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The map label for this gene is cbs [H]

Identifier: 158318159

GI number: 158318159

Start: 7803706

End: 7805097

Strand: Direct

Name: cbs [H]

Synonym: Franean1_6424

Alternate gene names: 158318159

Gene position: 7803706-7805097 (Clockwise)

Preceding gene: 158318158

Following gene: 158318160

Centisome position: 86.88

GC content: 72.99

Gene sequence:

>1392_bases
ATGGACGTGTACGACCACGTCACCGACCTGGTCGGTGACACGCCACTGGTGCGGCTGACGCCGGTGATCGCCGACACGGT
GACACCCGTGCTCGGCAAGCTCGAGTACCTCAACCCGGGCGGCTCGGTGAAGGACCGCATCGCCCTGTCGATGGTGGCGG
CGGCTGAGCGCGACGGCCGGCTCACCCCCGGCGGGACCATCGTCGAGCCCACCAGCGGGAACACCGGTGTGGGCCTGGCC
ATGGTCGCCGCGCGACGCGGCTATCGCTGTGTCTTCACCATGCCGGACAAGATCAGCGAGGAGAAGCGGGCCGTCCTGCG
GGCCTACGGGTCCGAGGTGATCGTCTGCCCGACGGCCGTCGCGCCGGACGACCCCCGCTCCTACTACTCGGTCGCCCGCC
GGGTGCTGAGCGAGACCCCCGGCGCCTGGAGCCCCGACCAGTACTCCAACCCTGACAACCCGGCCGCGCACGAGGCCTCC
ACCGGCCCGGAGATCTGGCGGGCCACCGACGGCCGGGTGACGCACTTCGTCGCCGGCATCGGCACCGGCGGGACGATCAG
CGGGACGGGCCGCCATCTCAAGGCGGTCAGCGGCGGCACCGTGCAGGTGATCGGCGCCGATCCCGAGGGCTCGGTCTACT
CCGGCGGCAGCGGCCGGCCCTACCTGGTCGAAGGCGTCGGCGAGGACATCTGGCCGACGACCTACGACAAGTCCGTGGTC
GACCGGGTGGAGGCCGTCAGCGACCGCGACTCGTTCCTGATGACGCGCGAGCTGGCCCGCCGGGCCGGGATCCTCGTCGG
TGGCTCCTGCGGCCTGGCGGTCGTCGCCGCGCTGCGGGTCGCCCGCGAGCTCGACGCGGCCGGGACGACCGACGCCTGCG
TCGTGGTGCTGCTCCCCGACTCCGGCCGCGGCTACCTGTCGAAGATCTTCAACGACGAGTGGATGTACGACAACGGGTTC
CTCGACCCGCCGTCCGACGAGCCGACGGTCGCCTCGGTGCTCGCGCACAAGGCCGCGCAGACGTCCGGGCCGCCGAACCT
CGTCCACGTGCATCCCGACGAGACCGTCGGGGCGGCCATCTCGTACCTGCGGGAGTATGGGGTCTCGCAGATGCCGGTGG
TGCGCCACGAGCCGCCGGTGCGGGCCGCGGAGGTGGCGGGCGCCGTGCTGGAGCGCGAGCTGCTCGACGCAGTCTTCGCC
GACCGGGGGACGGTGGACGCGCCCGTCGCCGACCACATGTCGCCACCGCTGCCGACGGTCGGCGCCGGCGAGCCCGTCTC
GGTGCTGGTGAGCGCGCTCGGCGAGAACCCGGCCGCCCTCGTCCTGGACGAGGGGAACCCGACGGGGATCCTCACCCGGG
CCGACCTGCTGGGGTTCCTCGCCGTCCGCTGA

Upstream 100 bases:

>100_bases
GTGCCGCGTCCGGAAGGCGGACGCGGCACACCGCCGGTAACGTCGTCGCTGGCGGCTACTGGCGGCGATCGGGGCGACGT
CTCCGGCGAGAGGCGGGCAG

Downstream 100 bases:

