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The map label for this gene is uxuB [H]

Identifier: 158315004

GI number: 158315004

Start: 3777263

End: 3778729

Strand: Direct

Name: uxuB [H]

Synonym: Franean1_3198

Alternate gene names: 158315004

Gene position: 3777263-3778729 (Clockwise)

Preceding gene: 158315003

Following gene: 158315006

Centisome position: 42.05

GC content: 74.3

Gene sequence:

>1467_bases
GTGAACCATTCCGCGGCCGTGCCTGTGAACCGCCCAGTGGCGGCGCCCGCCAGCGGCCCCGTGGCCCCGTCGCCGAGTCG
TCCTGCGGCTGTCGCTCGACCGCTGTCGCGGCCCGGTGGCGACGGGCGGCCGGCGGCTCGGGTTCGCATTCTGCATCTCG
GGCTCGGTAGCTTCTTCCGGGCCCATCAGGCCTGGTACACCGACCGGGCGCCGGACGCCCGGCAGTGGGGGATCGCGGCG
TTCTCCCACCGCCGCCGGGGCCTCGCGCACGCGCTGACCGCCCAGGACGGGCTCTACACCCTGCTGACGCGCGGTGCCGA
AGGCGACCGCTTCGACGTGATCAGCTCGCTTGCCGCCGCGCACGCGGGCAGCGACCACGACGCCTGGCTGGCGTACTGGC
GGCAGCCGGCCCTCGCCGTCGTCACCCTGACGGTCACGGAGGCCGGTTACGCCTGTGACCCCGACGGAGGTCTCGACCTG
GCGCGCGGGGACGTCGCCGCCGACATCGCGGCGCTGCGCACCGACCCCGGCGCCCTGGTGATGACGGCTCCCGCCCGCCT
GCTCGCCGGACTGCACGCGCGGGCCCGGGCCGGCCGCAGTCCGGTCGCGACAGTGCCGTGCGACAACCTGGCGGGCAACG
GCGCTGTGGCCGGGCGCGCGGTACGCGAGCTGGCCGCGGCGACCGGACGACCGGAGCTCGTCGCCGCCGCGGACGGCGCC
TCGTGGGTGACCACGATGGTCGACCGCATCACCCCGGGCACCACCGACGCCGACGGCGCCGCGGTGCGCGCCGCGACCGG
CCGCGACGACGCCGTGCCGGTGGTCACCGAGCCGTTCTCGGAATGGGTGCTCAGCGGTGACTTCCCGGGTGGGCGGCCCG
AGTGGGAACACGCGGGTGCCCGGTTCGTCGCCGACCTGACGCCGTTCGAGAACCGCAAGCTGTGGCTGCTCAACGGCGCG
CATTCACTGCTGGCCTACGCCGGTCCCCGCCGCGGGCACGTCACGGTCGCGCAGGCCGTCGCCGACCCCCGCTGCCGCGG
GTGGCTGATCGAGTGGTGGGCGGAAGCCTCCCGCCACCTGAGCATGACCAGGACCGAGCTCGAGTCCTATCAGCATGCGT
TGCTGGAACGCTTCGAGAACCCGCGGATTCGGCATCTGCTCGCTCAGATCGCCATGGATGGCTCTCTGAAGCTTCCGGTG
CGTATCCTGCCGGTCCTGCGCGCTGAACGTGCCCGCGGCGTGATGCCCCGGGCCGGAATCCGAGTGATCGCCGCCTGGAT
GCTGCATCTGCGGGAGGGGACGGCGTCGGTACGCGATGCTGAGGCGGGCCGGTCGGTCGCCGCGGCCCGGGCTCCGCTGC
CCGAAGCCGCCAGCCTGGTCCTCGATCTTCTCGGCCCCGGACTGGGCCGGGACGGGGAGCTGGTGGCGGCGTTGGCCGCA
CAGGTGACCGAGCTGGGCGATCCCTGA

Upstream 100 bases:

