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The map label for this gene is pfp [H]

Identifier: 158314256

GI number: 158314256

Start: 2887303

End: 2888640

Strand: Direct

Name: pfp [H]

Synonym: Franean1_2426

Alternate gene names: 158314256

Gene position: 2887303-2888640 (Clockwise)

Preceding gene: 158314255

Following gene: 158314258

Centisome position: 32.15

GC content: 69.06

Gene sequence:

>1338_bases
GTGGACGAGCCGCTGACCGTCGACGGCGCCGAGTTGGATGTCCGCAAGCTCGGCCCGTGCCGGATCGACTCGCCGCTGCT
CCCGTTGCTCGGTGCGCGGCCGACGACCCAGCACTACATCGACGAGGGCGACAAGGTCCTCTTCGACGACACCGTTTCGA
TGATCTCCGCGCGGAAGGTGCCGCTGGACGAGCTGCCGGGCTTCGAGCCCGCCGGGCCGCGCCGCAAGATCTACTTTGAC
CCGTCCAAGACCCGGGTGGGGATCGTGACCTGCGGGGGGCTCTGCCCCGGCCTGAACAACGTCATCCGCGGGCTGGTGCT
CGAGCTGACCAACCACTACGGCGTGAACCGGATCTTCGGGTTCCGGCACGGCTACCAGGGTTTCATCGCCAAGTACGGGC
ACAGCGTCGTCGACCTCACCCCGGAGCGGGTGGCGAACATCGACGAGGACGGCGGCACGATCCTCGGCACCTCCCGCGGC
CAACAGGACCCGGCAGAGATCGTCGACTGCCTTTCCCGGATGAACATCAACATCCTGTTCGTGATCGGCGGTGACGGCAC
GCTGCGCGGTGCGCGGGCGATCGCCGGCATCGTCGCCGAGCGCGGGGAGAAGATCGCGGTCGTCGGCATCCCGAAGACGA
TCGACAACGACATCCCCTACATCGACCAGAGCTTCGGGTTCCAGACCGCGTTCGCGAAGGCCGCCGAGTCGATCCGCGCC
GCGTACGCCGAGGCGACCTCGGCTCCCGGCGGGGTCGGTATTGTCCGGCTGATGGGCCGCCACTCCGGCTTCATCGCCTG
TTACGCGGTGCTGGCCAAGAGCGATGCGGACGTCGTGCTCATCCCGGAGCTGCCCTTCACCCTGGAGGGGGAGCGGGGCC
TGCTCGCCTACATCCGTCAGCGGGTCGAGAAGCGGGGCCATGCCGTCGTCGTCGTGGCGGAGGGCGCCGGGCAGGACCTG
GTCGCCGGCCTGCCCGAGTCGTCCGACGCCTCGGGGAACCGCAAGCTCTACGACATCGGCCCGGAGCTCTCCCGGCGGAT
CACCGAGGATTTCGCCGCCCGCGGCGCCGAGCTCAACTTGAAGTACATCGACCCGAGCTACCACATCCGCAGCGTGGCGG
CGAACCCGTACGACAACGTCTACACGATCCGGCTGGCGCACGCGGCGGTCCACGCCGCGATGTCCGGGCGCACGGAGATG
GTCGTCGGGCGCTGGCGCCGCCGGTTCATCCACATCCCGATCGCGCTTGCCGTCAGCCAGCGCAACCAGGTCGACCCGGC
CGGTGATCTGTGGATGTCGGTCCTGGAGGCCACCGGCCAGCCCTACCGCTTCGGCTGA

Upstream 100 bases:

>100_bases
CCGGTACGCTCGGTCCGAGAAACCGGAAGGGAGCTGGGGCGATCGTGGTCCGATCCAGTCGGGCGTCGGGGGACCGTAGC
GGTGTCGGGATCGGGGGGCC

Downstream 100 bases:

>100_bases
CCGGCGTCGGCCGTGTCCCGCGGCGGCCGGACGGTCAGCTGAGCGTCGCGCGCATGACCTCGTCCAGGCCGCCCGGTTCG
CCGTCCGGCTCGGTCTTCTC

Product: diphosphate--fructose-6-phosphate 1-phosphotransferase

Products: NA

Alternate protein names: 6-phosphofructokinase, pyrophosphate dependent; PPi-dependent phosphofructokinase; PPi-PFK; Pyrophosphate-dependent 6-phosphofructose-1-kinase [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MDEPLTVDGAELDVRKLGPCRIDSPLLPLLGARPTTQHYIDEGDKVLFDDTVSMISARKVPLDELPGFEPAGPRRKIYFD
PSKTRVGIVTCGGLCPGLNNVIRGLVLELTNHYGVNRIFGFRHGYQGFIAKYGHSVVDLTPERVANIDEDGGTILGTSRG
QQDPAEIVDCLSRMNINILFVIGGDGTLRGARAIAGIVAERGEKIAVVGIPKTIDNDIPYIDQSFGFQTAFAKAAESIRA
AYAEATSAPGGVGIVRLMGRHSGFIACYAVLAKSDADVVLIPELPFTLEGERGLLAYIRQRVEKRGHAVVVVAEGAGQDL
VAGLPESSDASGNRKLYDIGPELSRRITEDFAARGAELNLKYIDPSYHIRSVAANPYDNVYTIRLAHAAVHAAMSGRTEM
VVGRWRRRFIHIPIALAVSQRNQVDPAGDLWMSVLEATGQPYRFG

Sequences:

>Translated_445_residues
MDEPLTVDGAELDVRKLGPCRIDSPLLPLLGARPTTQHYIDEGDKVLFDDTVSMISARKVPLDELPGFEPAGPRRKIYFD
PSKTRVGIVTCGGLCPGLNNVIRGLVLELTNHYGVNRIFGFRHGYQGFIAKYGHSVVDLTPERVANIDEDGGTILGTSRG
QQDPAEIVDCLSRMNINILFVIGGDGTLRGARAIAGIVAERGEKIAVVGIPKTIDNDIPYIDQSFGFQTAFAKAAESIRA
AYAEATSAPGGVGIVRLMGRHSGFIACYAVLAKSDADVVLIPELPFTLEGERGLLAYIRQRVEKRGHAVVVVAEGAGQDL
VAGLPESSDASGNRKLYDIGPELSRRITEDFAARGAELNLKYIDPSYHIRSVAANPYDNVYTIRLAHAAVHAAMSGRTEM
VVGRWRRRFIHIPIALAVSQRNQVDPAGDLWMSVLEATGQPYRFG
>Mature_445_residues
MDEPLTVDGAELDVRKLGPCRIDSPLLPLLGARPTTQHYIDEGDKVLFDDTVSMISARKVPLDELPGFEPAGPRRKIYFD
PSKTRVGIVTCGGLCPGLNNVIRGLVLELTNHYGVNRIFGFRHGYQGFIAKYGHSVVDLTPERVANIDEDGGTILGTSRG
QQDPAEIVDCLSRMNINILFVIGGDGTLRGARAIAGIVAERGEKIAVVGIPKTIDNDIPYIDQSFGFQTAFAKAAESIRA
AYAEATSAPGGVGIVRLMGRHSGFIACYAVLAKSDADVVLIPELPFTLEGERGLLAYIRQRVEKRGHAVVVVAEGAGQDL
VAGLPESSDASGNRKLYDIGPELSRRITEDFAARGAELNLKYIDPSYHIRSVAANPYDNVYTIRLAHAAVHAAMSGRTEM
VVGRWRRRFIHIPIALAVSQRNQVDPAGDLWMSVLEATGQPYRFG

Specific function: Key control step of glycolysis. [C]

COG id: COG0205

COG function: function code G; 6-phosphofructokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphofructokinase family [H]

Homologues:

Organism=Homo sapiens, GI11321601, Length=272, Percent_Identity=28.6764705882353, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI266453619, Length=254, Percent_Identity=28.3464566929134, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI266453768, Length=254, Percent_Identity=28.3464566929134, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI266453748, Length=254, Percent_Identity=28.3464566929134, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4505749, Length=254, Percent_Identity=28.3464566929134, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI48762920, Length=258, Percent_Identity=28.6821705426357, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790350, Length=355, Percent_Identity=27.3239436619718, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17558788, Length=348, Percent_Identity=28.1609195402299, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25147584, Length=255, Percent_Identity=29.8039215686275, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321679, Length=270, Percent_Identity=28.8888888888889, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323861, Length=256, Percent_Identity=28.515625, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28573326, Length=254, Percent_Identity=30.7086614173228, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17647809, Length=254, Percent_Identity=31.1023622047244, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24652337, Length=254, Percent_Identity=31.1023622047244, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: 3981 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 950 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012003
- InterPro:   IPR012829
- InterPro:   IPR022953
- InterPro:   IPR015912
- InterPro:   IPR000023 [H]

