Click here to switch to the map view.

The map label for this gene is merA [H]

Identifier: 158317355

GI number: 158317355

Start: 6799848

End: 6801347

Strand: Reverse

Name: merA [H]

Synonym: Franean1_5605

Alternate gene names: 158317355

Gene position: 6801347-6799848 (Counterclockwise)

Preceding gene: 158317357

Following gene: 158317353

Centisome position: 75.72

GC content: 77.73

Gene sequence:

>1500_bases
ATGAGTAGGTCCGACGACGCCGACGGAGGCACGGGCGCCAGCGAGGTCGACGTGATCGTGATCGGAGCGGGGCCGGCGGG
CGAGGTGGTGGCCGGCCGGTGCGCCGCGGCGGGGCTGTCGGTGACGGTGGTCGAGCACGAGCGCGTCGGCGGGGAGTGCT
CCTACTGGGGCTGCATCCCCAGCAAGACCCTGCTGCGCCCTGGTGAGGTCGTGGCGGCCGCCAGGGCCGTCCCCGGGGCG
GCGGGCGCCGTCGGCGGGGCCCGCGCCGGGGTCGACGCCGCGGCGGCGTTCGCCCGGCGCGACGAGATGGTCGGCGGGTA
CTCCGACGAGGGCCAGCTCCCGTGGCTGCGCGAGCGTGGTGTGTCGGTGCGGCGCGGGGCCGGCCGGCTGGTCGGCGAGC
GCCGGGTCGCGGTGCTCGCGCCGGACGGCGGCGAGCAGGTCCTCACCGCGACCCGCGCGGTCGTCCTGGCGACGGGGACG
CGGGCCACCATTCCGCCCGTCCCCGGTCTCGCCGAGGCCGATCCGTGGGACAACCGGTCCGCGACCGGTGCCCGCGCGGT
GCCCGCCCGCCTCGCCGTGCTCGGTGGCGGCGCGGTCGGCGCCGAGCTCGCGCAGGCGTTCCGCCGTCTGGGCAGCGCGG
AGGTCACCGTCGTCGAGGGCGGTCCGCGCCTGCTCGCGCGCGAGGAGCCGTTCGCCGGCGACGAGGTGCGCGCGGCGTTC
GAGGCCGAGGGCATCACGGTTCACACCGGCCGACGGGCCGTGGCCGTCCGCAGGGAGGCACCGGGCACGCCGGGTGAGCC
GGGTGGGCCGGGCACGCCGCGTGGGCCCGTGGTGGTCACTCTGGACGGCGACGGCGGGCCCGAGCACGTCGCCGCGGACG
AGATCCTGGTCGCCGTCGGGCGGACCCCCGCCACCGGCGAGCTCGGCCTGCCCGCGGTCGGCCTGCCCGCGCGGGGCTTC
GTCGAGGTCGACGATCGGATGCGGGCCACCGGTGTGACCGGGGACTGGCTCTACGCCGTCGGGGACGTCAACGGCCGTGC
GCTGCTCACCCACATGGGCAAGTACCAGGCCCGGGTGGCGGCGGACGCCATCACCGGCCGCCTCGACCCGGCGGGCCGGC
CCGCCGCCGACCGCGCCGACCCGGGGGCCGTCCCGCGGGTGACGTTCACCGATCCGCAGGTGAGCGCCGTCGGCCGGACG
GAGGCGACGGCCCGCGCGGCCGGCCTGGATGTCCGTGCCGTCACCGTCCCGACGGCGTCGGTGGCCGGTTCGTCGGTGCG
CGGCACCGACGCCGTCGGGACGTCCCAGATCGTGGTGGACACCGCCCGCCGGGTGCTGGTCGGGGCGACGTTCGTCGGCC
ACGACACACAGGAGATGGTGCACGCCGCGGCCATCGCGATCGTCGGGGCCGTCCCGCTGGAGGATCTGTGGCACGCGGTG
CCGTCCTTCCCCACGGTCAGTGAGGTCTGGCTGCGGCTGCTGGAGGCCTACGGCCTTTGA

Upstream 100 bases:

>100_bases
CGGCCGGTGGGCTGCCGACCCGGTGCAGTGGCATTCGGGCGCGACGCGGCAGGTGAGATGGTGCCTCGCGACGCTGGTCC
CAACGCGGAGAGGTGTGCCC

Downstream 100 bases:

>100_bases
CCAGCCCGGGTGCCGACGCGGGGCGGAACATCCGTCCTGGAACGTCGGGGGCGGCGTGCCCACCGCAAAACCTCCCCGGG
ACGTCGGGCTCAGGCCGGGG

Product: FAD-dependent pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MSRSDDADGGTGASEVDVIVIGAGPAGEVVAGRCAAAGLSVTVVEHERVGGECSYWGCIPSKTLLRPGEVVAAARAVPGA
AGAVGGARAGVDAAAAFARRDEMVGGYSDEGQLPWLRERGVSVRRGAGRLVGERRVAVLAPDGGEQVLTATRAVVLATGT
RATIPPVPGLAEADPWDNRSATGARAVPARLAVLGGGAVGAELAQAFRRLGSAEVTVVEGGPRLLAREEPFAGDEVRAAF
EAEGITVHTGRRAVAVRREAPGTPGEPGGPGTPRGPVVVTLDGDGGPEHVAADEILVAVGRTPATGELGLPAVGLPARGF
VEVDDRMRATGVTGDWLYAVGDVNGRALLTHMGKYQARVAADAITGRLDPAGRPAADRADPGAVPRVTFTDPQVSAVGRT
EATARAAGLDVRAVTVPTASVAGSSVRGTDAVGTSQIVVDTARRVLVGATFVGHDTQEMVHAAAIAIVGAVPLEDLWHAV
PSFPTVSEVWLRLLEAYGL

Sequences:

>Translated_499_residues
MSRSDDADGGTGASEVDVIVIGAGPAGEVVAGRCAAAGLSVTVVEHERVGGECSYWGCIPSKTLLRPGEVVAAARAVPGA
AGAVGGARAGVDAAAAFARRDEMVGGYSDEGQLPWLRERGVSVRRGAGRLVGERRVAVLAPDGGEQVLTATRAVVLATGT
RATIPPVPGLAEADPWDNRSATGARAVPARLAVLGGGAVGAELAQAFRRLGSAEVTVVEGGPRLLAREEPFAGDEVRAAF
EAEGITVHTGRRAVAVRREAPGTPGEPGGPGTPRGPVVVTLDGDGGPEHVAADEILVAVGRTPATGELGLPAVGLPARGF
VEVDDRMRATGVTGDWLYAVGDVNGRALLTHMGKYQARVAADAITGRLDPAGRPAADRADPGAVPRVTFTDPQVSAVGRT
EATARAAGLDVRAVTVPTASVAGSSVRGTDAVGTSQIVVDTARRVLVGATFVGHDTQEMVHAAAIAIVGAVPLEDLWHAV
PSFPTVSEVWLRLLEAYGL
>Mature_498_residues
SRSDDADGGTGASEVDVIVIGAGPAGEVVAGRCAAAGLSVTVVEHERVGGECSYWGCIPSKTLLRPGEVVAAARAVPGAA
GAVGGARAGVDAAAAFARRDEMVGGYSDEGQLPWLRERGVSVRRGAGRLVGERRVAVLAPDGGEQVLTATRAVVLATGTR
ATIPPVPGLAEADPWDNRSATGARAVPARLAVLGGGAVGAELAQAFRRLGSAEVTVVEGGPRLLAREEPFAGDEVRAAFE
AEGITVHTGRRAVAVRREAPGTPGEPGGPGTPRGPVVVTLDGDGGPEHVAADEILVAVGRTPATGELGLPAVGLPARGFV
EVDDRMRATGVTGDWLYAVGDVNGRALLTHMGKYQARVAADAITGRLDPAGRPAADRADPGAVPRVTFTDPQVSAVGRTE
ATARAAGLDVRAVTVPTASVAGSSVRGTDAVGTSQIVVDTARRVLVGATFVGHDTQEMVHAAAIAIVGAVPLEDLWHAVP
SFPTVSEVWLRLLEAYGL

