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The map label for this gene is iclR [H]

Identifier: 158318700

GI number: 158318700

Start: 8493998

End: 8494849

Strand: Reverse

Name: iclR [H]

Synonym: Franean1_6969

Alternate gene names: 158318700

Gene position: 8494849-8493998 (Counterclockwise)

Preceding gene: 158318703

Following gene: 158318699

Centisome position: 94.58

GC content: 75.35

Gene sequence:

>852_bases
GTGTCAACACAGGCCGCGTCACCGCAGGGTGCGGCAACACAGGCCGCGTCGCCAGAGGTCGTCTCGCCGGAGGCCGGCCC
GCCAGAGGCCGCCTCGTCACAGGGGCCGGCCGTGCCCGGGGTGCAGTCGGTGCACCGTGCGTTGGACCTGCTCGAGATCC
TCGCGGCGGCCGGCGGCCGGCTTCCCATGGCCGAGGTCGCGGCGCGCGCGCAGCTGCCGACGCCGACCGTGCACCGGCTG
CTGCGCACCATGGTCGAGCGCGGGTACCTGCGGCAGCTGCCCGACCGCAGCTACGCGCTCGGCTTCCGGCTCGTTCCGCT
GGGCGCCCGCGCGAACGCGATGGTCGGCGCCAACGCGTCCGGTGTGCTGCACGACCTCGTCGCCGAGCTGGGCGAGACGG
CCAACCTGGCCGTGCTCTCCGGCGACCAGGCCGAGTACGTCGCCCAGGCGCCGTCGCGGTATGCGATGCGCATGTTCACC
GAGGTCGGGCGGCGGGTCGACCTGCACTCGACCGGCGTGGGCAAGGCACTGCTCGCACAGCTGGACGACGACGAGGCGCT
CGGGATCATCCGCAGCCGCGGGCTGCCGCGGTACACGGCGCACACGGTGGGCACCGAGACGGCGCTGCGCGCGGAGCTGC
GCCGCATCCGCGAGCGGGGTTTCGCGCTCGACGAGCAGGAGCAGGAGATCGGCGTGCGCTGCGTGGCCATCGCCCTCGAC
CCGGCGAGCGCGCCGGGGGTCGCGGTCTCGGTGTCCGGGCCGACGGCGCGGATGACCGACGAGCTGGTCGAGCGCGCGGT
CGGGCTGCTGCAGGCGGCGGCGTCCCGGCTGGCCGGAGACCTGCGGGACTGA

Upstream 100 bases:

>100_bases
AGTCCGACGACGTCGATGTAGTCAGGCACTAGCCCATCCCGAATTTCGTATGGTGGAATAGCCTTTTCGCTTATCGGACG
CTACCGAGGGATGTTGGACG

Downstream 100 bases:

>100_bases
CCCCCACTTCTTGACAGTGGGCCCACAGCGCTGTTCGTATCACGGAATAACTTTTCCATAACCTGGAAGATGCTGATGAC
CTCGCCGCTCGCCGTCAGCC

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MSTQAASPQGAATQAASPEVVSPEAGPPEAASSQGPAVPGVQSVHRALDLLEILAAAGGRLPMAEVAARAQLPTPTVHRL
LRTMVERGYLRQLPDRSYALGFRLVPLGARANAMVGANASGVLHDLVAELGETANLAVLSGDQAEYVAQAPSRYAMRMFT
EVGRRVDLHSTGVGKALLAQLDDDEALGIIRSRGLPRYTAHTVGTETALRAELRRIRERGFALDEQEQEIGVRCVAIALD
PASAPGVAVSVSGPTARMTDELVERAVGLLQAAASRLAGDLRD

Sequences:

>Translated_283_residues
MSTQAASPQGAATQAASPEVVSPEAGPPEAASSQGPAVPGVQSVHRALDLLEILAAAGGRLPMAEVAARAQLPTPTVHRL
LRTMVERGYLRQLPDRSYALGFRLVPLGARANAMVGANASGVLHDLVAELGETANLAVLSGDQAEYVAQAPSRYAMRMFT
EVGRRVDLHSTGVGKALLAQLDDDEALGIIRSRGLPRYTAHTVGTETALRAELRRIRERGFALDEQEQEIGVRCVAIALD
PASAPGVAVSVSGPTARMTDELVERAVGLLQAAASRLAGDLRD
>Mature_282_residues
STQAASPQGAATQAASPEVVSPEAGPPEAASSQGPAVPGVQSVHRALDLLEILAAAGGRLPMAEVAARAQLPTPTVHRLL
RTMVERGYLRQLPDRSYALGFRLVPLGARANAMVGANASGVLHDLVAELGETANLAVLSGDQAEYVAQAPSRYAMRMFTE
VGRRVDLHSTGVGKALLAQLDDDEALGIIRSRGLPRYTAHTVGTETALRAELRRIRERGFALDEQEQEIGVRCVAIALDP
ASAPGVAVSVSGPTARMTDELVERAVGLLQAAASRLAGDLRD

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=241, Percent_Identity=35.2697095435685, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI1788131, Length=245, Percent_Identity=33.469387755102, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786468, Length=230, Percent_Identity=32.6086956521739, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786715, Length=229, Percent_Identity=30.1310043668122, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1789999, Length=255, Percent_Identity=29.4117647058824, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1790752, Length=251, Percent_Identity=25.0996015936255, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788581, Length=254, Percent_Identity=26.7716535433071, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29633; Mature: 29502

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQAASPQGAATQAASPEVVSPEAGPPEAASSQGPAVPGVQSVHRALDLLEILAAAGGR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
LPMAEVAARAQLPTPTVHRLLRTMVERGYLRQLPDRSYALGFRLVPLGARANAMVGANAS
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEECCCCH
GVLHDLVAELGETANLAVLSGDQAEYVAQAPSRYAMRMFTEVGRRVDLHSTGVGKALLAQ
HHHHHHHHHHCCCCCEEEECCCHHHHHHHCHHHHHHHHHHHHCCEECCCCCCHHHHHHHH
LDDDEALGIIRSRGLPRYTAHTVGTETALRAELRRIRERGFALDEQEQEIGVRCVAIALD
CCCCHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEEEEEC
PASAPGVAVSVSGPTARMTDELVERAVGLLQAAASRLAGDLRD
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STQAASPQGAATQAASPEVVSPEAGPPEAASSQGPAVPGVQSVHRALDLLEILAAAGGR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
LPMAEVAARAQLPTPTVHRLLRTMVERGYLRQLPDRSYALGFRLVPLGARANAMVGANAS
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEECCCCH
GVLHDLVAELGETANLAVLSGDQAEYVAQAPSRYAMRMFTEVGRRVDLHSTGVGKALLAQ
HHHHHHHHHHCCCCCEEEECCCHHHHHHHCHHHHHHHHHHHHCCEECCCCCCHHHHHHHH
LDDDEALGIIRSRGLPRYTAHTVGTETALRAELRRIRERGFALDEQEQEIGVRCVAIALD
CCCCHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEEEEEC
PASAPGVAVSVSGPTARMTDELVERAVGLLQAAASRLAGDLRD
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]