Click here to switch to the map view.

The map label for this gene is trpA [H]

Identifier: 158313768

GI number: 158313768

Start: 2316180

End: 2317100

Strand: Direct

Name: trpA [H]

Synonym: Franean1_1933

Alternate gene names: 158313768

Gene position: 2316180-2317100 (Clockwise)

Preceding gene: 158313767

Following gene: 158313769

Centisome position: 25.79

GC content: 77.74

Gene sequence:

>921_bases
GTGGCGCACGACCAGTCGGCCCAGCAGGCATGGGCCCAGGAGCAGCCGGCGCGCGACCAGCCGGCGCCGAGCCGGCTCGA
GCCGTCCGGGCAGCGGCCGGCCCGGCGCGGCGGGCCGAGCCCGCTGGACGAGGCCTTCGCGGCCGCGCGCAAGGACGGGC
GGGCGGTGCTCGTCGGCTATCTCCCCGCCGGGTTCCCGACGGTGGACCGCGGCATCGCGGCGATGCGGGCGATGGTCGCG
GCGGGCGTGGACGTCGTCGAGGTCGGCCTGCCCTACTCGGATCCGACGATGGACGGCCCGGTCATCCAGGACGCCGCGGA
CACCGCGCTGCGCGGCGGCGTGACCACCAGGGACGTGCTGCGCACGGTCGAGGCGGTCGCCGAGACCGGGGCCCCCACCC
TGGTGATGACCTACTGGAACCCGGTGGAGCGGTACGGCATGGAGGCGTTCGCCGCCGACCTGGCCGCCGCCGGCGGGGCC
GGGGCGATCACCCCCGACCTGCCGCCGGAGGAGGCCGGCCCGTGGCTCGCGGCCAGCGCCACCCACGGCCTCGACCCGGT
CTTCCTGGTCGCGCCGAGCTCGACCACCGAACGGCTGCGCCTGGTGACGGCGCACAGCGGCGGCTTCGTCTACGCGGCGT
CGACCATGGGCGTCACCGGTGCGCGCGCCGCCGTCGGTGTGAAGGCGGCCGGCCTGGTCGCCCGGGTCCGGGAGGTGACC
GACCTGCCTGTGGCGGTTGGCCTCGGCGTCAGCACCGGTGCTCAGGCGTCCGAGGTGGCCGGCTTCGCCGACGGCGTCAT
CGTGGGCTCGGCGCTGGTCCGGGCCCTGGCGGCCGACGCGCGGGACGGCGCCGACGGCGTCGGTGCGATCGAGCGGCTGG
CGGCTGAGCTCGCCGCCGGCGTGCGTTCGGCCACCGCCTGA

Upstream 100 bases:

>100_bases
ACGACACGGACGCCGAGTCTCGGGGCGAGGGCGCAGCCCCGGCCACCGAACCGTCCGCCTGACGACAACGACGAGGAACG
GACGCACGGTGCGGAGTCAA

Downstream 100 bases:

>100_bases
CCAAGGCGGCCTCCGGTCGTCCCGCGCTCGCCGCGGCCTGCGGGCTGCCGCCGTCCGCAGGCGTTCGCCGCTGTCCGCTG
CCATCCGGCGGCGTGGCGGG

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MAHDQSAQQAWAQEQPARDQPAPSRLEPSGQRPARRGGPSPLDEAFAAARKDGRAVLVGYLPAGFPTVDRGIAAMRAMVA
AGVDVVEVGLPYSDPTMDGPVIQDAADTALRGGVTTRDVLRTVEAVAETGAPTLVMTYWNPVERYGMEAFAADLAAAGGA
GAITPDLPPEEAGPWLAASATHGLDPVFLVAPSSTTERLRLVTAHSGGFVYAASTMGVTGARAAVGVKAAGLVARVREVT
DLPVAVGLGVSTGAQASEVAGFADGVIVGSALVRALAADARDGADGVGAIERLAAELAAGVRSATA

Sequences:

>Translated_306_residues
MAHDQSAQQAWAQEQPARDQPAPSRLEPSGQRPARRGGPSPLDEAFAAARKDGRAVLVGYLPAGFPTVDRGIAAMRAMVA
AGVDVVEVGLPYSDPTMDGPVIQDAADTALRGGVTTRDVLRTVEAVAETGAPTLVMTYWNPVERYGMEAFAADLAAAGGA
GAITPDLPPEEAGPWLAASATHGLDPVFLVAPSSTTERLRLVTAHSGGFVYAASTMGVTGARAAVGVKAAGLVARVREVT
DLPVAVGLGVSTGAQASEVAGFADGVIVGSALVRALAADARDGADGVGAIERLAAELAAGVRSATA
>Mature_305_residues
AHDQSAQQAWAQEQPARDQPAPSRLEPSGQRPARRGGPSPLDEAFAAARKDGRAVLVGYLPAGFPTVDRGIAAMRAMVAA
GVDVVEVGLPYSDPTMDGPVIQDAADTALRGGVTTRDVLRTVEAVAETGAPTLVMTYWNPVERYGMEAFAADLAAAGGAG
AITPDLPPEEAGPWLAASATHGLDPVFLVAPSSTTERLRLVTAHSGGFVYAASTMGVTGARAAVGVKAAGLVARVREVTD
LPVAVGLGVSTGAQASEVAGFADGVIVGSALVRALAADARDGADGVGAIERLAAELAAGVRSATA

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=265, Percent_Identity=26.7924528301887, Blast_Score=115, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321412, Length=245, Percent_Identity=42.4489795918367, Blast_Score=186, Evalue=3e-48,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 30840; Mature: 30709

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHDQSAQQAWAQEQPARDQPAPSRLEPSGQRPARRGGPSPLDEAFAAARKDGRAVLVGY
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEE
LPAGFPTVDRGIAAMRAMVAAGVDVVEVGLPYSDPTMDGPVIQDAADTALRGGVTTRDVL
CCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHH
RTVEAVAETGAPTLVMTYWNPVERYGMEAFAADLAAAGGAGAITPDLPPEEAGPWLAASA
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECC
THGLDPVFLVAPSSTTERLRLVTAHSGGFVYAASTMGVTGARAAVGVKAAGLVARVREVT
CCCCCEEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
DLPVAVGLGVSTGAQASEVAGFADGVIVGSALVRALAADARDGADGVGAIERLAAELAAG
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
VRSATA
HHHCCC
>Mature Secondary Structure 
AHDQSAQQAWAQEQPARDQPAPSRLEPSGQRPARRGGPSPLDEAFAAARKDGRAVLVGY
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEE
LPAGFPTVDRGIAAMRAMVAAGVDVVEVGLPYSDPTMDGPVIQDAADTALRGGVTTRDVL
CCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHH
RTVEAVAETGAPTLVMTYWNPVERYGMEAFAADLAAAGGAGAITPDLPPEEAGPWLAASA
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECC
THGLDPVFLVAPSSTTERLRLVTAHSGGFVYAASTMGVTGARAAVGVKAAGLVARVREVT
CCCCCEEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
DLPVAVGLGVSTGAQASEVAGFADGVIVGSALVRALAADARDGADGVGAIERLAAELAAG
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
VRSATA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]