>100_bases
TGCTCGCCGAGCTCGTCGCCGAGCACCGGCTGGAGGAGGACGAGGCCTTCGAGACCGCCGTCGAGCTGGTGGCGGTCAGG
CCGCGAGAGGCCTTCCGTCT

Downstream 100 bases:

>100_bases
GTATGCGGGCCACCCGAAGGCGGCGCCTTCACGCATCCGTCGATGCGGCAGCGTCCGACGAGCTGCCGCGTCGTTCATGA
CCGCTGGCCGGGAGGACGCC

Product: mannitol dehydrogenase domain-containing protein

Products: NA

Alternate protein names: Fructuronate reductase [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MNHSAAVPVNRPVAAPASGPVAPSPSRPAAVARPLSRPGGDGRPAARVRILHLGLGSFFRAHQAWYTDRAPDARQWGIAA
FSHRRRGLAHALTAQDGLYTLLTRGAEGDRFDVISSLAAAHAGSDHDAWLAYWRQPALAVVTLTVTEAGYACDPDGGLDL
ARGDVAADIAALRTDPGALVMTAPARLLAGLHARARAGRSPVATVPCDNLAGNGAVAGRAVRELAAATGRPELVAAADGA
SWVTTMVDRITPGTTDADGAAVRAATGRDDAVPVVTEPFSEWVLSGDFPGGRPEWEHAGARFVADLTPFENRKLWLLNGA
HSLLAYAGPRRGHVTVAQAVADPRCRGWLIEWWAEASRHLSMTRTELESYQHALLERFENPRIRHLLAQIAMDGSLKLPV
RILPVLRAERARGVMPRAGIRVIAAWMLHLREGTASVRDAEAGRSVAAARAPLPEAASLVLDLLGPGLGRDGELVAALAA
QVTELGDP

Sequences:

>Translated_488_residues
MNHSAAVPVNRPVAAPASGPVAPSPSRPAAVARPLSRPGGDGRPAARVRILHLGLGSFFRAHQAWYTDRAPDARQWGIAA
FSHRRRGLAHALTAQDGLYTLLTRGAEGDRFDVISSLAAAHAGSDHDAWLAYWRQPALAVVTLTVTEAGYACDPDGGLDL
ARGDVAADIAALRTDPGALVMTAPARLLAGLHARARAGRSPVATVPCDNLAGNGAVAGRAVRELAAATGRPELVAAADGA
SWVTTMVDRITPGTTDADGAAVRAATGRDDAVPVVTEPFSEWVLSGDFPGGRPEWEHAGARFVADLTPFENRKLWLLNGA
HSLLAYAGPRRGHVTVAQAVADPRCRGWLIEWWAEASRHLSMTRTELESYQHALLERFENPRIRHLLAQIAMDGSLKLPV
RILPVLRAERARGVMPRAGIRVIAAWMLHLREGTASVRDAEAGRSVAAARAPLPEAASLVLDLLGPGLGRDGELVAALAA
QVTELGDP
>Mature_488_residues
MNHSAAVPVNRPVAAPASGPVAPSPSRPAAVARPLSRPGGDGRPAARVRILHLGLGSFFRAHQAWYTDRAPDARQWGIAA
FSHRRRGLAHALTAQDGLYTLLTRGAEGDRFDVISSLAAAHAGSDHDAWLAYWRQPALAVVTLTVTEAGYACDPDGGLDL
ARGDVAADIAALRTDPGALVMTAPARLLAGLHARARAGRSPVATVPCDNLAGNGAVAGRAVRELAAATGRPELVAAADGA
SWVTTMVDRITPGTTDADGAAVRAATGRDDAVPVVTEPFSEWVLSGDFPGGRPEWEHAGARFVADLTPFENRKLWLLNGA
HSLLAYAGPRRGHVTVAQAVADPRCRGWLIEWWAEASRHLSMTRTELESYQHALLERFENPRIRHLLAQIAMDGSLKLPV
RILPVLRAERARGVMPRAGIRVIAAWMLHLREGTASVRDAEAGRSVAAARAPLPEAASLVLDLLGPGLGRDGELVAALAA
QVTELGDP

