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The map label for this gene is fdh [H]

Identifier: 158317145

GI number: 158317145

Start: 6501764

End: 6502978

Strand: Direct

Name: fdh [H]

Synonym: Franean1_5391

Alternate gene names: 158317145

Gene position: 6501764-6502978 (Clockwise)

Preceding gene: 158317144

Following gene: 158317150

Centisome position: 72.39

GC content: 65.6

Gene sequence:

>1215_bases
ATGAGAGCAGTCGTGTGGCACGGCGTGGGCGACATCCGCCTTGACACCGTCACCGAACCGAAGATCGAACAGCCGACCGA
TGCCGTCGTTCGCATCACCACCGCGGCGATCTGTGGCACGGATCTTCATTTCGTCCGGGGCACAGTACCGGGGATGAAGC
CGGGCCTCATCATCGGGCACGAAGGGGTCGGCGTGGTCGAAGAGGTCGGCCAGAGCGTCCGCAACTTCAGGCGCGGCGAT
CGGGTGCTGCTGTCCGCCGTCCTCGGGTGCGGCTCCTGCACCTACTGCCGCAGCGGCTATTTCGCCCAATGTGACGACAT
CAACCCGTACGGCCGCAGGACCGGATCTGCCTTCTACGGCGCTCCGAGGGACAATGGCTCGTTCGACGGGTTGCAGGCTG
AGTACGCCCGCGTACCCTACGCCCACACCAATCTGTTCCGGCTGTCAGACTCGATCTCCGATGATCAGGCGATCCCGCTG
TCGGACATCTACCCCACCGGATACTTCGGCGCAGTCATCGCGGAAGTATCGGATGGCGACGTGGTGGCGGTCTGGGGCTG
CGGGCCGGTGGGACAGTTCGCCGTTCTGTCCTCATTCCAGCGCGGCGCCGCGCGGGTGATCGCGATCGATGGTCACGCCG
ACCGACTCGACCGTGCCCAGGCGCTCGGAGCCGAGGTGGTCAACTTCAACGAAGAGGACCCTGTCGAGGCAATCCTGGAT
CTGACACGCGGTATCGGTCCCGACCGGGCCATCGACGCCGTGGGGGTGGACGCGGAAAGCCCGAAGTCCGGCCCCGCCGC
CGCCCGCGCCCGCGAACAGGACGATCAGCACCGCGAGGAACTGCGTCAGATCGCCCCCGAGACTCACGCGCACAACGGAC
ACTGGAAGCCTGGCGACGCGCCGACGCAGGCCCACTCCTGGGCAGTCGAGAGCCTGGCCAAGGCAGGCACGCTGGGCATC
ATCGGGGTGTATCCGCCGACCGACAGGTTCTTCCCGATCGGCACCGCGATGAACAAGAACCTCACCATCAACATGGGAAA
CGGCAACCATCCGCGGTACATCCCGAAGCTGCTGGATATGGTGGAGTCGGGAGTGGTGCACCCACAGAAAATGGTCACCC
AGCATGAGCCGATGCGGGACGTGCTCGCCGCCTACGAGGAGTTCGACCTGCGCCGTCCTGGCTGGCTCAAGGTGGCCCTG
GACCTGACCAGCTAA

Upstream 100 bases:

>100_bases
CTGGAACGAAAGTCGGCGGAGTTGAGGCCCGCGGTGAGTCGGACCGGCGGGAGATCGCGATCAGTACTGCGCGCCCGAAG
AACGGAAGGAGCGGAAGGTG

Downstream 100 bases:

