACGAGCGTTCACTCGATGACGGTTG
TGCTCACTGTCGAGAACACCGGCCAGAAGCTCGCCCCACAAGTGGCTTCCACGCTTGTCGAGCCGTTTCAACGCGGCACT
GGACGCACTCGCACCGACCACGCAGGTGCCGGCCTCGGCCTGGCAATCGTCAAGAGCATCGCCCAGGCACACGACGGAAC
CATCACCCTCACCCCCCGGGATGCTGGGGGGCTCTGCGTCACGGTGCGACTACCCGTCGCGCCACTGCGCGCTGGCAGAT
AA

Upstream 100 bases:

>100_bases
CTGCGCAAACGCCTCGGCGAACCCTGGATCATCGCCACCGTGCCCAGCGTTGGGTACCGCATCGACACAGCACCCGGCAC
CGGGCGTGAGGGAGGGGACC

Downstream 100 bases:

>100_bases
CGATCAGTCGAGGTCTGCCGTGGGTGCGTGGTCGGCCGTGGTCCTCATGAGGCGAACCCCCGTTGCTCGGCGACCGCGGT
GAGCACGTGCCGGGCCAGGA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MDRAPGLSVRLKLTLSYAGFLMLAGVLLLAVVWVFLLRYVPETIYTAPPETGSRPGPFMFIPDRSDLLQAFVPKAAAMLA
FLLMFSLLGGWILAGSMLAPLTRITNATRLTANGSLSHRIQLEGRKDEFRELADAFDAMLARLEAHDAEQQRFAANASHE
LRTPLAITQTLLDVARKDLNRDAGELVDRLHLVNTRAIDLTEALLLLSRANQRSFTRERVDLSLAAEEATETLLPLAEKH
GVTIETSGDMAATIGSHALLLQMTTNLAHNAIVHNLPEQGTVWVTTSVHSMTVVLTVENTGQKLAPQVASTLVEPFQRGT
GRTRTDHAGAGLGLAIVKSIAQAHDGTITLTPRDAGGLCVTVRLPVAPLRAGR

Sequences:

>Translated_373_residues
MDRAPGLSVRLKLTLSYAGFLMLAGVLLLAVVWVFLLRYVPETIYTAPPETGSRPGPFMFIPDRSDLLQAFVPKAAAMLA
FLLMFSLLGGWILAGSMLAPLTRITNATRLTANGSLSHRIQLEGRKDEFRELADAFDAMLARLEAHDAEQQRFAANASHE
LRTPLAITQTLLDVARKDLNRDAGELVDRLHLVNTRAIDLTEALLLLSRANQRSFTRERVDLSLAAEEATETLLPLAEKH
GVTIETSGDMAATIGSHALLLQMTTNLAHNAIVHNLPEQGTVWVTTSVHSMTVVLTVENTGQKLAPQVASTLVEPFQRGT
GRTRTDHAGAGLGLAIVKSIAQAHDGTITLTPRDAGGLCVTVRLPVAPLRAGR
>Mature_373_residues
MDRAPGLSVRLKLTLSYAGFLMLAGVLLLAVVWVFLLRYVPETIYTAPPETGSRPGPFMFIPDRSDLLQAFVPKAAAMLA
FLLMFSLLGGWILAGSMLAPLTRITNATRLTANGSLSHRIQLEGRKDEFRELADAFDAMLARLEAHDAEQQRFAANASHE
LRTPLAITQTLLDVARKDLNRDAGELVDRLHLVNTRAIDLTEALLLLSRANQRSFTRERVDLSLAAEEATETLLPLAEKH
GVTIETSGDMAATIGSHALLLQMTTNLAHNAIVHNLPEQGTVWVTTSVHSMTVVLTVENTGQKLAPQVASTLVEPFQRGT
GRTRTDHAGAGLGLAIVKSIAQAHDGTITLTPRDAGGLCVTVRLPVAPLRAGR

Specific function: Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=309, Percent_Identity=29.126213592233, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=27.8388278388278, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=27.2058823529412, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI87082128, Length=300, Percent_Identity=26, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790861, Length=243, Percent_Identity=28.8065843621399, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789808, Length=309, Percent_Identity=26.8608414239482, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787894, Length=332, Percent_Identity=25.3012048192771, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=283, Percent_Identity=27.5618374558304, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786912, Length=233, Percent_Identity=29.6137339055794, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790551, Length=245, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=27.8260869565217, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 40336; Mature: 40336

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRAPGLSVRLKLTLSYAGFLMLAGVLLLAVVWVFLLRYVPETIYTAPPETGSRPGPFMF
CCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCEEE
IPDRSDLLQAFVPKAAAMLAFLLMFSLLGGWILAGSMLAPLTRITNATRLTANGSLSHRI
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEE
QLEGRKDEFRELADAFDAMLARLEAHDAEQQRFAANASHELRTPLAITQTLLDVARKDLN
EECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHCC
RDAGELVDRLHLVNTRAIDLTEALLLLSRANQRSFTRERVDLSLAAEEATETLLPLAEKH
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVTIETSGDMAATIGSHALLLQMTTNLAHNAIVHNLPEQGTVWVTTSVHSMTVVLTVENT
CEEEEECCCCHHHHCCCEEEEHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEEEEECCC
GQKLAPQVASTLVEPFQRGTGRTRTDHAGAGLGLAIVKSIAQAHDGTITLTPRDAGGLCV
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEE
TVRLPVAPLRAGR
EEECCCCCCCCCC
>Mature Secondary Structure
MDRAPGLSVRLKLTLSYAGFLMLAGVLLLAVVWVFLLRYVPETIYTAPPETGSRPGPFMF
CCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCEEE
IPDRSDLLQAFVPKAAAMLAFLLMFSLLGGWILAGSMLAPLTRITNATRLTANGSLSHRI
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEE
QLEGRKDEFRELADAFDAMLARLEAHDAEQQRFAANASHELRTPLAITQTLLDVARKDLN
EECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHCC
RDAGELVDRLHLVNTRAIDLTEALLLLSRANQRSFTRERVDLSLAAEEATETLLPLAEKH
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVTIETSGDMAATIGSHALLLQMTTNLAHNAIVHNLPEQGTVWVTTSVHSMTVVLTVENT
CEEEEECCCCHHHHCCCEEEEHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEEEEECCC
GQKLAPQVASTLVEPFQRGTGRTRTDHAGAGLGLAIVKSIAQAHDGTITLTPRDAGGLCV
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEE
TVRLPVAPLRAGR
EEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]