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The map label for this gene is dtxR [H]

Identifier: 158317947

GI number: 158317947

Start: 7540726

End: 7541466

Strand: Reverse

Name: dtxR [H]

Synonym: Franean1_6206

Alternate gene names: 158317947

Gene position: 7541466-7540726 (Counterclockwise)

Preceding gene: 158317949

Following gene: 158317945

Centisome position: 83.96

GC content: 68.42

Gene sequence:

>741_bases
ATGCGGCTCCTCCTGCCAGGCGTTGCGGCGTACTCTGGTTGCGGACGAAGGAGACCGGTGACTGGACTGATCGACAGTAC
CGAGATGTACCTCCGGACCCTGTATGAACTACGGGAGGAGGGCATCACCCCGCTGCGCGCGCGCCTGGTCGAGCGCCTTC
ACGTGAGCGCGCCGGCCGCGAGTGAGTCGACCGCGCGCCTCGCGAACGAGGGCCTCGTCGCGCTCGCCGACGACCGGACC
GTGCAGTTCACGGAGAAGGGCCTGGTCAGAGCGACGGCGGTCATGCGGAAGCACCGCCTGGCCGAGTTGCTCCTCACCAA
GGTCATTGGCCTGGACTGGGCGCTGGTCCACAACGAGGCCTGCCGCTGGGAGCATGTGATCTCGGACGAGGTCGAGGCCC
GGCTGACAGTCCTGCTCGGTGACCCGAAGCGGTGCCCGTTCGGGAACGAGATCCCGGCGCAGCTCGAGACGGCGCAGCCG
CCTGGTGTGGCACCGGTGAGCCTGCTCACATCGGCTGAGCGAAGCAACACCGGGACCAAGTCGGTGACGGTGGCCTGGAT
CTCGGAGCGCCTCCAGACCGACGAGGAGGCGATGCGCGTCCTGCGGGACGCCGCGATCGTGCCCGGGGCACAGCTCTACC
TGAACGCGCGCGGCGACAGGGTGTACATCGCCAAGCCGGACGGCGACAGCGAGGCCGAGATCGACCGCAGCACAGCGGCG
CTCGTCTACGTCAATCACTGA

Upstream 100 bases:

>100_bases
TGTACTTGCATCGATACTCTGAGTGGGAGCCAGTCTGGCCGGCGACACGGTGACGGAACGGGCACGGACATACCACACTC
CGCCATCAGGACGCAGAGGA

Downstream 100 bases:

>100_bases
TCCGGGAAACGACAGCACACACGGCACACAGAGCACGCAGCACCTGTACAGAGCCACACAGCACGTAAGCATCTGTACGG
ATGTGGACCTGACTGTCGGG

Product: DtxR family iron dependent repressor

Products: NA

Alternate protein names: Iron-dependent diphtheria tox regulatory element; Tox regulatory factor [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MRLLLPGVAAYSGCGRRRPVTGLIDSTEMYLRTLYELREEGITPLRARLVERLHVSAPAASESTARLANEGLVALADDRT
VQFTEKGLVRATAVMRKHRLAELLLTKVIGLDWALVHNEACRWEHVISDEVEARLTVLLGDPKRCPFGNEIPAQLETAQP
PGVAPVSLLTSAERSNTGTKSVTVAWISERLQTDEEAMRVLRDAAIVPGAQLYLNARGDRVYIAKPDGDSEAEIDRSTAA
LVYVNH

Sequences:

>Translated_246_residues
MRLLLPGVAAYSGCGRRRPVTGLIDSTEMYLRTLYELREEGITPLRARLVERLHVSAPAASESTARLANEGLVALADDRT
VQFTEKGLVRATAVMRKHRLAELLLTKVIGLDWALVHNEACRWEHVISDEVEARLTVLLGDPKRCPFGNEIPAQLETAQP
PGVAPVSLLTSAERSNTGTKSVTVAWISERLQTDEEAMRVLRDAAIVPGAQLYLNARGDRVYIAKPDGDSEAEIDRSTAA
LVYVNH
>Mature_246_residues
MRLLLPGVAAYSGCGRRRPVTGLIDSTEMYLRTLYELREEGITPLRARLVERLHVSAPAASESTARLANEGLVALADDRT
VQFTEKGLVRATAVMRKHRLAELLLTKVIGLDWALVHNEACRWEHVISDEVEARLTVLLGDPKRCPFGNEIPAQLETAQP
PGVAPVSLLTSAERSNTGTKSVTVAWISERLQTDEEAMRVLRDAAIVPGAQLYLNARGDRVYIAKPDGDSEAEIDRSTAA
LVYVNH

Specific function: Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess [H]

COG id: COG1321

COG function: function code K; Mn-dependent transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH dtxR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007167
- InterPro:   IPR001367
- InterPro:   IPR022689
- InterPro:   IPR022687
- InterPro:   IPR008988
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02742 Fe_dep_repr_C; PF01325 Fe_dep_repress [H]

EC number: NA

Molecular weight: Translated: 27017; Mature: 27017

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50944 HTH_DTXR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLLPGVAAYSGCGRRRPVTGLIDSTEMYLRTLYELREEGITPLRARLVERLHVSAPAA
CCEECCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
SESTARLANEGLVALADDRTVQFTEKGLVRATAVMRKHRLAELLLTKVIGLDWALVHNEA
CHHHHHHHCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
CRWEHVISDEVEARLTVLLGDPKRCPFGNEIPAQLETAQPPGVAPVSLLTSAERSNTGTK
HHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHCCCCCCC
SVTVAWISERLQTDEEAMRVLRDAAIVPGAQLYLNARGDRVYIAKPDGDSEAEIDRSTAA
EEEHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCEEE
LVYVNH
EEEEEC
>Mature Secondary Structure
MRLLLPGVAAYSGCGRRRPVTGLIDSTEMYLRTLYELREEGITPLRARLVERLHVSAPAA
CCEECCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
SESTARLANEGLVALADDRTVQFTEKGLVRATAVMRKHRLAELLLTKVIGLDWALVHNEA
CHHHHHHHCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
CRWEHVISDEVEARLTVLLGDPKRCPFGNEIPAQLETAQPPGVAPVSLLTSAERSNTGTK
HHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHCCCCCCC
SVTVAWISERLQTDEEAMRVLRDAAIVPGAQLYLNARGDRVYIAKPDGDSEAEIDRSTAA
EEEHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCEEE
LVYVNH
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2116013; 1735717; 14602910; 1502169; 1400485; 8823163; 7568230; 9697776; 10085021; 10339551 [H]