>100_bases
CACGGAAAAGCCGCCACCACGGGTATGGCTTGTCGAGTGGGATCGGTGAATCTGGCGAGTTGCTCGCGTGCGCTTTCGGC
CGGCTCGGGCGGGACTGCTC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MRAVVWHGVGDIRLDTVTEPKIEQPTDAVVRITTAAICGTDLHFVRGTVPGMKPGLIIGHEGVGVVEEVGQSVRNFRRGD
RVLLSAVLGCGSCTYCRSGYFAQCDDINPYGRRTGSAFYGAPRDNGSFDGLQAEYARVPYAHTNLFRLSDSISDDQAIPL
SDIYPTGYFGAVIAEVSDGDVVAVWGCGPVGQFAVLSSFQRGAARVIAIDGHADRLDRAQALGAEVVNFNEEDPVEAILD
LTRGIGPDRAIDAVGVDAESPKSGPAAARAREQDDQHREELRQIAPETHAHNGHWKPGDAPTQAHSWAVESLAKAGTLGI
IGVYPPTDRFFPIGTAMNKNLTINMGNGNHPRYIPKLLDMVESGVVHPQKMVTQHEPMRDVLAAYEEFDLRRPGWLKVAL
DLTS

Sequences:

>Translated_404_residues
MRAVVWHGVGDIRLDTVTEPKIEQPTDAVVRITTAAICGTDLHFVRGTVPGMKPGLIIGHEGVGVVEEVGQSVRNFRRGD
RVLLSAVLGCGSCTYCRSGYFAQCDDINPYGRRTGSAFYGAPRDNGSFDGLQAEYARVPYAHTNLFRLSDSISDDQAIPL
SDIYPTGYFGAVIAEVSDGDVVAVWGCGPVGQFAVLSSFQRGAARVIAIDGHADRLDRAQALGAEVVNFNEEDPVEAILD
LTRGIGPDRAIDAVGVDAESPKSGPAAARAREQDDQHREELRQIAPETHAHNGHWKPGDAPTQAHSWAVESLAKAGTLGI
IGVYPPTDRFFPIGTAMNKNLTINMGNGNHPRYIPKLLDMVESGVVHPQKMVTQHEPMRDVLAAYEEFDLRRPGWLKVAL
DLTS
>Mature_404_residues
MRAVVWHGVGDIRLDTVTEPKIEQPTDAVVRITTAAICGTDLHFVRGTVPGMKPGLIIGHEGVGVVEEVGQSVRNFRRGD
RVLLSAVLGCGSCTYCRSGYFAQCDDINPYGRRTGSAFYGAPRDNGSFDGLQAEYARVPYAHTNLFRLSDSISDDQAIPL
SDIYPTGYFGAVIAEVSDGDVVAVWGCGPVGQFAVLSSFQRGAARVIAIDGHADRLDRAQALGAEVVNFNEEDPVEAILD
LTRGIGPDRAIDAVGVDAESPKSGPAAARAREQDDQHREELRQIAPETHAHNGHWKPGDAPTQAHSWAVESLAKAGTLGI
IGVYPPTDRFFPIGTAMNKNLTINMGNGNHPRYIPKLLDMVESGVVHPQKMVTQHEPMRDVLAAYEEFDLRRPGWLKVAL
DLTS

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=252, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI156627571, Length=278, Percent_Identity=29.136690647482, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI4501933, Length=235, Percent_Identity=30.6382978723404, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI34577061, Length=264, Percent_Identity=31.0606060606061, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI71565152, Length=241, Percent_Identity=30.2904564315353, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI71565154, Length=238, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI262073058, Length=218, Percent_Identity=28.8990825688073, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI71743840, Length=218, Percent_Identity=28.8990825688073, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI4501939, Length=252, Percent_Identity=27.7777777777778, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI156523966, Length=253, Percent_Identity=28.4584980237154, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1786825, Length=412, Percent_Identity=32.7669902912621, Blast_Score=221, Evalue=5e-59,
Organism=Escherichia coli, GI87082125, Length=255, Percent_Identity=34.1176470588235, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1787863, Length=245, Percent_Identity=29.3877551020408, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1788073, Length=254, Percent_Identity=27.9527559055118, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790045, Length=237, Percent_Identity=30.8016877637131, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI87081918, Length=220, Percent_Identity=30, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788407, Length=233, Percent_Identity=27.0386266094421, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786552, Length=242, Percent_Identity=31.404958677686, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788075, Length=228, Percent_Identity=29.8245614035088, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI226510992, Length=166, Percent_Identity=27.1084337349398, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790718, Length=215, Percent_Identity=26.5116279069767, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17562878, Length=266, Percent_Identity=29.3233082706767, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=263, Percent_Identity=28.5171102661597, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI25146526, Length=237, Percent_Identity=29.957805907173, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=236, Percent_Identity=28.8135593220339, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=215, Percent_Identity=29.3023255813954, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=241, Percent_Identity=28.2157676348548, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=235, Percent_Identity=30.2127659574468, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320033, Length=257, Percent_Identity=31.1284046692607, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=234, Percent_Identity=33.7606837606838, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=231, Percent_Identity=25.974025974026, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=249, Percent_Identity=28.5140562248996, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=249, Percent_Identity=28.5140562248996, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=289, Percent_Identity=25.6055363321799, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=247, Percent_Identity=28.3400809716599, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=288, Percent_Identity=25, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=252, Percent_Identity=27.3809523809524, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=240, Percent_Identity=29.1666666666667, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17137530, Length=264, Percent_Identity=28.030303030303, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17737897, Length=264, Percent_Identity=28.030303030303, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17737895, Length=245, Percent_Identity=30.2040816326531, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 43689; Mature: 43689

