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The map label for this gene is ubiE

Identifier: 158317839

GI number: 158317839

Start: 7422439

End: 7423203

Strand: Reverse

Name: ubiE

Synonym: Franean1_6097

Alternate gene names: 158317839

Gene position: 7423203-7422439 (Counterclockwise)

Preceding gene: 158317840

Following gene: 158317837

Centisome position: 82.64

GC content: 76.08

Gene sequence:

>765_bases
GTGAGTCGAGCAGGTCTGGACAAGAAGCCCGACCAGGTGGCCGCGATGTTCGACCAGGTCGCGCGGCGGTACGACGTGAC
GAACGCGGTGCTGTCGGCCGGCCTGGACCGCACCTGGCGGACCGCGACCGCGCGGGCCCTGGCCCTGGCGCCGGGCCTGC
GGGTCCTCGACGTCGCGGCCGGGACGGCGACGTCGTCCCGGGCCTTCGCCGCCGCCGGGGCCGATGTCGTGGCTTGCGAC
TTCTCTCTCGGCATGCTGGCCCAGGCCCGGCGCCGGCTCGCCGACGCGGCCGCGCGGGCGGGCGCCGGGGCGGGAACGGG
TGGGGCGGGAACGGGTGGCGGCCGGGTGCTGCTGGCGGCTGGTGACGGCCTGCGCCTGCCCTTCGCGGACGGCTCCTTCG
ACCGGGTCACGATCTCCTTCGGTCTGCGCAACGTGGCCGAGGGCGACGTCTGCCTCGCCGAGTTGCTGCGGGTCACCCGG
CCGGGGGGCGTGCTGGCGGTCTGCGAGTTCAGCCGTCCGGTGTGGCGGCCGGTGCGCACGGCGTACATGGAGTACCTGAT
GCGCGCGCTGCCCGCGGTCGCGCGGGCGGTGAGCAGCAGCCCGGACTCGTACGTGTACCTGGCGGAGTCCATCCGGGCCT
GGCCGGGGCAGGCCGCGCTGGCGGAGACGATCCGCGCGGCCGGCTGGACAAGGGTGGGCTGGCGCAATCTCAGCGGCGGC
ATCGTCGCCGTCCACCGCGCCGTCCGCCCCGGCGGAGACGACTGA

Upstream 100 bases:

>100_bases
GCTGGGTCCGCGCTGGCCGGGTCCGCGCTGGCCGGGTCTGACGCGGCTGGGTCCGCGACGGCGGGGTCCGTGGCCATGAC
GAACGCAGAGGGATGAGCCG

Downstream 100 bases:

>100_bases
CGTACGGCGTCGGTTGGCACCGCCGTCCCGGTTCCGCGGAACCTCAAGATCGACCGTGGCCCGTGGTGGTTGCGCCGTCG
AGCGGACTGCGCGGCGGCGT

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSRAGLDKKPDQVAAMFDQVARRYDVTNAVLSAGLDRTWRTATARALALAPGLRVLDVAAGTATSSRAFAAAGADVVACD
FSLGMLAQARRRLADAAARAGAGAGTGGAGTGGGRVLLAAGDGLRLPFADGSFDRVTISFGLRNVAEGDVCLAELLRVTR
PGGVLAVCEFSRPVWRPVRTAYMEYLMRALPAVARAVSSSPDSYVYLAESIRAWPGQAALAETIRAAGWTRVGWRNLSGG
IVAVHRAVRPGGDD

Sequences:

>Translated_254_residues
MSRAGLDKKPDQVAAMFDQVARRYDVTNAVLSAGLDRTWRTATARALALAPGLRVLDVAAGTATSSRAFAAAGADVVACD
FSLGMLAQARRRLADAAARAGAGAGTGGAGTGGGRVLLAAGDGLRLPFADGSFDRVTISFGLRNVAEGDVCLAELLRVTR
PGGVLAVCEFSRPVWRPVRTAYMEYLMRALPAVARAVSSSPDSYVYLAESIRAWPGQAALAETIRAAGWTRVGWRNLSGG
IVAVHRAVRPGGDD
>Mature_253_residues
SRAGLDKKPDQVAAMFDQVARRYDVTNAVLSAGLDRTWRTATARALALAPGLRVLDVAAGTATSSRAFAAAGADVVACDF
SLGMLAQARRRLADAAARAGAGAGTGGAGTGGGRVLLAAGDGLRLPFADGSFDRVTISFGLRNVAEGDVCLAELLRVTRP
GGVLAVCEFSRPVWRPVRTAYMEYLMRALPAVARAVSSSPDSYVYLAESIRAWPGQAALAETIRAAGWTRVGWRNLSGGI
VAVHRAVRPGGDD

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=279, Percent_Identity=29.0322580645161, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI48994983, Length=247, Percent_Identity=38.0566801619433, Blast_Score=163, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17557039, Length=247, Percent_Identity=29.1497975708502, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323526, Length=259, Percent_Identity=28.957528957529, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24641702, Length=252, Percent_Identity=30.5555555555556, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_FRASN (A8LCA4)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001510347.1
- ProteinModelPortal:   A8LCA4
- SMR:   A8LCA4
- GeneID:   5674418
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_6097
- HOGENOM:   HBG559580
- OMA:   FDVYTIA
- ProtClustDB:   PRK00216
- BioCyc:   FSP1855:FRANEAN1_6097-MONOMER
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 26415; Mature: 26284

Theoretical pI: Translated: 10.62; Mature: 10.62

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAGLDKKPDQVAAMFDQVARRYDVTNAVLSAGLDRTWRTATARALALAPGLRVLDVAA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEC
GTATSSRAFAAAGADVVACDFSLGMLAQARRRLADAAARAGAGAGTGGAGTGGGRVLLAA
CCCCCCCHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEE
GDGLRLPFADGSFDRVTISFGLRNVAEGDVCLAELLRVTRPGGVLAVCEFSRPVWRPVRT
CCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHH
AYMEYLMRALPAVARAVSSSPDSYVYLAESIRAWPGQAALAETIRAAGWTRVGWRNLSGG
HHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCC
IVAVHRAVRPGGDD
EEEEEHHCCCCCCC
>Mature Secondary Structure 
SRAGLDKKPDQVAAMFDQVARRYDVTNAVLSAGLDRTWRTATARALALAPGLRVLDVAA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEC
GTATSSRAFAAAGADVVACDFSLGMLAQARRRLADAAARAGAGAGTGGAGTGGGRVLLAA
CCCCCCCHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEE
GDGLRLPFADGSFDRVTISFGLRNVAEGDVCLAELLRVTRPGGVLAVCEFSRPVWRPVRT
CCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHH
AYMEYLMRALPAVARAVSSSPDSYVYLAESIRAWPGQAALAETIRAAGWTRVGWRNLSGG
HHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCC
IVAVHRAVRPGGDD
EEEEEHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA