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The map label for this gene is uppS [H]

Identifier: 158314885

GI number: 158314885

Start: 3629894

End: 3630670

Strand: Direct

Name: uppS [H]

Synonym: Franean1_3075

Alternate gene names: 158314885

Gene position: 3629894-3630670 (Clockwise)

Preceding gene: 158314884

Following gene: 158314886

Centisome position: 40.41

GC content: 69.37

Gene sequence:

>777_bases
GTGCCAATACGCGATCTTGCCTACACCGTGTACGCCCGTCGGCTCCGCGCATCGCTCAAGGGAGCCGAGCTACCGAGGCA
CGTTGGCCTGATCATGGACGGCAACCGCCGCTGGGCCCGCCAGATGGGGATGGCCAATCCCAGCCTCGGCCACAAGTTCG
GCGCCGACCATGTCGAGGACGTGCTGTCGTGGTGCGAGGCGGCCGGTATCAAGCACGTGACCGTCTTCGTCTGCTCCACC
GAGAACCTGGCCCACCGCGAGGATGCCGAGATCGCGTTCCTCATGCGGGTCATCGAGCAGGTTGTCTCCGACAAGATCGC
GACTCCCGATCCGGCGTGGCAGATGCACATCGCGGGGCTGCTCGACGCGCTGCCGGACAGCACGGCCCGTGCGCTCAAGA
ACGCCGAGGAGGTCACCCGATCCTGCTCGACGGGGGCGCACGTCACCCTCGCCGTGGGGTACGGCGGCCGGCAGGAGGTC
GTCGACGCGTTCCGGGCCCTCCTGCACGAGCAGGCCGAGACGGGCGGCTCGCTGGCCGACCTGGCCGAGACCCTCACCGC
CGAGGACGTCGCCCGCCACCTCTACACGGCCGGCCAGCCTGACCCCGACCTGGTCATCCGCACCAGCGGCGAGCAGCGCA
TGTCGAACTTCCTGCTCTGGCAGAGCGCGTACTCCGAGCTGTACTTCTGCGAGGCGTACTGGCCCGCGTTCCGCGAGATC
GACTTCCTGCGGGCGCTGCGCAGCTACGCCGCCCGTGGCCGTCGCCACGGCGCCTAA

Upstream 100 bases:

>100_bases
TTCGGTGTTGGCCTTGGCGGTCCAACGTACAGATTGCCGTCGCCGCCTCGGCGTGGCCCCGCCGAGCCGGCCCGAGGACA
GGCGGGCATAGATTCAGGCT

Downstream 100 bases:

>100_bases
CCTGGTGGCTTTCCGACGGCCTGCCGGCTCTGCCGCCGGCTCGCCGTCCGGTGCCACCGCCGGCGCGTGAAACCTCCAGG
AGGACGACGCGCTGCGCGAG

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MPIRDLAYTVYARRLRASLKGAELPRHVGLIMDGNRRWARQMGMANPSLGHKFGADHVEDVLSWCEAAGIKHVTVFVCST
ENLAHREDAEIAFLMRVIEQVVSDKIATPDPAWQMHIAGLLDALPDSTARALKNAEEVTRSCSTGAHVTLAVGYGGRQEV
VDAFRALLHEQAETGGSLADLAETLTAEDVARHLYTAGQPDPDLVIRTSGEQRMSNFLLWQSAYSELYFCEAYWPAFREI
DFLRALRSYAARGRRHGA

Sequences:

>Translated_258_residues
MPIRDLAYTVYARRLRASLKGAELPRHVGLIMDGNRRWARQMGMANPSLGHKFGADHVEDVLSWCEAAGIKHVTVFVCST
ENLAHREDAEIAFLMRVIEQVVSDKIATPDPAWQMHIAGLLDALPDSTARALKNAEEVTRSCSTGAHVTLAVGYGGRQEV
VDAFRALLHEQAETGGSLADLAETLTAEDVARHLYTAGQPDPDLVIRTSGEQRMSNFLLWQSAYSELYFCEAYWPAFREI
DFLRALRSYAARGRRHGA
>Mature_257_residues
PIRDLAYTVYARRLRASLKGAELPRHVGLIMDGNRRWARQMGMANPSLGHKFGADHVEDVLSWCEAAGIKHVTVFVCSTE
NLAHREDAEIAFLMRVIEQVVSDKIATPDPAWQMHIAGLLDALPDSTARALKNAEEVTRSCSTGAHVTLAVGYGGRQEVV
DAFRALLHEQAETGGSLADLAETLTAEDVARHLYTAGQPDPDLVIRTSGEQRMSNFLLWQSAYSELYFCEAYWPAFREID
FLRALRSYAARGRRHGA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=252, Percent_Identity=29.3650793650794, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI45580742, Length=252, Percent_Identity=29.3650793650794, Blast_Score=115, Evalue=3e-26,
Organism=Escherichia coli, GI1786371, Length=234, Percent_Identity=35.4700854700855, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71993029, Length=239, Percent_Identity=28.0334728033473, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319474, Length=235, Percent_Identity=34.0425531914894, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323748, Length=234, Percent_Identity=26.9230769230769, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18857969, Length=253, Percent_Identity=30.4347826086957, Blast_Score=114, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28653; Mature: 28522

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRDLAYTVYARRLRASLKGAELPRHVGLIMDGNRRWARQMGMANPSLGHKFGADHVED
CCHHHHHHHHHHHHHHHHHCCCCCHHHCCEEECCCHHHHHHHCCCCCCCCCCCCHHHHHH
VLSWCEAAGIKHVTVFVCSTENLAHREDAEIAFLMRVIEQVVSDKIATPDPAWQMHIAGL
HHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LDALPDSTARALKNAEEVTRSCSTGAHVTLAVGYGGRQEVVDAFRALLHEQAETGGSLAD
HHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHH
LAETLTAEDVARHLYTAGQPDPDLVIRTSGEQRMSNFLLWQSAYSELYFCEAYWPAFREI
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEEHHHHHHHHHHH
DFLRALRSYAARGRRHGA
HHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PIRDLAYTVYARRLRASLKGAELPRHVGLIMDGNRRWARQMGMANPSLGHKFGADHVED
CHHHHHHHHHHHHHHHHHCCCCCHHHCCEEECCCHHHHHHHCCCCCCCCCCCCHHHHHH
VLSWCEAAGIKHVTVFVCSTENLAHREDAEIAFLMRVIEQVVSDKIATPDPAWQMHIAGL
HHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LDALPDSTARALKNAEEVTRSCSTGAHVTLAVGYGGRQEVVDAFRALLHEQAETGGSLAD
HHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHH
LAETLTAEDVARHLYTAGQPDPDLVIRTSGEQRMSNFLLWQSAYSELYFCEAYWPAFREI
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEEHHHHHHHHHHH
DFLRALRSYAARGRRHGA
HHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2155856; 8091860 [H]