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The map label for this gene is fadK [H]

Identifier: 158316095

GI number: 158316095

Start: 5152450

End: 5154045

Strand: Reverse

Name: fadK [H]

Synonym: Franean1_4313

Alternate gene names: 158316095

Gene position: 5154045-5152450 (Counterclockwise)

Preceding gene: 158316097

Following gene: 158316094

Centisome position: 57.38

GC content: 71.99

Gene sequence:

>1596_bases
ATGCGCACGATCCCACCTGAGCTGGTCAAACGGTACGAGAACGAGGGGTGGTGGACACCCGAGACGCTGGGCGACCTGCT
CGCCGCCGGCCTCGACGCGACCCCCGGCGCCGAGTTCCGCGTGCACTCGGCGGTCCGGCCGTGGTCCGGGACGTTCCGTG
ATGTCGAGCAGGTCGCCCGCCGGCTCGCCGCCGGCCTGCGCGCCCGCGGTGTCGGCCCCGGTGACGTCGTCGTCTTCCAG
CTGCCGAACTGGATGGAGGCGGCCGCCGTCTTCTGGGCGTCGTCCTTCCTCGGGGCGGTTGTGGTCCCCGTCGTGCACTT
CTACGGGCGCAAAGAGCTCGGCCACATCCTGGAGCGGACCTCACCCAAGGTCTTCGTCACCGCCGAGGGCTTCGGGCGGA
TGGAGTACCAGCCCGACCTGAGCCGGGACGTCCCCGTCGTCGGCGTGGTCGGCCGCGACTTCGACGAGCTGCTCGCCGAC
GCTCCGCTGCCCGGCGTGATCGCCACCGATCCGGCCGCCCAGGCGGTGATCGCGTTCACCTCGGGAACCACCCGTGACCC
CAAGGGGGTCATCCACACCCATCAGACCCTCGGCTTCGAGACGCGCCAGCTCGCCGGCCTCTACCCGCCGGACCGCGGCC
GCCAGCTCACCGCCGCGCCGGTGGGGCACTTCATCGGCATGCTGAACGCGTTCCTGATCCCCGTCCTGGACGGCCGGCCG
ATCAACCTGGCCGACGTCTGGGACCCGGCCCGGGCCCTGGAACTGATGGTGAGCGACGGGCTGACTGTCGGCGGCGGCGC
CACCTACTTCGTGACGAGCCTGCTGGACCACCCGAGCTTTTCGCCCGAGCAGCACCTGCCGGCGATGAAGTACGCCGGGC
TGGGCGGGTCGTCCGTGCCGGCGGCGGTCACCACCCGGCTGGACGAGCTCGGCATCACCGTCTTCCGGTCCTACGGCAGC
ACCGAGCATCCGTCGATCACCGGCTCGCGCCACACCGCGCCGGCGGAGAAGCGGCTGTTCACCGACGGGGACCCGCTGCC
CGGGGTGGAGATCCGCCTCGACGCCGACGGCGAGATCCTCAGCCGCGGCCCGGACCTCTGCCTCGGCTACCTCGACGAGG
CCCTGACCGAGCAGGTCTTCGACGCCGACGGCTGGTACCGCACGGGCGATGTCGGTGTCCTCGACGCCGACGGCTACCTT
ACGATCGTCGACCGCAAGGCGGACTTCATCATCCGCGGCGGGGAGAACATCAGCGCGCTCGAGGTCGAGGAGGTGCTGCT
CACCATGCCCGAGGTCGCCGAGGTCGCGGTGGTCGCGGCCCCCGACGCCAGGCTCGGCGAGCACGCCGCCGCGATCCTGC
GGCTGCAGCCCGGGAGCGAGCTGCCCACCCTGGAGGAGGTGCAGGCGCACTTCGCGCGGGCCGGTCTGGCCCGGCAGAAG
TGGCCCGAGGAGCTTCGCGCGATCGAGGACTTCCCCCGGACGCCCAGCGGTAAAATCCAGAAGGCCGTGCTCCGCCGGGA
GCTGCGCGCCGTCCCGCAGGGGGGCCGGCAGGGGGACCCGTCGGGACACATTGCGGCTGGGCAGGGAAGAGAATAG

Upstream 100 bases:

>100_bases
CGGCCGGCCAGGCGCCGGCGCCGCTGGCCGTCGGGAGAGGTGGAACTTGTCTTCTCTGCCTGAGAGAGTCTAGGTATCGC
CAGAGATCGGAGCTCGCGTC

Downstream 100 bases:

>100_bases
GGTTCTCCTTATCAGTAAGGGAGGATCTCAATGTCTACGCGAGTGCCGCCGTACCCGATCTTCGACGCGGACAACCACCT
GTACGAGACCCAGGACGCGT

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Acyl-CoA synthetase [H]

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MRTIPPELVKRYENEGWWTPETLGDLLAAGLDATPGAEFRVHSAVRPWSGTFRDVEQVARRLAAGLRARGVGPGDVVVFQ
LPNWMEAAAVFWASSFLGAVVVPVVHFYGRKELGHILERTSPKVFVTAEGFGRMEYQPDLSRDVPVVGVVGRDFDELLAD
APLPGVIATDPAAQAVIAFTSGTTRDPKGVIHTHQTLGFETRQLAGLYPPDRGRQLTAAPVGHFIGMLNAFLIPVLDGRP
INLADVWDPARALELMVSDGLTVGGGATYFVTSLLDHPSFSPEQHLPAMKYAGLGGSSVPAAVTTRLDELGITVFRSYGS
TEHPSITGSRHTAPAEKRLFTDGDPLPGVEIRLDADGEILSRGPDLCLGYLDEALTEQVFDADGWYRTGDVGVLDADGYL
TIVDRKADFIIRGGENISALEVEEVLLTMPEVAEVAVVAAPDARLGEHAAAILRLQPGSELPTLEEVQAHFARAGLARQK
WPEELRAIEDFPRTPSGKIQKAVLRRELRAVPQGGRQGDPSGHIAAGQGRE

Sequences:

>Translated_531_residues
MRTIPPELVKRYENEGWWTPETLGDLLAAGLDATPGAEFRVHSAVRPWSGTFRDVEQVARRLAAGLRARGVGPGDVVVFQ
LPNWMEAAAVFWASSFLGAVVVPVVHFYGRKELGHILERTSPKVFVTAEGFGRMEYQPDLSRDVPVVGVVGRDFDELLAD
APLPGVIATDPAAQAVIAFTSGTTRDPKGVIHTHQTLGFETRQLAGLYPPDRGRQLTAAPVGHFIGMLNAFLIPVLDGRP
INLADVWDPARALELMVSDGLTVGGGATYFVTSLLDHPSFSPEQHLPAMKYAGLGGSSVPAAVTTRLDELGITVFRSYGS
TEHPSITGSRHTAPAEKRLFTDGDPLPGVEIRLDADGEILSRGPDLCLGYLDEALTEQVFDADGWYRTGDVGVLDADGYL
TIVDRKADFIIRGGENISALEVEEVLLTMPEVAEVAVVAAPDARLGEHAAAILRLQPGSELPTLEEVQAHFARAGLARQK
WPEELRAIEDFPRTPSGKIQKAVLRRELRAVPQGGRQGDPSGHIAAGQGRE
>Mature_531_residues
MRTIPPELVKRYENEGWWTPETLGDLLAAGLDATPGAEFRVHSAVRPWSGTFRDVEQVARRLAAGLRARGVGPGDVVVFQ
LPNWMEAAAVFWASSFLGAVVVPVVHFYGRKELGHILERTSPKVFVTAEGFGRMEYQPDLSRDVPVVGVVGRDFDELLAD
APLPGVIATDPAAQAVIAFTSGTTRDPKGVIHTHQTLGFETRQLAGLYPPDRGRQLTAAPVGHFIGMLNAFLIPVLDGRP
INLADVWDPARALELMVSDGLTVGGGATYFVTSLLDHPSFSPEQHLPAMKYAGLGGSSVPAAVTTRLDELGITVFRSYGS
TEHPSITGSRHTAPAEKRLFTDGDPLPGVEIRLDADGEILSRGPDLCLGYLDEALTEQVFDADGWYRTGDVGVLDADGYL
TIVDRKADFIIRGGENISALEVEEVLLTMPEVAEVAVVAAPDARLGEHAAAILRLQPGSELPTLEEVQAHFARAGLARQK
WPEELRAIEDFPRTPSGKIQKAVLRRELRAVPQGGRQGDPSGHIAAGQGRE

