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The map label for this gene is adk [H]

Identifier: 158317770

GI number: 158317770

Start: 7349905

End: 7350558

Strand: Reverse

Name: adk [H]

Synonym: Franean1_6028

Alternate gene names: 158317770

Gene position: 7350558-7349905 (Counterclockwise)

Preceding gene: 158317771

Following gene: 158317769

Centisome position: 81.84

GC content: 68.04

Gene sequence:

>654_bases
GTGCGCCTCGTACTGGTCGGACCGCCAGGCGCCGGCAAGGGGACGCAGGCTGCCTTCATCGCGCAGGCGAGATCCATTCC
GAAGATCTCGACCGGCGACATCTTCCGGGCGAACGTCCGCGAGGGAACCGAACTCGGTGTCCAGGCGAAGGCGTTCATGG
ACTCCGGCGACCTCGTCCCCGACGAGATCACCATCGGCATGGTGCGCAACCGTCTCGCCGAGGACGACGCGGTCAAGGGC
TTCCTCCTGGACGGCTTCCCGCGCAACGTCCCGCAGGCCGAGGTGCTCGGCGGAATGCTGGACGCGATGGGTACGCGTCT
CGATGTGGTCCTCGAGTTGGTCGTCGACGACGACGAGGTGGTGCGGCGGCTCTCCGGCCGGCGGACCTGCCGGAACTGCG
GGCACATCTGGCACCTCGACTTCGACCCGTCCCGGGTCGAGGGAATCTGTGACCGGTGCTCGGGGGAGCTGTTCCAGCGC
GATGACGACCGTCCTGAGACGGTGCGCCACCGCCTCGAGGTGTATGCGGAGCAGACCTCCCCGCTTGTCGCCTACTACGC
GGCCAAGGGCGTGCTCATCGGCATCGATGCGACCGGCCCGGTCGACAACGTAACCGATCGTGCCCTGGACGCGCTGCGCC
ACTACGGCGACTGA

Upstream 100 bases:

>100_bases
CTGGTACCTCGGTTCTGATCATGGTGGGAGTGGGGCTGGAGACCGTGAAACAGATTGAAAGCCAGCTCATGCTGCGCAAC
TACGAAGGATTCCTCCGGTA

Downstream 100 bases:

>100_bases
CCGAGGCCGCCCCGCTCGCCGCGCCGTGACTCCGCCATACCTCGCGTCTCCGGCGGTTCCCGCACGGAACGCGGGCTCGG
TGGCCCGAGGCCCTGCGTTC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MRLVLVGPPGAGKGTQAAFIAQARSIPKISTGDIFRANVREGTELGVQAKAFMDSGDLVPDEITIGMVRNRLAEDDAVKG
FLLDGFPRNVPQAEVLGGMLDAMGTRLDVVLELVVDDDEVVRRLSGRRTCRNCGHIWHLDFDPSRVEGICDRCSGELFQR
DDDRPETVRHRLEVYAEQTSPLVAYYAAKGVLIGIDATGPVDNVTDRALDALRHYGD

Sequences:

>Translated_217_residues
MRLVLVGPPGAGKGTQAAFIAQARSIPKISTGDIFRANVREGTELGVQAKAFMDSGDLVPDEITIGMVRNRLAEDDAVKG
FLLDGFPRNVPQAEVLGGMLDAMGTRLDVVLELVVDDDEVVRRLSGRRTCRNCGHIWHLDFDPSRVEGICDRCSGELFQR
DDDRPETVRHRLEVYAEQTSPLVAYYAAKGVLIGIDATGPVDNVTDRALDALRHYGD
>Mature_217_residues
MRLVLVGPPGAGKGTQAAFIAQARSIPKISTGDIFRANVREGTELGVQAKAFMDSGDLVPDEITIGMVRNRLAEDDAVKG
FLLDGFPRNVPQAEVLGGMLDAMGTRLDVVLELVVDDDEVVRRLSGRRTCRNCGHIWHLDFDPSRVEGICDRCSGELFQR
DDDRPETVRHRLEVYAEQTSPLVAYYAAKGVLIGIDATGPVDNVTDRALDALRHYGD

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=213, Percent_Identity=40.8450704225352, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI4502013, Length=213, Percent_Identity=40.8450704225352, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI19923437, Length=198, Percent_Identity=38.8888888888889, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI310110345, Length=198, Percent_Identity=35.8585858585859, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI53832003, Length=198, Percent_Identity=35.8585858585859, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI8051579, Length=198, Percent_Identity=35.8585858585859, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI53832001, Length=198, Percent_Identity=35.8585858585859, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI4502011, Length=217, Percent_Identity=33.6405529953917, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI22749187, Length=194, Percent_Identity=28.8659793814433, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI7706497, Length=221, Percent_Identity=28.0542986425339, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI28144897, Length=209, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI28144899, Length=209, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1786680, Length=209, Percent_Identity=47.3684210526316, Blast_Score=190, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17552384, Length=204, Percent_Identity=42.156862745098, Blast_Score=165, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17567503, Length=204, Percent_Identity=32.843137254902, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17537943, Length=199, Percent_Identity=32.1608040201005, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17533833, Length=213, Percent_Identity=28.169014084507, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=205, Percent_Identity=27.3170731707317, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=214, Percent_Identity=42.5233644859813, Blast_Score=174, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6321018, Length=190, Percent_Identity=33.1578947368421, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322828, Length=216, Percent_Identity=27.7777777777778, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI22026816, Length=202, Percent_Identity=41.5841584158416, Blast_Score=167, Evalue=6e-42,
Organism=Drosophila melanogaster, GI17737899, Length=192, Percent_Identity=38.0208333333333, Blast_Score=133, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24645822, Length=192, Percent_Identity=38.0208333333333, Blast_Score=133, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24663208, Length=201, Percent_Identity=28.3582089552239, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17647141, Length=201, Percent_Identity=28.3582089552239, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI221459597, Length=205, Percent_Identity=27.8048780487805, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356893, Length=205, Percent_Identity=27.8048780487805, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23734; Mature: 23734

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVLVGPPGAGKGTQAAFIAQARSIPKISTGDIFRANVREGTELGVQAKAFMDSGDLVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCEEECCCCCCCC
DEITIGMVRNRLAEDDAVKGFLLDGFPRNVPQAEVLGGMLDAMGTRLDVVLELVVDDDEV
CHHHHHHHHHHHCCCHHHCEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCHHH
VRRLSGRRTCRNCGHIWHLDFDPSRVEGICDRCSGELFQRDDDRPETVRHRLEVYAEQTS
HHHHHCCHHHHHCCCEEEECCCHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCC
PLVAYYAAKGVLIGIDATGPVDNVTDRALDALRHYGD
CEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLVLVGPPGAGKGTQAAFIAQARSIPKISTGDIFRANVREGTELGVQAKAFMDSGDLVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCEEECCCCCCCC
DEITIGMVRNRLAEDDAVKGFLLDGFPRNVPQAEVLGGMLDAMGTRLDVVLELVVDDDEV
CHHHHHHHHHHHCCCHHHCEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCHHH
VRRLSGRRTCRNCGHIWHLDFDPSRVEGICDRCSGELFQRDDDRPETVRHRLEVYAEQTS
HHHHHCCHHHHHCCCEEEECCCHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCC
PLVAYYAAKGVLIGIDATGPVDNVTDRALDALRHYGD
CEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA