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The map label for this gene is fadD [C]

Identifier: 158315748

GI number: 158315748

Start: 4741066

End: 4742973

Strand: Reverse

Name: fadD [C]

Synonym: Franean1_3960

Alternate gene names: 158315748

Gene position: 4742973-4741066 (Counterclockwise)

Preceding gene: 158315749

Following gene: 158315747

Centisome position: 52.81

GC content: 74.37

Gene sequence:

>1908_bases
GTGCAGCAGTACACCCTGGGAGCGGGCCGGGTCCTTCCTGACGACCGCGGTCTTTATTCCCTCGTCGACGACCGCGTCCG
TACCGATCCGGACCGGGTGATCCTCAGCCGGCCCACCGGGACGGACTGGCACGACGTCACCTTCCGCGAGCTCGACGCCC
ACGTGCGCCGGGTCGCCGCGGTGCTCCTCGGCCACGGGGTGGGCGTGGGCGACCGCGTCGGCATCGTCGGCCGCACCAGC
TACGAGTGGGTGGTCGCCGACCTCGCGGTCCTCGCCCTCGGCGCGATCACCGTGCCGATCTTCCCGACCGCCTCGCCGGC
GCAGATCACCCACATCGTGACCGACTCCGGCATGGCGTGGTGCTTCGTCGAGACCCCGGAGCACCACAGCGCGGTCGCCA
CGGCCGGCGCCGGGACGCTGCTCGCGCTGCCCTGGCAGCTGGCCGACCTGAACGGCTGGCAGGCCCCCGCCGACGACGCG
AGCCACGACGCGGGCCACGCGGCCGGCGGCGGTGACCTGGCCGCGGCGGACGAGTTCGCCGGGCGCCGGGACGCCGTCCG
GGCGGACTCGCTCGCGACGATCGTCTACACCAGCGGGACGACCGGCATGCCCAAGGGCTGCATTCTCACCCACGGCAACC
TGTTCGCCTCCAGCGCCAACACCGTCGAGCACACCGGCGAGCTGTTCCGGGTGTGGCGGCCCGCCGCGGGCACCGGAGCG
GCCGAGGGGTCGGCGGGATCAGAGGCGTCGGTCGAGCAGGCGTCGACCCTGCTCTGCCTGCCGCTGGCACACGTCTTCGG
CCGGACGATCCTCGTCGCCTGCATCTATGCCGGAACGCGGACCGGCCTGCTGGCGGCGGTCCCGGACATCCTGCCCGCGA
TGGCGACCTTCCGGCCGACCGTGCTCGCGCTCGTCCCCTACGCCCTGGAGAAGATCCGCAAGGGGCTGCGCGGCGTCGTC
GACACCGACACCGAGCTCGCGGCGGTGGCCGCCGGGCTGGCCGGCGACCCGGCCGACGGCCCAGCCACCAGCCCGGCCGC
CGAGCGGCGGCCCGCCCCGGCTGCGCTGGCCCGGATCAACGGCGTGTTCGGTGGCCGGCTGACCCACGTGATCAGCGGCG
GCGCGTCGCTGGACGCCACCACGGCGGCCTTCTACCGCGGGGTCGGCGTGCGGATCCTGAACTGCTACGGCCTCACCGAG
GCCGCGACGGCGGTGACCGTCAACCAACCCGGCACCAACCGCATCGGCACGGTCGGCCAGCCGATCCCCGGCACCACCGT
GGCGATCTCCCCGGACGGCGAGGTGCTGGTCGCCGGCCCCAACGTCTCCCCCGGCTACTGGCGGGCCGGCCAGGCCCCGT
GGATCGAGCCCGCCGGCACCCAGGCCGAGCCCGGCGCCGGCCCGTCCCGCTGGCTGCACACCGGCGACCTGGGCCACCTC
GACGCCGACGGCTTCCTCGTCATCACCGGCCGCCGCAAGGAAATCCTGGTCACCAGCGGTGGCAAGAACGTCACGCCGAC
CCTGCTCGAGGACAGGATGCGGCTGCACCCGCTGGTCGCCGACTGCATGGTCGTCGGTGAGGCCCGCCCGTACGTCGCCG
CCCTGGTGACGACCGACCAGGGTGCGCTCAACGCCCTGGCCGCGGCGCACGGCATCGACCTCGCCGCCTCCGGCTGGTGG
GAGCACCCCGCCCTGCTCGACCGGGTGCAGGAGGCGGTCGACGACGCCAACGGCCTGGTCTCCCGGGCCGAGTCCATCCG
CCGGTTCCGAATCCTCCCCACCCAGCTCACCATCGACGCCGGTCACCTGACGCCCTCGATGAAGCTGCGCCGCGCACCGA
TCGAGACGGCCTTCGCCACCGAGATCGAGCAGCTCTACTCCCCGGCCGCCGCCCCGGCACCGGCCTGA

