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The map label for this gene is ada [H]

Identifier: 158318155

GI number: 158318155

Start: 7795709

End: 7797331

Strand: Reverse

Name: ada [H]

Synonym: Franean1_6420

Alternate gene names: 158318155

Gene position: 7797331-7795709 (Counterclockwise)

Preceding gene: 158318156

Following gene: 158318154

Centisome position: 86.81

GC content: 76.03

Gene sequence:

>1623_bases
GTGCCCGCCAGTCCGCATCTCGACGCCGAGCTGTGCGCGCGGGTGGTGCGGTCCCGGGACGCCCGGTTCGACGGGTGGTT
CTTCGTCGCGGTGACCTCCACCGGCATCTACTGCCGGCCGAGCTGCCCGGCGCGGCCACCCAGGACCGAGAACATGCGGT
TCCACCCGACCGCCGCGTCCGCCCAGCGCGCCGGGTTCCGGGCCTGCAAGCGCTGCCGCCCGGACGCGAGTCCCGGCTCA
CCGGAGTGGAACCACCGCGCCGACGTCGTGGCGCGCGCGATGCGGCTCATCGTGGACGGCGTCGTCGACCGTGAGGGTGT
CCCCGGGCTTGCCGGTCAGCTCGGCTACAGCGCACGCCAGGTGGAGCGGCACCTGTCAGCCGAGCTCGGTGCCGGGCCGC
TCGCGCTGGCCCGCGCCCAGCGCGCCCAGACCGCCCGGCTCCTGCTCGAGACCACGGACCTGAGCATGGGCGACGTCGCG
ACCGCCGCCGGCTTCAACAGCATCCGCGCCTTCAACGACACCATGCGCGAGGTCTTCGCCGCCGCGCCGAGCGATCTGCG
ACGCCGTCGCAACCCGGCGAGGCCCCCGTCCGTCGTGCCGGTACCGAGGGCGGCTACCGGTGCCGTGACGTTGACCGTCC
GGCTGCCGTTCCGGGCCCCGCTGTATCCCGACAACCTGTTCGGGCACCTCGTCGCGACGGCCGTTCCCGGGGTCGAGGAG
TGGCGGGACGGTGCCTACCGGCGCACGATGCGCACGCTGCACGGGCACGCGATCGTCGCCCTGCGGCCGCTGCCCGACCA
CATCGGCTGCCGGCTCGCCCTCACCGACGTGCGCGACCTCGCGCCGGTCATCGGCCGCTGCCGCCGGCTGCTCGACCTCG
ACGCGGACCCGATCGCCGTCGACGGGCAGCTCGCCGCCGACCCGGCGCTGGCGCCGCTGGTCGCGCGGGCACCGGGCCGG
CGTGTTCCGCGCACCGTCGACCCGGCCGAGCTCGCGGTGCGCGCAGTCCTCGGACAGCAGGTCTCCGTCGCGGCGGCGCG
GACCCACGCCGCGCGGCTCGTCACGGCCGTCGGCACGCCGATCCATGATCCGGAAGGCGGCCTCACCCACCTCTGGCCAC
AGATCGCGGACCTCGCCGAGCACATCGAGCGCACCGAGTACGCCGAGTGCACCGACCTCGCGGACGCTGTCCCGGCCGGC
CGCCGGGCCGGGGCGCCGCGCGGGCTCGCCCTGCCGGCCGCCCGGCGGCGGACCTTCGCCGCGCTGGTCGGCGGGCTGGT
GTCCGGCATGATCGAGCTGGGTGCGGGCGGAGACTGGGAGCGGGCCCGCGCCGCGCTGGCGGCTCTGCCCGGCATCGGCC
CGTGGACGCTCGAGACCATCGCGATGCGGGCCCTCGGTGACCCGGACGCATTCCTGCCCGGTGATCTCGGTGTCCGCCGA
GGGGCCGAACGGCTCGGTCTGCCGGCCACCCCCGCCGCGCTGTCCCGGCATGCCGCCGCCTGGCGCCCCTGGCGGGCCTA
TGCCGTCCAGCACCTGTGGGCGGTGCTCGACCATCCAGTCAACCGGATGCCCGCGCCGGATCATCCCGGCCCGGTCACCG
CCCGCCGAGAGGAACGCCTGTGA