>100_bases
GATCCGGTGAGATCCCGCTCCGCCTCCTGAAATCGCCGCTTGTTGAAGTCGCCGCTTGTTTGAAGTCCGGGCTCGAGTGC
GAGGGTTGTGGCCATGGGTG

Product: cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MDVYDHVTDLVGDTPLVRLTPVIADTVTPVLGKLEYLNPGGSVKDRIALSMVAAAERDGRLTPGGTIVEPTSGNTGVGLA
MVAARRGYRCVFTMPDKISEEKRAVLRAYGSEVIVCPTAVAPDDPRSYYSVARRVLSETPGAWSPDQYSNPDNPAAHEAS
TGPEIWRATDGRVTHFVAGIGTGGTISGTGRHLKAVSGGTVQVIGADPEGSVYSGGSGRPYLVEGVGEDIWPTTYDKSVV
DRVEAVSDRDSFLMTRELARRAGILVGGSCGLAVVAALRVARELDAAGTTDACVVVLLPDSGRGYLSKIFNDEWMYDNGF
LDPPSDEPTVASVLAHKAAQTSGPPNLVHVHPDETVGAAISYLREYGVSQMPVVRHEPPVRAAEVAGAVLERELLDAVFA
DRGTVDAPVADHMSPPLPTVGAGEPVSVLVSALGENPAALVLDEGNPTGILTRADLLGFLAVR

Sequences:

>Translated_463_residues
MDVYDHVTDLVGDTPLVRLTPVIADTVTPVLGKLEYLNPGGSVKDRIALSMVAAAERDGRLTPGGTIVEPTSGNTGVGLA
MVAARRGYRCVFTMPDKISEEKRAVLRAYGSEVIVCPTAVAPDDPRSYYSVARRVLSETPGAWSPDQYSNPDNPAAHEAS
TGPEIWRATDGRVTHFVAGIGTGGTISGTGRHLKAVSGGTVQVIGADPEGSVYSGGSGRPYLVEGVGEDIWPTTYDKSVV
DRVEAVSDRDSFLMTRELARRAGILVGGSCGLAVVAALRVARELDAAGTTDACVVVLLPDSGRGYLSKIFNDEWMYDNGF
LDPPSDEPTVASVLAHKAAQTSGPPNLVHVHPDETVGAAISYLREYGVSQMPVVRHEPPVRAAEVAGAVLERELLDAVFA
DRGTVDAPVADHMSPPLPTVGAGEPVSVLVSALGENPAALVLDEGNPTGILTRADLLGFLAVR
>Mature_463_residues
MDVYDHVTDLVGDTPLVRLTPVIADTVTPVLGKLEYLNPGGSVKDRIALSMVAAAERDGRLTPGGTIVEPTSGNTGVGLA
MVAARRGYRCVFTMPDKISEEKRAVLRAYGSEVIVCPTAVAPDDPRSYYSVARRVLSETPGAWSPDQYSNPDNPAAHEAS
TGPEIWRATDGRVTHFVAGIGTGGTISGTGRHLKAVSGGTVQVIGADPEGSVYSGGSGRPYLVEGVGEDIWPTTYDKSVV
DRVEAVSDRDSFLMTRELARRAGILVGGSCGLAVVAALRVARELDAAGTTDACVVVLLPDSGRGYLSKIFNDEWMYDNGF
LDPPSDEPTVASVLAHKAAQTSGPPNLVHVHPDETVGAAISYLREYGVSQMPVVRHEPPVRAAEVAGAVLERELLDAVFA
DRGTVDAPVADHMSPPLPTVGAGEPVSVLVSALGENPAALVLDEGNPTGILTRADLLGFLAVR