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVVWHGVGDIRLDTVTEPKIEQPTDAVVRITTAAICGTDLHFVRGTVPGMKPGLIIGH
CCEEEEECCCCEEEECCCCCCCCCCCCCEEEEEHHHHHCCCHHHHHCCCCCCCCCEEECC
EGVGVVEEVGQSVRNFRRGDRVLLSAVLGCGSCTYCRSGYFAQCDDINPYGRRTGSAFYG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEECCCCCHHHCCCCCEEEC
APRDNGSFDGLQAEYARVPYAHTNLFRLSDSISDDQAIPLSDIYPTGYFGAVIAEVSDGD
CCCCCCCCCCCCHHHHHCCCCCCCEEEECCCCCCCCCCCHHHCCCCCHHEEEEEEECCCC
VVAVWGCGPVGQFAVLSSFQRGAARVIAIDGHADRLDRAQALGAEVVNFNEEDPVEAILD
EEEEECCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LTRGIGPDRAIDAVGVDAESPKSGPAAARAREQDDQHREELRQIAPETHAHNGHWKPGDA
HHHCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PTQAHSWAVESLAKAGTLGIIGVYPPTDRFFPIGTAMNKNLTINMGNGNHPRYIPKLLDM
CCHHHHHHHHHHHHCCCEEEEEECCCCCCEEECCCCCCCCEEEECCCCCCCHHHHHHHHH
VESGVVHPQKMVTQHEPMRDVLAAYEEFDLRRPGWLKVALDLTS
HHHCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEEECC
>Mature Secondary Structure
MRAVVWHGVGDIRLDTVTEPKIEQPTDAVVRITTAAICGTDLHFVRGTVPGMKPGLIIGH
CCEEEEECCCCEEEECCCCCCCCCCCCCEEEEEHHHHHCCCHHHHHCCCCCCCCCEEECC
EGVGVVEEVGQSVRNFRRGDRVLLSAVLGCGSCTYCRSGYFAQCDDINPYGRRTGSAFYG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEECCCCCHHHCCCCCEEEC
APRDNGSFDGLQAEYARVPYAHTNLFRLSDSISDDQAIPLSDIYPTGYFGAVIAEVSDGD
CCCCCCCCCCCCHHHHHCCCCCCCEEEECCCCCCCCCCCHHHCCCCCHHEEEEEEECCCC
VVAVWGCGPVGQFAVLSSFQRGAARVIAIDGHADRLDRAQALGAEVVNFNEEDPVEAILD
EEEEECCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LTRGIGPDRAIDAVGVDAESPKSGPAAARAREQDDQHREELRQIAPETHAHNGHWKPGDA
HHHCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PTQAHSWAVESLAKAGTLGIIGVYPPTDRFFPIGTAMNKNLTINMGNGNHPRYIPKLLDM
CCHHHHHHHHHHHHCCCEEEEEECCCCCCEEECCCCCCCCEEEECCCCCCCHHHHHHHHH
VESGVVHPQKMVTQHEPMRDVLAAYEEFDLRRPGWLKVALDLTS
HHHCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]