Upstream 100 bases:

>100_bases
GGTCGATGCTGCTGCCGGACCCGACCGCCGGACCGTCATGTCGGTTTCTCGCTGGACCTGGCGGATCCGGCGCGCGAATG
CTGGACGGGTGCCCATCGCC

Downstream 100 bases:

>100_bases
CCCGCAGCCAACCCGTCCCGCCGGACGCCGCCGAGCGCACGCACGCCGTCGTGGAGAGCCCGGTCGGGCCGCTGACGCTG
GTGGCGAGCGGCGGCGCGCT

Product: AraC family transcriptional regulator

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MPASPHLDAELCARVVRSRDARFDGWFFVAVTSTGIYCRPSCPARPPRTENMRFHPTAASAQRAGFRACKRCRPDASPGS
PEWNHRADVVARAMRLIVDGVVDREGVPGLAGQLGYSARQVERHLSAELGAGPLALARAQRAQTARLLLETTDLSMGDVA
TAAGFNSIRAFNDTMREVFAAAPSDLRRRRNPARPPSVVPVPRAATGAVTLTVRLPFRAPLYPDNLFGHLVATAVPGVEE
WRDGAYRRTMRTLHGHAIVALRPLPDHIGCRLALTDVRDLAPVIGRCRRLLDLDADPIAVDGQLAADPALAPLVARAPGR
RVPRTVDPAELAVRAVLGQQVSVAAARTHAARLVTAVGTPIHDPEGGLTHLWPQIADLAEHIERTEYAECTDLADAVPAG
RRAGAPRGLALPAARRRTFAALVGGLVSGMIELGAGGDWERARAALAALPGIGPWTLETIAMRALGDPDAFLPGDLGVRR
GAERLGLPATPAALSRHAAAWRPWRAYAVQHLWAVLDHPVNRMPAPDHPGPVTARREERL

Sequences:

>Translated_540_residues
MPASPHLDAELCARVVRSRDARFDGWFFVAVTSTGIYCRPSCPARPPRTENMRFHPTAASAQRAGFRACKRCRPDASPGS
PEWNHRADVVARAMRLIVDGVVDREGVPGLAGQLGYSARQVERHLSAELGAGPLALARAQRAQTARLLLETTDLSMGDVA
TAAGFNSIRAFNDTMREVFAAAPSDLRRRRNPARPPSVVPVPRAATGAVTLTVRLPFRAPLYPDNLFGHLVATAVPGVEE
WRDGAYRRTMRTLHGHAIVALRPLPDHIGCRLALTDVRDLAPVIGRCRRLLDLDADPIAVDGQLAADPALAPLVARAPGR
RVPRTVDPAELAVRAVLGQQVSVAAARTHAARLVTAVGTPIHDPEGGLTHLWPQIADLAEHIERTEYAECTDLADAVPAG
RRAGAPRGLALPAARRRTFAALVGGLVSGMIELGAGGDWERARAALAALPGIGPWTLETIAMRALGDPDAFLPGDLGVRR
GAERLGLPATPAALSRHAAAWRPWRAYAVQHLWAVLDHPVNRMPAPDHPGPVTARREERL
>Mature_539_residues
PASPHLDAELCARVVRSRDARFDGWFFVAVTSTGIYCRPSCPARPPRTENMRFHPTAASAQRAGFRACKRCRPDASPGSP
EWNHRADVVARAMRLIVDGVVDREGVPGLAGQLGYSARQVERHLSAELGAGPLALARAQRAQTARLLLETTDLSMGDVAT
AAGFNSIRAFNDTMREVFAAAPSDLRRRRNPARPPSVVPVPRAATGAVTLTVRLPFRAPLYPDNLFGHLVATAVPGVEEW
RDGAYRRTMRTLHGHAIVALRPLPDHIGCRLALTDVRDLAPVIGRCRRLLDLDADPIAVDGQLAADPALAPLVARAPGRR
VPRTVDPAELAVRAVLGQQVSVAAARTHAARLVTAVGTPIHDPEGGLTHLWPQIADLAEHIERTEYAECTDLADAVPAGR
RAGAPRGLALPAARRRTFAALVGGLVSGMIELGAGGDWERARAALAALPGIGPWTLETIAMRALGDPDAFLPGDLGVRRG
AERLGLPATPAALSRHAAAWRPWRAYAVQHLWAVLDHPVNRMPAPDHPGPVTARREERL