Pfam domain/function: PF00365 PFK [H]

EC number: =2.7.1.90 [H]

Molecular weight: Translated: 48230; Mature: 48230

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEPLTVDGAELDVRKLGPCRIDSPLLPLLGARPTTQHYIDEGDKVLFDDTVSMISARKV
CCCCCCCCCCCCCHHHCCCCCCCCCCHHHHCCCCCHHHHHCCCCEEEEHHHHHHHHHCCC
PLDELPGFEPAGPRRKIYFDPSKTRVGIVTCGGLCPGLNNVIRGLVLELTNHYGVNRIFG
CHHHCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHH
FRHGYQGFIAKYGHSVVDLTPERVANIDEDGGTILGTSRGQQDPAEIVDCLSRMNINILF
CCCCHHHHHHHHCCCEEECCHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCEEEE
VIGGDGTLRGARAIAGIVAERGEKIAVVGIPKTIDNDIPYIDQSFGFQTAFAKAAESIRA
EECCCCCCCHHHHHHHHHHHCCCEEEEEECCHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
AYAEATSAPGGVGIVRLMGRHSGFIACYAVLAKSDADVVLIPELPFTLEGERGLLAYIRQ
HHHHHCCCCCCHHHHEECCCCCCHHHHHHHHHCCCCCEEEECCCCCEECCCCCHHHHHHH
RVEKRGHAVVVVAEGAGQDLVAGLPESSDASGNRKLYDIGPELSRRITEDFAARGAELNL
HHHHCCCEEEEEECCCCCHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCEEEE
KYIDPSYHIRSVAANPYDNVYTIRLAHAAVHAAMSGRTEMVVGRWRRRFIHIPIALAVSQ
EEECCCCEEEEEECCCCCCEEEEEEHHHHHHHHHCCCHHHHHHHHHHEEEEEEEEEEECC
RNQVDPAGDLWMSVLEATGQPYRFG
CCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDEPLTVDGAELDVRKLGPCRIDSPLLPLLGARPTTQHYIDEGDKVLFDDTVSMISARKV
CCCCCCCCCCCCCHHHCCCCCCCCCCHHHHCCCCCHHHHHCCCCEEEEHHHHHHHHHCCC
PLDELPGFEPAGPRRKIYFDPSKTRVGIVTCGGLCPGLNNVIRGLVLELTNHYGVNRIFG
CHHHCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHH
FRHGYQGFIAKYGHSVVDLTPERVANIDEDGGTILGTSRGQQDPAEIVDCLSRMNINILF
CCCCHHHHHHHHCCCEEECCHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCEEEE
VIGGDGTLRGARAIAGIVAERGEKIAVVGIPKTIDNDIPYIDQSFGFQTAFAKAAESIRA
EECCCCCCCHHHHHHHHHHHCCCEEEEEECCHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
AYAEATSAPGGVGIVRLMGRHSGFIACYAVLAKSDADVVLIPELPFTLEGERGLLAYIRQ
HHHHHCCCCCCHHHHEECCCCCCHHHHHHHHHCCCCCEEEECCCCCEECCCCCHHHHHHH
RVEKRGHAVVVVAEGAGQDLVAGLPESSDASGNRKLYDIGPELSRRITEDFAARGAELNL
HHHHCCCEEEEEECCCCCHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCEEEE
KYIDPSYHIRSVAANPYDNVYTIRLAHAAVHAAMSGRTEMVVGRWRRRFIHIPIALAVSQ
EEECCCCEEEEEECCCCCCEEEEEEHHHHHHHHHCCCHHHHHHHHHHEEEEEEEEEEECC
RNQVDPAGDLWMSVLEATGQPYRFG
CCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10913106 [H]