Upstream 100 bases:

>100_bases
AGCTAGAAGCACATTGCCAGCCGACCGACGATGCATTGAGACTGGGTTCGGTAAATCCACCGAGAAATATCCGAACCCTC
GTCACGAGTAGGTGGTCGGT

Downstream 100 bases:

>100_bases
CCCGACGCCGGCGGACGTCCCCGCAGGGAGACGCCGCCGCTCGCAGACATCCCAGCCCGCTGACATCTCCGCCGCATGAC
CGACGGGAGCACTCAAGGAT

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MQQYTLGAGRVLPDDRGLYSLVDDRVRTDPDRVILSRPTGTDWHDVTFRELDAHVRRVAAVLLGHGVGVGDRVGIVGRTS
YEWVVADLAVLALGAITVPIFPTASPAQITHIVTDSGMAWCFVETPEHHSAVATAGAGTLLALPWQLADLNGWQAPADDA
SHDAGHAAGGGDLAAADEFAGRRDAVRADSLATIVYTSGTTGMPKGCILTHGNLFASSANTVEHTGELFRVWRPAAGTGA
AEGSAGSEASVEQASTLLCLPLAHVFGRTILVACIYAGTRTGLLAAVPDILPAMATFRPTVLALVPYALEKIRKGLRGVV
DTDTELAAVAAGLAGDPADGPATSPAAERRPAPAALARINGVFGGRLTHVISGGASLDATTAAFYRGVGVRILNCYGLTE
AATAVTVNQPGTNRIGTVGQPIPGTTVAISPDGEVLVAGPNVSPGYWRAGQAPWIEPAGTQAEPGAGPSRWLHTGDLGHL
DADGFLVITGRRKEILVTSGGKNVTPTLLEDRMRLHPLVADCMVVGEARPYVAALVTTDQGALNALAAAHGIDLAASGWW
EHPALLDRVQEAVDDANGLVSRAESIRRFRILPTQLTIDAGHLTPSMKLRRAPIETAFATEIEQLYSPAAAPAPA

Sequences:

>Translated_635_residues
MQQYTLGAGRVLPDDRGLYSLVDDRVRTDPDRVILSRPTGTDWHDVTFRELDAHVRRVAAVLLGHGVGVGDRVGIVGRTS
YEWVVADLAVLALGAITVPIFPTASPAQITHIVTDSGMAWCFVETPEHHSAVATAGAGTLLALPWQLADLNGWQAPADDA
SHDAGHAAGGGDLAAADEFAGRRDAVRADSLATIVYTSGTTGMPKGCILTHGNLFASSANTVEHTGELFRVWRPAAGTGA
AEGSAGSEASVEQASTLLCLPLAHVFGRTILVACIYAGTRTGLLAAVPDILPAMATFRPTVLALVPYALEKIRKGLRGVV
DTDTELAAVAAGLAGDPADGPATSPAAERRPAPAALARINGVFGGRLTHVISGGASLDATTAAFYRGVGVRILNCYGLTE
AATAVTVNQPGTNRIGTVGQPIPGTTVAISPDGEVLVAGPNVSPGYWRAGQAPWIEPAGTQAEPGAGPSRWLHTGDLGHL
DADGFLVITGRRKEILVTSGGKNVTPTLLEDRMRLHPLVADCMVVGEARPYVAALVTTDQGALNALAAAHGIDLAASGWW
EHPALLDRVQEAVDDANGLVSRAESIRRFRILPTQLTIDAGHLTPSMKLRRAPIETAFATEIEQLYSPAAAPAPA
>Mature_635_residues
MQQYTLGAGRVLPDDRGLYSLVDDRVRTDPDRVILSRPTGTDWHDVTFRELDAHVRRVAAVLLGHGVGVGDRVGIVGRTS
YEWVVADLAVLALGAITVPIFPTASPAQITHIVTDSGMAWCFVETPEHHSAVATAGAGTLLALPWQLADLNGWQAPADDA
SHDAGHAAGGGDLAAADEFAGRRDAVRADSLATIVYTSGTTGMPKGCILTHGNLFASSANTVEHTGELFRVWRPAAGTGA
AEGSAGSEASVEQASTLLCLPLAHVFGRTILVACIYAGTRTGLLAAVPDILPAMATFRPTVLALVPYALEKIRKGLRGVV
DTDTELAAVAAGLAGDPADGPATSPAAERRPAPAALARINGVFGGRLTHVISGGASLDATTAAFYRGVGVRILNCYGLTE
AATAVTVNQPGTNRIGTVGQPIPGTTVAISPDGEVLVAGPNVSPGYWRAGQAPWIEPAGTQAEPGAGPSRWLHTGDLGHL
DADGFLVITGRRKEILVTSGGKNVTPTLLEDRMRLHPLVADCMVVGEARPYVAALVTTDQGALNALAAAHGIDLAASGWW
EHPALLDRVQEAVDDANGLVSRAESIRRFRILPTQLTIDAGHLTPSMKLRRAPIETAFATEIEQLYSPAAAPAPA