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=303, Percent_Identity=31.6831683168317, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1788542, Length=155, Percent_Identity=36.1290322580645, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 57968; Mature: 57837

Theoretical pI: Translated: 10.65; Mature: 10.65

Prosite motif: PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASPHLDAELCARVVRSRDARFDGWFFVAVTSTGIYCRPSCPARPPRTENMRFHPTAAS
CCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCEEECCCHHH
AQRAGFRACKRCRPDASPGSPEWNHRADVVARAMRLIVDGVVDREGVPGLAGQLGYSARQ
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCHHHHH
VERHLSAELGAGPLALARAQRAQTARLLLETTDLSMGDVATAAGFNSIRAFNDTMREVFA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHCHHHHHHHHHHHHHHHH
AAPSDLRRRRNPARPPSVVPVPRAATGAVTLTVRLPFRAPLYPDNLFGHLVATAVPGVEE
CCCHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHH
WRDGAYRRTMRTLHGHAIVALRPLPDHIGCRLALTDVRDLAPVIGRCRRLLDLDADPIAV
HHCHHHHHHHHHHCCCEEEEEECCCHHHCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEE
DGQLAADPALAPLVARAPGRRVPRTVDPAELAVRAVLGQQVSVAAARTHAARLVTAVGTP
CCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
IHDPEGGLTHLWPQIADLAEHIERTEYAECTDLADAVPAGRRAGAPRGLALPAARRRTFA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
ALVGGLVSGMIELGAGGDWERARAALAALPGIGPWTLETIAMRALGDPDAFLPGDLGVRR
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHC
GAERLGLPATPAALSRHAAAWRPWRAYAVQHLWAVLDHPVNRMPAPDHPGPVTARREERL
CHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure 
PASPHLDAELCARVVRSRDARFDGWFFVAVTSTGIYCRPSCPARPPRTENMRFHPTAAS
CCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCEEECCCHHH
AQRAGFRACKRCRPDASPGSPEWNHRADVVARAMRLIVDGVVDREGVPGLAGQLGYSARQ
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCHHHHH
VERHLSAELGAGPLALARAQRAQTARLLLETTDLSMGDVATAAGFNSIRAFNDTMREVFA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHCHHHHHHHHHHHHHHHH
AAPSDLRRRRNPARPPSVVPVPRAATGAVTLTVRLPFRAPLYPDNLFGHLVATAVPGVEE
CCCHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHH
WRDGAYRRTMRTLHGHAIVALRPLPDHIGCRLALTDVRDLAPVIGRCRRLLDLDADPIAV
HHCHHHHHHHHHHCCCEEEEEECCCHHHCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEE
DGQLAADPALAPLVARAPGRRVPRTVDPAELAVRAVLGQQVSVAAARTHAARLVTAVGTP
CCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
IHDPEGGLTHLWPQIADLAEHIERTEYAECTDLADAVPAGRRAGAPRGLALPAARRRTFA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
ALVGGLVSGMIELGAGGDWERARAALAALPGIGPWTLETIAMRALGDPDAFLPGDLGVRR
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHC
GAERLGLPATPAALSRHAAAWRPWRAYAVQHLWAVLDHPVNRMPAPDHPGPVTARREERL
CHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]