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=405, Percent_Identity=37.7777777777778, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1788497, Length=381, Percent_Identity=35.6955380577428, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1787823, Length=370, Percent_Identity=35.6756756756757, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI48994885, Length=389, Percent_Identity=28.2776349614396, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1790028, Length=232, Percent_Identity=27.5862068965517, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324401, Length=382, Percent_Identity=30.8900523560209, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6320765, Length=382, Percent_Identity=30.8900523560209, Blast_Score=172, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.57 [H]

Molecular weight: Translated: 51555; Mature: 51555

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHSAAVPVNRPVAAPASGPVAPSPSRPAAVARPLSRPGGDGRPAARVRILHLGLGSFFR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEECHHHHHH
AHQAWYTDRAPDARQWGIAAFSHRRRGLAHALTAQDGLYTLLTRGAEGDRFDVISSLAAA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHH
HAGSDHDAWLAYWRQPALAVVTLTVTEAGYACDPDGGLDLARGDVAADIAALRTDPGALV
HCCCCCHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCEECCCHHHHHHHHHCCCCCCEE
MTAPARLLAGLHARARAGRSPVATVPCDNLAGNGAVAGRAVRELAAATGRPELVAAADGA
EECHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCH
SWVTTMVDRITPGTTDADGAAVRAATGRDDAVPVVTEPFSEWVLSGDFPGGRPEWEHAGA
HHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCEEECCHHHHEEECCCCCCCCCHHHCCC
RFVADLTPFENRKLWLLNGAHSLLAYAGPRRGHVTVAQAVADPRCRGWLIEWWAEASRHL
EEEEECCCCCCCEEEEEECHHHHHHHCCCCCCCEEHHHHHCCCCHHHHHHHHHHHHHHHH
SMTRTELESYQHALLERFENPRIRHLLAQIAMDGSLKLPVRILPVLRAERARGVMPRAGI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHH
RVIAAWMLHLREGTASVRDAEAGRSVAAARAPLPEAASLVLDLLGPGLGRDGELVAALAA
HHHHHHHHHHHHCCCHHHHHHCCCHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
QVTELGDP
HHHHCCCC
>Mature Secondary Structure
MNHSAAVPVNRPVAAPASGPVAPSPSRPAAVARPLSRPGGDGRPAARVRILHLGLGSFFR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEECHHHHHH
AHQAWYTDRAPDARQWGIAAFSHRRRGLAHALTAQDGLYTLLTRGAEGDRFDVISSLAAA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHH
HAGSDHDAWLAYWRQPALAVVTLTVTEAGYACDPDGGLDLARGDVAADIAALRTDPGALV
HCCCCCHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCEECCCHHHHHHHHHCCCCCCEE
MTAPARLLAGLHARARAGRSPVATVPCDNLAGNGAVAGRAVRELAAATGRPELVAAADGA
EECHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCH
SWVTTMVDRITPGTTDADGAAVRAATGRDDAVPVVTEPFSEWVLSGDFPGGRPEWEHAGA
HHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCEEECCHHHHEEECCCCCCCCCHHHCCC
RFVADLTPFENRKLWLLNGAHSLLAYAGPRRGHVTVAQAVADPRCRGWLIEWWAEASRHL
EEEEECCCCCCCEEEEEECHHHHHHHCCCCCCCEEHHHHHCCCCHHHHHHHHHHHHHHHH
SMTRTELESYQHALLERFENPRIRHLLAQIAMDGSLKLPVRILPVLRAERARGVMPRAGI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHH
RVIAAWMLHLREGTASVRDAEAGRSVAAARAPLPEAASLVLDLLGPGLGRDGELVAALAA
HHHHHHHHHHHHCCCHHHHHHCCCHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
QVTELGDP
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]