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42794756, Length=614, Percent_Identity=24.5928338762215, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI42794760, Length=614, Percent_Identity=24.5928338762215, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI42794758, Length=614, Percent_Identity=24.5928338762215, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI83745141, Length=636, Percent_Identity=23.7421383647799, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI27477105, Length=642, Percent_Identity=24.4548286604361, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI40807491, Length=624, Percent_Identity=25.1602564102564, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI57165410, Length=617, Percent_Identity=24.3111831442464, Blast_Score=156, Evalue=7e-38,
Organism=Homo sapiens, GI57165412, Length=618, Percent_Identity=24.4336569579288, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI4758332, Length=659, Percent_Identity=21.6995447647951, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI12669909, Length=659, Percent_Identity=21.6995447647951, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI42794754, Length=482, Percent_Identity=25.9336099585062, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI42794752, Length=482, Percent_Identity=25.9336099585062, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1788107, Length=507, Percent_Identity=26.0355029585799, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI1789201, Length=142, Percent_Identity=32.3943661971831, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI145693145, Length=172, Percent_Identity=30.2325581395349, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI221142682, Length=177, Percent_Identity=29.9435028248588, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17541856, Length=595, Percent_Identity=27.0588235294118, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17553312, Length=625, Percent_Identity=26.08, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17510401, Length=601, Percent_Identity=25.6239600665557, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI25147511, Length=631, Percent_Identity=23.6133122028526, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI193204819, Length=646, Percent_Identity=24.922600619195, Blast_Score=139, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17564090, Length=594, Percent_Identity=23.9057239057239, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17558820, Length=476, Percent_Identity=25.8403361344538, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI32563687, Length=476, Percent_Identity=25.8403361344538, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17556552, Length=617, Percent_Identity=21.5559157212318, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17559526, Length=342, Percent_Identity=28.3625730994152, Blast_Score=87, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324893, Length=481, Percent_Identity=25.5717255717256, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320852, Length=608, Percent_Identity=21.7105263157895, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6322182, Length=465, Percent_Identity=24.3010752688172, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323903, Length=472, Percent_Identity=23.728813559322, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6319699, Length=513, Percent_Identity=24.9512670565302, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17933690, Length=628, Percent_Identity=23.2484076433121, Blast_Score=180, Evalue=3e-45,
Organism=Drosophila melanogaster, GI19921316, Length=663, Percent_Identity=25.1885369532428, Blast_Score=175, Evalue=1e-43,
Organism=Drosophila melanogaster, GI281366413, Length=611, Percent_Identity=24.0589198036007, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24666501, Length=611, Percent_Identity=24.0589198036007, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24666497, Length=611, Percent_Identity=24.0589198036007, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI62471681, Length=487, Percent_Identity=24.435318275154, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI62471687, Length=487, Percent_Identity=24.435318275154, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24586634, Length=487, Percent_Identity=24.435318275154, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI22026970, Length=487, Percent_Identity=24.435318275154, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI62471689, Length=487, Percent_Identity=24.435318275154, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI62471679, Length=487, Percent_Identity=24.435318275154, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI62471683, Length=487, Percent_Identity=24.435318275154, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI62471685, Length=487, Percent_Identity=24.435318275154, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24586636, Length=487, Percent_Identity=24.435318275154, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24581924, Length=450, Percent_Identity=23.5555555555556, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 65992; Mature: 65992

