Click here to switch to the map view.

The map label for this gene is deoA [H]

Identifier: 158317676

GI number: 158317676

Start: 7207246

End: 7208580

Strand: Reverse

Name: deoA [H]

Synonym: Franean1_5934

Alternate gene names: 158317676

Gene position: 7208580-7207246 (Counterclockwise)

Preceding gene: 158317677

Following gene: 158317675

Centisome position: 80.26

GC content: 74.53

Gene sequence:

>1335_bases
ATGAGCGCTGATGCCCCCGGCAGCGATCACGGCGGTCCTGCGGCGTCCCACGACGTCGTCGACCTCATCCGGGCCAAGCG
CGACGGGGCGGCGCTGCCGGCGGACGCGGTCGCCTGGCTCATCGACGCCTACACCCACGGCCGGGTCGCCGACGAGCAGA
TGTCCGCCTACCTGATGGCCGTGGTCTGGCGCGGCATGGCCTCCGACGAACTGGATCACTGGACGTCGGCGATGATCGCC
AGCGGCGAACGGCTGGACCTGTCCGGCCTGACCCGCCCGACGGTCGACAAGCATTCCACCGGCGGGGTCGGGGACAAGGT
CTCGCTGGTCCTCGCCCCGCTGGTGGCCGCGTGCGGAGCGGCCGTCCCGCAGCTGTCCGGACGTGGGCTCGGGCACACCG
GCGGGACGCTTGACAAAATGGAGGCGATCCCCGGCTGGCGCGCCGATCTCGACCCGGGCACCATGCGTGCCGTGCTGGCG
GACGTCGGCGCCGTCATCTGCGCCGCCGGCCCCGGCCTGGCTCCCGCGGACCGCAGGCTGTACGCCCTGCGCGACGTCAC
CGGCACGGTCGAGTCCATCCCGCTGATCGCCTCCTCGATCATGAGCAAGAAGATCGCGGAGGGGACGTCCGCGCTGGTCC
TGGACGTCAAGGTCGGCGCCGGCGCCTTCATGACCTCACTCGCCGACGCCCGCGAGCTCGCGCGGACGATGGTCGGCCTG
GGCGCCCGCGCCGGGGTGCGCACCGAGGCCCTGCTCACCGCGATGGACACCCCGCTGGGCCGCACCGCGGGCAACGGCCC
CGAGGTGACCGAGGCGGTCGAGACCCTGCGCGGGGCGGGCCCGTCGGACCTCGTCGAGGTGACCGTCGCCCTCGCCCGCG
TCATGCTGGACATCGTCGGCCTCAGCGGTGGTTCCGGTGCCGCGCCGGATCCGGCGGAGGTCCTGGCCTCCGGGGCGGCA
TACGACGTGTGGCGCGCGATGGTCGCCGCCCAGGGCGGCGATCCGGACGCCCCGCTGCCGACCGCCGCGTTCACCCGCAC
TGTCTCCGCTCCGGCGGACGGCTACCTGAGCCGCCTCGACGCCCGCGCCCTGGGCATCGCCGCCTGGCGCCTGGGCGCGG
GGCGCGCGCGGAAGGAAGATCCCGTCTCGCCGGCAGCTGGACTGCGTTGGCTGGCGGCGGTGGGGGAGCAGGTCCAGGCC
GGCGCCCCCCTGATCGAGCTCTACTCCGACGACGAGGCGACCTTCCCCCGCGCGCTCTCCGCACTCGCGGACGCCGTCTC
GGTCACCGACGAGCCGCCCCCTCCCACCCCCCTGATCCTCGACCACATCCGCTGA

Upstream 100 bases:

>100_bases
GCGCCTTCGGCCCGGCGGACCTGCCGCCCGCGGCGGAGCAGGCACCTGCGGTGGAGCGGGCACCTGCGGCGGAGCGGGCA
CCTGCGGCGGAGCGCGGAGC

Downstream 100 bases:

>100_bases
CCCGCGCCCCGCCCCGCTGATCTGCGCGCCGCGCTGCTGATCCGCGCGACATGCCATTTTGGTGTGTGCAGATTGTTTTC
TGTTTGGGTTATTTGTGAAT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSADAPGSDHGGPAASHDVVDLIRAKRDGAALPADAVAWLIDAYTHGRVADEQMSAYLMAVVWRGMASDELDHWTSAMIA
SGERLDLSGLTRPTVDKHSTGGVGDKVSLVLAPLVAACGAAVPQLSGRGLGHTGGTLDKMEAIPGWRADLDPGTMRAVLA
DVGAVICAAGPGLAPADRRLYALRDVTGTVESIPLIASSIMSKKIAEGTSALVLDVKVGAGAFMTSLADARELARTMVGL
GARAGVRTEALLTAMDTPLGRTAGNGPEVTEAVETLRGAGPSDLVEVTVALARVMLDIVGLSGGSGAAPDPAEVLASGAA
YDVWRAMVAAQGGDPDAPLPTAAFTRTVSAPADGYLSRLDARALGIAAWRLGAGRARKEDPVSPAAGLRWLAAVGEQVQA
GAPLIELYSDDEATFPRALSALADAVSVTDEPPPPTPLILDHIR