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=474, Percent_Identity=38.6075949367089, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI295821200, Length=474, Percent_Identity=38.6075949367089, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI4557415, Length=474, Percent_Identity=38.6075949367089, Blast_Score=289, Evalue=3e-78,
Organism=Escherichia coli, GI2367138, Length=309, Percent_Identity=43.6893203883495, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1788754, Length=321, Percent_Identity=37.3831775700935, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17534315, Length=330, Percent_Identity=46.969696969697, Blast_Score=244, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI25147552, Length=329, Percent_Identity=44.3768996960486, Blast_Score=234, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17535051, Length=312, Percent_Identity=38.7820512820513, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI115535073, Length=311, Percent_Identity=40.1929260450161, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17562970, Length=309, Percent_Identity=38.8349514563107, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI32566674, Length=285, Percent_Identity=41.0526315789474, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17561720, Length=330, Percent_Identity=38.7878787878788, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI32566672, Length=223, Percent_Identity=35.4260089686099, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71996324, Length=343, Percent_Identity=25.6559766763848, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6321594, Length=506, Percent_Identity=34.9802371541502, Blast_Score=266, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6321449, Length=335, Percent_Identity=33.7313432835821, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24643623, Length=474, Percent_Identity=37.3417721518987, Blast_Score=261, Evalue=8e-70,
Organism=Drosophila melanogaster, GI20129101, Length=474, Percent_Identity=37.3417721518987, Blast_Score=261, Evalue=8e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 48536; Mature: 48536

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVYDHVTDLVGDTPLVRLTPVIADTVTPVLGKLEYLNPGGSVKDRIALSMVAAAERDGR
CCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCC
LTPGGTIVEPTSGNTGVGLAMVAARRGYRCVFTMPDKISEEKRAVLRAYGSEVIVCPTAV
CCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEECCCC
APDDPRSYYSVARRVLSETPGAWSPDQYSNPDNPAAHEASTGPEIWRATDGRVTHFVAGI
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCEEEEEEEC
GTGGTISGTGRHLKAVSGGTVQVIGADPEGSVYSGGSGRPYLVEGVGEDIWPTTYDKSVV
CCCCCCCCCCCEEEEECCCEEEEEECCCCCCEECCCCCCCEEEECCCCCCCCCCCCHHHH
DRVEAVSDRDSFLMTRELARRAGILVGGSCGLAVVAALRVARELDAAGTTDACVVVLLPD
HHHHHHCCCHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECC
SGRGYLSKIFNDEWMYDNGFLDPPSDEPTVASVLAHKAAQTSGPPNLVHVHPDETVGAAI
CCCHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHH
SYLREYGVSQMPVVRHEPPVRAAEVAGAVLERELLDAVFADRGTVDAPVADHMSPPLPTV
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCC
GAGEPVSVLVSALGENPAALVLDEGNPTGILTRADLLGFLAVR
CCCCHHHHHHHHHCCCCEEEEEECCCCCEEEEHHHHHHHHHCC
>Mature Secondary Structure
MDVYDHVTDLVGDTPLVRLTPVIADTVTPVLGKLEYLNPGGSVKDRIALSMVAAAERDGR
CCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCC
LTPGGTIVEPTSGNTGVGLAMVAARRGYRCVFTMPDKISEEKRAVLRAYGSEVIVCPTAV
CCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEECCCC
APDDPRSYYSVARRVLSETPGAWSPDQYSNPDNPAAHEASTGPEIWRATDGRVTHFVAGI
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCEEEEEEEC
GTGGTISGTGRHLKAVSGGTVQVIGADPEGSVYSGGSGRPYLVEGVGEDIWPTTYDKSVV
CCCCCCCCCCCEEEEECCCEEEEEECCCCCCEECCCCCCCEEEECCCCCCCCCCCCHHHH
DRVEAVSDRDSFLMTRELARRAGILVGGSCGLAVVAALRVARELDAAGTTDACVVVLLPD
HHHHHHCCCHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECC
SGRGYLSKIFNDEWMYDNGFLDPPSDEPTVASVLAHKAAQTSGPPNLVHVHPDETVGAAI
CCCHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHH
SYLREYGVSQMPVVRHEPPVRAAEVAGAVLERELLDAVFADRGTVDAPVADHMSPPLPTV
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCC
GAGEPVSVLVSALGENPAALVLDEGNPTGILTRADLLGFLAVR
CCCCHHHHHHHHHCCCCEEEEEECCCCCEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]