Specific function: Catalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It has a low activity on medium or long chain fatty acids and is ma

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Membrane; Peripheral membrane protein. Note=Partially membrane-associated [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=547, Percent_Identity=29.0676416819013, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI187761345, Length=516, Percent_Identity=26.3565891472868, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI187761343, Length=516, Percent_Identity=26.3565891472868, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI42544132, Length=496, Percent_Identity=24.3951612903226, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI38505220, Length=501, Percent_Identity=24.9500998003992, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI115511026, Length=494, Percent_Identity=23.6842105263158, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI58082049, Length=384, Percent_Identity=27.34375, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI122937307, Length=496, Percent_Identity=25.2016129032258, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI157311624, Length=379, Percent_Identity=26.6490765171504, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI157311622, Length=379, Percent_Identity=26.6490765171504, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI27477105, Length=468, Percent_Identity=23.2905982905983, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI57165410, Length=141, Percent_Identity=34.0425531914894, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI57165412, Length=141, Percent_Identity=34.0425531914894, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI40807491, Length=157, Percent_Identity=33.7579617834395, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI145693145, Length=533, Percent_Identity=33.9587242026266, Blast_Score=255, Evalue=6e-69,
Organism=Escherichia coli, GI1786810, Length=536, Percent_Identity=27.6119402985075, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1788107, Length=511, Percent_Identity=27.2015655577299, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI221142682, Length=500, Percent_Identity=28, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1789201, Length=386, Percent_Identity=26.6839378238342, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1788595, Length=285, Percent_Identity=27.719298245614, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1786801, Length=428, Percent_Identity=25.9345794392523, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786529, Length=539, Percent_Identity=24.1187384044527, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994703, Length=558, Percent_Identity=26.5232974910394, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71994694, Length=558, Percent_Identity=26.5232974910394, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71994690, Length=558, Percent_Identity=26.5232974910394, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17560308, Length=543, Percent_Identity=27.8084714548803, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17558820, Length=477, Percent_Identity=28.3018867924528, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI32563687, Length=467, Percent_Identity=28.051391862955, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71996755, Length=466, Percent_Identity=25.1072961373391, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17557194, Length=514, Percent_Identity=24.7081712062257, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17538037, Length=505, Percent_Identity=23.7623762376238, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17531443, Length=362, Percent_Identity=24.0331491712707, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=503, Percent_Identity=25.4473161033797, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=374, Percent_Identity=27.807486631016, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17560140, Length=489, Percent_Identity=24.9488752556237, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71982997, Length=561, Percent_Identity=25.1336898395722, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71983001, Length=561, Percent_Identity=25.1336898395722, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=345, Percent_Identity=26.9565217391304, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319264, Length=533, Percent_Identity=24.953095684803, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24581924, Length=511, Percent_Identity=27.5929549902153, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI18859661, Length=502, Percent_Identity=27.0916334661355, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21355181, Length=514, Percent_Identity=24.3190661478599, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24648255, Length=477, Percent_Identity=25.1572327044025, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648260, Length=493, Percent_Identity=25.1521298174442, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24648253, Length=477, Percent_Identity=24.9475890985325, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21356947, Length=486, Percent_Identity=24.6913580246914, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24653035, Length=257, Percent_Identity=29.9610894941634, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI20130357, Length=364, Percent_Identity=27.4725274725275, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356441, Length=475, Percent_Identity=22.7368421052632, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648257, Length=302, Percent_Identity=27.8145695364238, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161076582, Length=264, Percent_Identity=28.030303030303, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI281365686, Length=453, Percent_Identity=24.2825607064018, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17933690, Length=182, Percent_Identity=31.3186813186813, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 57234; Mature: 57234