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQYTLGAGRVLPDDRGLYSLVDDRVRTDPDRVILSRPTGTDWHDVTFRELDAHVRRVAA
CCCEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
VLLGHGVGVGDRVGIVGRTSYEWVVADLAVLALGAITVPIFPTASPAQITHIVTDSGMAW
HHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEECCCCEE
CFVETPEHHSAVATAGAGTLLALPWQLADLNGWQAPADDASHDAGHAAGGGDLAAADEFA
EEEECCCCCCCEEECCCCCEEECCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHC
GRRDAVRADSLATIVYTSGTTGMPKGCILTHGNLFASSANTVEHTGELFRVWRPAAGTGA
CCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCEEECCCCHHHHHHHHHHHCCCCCCCCC
AEGSAGSEASVEQASTLLCLPLAHVFGRTILVACIYAGTRTGLLAAVPDILPAMATFRPT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHH
VLALVPYALEKIRKGLRGVVDTDTELAAVAAGLAGDPADGPATSPAAERRPAPAALARIN
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCHHHHHHC
GVFGGRLTHVISGGASLDATTAAFYRGVGVRILNCYGLTEAATAVTVNQPGTNRIGTVGQ
CCCCCHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCC
PIPGTTVAISPDGEVLVAGPNVSPGYWRAGQAPWIEPAGTQAEPGAGPSRWLHTGDLGHL
CCCCCEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCC
DADGFLVITGRRKEILVTSGGKNVTPTLLEDRMRLHPLVADCMVVGEARPYVAALVTTDQ
CCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEECCC
GALNALAAAHGIDLAASGWWEHPALLDRVQEAVDDANGLVSRAESIRRFRILPTQLTIDA
HHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECEEEEEEC
GHLTPSMKLRRAPIETAFATEIEQLYSPAAAPAPA
CCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQQYTLGAGRVLPDDRGLYSLVDDRVRTDPDRVILSRPTGTDWHDVTFRELDAHVRRVAA
CCCEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
VLLGHGVGVGDRVGIVGRTSYEWVVADLAVLALGAITVPIFPTASPAQITHIVTDSGMAW
HHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEECCCCEE
CFVETPEHHSAVATAGAGTLLALPWQLADLNGWQAPADDASHDAGHAAGGGDLAAADEFA
EEEECCCCCCCEEECCCCCEEECCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHC
GRRDAVRADSLATIVYTSGTTGMPKGCILTHGNLFASSANTVEHTGELFRVWRPAAGTGA
CCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCEEECCCCHHHHHHHHHHHCCCCCCCCC
AEGSAGSEASVEQASTLLCLPLAHVFGRTILVACIYAGTRTGLLAAVPDILPAMATFRPT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHH
VLALVPYALEKIRKGLRGVVDTDTELAAVAAGLAGDPADGPATSPAAERRPAPAALARIN
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCHHHHHHC
GVFGGRLTHVISGGASLDATTAAFYRGVGVRILNCYGLTEAATAVTVNQPGTNRIGTVGQ
CCCCCHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCC
PIPGTTVAISPDGEVLVAGPNVSPGYWRAGQAPWIEPAGTQAEPGAGPSRWLHTGDLGHL
CCCCCEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCC
DADGFLVITGRRKEILVTSGGKNVTPTLLEDRMRLHPLVADCMVVGEARPYVAALVTTDQ
CCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEECCC
GALNALAAAHGIDLAASGWWEHPALLDRVQEAVDDANGLVSRAESIRRFRILPTQLTIDA
HHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECEEEEEEC
GHLTPSMKLRRAPIETAFATEIEQLYSPAAAPAPA
CCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]