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=494, Percent_Identity=27.1255060728745, Blast_Score=148, Evalue=1e-35,
Organism=Escherichia coli, GI1786307, Length=484, Percent_Identity=29.5454545454545, Blast_Score=178, Evalue=9e-46,
Organism=Escherichia coli, GI87081717, Length=483, Percent_Identity=25.879917184265, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI87082354, Length=485, Percent_Identity=26.1855670103093, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789915, Length=473, Percent_Identity=25.369978858351, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI32565766, Length=495, Percent_Identity=28.2828282828283, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321091, Length=485, Percent_Identity=26.5979381443299, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6325240, Length=493, Percent_Identity=23.3265720081136, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21358499, Length=496, Percent_Identity=27.4193548387097, Blast_Score=138, Evalue=7e-33,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 50569; Mature: 50437

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSDDADGGTGASEVDVIVIGAGPAGEVVAGRCAAAGLSVTVVEHERVGGECSYWGCIP
CCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCEEEEECCC
SKTLLRPGEVVAAARAVPGAAGAVGGARAGVDAAAAFARRDEMVGGYSDEGQLPWLRERG
CCHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHCC
VSVRRGAGRLVGERRVAVLAPDGGEQVLTATRAVVLATGTRATIPPVPGLAEADPWDNRS
CEEECCCCCCCCCCEEEEECCCCCCHHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCC
ATGARAVPARLAVLGGGAVGAELAQAFRRLGSAEVTVVEGGPRLLAREEPFAGDEVRAAF
CCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCHHHHEE
EAEGITVHTGRRAVAVRREAPGTPGEPGGPGTPRGPVVVTLDGDGGPEHVAADEILVAVG
ECCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEC
RTPATGELGLPAVGLPARGFVEVDDRMRATGVTGDWLYAVGDVNGRALLTHMGKYQARVA
CCCCCCCCCCCCCCCCCCCEEEECCCEECCCCCCCEEEEEECCCCCEEEHHHHHHHHHHH
ADAITGRLDPAGRPAADRADPGAVPRVTFTDPQVSAVGRTEATARAAGLDVRAVTVPTAS
HHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHCCCEEEEEEECCHH
VAGSSVRGTDAVGTSQIVVDTARRVLVGATFVGHDTQEMVHAAAIAIVGAVPLEDLWHAV
HCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHH
PSFPTVSEVWLRLLEAYGL
CCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRSDDADGGTGASEVDVIVIGAGPAGEVVAGRCAAAGLSVTVVEHERVGGECSYWGCIP
CCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCEEEEECCC
SKTLLRPGEVVAAARAVPGAAGAVGGARAGVDAAAAFARRDEMVGGYSDEGQLPWLRERG
CCHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHCC
VSVRRGAGRLVGERRVAVLAPDGGEQVLTATRAVVLATGTRATIPPVPGLAEADPWDNRS
CEEECCCCCCCCCCEEEEECCCCCCHHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCC
ATGARAVPARLAVLGGGAVGAELAQAFRRLGSAEVTVVEGGPRLLAREEPFAGDEVRAAF
CCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCHHHHEE
EAEGITVHTGRRAVAVRREAPGTPGEPGGPGTPRGPVVVTLDGDGGPEHVAADEILVAVG
ECCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEC
RTPATGELGLPAVGLPARGFVEVDDRMRATGVTGDWLYAVGDVNGRALLTHMGKYQARVA
CCCCCCCCCCCCCCCCCCCEEEECCCEECCCCCCCEEEEEECCCCCEEEHHHHHHHHHHH
ADAITGRLDPAGRPAADRADPGAVPRVTFTDPQVSAVGRTEATARAAGLDVRAVTVPTAS
HHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHCCCEEEEEEECCHH
VAGSSVRGTDAVGTSQIVVDTARRVLVGATFVGHDTQEMVHAAAIAIVGAVPLEDLWHAV
HCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHH
PSFPTVSEVWLRLLEAYGL
CCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]