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The map label for this gene is fabG [C]

Identifier: 158318107

GI number: 158318107

Start: 7731044

End: 7731769

Strand: Reverse

Name: fabG [C]

Synonym: Franean1_6371

Alternate gene names: 158318107

Gene position: 7731769-7731044 (Counterclockwise)

Preceding gene: 158318110

Following gene: 158318106

Centisome position: 86.08

GC content: 70.11

Gene sequence:

>726_bases
GTGCAGCCTCTGGTACTCGAACGTGCTGGTCGCAAGCATTTGAGCGGCCATCGTTCGATGCAGTTCGGTCGAGAGACGAC
GGCCGCCGAGGTGCTCCAGGGAGTGGATCTCGAAGGCCGCCGCGCCATCGTGACCGGGGCGTCGTCCGGGATCGGTGTCG
AGACGGCCCGCGCGTTGGCGGACGCCGGCGCCGAGGTCACGCTGGCGGTCCGCAACACCGAGGCCGGTGGCCGCGTGGCG
GACGACATAATCGCCGGCACGGGGAACAAGGCGATCTTCGTATCGAAGCTCGACCTGGCCGACCGGGCGTCGGTGACCGG
GCTCGTCGAGGCCTGGAACGGCCCGCTCCACATCCTCGTGAACAACGGCGGGGTCATGGCGCTGCCTCAGCTCCAGCGGA
CCCCGGAGGGGTGGGAGCAGCACTTCGCCACCAGCCATCTCGGCCACTTCGCCCTCGCGCTGGGCCTGCGCGACGCCCTG
GCGGCGGCGGGGAGCTCCCGCGTCGTCTCGGTGAGCTCCGACGGCCATGTACACGCCAACGCGCCGGTGGACTTCGACGA
CATCCGCTTCGAGCGCCGCGACTACAGCGGGCACCGAGCCTACGCACAGTCGAAGACGGCGAACATCCTCTTCGCGGTCG
AGGGCGCCAAGCGCTGGGCGAAGGACGGCATCGCGGTGAACGCCCTGCACCCGGCGGGATCCAGACCGGCATCCAGCGGC
ACATGA

Upstream 100 bases:

>100_bases
TGTTGCACTCCCGATATCCGCGGTGGTCGCCGCGTCGGGCGCCCGCGCATCCGCCTGCGTTGAAGCCGCGGAATCCGCGG
CCCACTGGGAAATTTCGGCG

Downstream 100 bases:

>100_bases
ACGCGGTCCTGCCCGAGGAGATGCGCAGGGCGCTGGAGGCGAAGTGGCCGTGGCGGAGTGTGGAGCAGGGCGCGGCCACG
AGCGTCCTTGTCGCGGGCTC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MQPLVLERAGRKHLSGHRSMQFGRETTAAEVLQGVDLEGRRAIVTGASSGIGVETARALADAGAEVTLAVRNTEAGGRVA
DDIIAGTGNKAIFVSKLDLADRASVTGLVEAWNGPLHILVNNGGVMALPQLQRTPEGWEQHFATSHLGHFALALGLRDAL
AAAGSSRVVSVSSDGHVHANAPVDFDDIRFERRDYSGHRAYAQSKTANILFAVEGAKRWAKDGIAVNALHPAGSRPASSG
T

Sequences:

>Translated_241_residues
MQPLVLERAGRKHLSGHRSMQFGRETTAAEVLQGVDLEGRRAIVTGASSGIGVETARALADAGAEVTLAVRNTEAGGRVA
DDIIAGTGNKAIFVSKLDLADRASVTGLVEAWNGPLHILVNNGGVMALPQLQRTPEGWEQHFATSHLGHFALALGLRDAL
AAAGSSRVVSVSSDGHVHANAPVDFDDIRFERRDYSGHRAYAQSKTANILFAVEGAKRWAKDGIAVNALHPAGSRPASSG
T
>Mature_241_residues
MQPLVLERAGRKHLSGHRSMQFGRETTAAEVLQGVDLEGRRAIVTGASSGIGVETARALADAGAEVTLAVRNTEAGGRVA
DDIIAGTGNKAIFVSKLDLADRASVTGLVEAWNGPLHILVNNGGVMALPQLQRTPEGWEQHFATSHLGHFALALGLRDAL
AAAGSSRVVSVSSDGHVHANAPVDFDDIRFERRDYSGHRAYAQSKTANILFAVEGAKRWAKDGIAVNALHPAGSRPASSG
T

