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The map label for this gene is idnD [C]

Identifier: 158315951

GI number: 158315951

Start: 4954737

End: 4955999

Strand: Reverse

Name: idnD [C]

Synonym: Franean1_4169

Alternate gene names: 158315951

Gene position: 4955999-4954737 (Counterclockwise)

Preceding gene: 158315952

Following gene: 158315950

Centisome position: 55.18

GC content: 74.74

Gene sequence:

>1263_bases
GTGACACGCGGTCTGGAGCTGTACCGGTCGCTGCCGCGGTACGCGGCGGCGCGGGTGGTGTCGGGCCGGTTCCCGCGGCT
GTCGGGGGCGGCGGCGACGACCGCGGCGCCGCTGCGGCTGGTCGACCGGGGGGATCCGGGTCTGCCGGGGCCGGGGTGGG
TGACGGTGCGGCCACGGCTGGCGGGGATCTGCGGGTCGGATCTGGCGACGGTGACGGGGCAGAGCTCGTTCTACTTCTCC
CCGCTGGTGTCGATGCCGTTCACCCCCGGCCATGAGATCGTCGGTGACCTGCAGGAGGCGGTGACGCTCGCCGACGGGCG
CCGGTTGGACGCCGGTGCCCGGGTGGTGATCGACCCGGTGCTGGGCTGCGCGGCCCGCGGGTTGGAGCTGTGCGTGGGCT
GCGCGGCGGGCCGGACGTCACGCTGCGACCGGATCACGGTGGGGCATCTGGCGCCGGGGTTGCAGACCGGGTTCTGCGCG
GACACCGGTGGCGGGTGGAGCCGGGCGCTGGTCGCCCATCACAGCCAGCTGCATCCGGTGCCCGACACGCTGCCCGACTC
TCGGGCGGTGCTGGTCGAGCCGTTGGCGACCGCCGTGCACACCGCGGGCCGCTGCGGGGTGCGTTCCGGGGACCGGGTGC
TGATCATCGGGTCGGGGGCGGTGGGCCTGCTGACGCTGCTGGCCATCCGCGCCTATACGAAGGCCGAGCATGTGACGATG
GTCGCCAAGCATCGGCGGCAGGTGGAGCTGGCGCGTCGTTTCGGCGCGGACGAGGTGCTCGCCCCCGACGACGCGGTCGG
CGGGGTGCGCCGCGCGAACCGGGCGTTGCGGCTGACCCCGCAGCTGGGTGGGGAGTATCTGCTCGGCGGGGTGGATGTGG
CGATCGACTGTGCGGGCAGCGCGTCGTCGCTGTCGACGGCGCTGCGGGTGACCCGGGCCGGTGGCCGGGTGGTGCTCTCC
GGGGTGCCGGCGGGGTCGGTGGATCTGACCCCGCTGTGGTTCCGGGAGCTGGAGCTGGTGGGGACGTACGCGTCGTCCGG
TGGCGCCCGGCCCGGCCGGGCCGGTACCGAACCGGCGGGACCAGCGGAGCCGGTGGAGTCGGATTTCGGGCGGGCGTTGG
CGCTGGCCGCCACGGCCCCGCTCGACGGGGTGGTGTCGGCGGTGTATCCGCTCACCCGGTGGCGGGAGGCGTTGGACCAT
GCGTTGTCCGCGGGGCGTCTCGGCGCCGTGAAGATCGTTTTTGATCCGGCGGCGTCGGCGTGA

Upstream 100 bases:

>100_bases
TGTTCGCCGCGGCGGCCCGCGCCCGGGTTGCCGCGGGCGGCCTGTCAGGGTCGGGGTCGGGTGGGAGTGGTGTTGTGCGG
GTGGAAGTGGGTGAGGGCCG

Downstream 100 bases:

>100_bases
GCGCGACGCGCGCCGCGCCGGTGCGGTCCGGTGGGCGTGGGGGCGCCGGTGGGAGTGGCACGGTCGGGGTATACGGGATT
GTCTCCCCGCGCGGCGGTCC

Product: alcohol dehydrogenase

Products: NADH; 5-ketogluconate [C]

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTRGLELYRSLPRYAAARVVSGRFPRLSGAAATTAAPLRLVDRGDPGLPGPGWVTVRPRLAGICGSDLATVTGQSSFYFS
PLVSMPFTPGHEIVGDLQEAVTLADGRRLDAGARVVIDPVLGCAARGLELCVGCAAGRTSRCDRITVGHLAPGLQTGFCA
DTGGGWSRALVAHHSQLHPVPDTLPDSRAVLVEPLATAVHTAGRCGVRSGDRVLIIGSGAVGLLTLLAIRAYTKAEHVTM
VAKHRRQVELARRFGADEVLAPDDAVGGVRRANRALRLTPQLGGEYLLGGVDVAIDCAGSASSLSTALRVTRAGGRVVLS
GVPAGSVDLTPLWFRELELVGTYASSGGARPGRAGTEPAGPAEPVESDFGRALALAATAPLDGVVSAVYPLTRWREALDH
ALSAGRLGAVKIVFDPAASA

Sequences:

>Translated_420_residues
MTRGLELYRSLPRYAAARVVSGRFPRLSGAAATTAAPLRLVDRGDPGLPGPGWVTVRPRLAGICGSDLATVTGQSSFYFS
PLVSMPFTPGHEIVGDLQEAVTLADGRRLDAGARVVIDPVLGCAARGLELCVGCAAGRTSRCDRITVGHLAPGLQTGFCA
DTGGGWSRALVAHHSQLHPVPDTLPDSRAVLVEPLATAVHTAGRCGVRSGDRVLIIGSGAVGLLTLLAIRAYTKAEHVTM
VAKHRRQVELARRFGADEVLAPDDAVGGVRRANRALRLTPQLGGEYLLGGVDVAIDCAGSASSLSTALRVTRAGGRVVLS
GVPAGSVDLTPLWFRELELVGTYASSGGARPGRAGTEPAGPAEPVESDFGRALALAATAPLDGVVSAVYPLTRWREALDH
ALSAGRLGAVKIVFDPAASA
>Mature_419_residues
TRGLELYRSLPRYAAARVVSGRFPRLSGAAATTAAPLRLVDRGDPGLPGPGWVTVRPRLAGICGSDLATVTGQSSFYFSP
LVSMPFTPGHEIVGDLQEAVTLADGRRLDAGARVVIDPVLGCAARGLELCVGCAAGRTSRCDRITVGHLAPGLQTGFCAD
TGGGWSRALVAHHSQLHPVPDTLPDSRAVLVEPLATAVHTAGRCGVRSGDRVLIIGSGAVGLLTLLAIRAYTKAEHVTMV
AKHRRQVELARRFGADEVLAPDDAVGGVRRANRALRLTPQLGGEYLLGGVDVAIDCAGSASSLSTALRVTRAGGRVVLSG
VPAGSVDLTPLWFRELELVGTYASSGGARPGRAGTEPAGPAEPVESDFGRALALAATAPLDGVVSAVYPLTRWREALDHA
LSAGRLGAVKIVFDPAASA

Specific function: Catalyzes The NADH/Nadph-Dependent Oxidation Of L- Idonate To 5-Ketogluconate (5kg). [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=310, Percent_Identity=28.7096774193548, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1790718, Length=357, Percent_Identity=26.0504201680672, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787863, Length=284, Percent_Identity=26.7605633802817, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1790045, Length=364, Percent_Identity=24.1758241758242, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788073, Length=286, Percent_Identity=26.9230769230769, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI226510992, Length=362, Percent_Identity=25.1381215469613, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082125, Length=309, Percent_Identity=26.8608414239482, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788407, Length=322, Percent_Identity=21.7391304347826, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786825, Length=319, Percent_Identity=26.9592476489028, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=297, Percent_Identity=29.6296296296296, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17562878, Length=302, Percent_Identity=30.4635761589404, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=310, Percent_Identity=28.7096774193548, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=381, Percent_Identity=24.9343832020997, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319955, Length=381, Percent_Identity=24.6719160104987, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=268, Percent_Identity=25.7462686567164, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737897, Length=362, Percent_Identity=27.3480662983425, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17137530, Length=290, Percent_Identity=29.3103448275862, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.264 [C]

Molecular weight: Translated: 43367; Mature: 43236

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRGLELYRSLPRYAAARVVSGRFPRLSGAAATTAAPLRLVDRGDPGLPGPGWVTVRPRL
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEEEECCCCCCCCCCEEEECHHH
AGICGSDLATVTGQSSFYFSPLVSMPFTPGHEIVGDLQEAVTLADGRRLDAGARVVIDPV
HCCCCCCHHEECCCCCEEECHHHCCCCCCCHHHHHHHHHHHHHHCCCEECCCCEEEEHHH
LGCAARGLELCVGCAAGRTSRCDRITVGHLAPGLQTGFCADTGGGWSRALVAHHSQLHPV
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCC
PDTLPDSRAVLVEPLATAVHTAGRCGVRSGDRVLIIGSGAVGLLTLLAIRAYTKAEHVTM
CCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
VAKHRRQVELARRFGADEVLAPDDAVGGVRRANRALRLTPQLGGEYLLGGVDVAIDCAGS
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCEEECCEEEEEECCCC
ASSLSTALRVTRAGGRVVLSGVPAGSVDLTPLWFRELELVGTYASSGGARPGRAGTEPAG
HHHHHHHHHEEECCCEEEEECCCCCCCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCCCC
PAEPVESDFGRALALAATAPLDGVVSAVYPLTRWREALDHALSAGRLGAVKIVFDPAASA
CCCCCHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
TRGLELYRSLPRYAAARVVSGRFPRLSGAAATTAAPLRLVDRGDPGLPGPGWVTVRPRL
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEEEECCCCCCCCCCEEEECHHH
AGICGSDLATVTGQSSFYFSPLVSMPFTPGHEIVGDLQEAVTLADGRRLDAGARVVIDPV
HCCCCCCHHEECCCCCEEECHHHCCCCCCCHHHHHHHHHHHHHHCCCEECCCCEEEEHHH
LGCAARGLELCVGCAAGRTSRCDRITVGHLAPGLQTGFCADTGGGWSRALVAHHSQLHPV
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCC
PDTLPDSRAVLVEPLATAVHTAGRCGVRSGDRVLIIGSGAVGLLTLLAIRAYTKAEHVTM
CCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
VAKHRRQVELARRFGADEVLAPDDAVGGVRRANRALRLTPQLGGEYLLGGVDVAIDCAGS
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCEEECCEEEEEECCCC
ASSLSTALRVTRAGGRVVLSGVPAGSVDLTPLWFRELELVGTYASSGGARPGRAGTEPAG
HHHHHHHHHEEECCCEEEEECCCCCCCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCCCC
PAEPVESDFGRALALAATAPLDGVVSAVYPLTRWREALDHALSAGRLGAVKIVFDPAASA
CCCCCHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-idonate; NAD [C]

Specific reaction: L-idonate + NAD = NADH + 5-ketogluconate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]