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The map label for this gene is tcmR [H]

Identifier: 158315629

GI number: 158315629

Start: 4561583

End: 4562338

Strand: Reverse

Name: tcmR [H]

Synonym: Franean1_3839

Alternate gene names: 158315629

Gene position: 4562338-4561583 (Counterclockwise)

Preceding gene: 158315634

Following gene: 158315628

Centisome position: 50.79

GC content: 71.3

Gene sequence:

>756_bases
ATGCCACCGTCGATATCCTGGGGCAGGTGTGGCGCGGCGTATAGTACGACTGTGGCGGGTGAGGTGTCAGCAGGGCTCGA
CCTCCGCGAGCGCACCCGGCGCGCCGTGCGGACCGAGCTGATGTCCGTCGCGATGGACCTCTTCGTTCGCAACGGCTACG
AGGCCACGACGATCGACGAGATCGTGGCCGCCGCCGGGATGTCGCGTCGCAGCTTCTTCCGCTACTTCGGGTCGAAGGAA
GACGTCGTCCTGGGGCACCTCGACGCCCTCGGCGCGTCCCTGGCCGAGGCCCTGGGCCAGCGCCCCGCGAACGAGGACGC
CTGGACCGCGCTGCGCCGGGCCTTCGACACCCTGATCGCCCACCAGACCAGCGACCCGCAGGCCGCCCTCTCAATGCGGC
AGATGCTCGACGGCAATCCCGGGTTGCAAGCCCGCAACCTGGAAAGGCAGTGCCGATGGCACGACCGGCTCGCGCCCCAG
ATCGCCGCACGCCTCAGCTACACGGGAACCGGACCCGCGGATGACAGTCCCGCGGGAGCTGGCGCCGTAGTCGACAGCCA
CCCGGGTGACAGCCACCCAGGTGACAGCCACCCGGGTGCCGGCCCCGCCGCCGGCGCTCGCACAGCCGCGGTCATCGGCG
CCGCGCTGGCCTGTATGGAGGCGGCAAACCGCGCCTGGATGGCCACCGACGGCCGCACCCCGCTGGCCACCATCCTCGAC
GACGTCATGCGCACCGTCCGCCCCGCCGCTTTCTAA

Upstream 100 bases:

>100_bases
GTGCCGGACCACATCACCCAGCCGATGCTCTCCGCTGAACCGGTCATCCGCGACACCTGCCCCTCAGTCACCCGGCACAC
TACGCCGGAAACGACACTCA

Downstream 100 bases:

>100_bases
CCCGTCGCACTCAGCCCAGGCCGGGTTCGGCGCAGGCCGGCTGATATTCAGCAGATCCGGATACCGGGGCAGGTTCCCTA
TCTGACGGATTTCGCCGCAG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Tetracenomycin C transcriptional repressor [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MPPSISWGRCGAAYSTTVAGEVSAGLDLRERTRRAVRTELMSVAMDLFVRNGYEATTIDEIVAAAGMSRRSFFRYFGSKE
DVVLGHLDALGASLAEALGQRPANEDAWTALRRAFDTLIAHQTSDPQAALSMRQMLDGNPGLQARNLERQCRWHDRLAPQ
IAARLSYTGTGPADDSPAGAGAVVDSHPGDSHPGDSHPGAGPAAGARTAAVIGAALACMEAANRAWMATDGRTPLATILD
DVMRTVRPAAF

Sequences:

>Translated_251_residues
MPPSISWGRCGAAYSTTVAGEVSAGLDLRERTRRAVRTELMSVAMDLFVRNGYEATTIDEIVAAAGMSRRSFFRYFGSKE
DVVLGHLDALGASLAEALGQRPANEDAWTALRRAFDTLIAHQTSDPQAALSMRQMLDGNPGLQARNLERQCRWHDRLAPQ
IAARLSYTGTGPADDSPAGAGAVVDSHPGDSHPGDSHPGAGPAAGARTAAVIGAALACMEAANRAWMATDGRTPLATILD
DVMRTVRPAAF
>Mature_250_residues
PPSISWGRCGAAYSTTVAGEVSAGLDLRERTRRAVRTELMSVAMDLFVRNGYEATTIDEIVAAAGMSRRSFFRYFGSKED
VVLGHLDALGASLAEALGQRPANEDAWTALRRAFDTLIAHQTSDPQAALSMRQMLDGNPGLQARNLERQCRWHDRLAPQI
AARLSYTGTGPADDSPAGAGAVVDSHPGDSHPGDSHPGAGPAAGARTAAVIGAALACMEAANRAWMATDGRTPLATILDD
VMRTVRPAAF

Specific function: Represses transcription of the divergently oriented tcmR and tcmA (tetracenomycin C resistance and export) genes by binding to an intergenic operator region. This binding is inhibited by tetracenomycin C [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 26544; Mature: 26413

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPSISWGRCGAAYSTTVAGEVSAGLDLRERTRRAVRTELMSVAMDLFVRNGYEATTIDE
CCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IVAAAGMSRRSFFRYFGSKEDVVLGHLDALGASLAEALGQRPANEDAWTALRRAFDTLIA
HHHHHCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
HQTSDPQAALSMRQMLDGNPGLQARNLERQCRWHDRLAPQIAARLSYTGTGPADDSPAGA
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GAVVDSHPGDSHPGDSHPGAGPAAGARTAAVIGAALACMEAANRAWMATDGRTPLATILD
CCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHH
DVMRTVRPAAF
HHHHHHCCCCC
>Mature Secondary Structure 
PPSISWGRCGAAYSTTVAGEVSAGLDLRERTRRAVRTELMSVAMDLFVRNGYEATTIDE
CCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IVAAAGMSRRSFFRYFGSKEDVVLGHLDALGASLAEALGQRPANEDAWTALRRAFDTLIA
HHHHHCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
HQTSDPQAALSMRQMLDGNPGLQARNLERQCRWHDRLAPQIAARLSYTGTGPADDSPAGA
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GAVVDSHPGDSHPGDSHPGAGPAAGARTAAVIGAALACMEAANRAWMATDGRTPLATILD
CCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHH
DVMRTVRPAAF
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1592819; 1592820 [H]