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7706523, Length=214, Percent_Identity=39.7196261682243, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI186928839, Length=200, Percent_Identity=42.5, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI166795268, Length=200, Percent_Identity=41.5, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI225579078, Length=203, Percent_Identity=39.9014778325123, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI193804850, Length=196, Percent_Identity=39.7959183673469, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI10190746, Length=213, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI146231950, Length=202, Percent_Identity=39.1089108910891, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI19923931, Length=160, Percent_Identity=39.375, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI72534732, Length=162, Percent_Identity=29.0123456790123, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI13375997, Length=162, Percent_Identity=29.0123456790123, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532805, Length=227, Percent_Identity=36.5638766519824, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17532791, Length=227, Percent_Identity=33.0396475770925, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI193207620, Length=225, Percent_Identity=31.1111111111111, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI32565532, Length=226, Percent_Identity=32.7433628318584, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71992402, Length=237, Percent_Identity=30.379746835443, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17535059, Length=225, Percent_Identity=31.5555555555556, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17505416, Length=210, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17558006, Length=209, Percent_Identity=30.1435406698565, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI72001364, Length=208, Percent_Identity=32.6923076923077, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28573296, Length=215, Percent_Identity=40, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI20129347, Length=221, Percent_Identity=39.3665158371041, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI22024069, Length=211, Percent_Identity=40.2843601895735, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI161076371, Length=199, Percent_Identity=41.7085427135678, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24586328, Length=214, Percent_Identity=36.9158878504673, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19921754, Length=205, Percent_Identity=38.0487804878049, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI45554248, Length=202, Percent_Identity=38.1188118811881, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24640117, Length=202, Percent_Identity=38.1188118811881, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24647946, Length=216, Percent_Identity=34.7222222222222, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45553409, Length=198, Percent_Identity=35.8585858585859, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24647948, Length=198, Percent_Identity=35.8585858585859, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24656154, Length=202, Percent_Identity=32.6732673267327, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI19922628, Length=202, Percent_Identity=32.6732673267327, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24647931, Length=216, Percent_Identity=31.9444444444444, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25283; Mature: 25283

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLVLERAGRKHLSGHRSMQFGRETTAAEVLQGVDLEGRRAIVTGASSGIGVETARALA
CCCCHHHHCCHHHHCCCHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHH
DAGAEVTLAVRNTEAGGRVADDIIAGTGNKAIFVSKLDLADRASVTGLVEAWNGPLHILV
HCCCEEEEEEECCCCCCCCHHHHEECCCCCEEEEEECCCCCCCHHHHHEECCCCCEEEEE
NNGGVMALPQLQRTPEGWEQHFATSHLGHFALALGLRDALAAAGSSRVVSVSSDGHVHAN
CCCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEC
APVDFDDIRFERRDYSGHRAYAQSKTANILFAVEGAKRWAKDGIAVNALHPAGSRPASSG
CCCCHHHHEEECCCCCCCHHHHCCCCCEEEEEECCCHHHHHCCEEEEEECCCCCCCCCCC
T
C
>Mature Secondary Structure
MQPLVLERAGRKHLSGHRSMQFGRETTAAEVLQGVDLEGRRAIVTGASSGIGVETARALA
CCCCHHHHCCHHHHCCCHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHH
DAGAEVTLAVRNTEAGGRVADDIIAGTGNKAIFVSKLDLADRASVTGLVEAWNGPLHILV
HCCCEEEEEEECCCCCCCCHHHHEECCCCCEEEEEECCCCCCCHHHHHEECCCCCEEEEE
NNGGVMALPQLQRTPEGWEQHFATSHLGHFALALGLRDALAAAGSSRVVSVSSDGHVHAN
CCCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEC
APVDFDDIRFERRDYSGHRAYAQSKTANILFAVEGAKRWAKDGIAVNALHPAGSRPASSG
CCCCHHHHEEECCCCCCCHHHHCCCCCEEEEEECCCHHHHHCCEEEEEECCCCCCCCCCC
T
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]