Sequences:

>Translated_444_residues
MSADAPGSDHGGPAASHDVVDLIRAKRDGAALPADAVAWLIDAYTHGRVADEQMSAYLMAVVWRGMASDELDHWTSAMIA
SGERLDLSGLTRPTVDKHSTGGVGDKVSLVLAPLVAACGAAVPQLSGRGLGHTGGTLDKMEAIPGWRADLDPGTMRAVLA
DVGAVICAAGPGLAPADRRLYALRDVTGTVESIPLIASSIMSKKIAEGTSALVLDVKVGAGAFMTSLADARELARTMVGL
GARAGVRTEALLTAMDTPLGRTAGNGPEVTEAVETLRGAGPSDLVEVTVALARVMLDIVGLSGGSGAAPDPAEVLASGAA
YDVWRAMVAAQGGDPDAPLPTAAFTRTVSAPADGYLSRLDARALGIAAWRLGAGRARKEDPVSPAAGLRWLAAVGEQVQA
GAPLIELYSDDEATFPRALSALADAVSVTDEPPPPTPLILDHIR
>Mature_443_residues
SADAPGSDHGGPAASHDVVDLIRAKRDGAALPADAVAWLIDAYTHGRVADEQMSAYLMAVVWRGMASDELDHWTSAMIAS
GERLDLSGLTRPTVDKHSTGGVGDKVSLVLAPLVAACGAAVPQLSGRGLGHTGGTLDKMEAIPGWRADLDPGTMRAVLAD
VGAVICAAGPGLAPADRRLYALRDVTGTVESIPLIASSIMSKKIAEGTSALVLDVKVGAGAFMTSLADARELARTMVGLG
ARAGVRTEALLTAMDTPLGRTAGNGPEVTEAVETLRGAGPSDLVEVTVALARVMLDIVGLSGGSGAAPDPAEVLASGAAY
DVWRAMVAAQGGDPDAPLPTAAFTRTVSAPADGYLSRLDARALGIAAWRLGAGRARKEDPVSPAAGLRWLAAVGEQVQAG
APLIELYSDDEATFPRALSALADAVSVTDEPPPPTPLILDHIR

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=436, Percent_Identity=43.1192660550459, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI4503445, Length=436, Percent_Identity=43.1192660550459, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI166158922, Length=436, Percent_Identity=43.1192660550459, Blast_Score=287, Evalue=1e-77,
Organism=Escherichia coli, GI1790842, Length=439, Percent_Identity=43.5079726651481, Blast_Score=308, Evalue=4e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 45282; Mature: 45151

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADAPGSDHGGPAASHDVVDLIRAKRDGAALPADAVAWLIDAYTHGRVADEQMSAYLMA
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
VVWRGMASDELDHWTSAMIASGERLDLSGLTRPTVDKHSTGGVGDKVSLVLAPLVAACGA
HHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AVPQLSGRGLGHTGGTLDKMEAIPGWRADLDPGTMRAVLADVGAVICAAGPGLAPADRRL
HHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHE
YALRDVTGTVESIPLIASSIMSKKIAEGTSALVLDVKVGAGAFMTSLADARELARTMVGL
EHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHC
GARAGVRTEALLTAMDTPLGRTAGNGPEVTEAVETLRGAGPSDLVEVTVALARVMLDIVG
CCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
LSGGSGAAPDPAEVLASGAAYDVWRAMVAAQGGDPDAPLPTAAFTRTVSAPADGYLSRLD
CCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCHHHHHHHH
ARALGIAAWRLGAGRARKEDPVSPAAGLRWLAAVGEQVQAGAPLIELYSDDEATFPRALS
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHH
ALADAVSVTDEPPPPTPLILDHIR
HHHHHHHCCCCCCCCCCCHHCCCC
>Mature Secondary Structure 
SADAPGSDHGGPAASHDVVDLIRAKRDGAALPADAVAWLIDAYTHGRVADEQMSAYLMA
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
VVWRGMASDELDHWTSAMIASGERLDLSGLTRPTVDKHSTGGVGDKVSLVLAPLVAACGA
HHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AVPQLSGRGLGHTGGTLDKMEAIPGWRADLDPGTMRAVLADVGAVICAAGPGLAPADRRL
HHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHE
YALRDVTGTVESIPLIASSIMSKKIAEGTSALVLDVKVGAGAFMTSLADARELARTMVGL
EHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHC
GARAGVRTEALLTAMDTPLGRTAGNGPEVTEAVETLRGAGPSDLVEVTVALARVMLDIVG
CCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
LSGGSGAAPDPAEVLASGAAYDVWRAMVAAQGGDPDAPLPTAAFTRTVSAPADGYLSRLD
CCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCHHHHHHHH
ARALGIAAWRLGAGRARKEDPVSPAAGLRWLAAVGEQVQAGAPLIELYSDDEATFPRALS
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHH
ALADAVSVTDEPPPPTPLILDHIR
HHHHHHHCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]