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTIPPELVKRYENEGWWTPETLGDLLAAGLDATPGAEFRVHSAVRPWSGTFRDVEQVAR
CCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHH
RLAAGLRARGVGPGDVVVFQLPNWMEAAAVFWASSFLGAVVVPVVHFYGRKELGHILERT
HHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCC
SPKVFVTAEGFGRMEYQPDLSRDVPVVGVVGRDFDELLADAPLPGVIATDPAAQAVIAFT
CCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHCCCCCCEEECCCCCCEEEEEE
SGTTRDPKGVIHTHQTLGFETRQLAGLYPPDRGRQLTAAPVGHFIGMLNAFLIPVLDGRP
CCCCCCCCCCEEEHHHCCCCHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHEEECCCC
INLADVWDPARALELMVSDGLTVGGGATYFVTSLLDHPSFSPEQHLPAMKYAGLGGSSVP
CCHHHHCCHHHHHHHHHHCCEEECCCHHHHHHHHHCCCCCCHHHCCCCHHCCCCCCCCCC
AAVTTRLDELGITVFRSYGSTEHPSITGSRHTAPAEKRLFTDGDPLPGVEIRLDADGEIL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCCHHH
SRGPDLCLGYLDEALTEQVFDADGWYRTGDVGVLDADGYLTIVDRKADFIIRGGENISAL
HCCHHHHHHHHHHHHHHHHHCCCCCEECCCEEEEECCCEEEEEECCCCEEEECCCCCCHH
EVEEVLLTMPEVAEVAVVAAPDARLGEHAAAILRLQPGSELPTLEEVQAHFARAGLARQK
HHHHHHHCCCCHHCEEEEECCCCHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
WPEELRAIEDFPRTPSGKIQKAVLRRELRAVPQGGRQGDPSGHIAAGQGRE
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRTIPPELVKRYENEGWWTPETLGDLLAAGLDATPGAEFRVHSAVRPWSGTFRDVEQVAR
CCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHH
RLAAGLRARGVGPGDVVVFQLPNWMEAAAVFWASSFLGAVVVPVVHFYGRKELGHILERT
HHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCC
SPKVFVTAEGFGRMEYQPDLSRDVPVVGVVGRDFDELLADAPLPGVIATDPAAQAVIAFT
CCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHCCCCCCEEECCCCCCEEEEEE
SGTTRDPKGVIHTHQTLGFETRQLAGLYPPDRGRQLTAAPVGHFIGMLNAFLIPVLDGRP
CCCCCCCCCCEEEHHHCCCCHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHEEECCCC
INLADVWDPARALELMVSDGLTVGGGATYFVTSLLDHPSFSPEQHLPAMKYAGLGGSSVP
CCHHHHCCHHHHHHHHHHCCEEECCCHHHHHHHHHCCCCCCHHHCCCCHHCCCCCCCCCC
AAVTTRLDELGITVFRSYGSTEHPSITGSRHTAPAEKRLFTDGDPLPGVEIRLDADGEIL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCCHHH
SRGPDLCLGYLDEALTEQVFDADGWYRTGDVGVLDADGYLTIVDRKADFIIRGGENISAL
HCCHHHHHHHHHHHHHHHHHCCCCCEECCCEEEEECCCEEEEEECCCCEEEECCCCCCHH
EVEEVLLTMPEVAEVAVVAAPDARLGEHAAAILRLQPGSELPTLEEVQAHFARAGLARQK
HHHHHHHCCCCHHCEEEEECCCCHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
WPEELRAIEDFPRTPSGKIQKAVLRRELRAVPQGGRQGDPSGHIAAGQGRE
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 7984428; 12535077 [H]