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The map label for this gene is hisI [H]

Identifier: 158313762

GI number: 158313762

Start: 2309891

End: 2310400

Strand: Direct

Name: hisI [H]

Synonym: Franean1_1927

Alternate gene names: 158313762

Gene position: 2309891-2310400 (Clockwise)

Preceding gene: 158313761

Following gene: 158313763

Centisome position: 25.72

GC content: 73.33

Gene sequence:

>510_bases
GTGGTGACCTGGAGGCCTGCTGGCCGCGGGGGGCAGAATGGGCGGGTGACCGCACGTGCCTCCGATCTCGACCCCGCCAT
TGCCCGGCAGCTCAAGCGGGACGGCTCCGGACTGTTCCCGGCCGTCGCCCAGCAGTACGACTCGGGTGAGGTGCTCATGG
TCGGATGGATGGACGACGAGGCGTTGCACCGGACCCTCACCACCGGCCGGGCCACCTACTGGAGCCGCAGCCGGGCCGAG
TACTGGGTCAAGGGCGACACCAGCGGGCACGTGCAGTGGGTGCGGTCGGTCGCCCTCGACTGCGACGGCGACACCGTGCT
GGTCCAGGTGGACCAGGTGGGCCCGGCCTGCCACACCGGCACGCGTACCTGCTTCACCGCCCGCGAGCTGCAGGTCGGCG
GCGCCCGGCCCCTGCAGCCCCCGGCCGTGAACCCCACGCCGACGCCGACCTCCACGCCCATGTCCATGCCGGCAGCGGCG
CCGGCGCCGACGACGGGAGCACCACGATGA

Upstream 100 bases:

>100_bases
GTCTACCGGCGGCTGCACGAATCCTGGGCGGCCGGGGTCTCGTCGCACTGACCGCCACCCGGAGGGGTGACCCCGGTCGG
CGGGTCCCGGCCCGCCTGCC

Downstream 100 bases:

>100_bases
CCACCGGCGAGATCACACCGAGCCGGGCGGAGTTCCACGAGCTCGCCGCGCGCCAGCCGGTCGTCGCGGTGTCCCGCCGC
CTGCTCGCCGACGGCGAGAC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MVTWRPAGRGGQNGRVTARASDLDPAIARQLKRDGSGLFPAVAQQYDSGEVLMVGWMDDEALHRTLTTGRATYWSRSRAE
YWVKGDTSGHVQWVRSVALDCDGDTVLVQVDQVGPACHTGTRTCFTARELQVGGARPLQPPAVNPTPTPTSTPMSMPAAA
PAPTTGAPR

Sequences:

>Translated_169_residues
MVTWRPAGRGGQNGRVTARASDLDPAIARQLKRDGSGLFPAVAQQYDSGEVLMVGWMDDEALHRTLTTGRATYWSRSRAE
YWVKGDTSGHVQWVRSVALDCDGDTVLVQVDQVGPACHTGTRTCFTARELQVGGARPLQPPAVNPTPTPTSTPMSMPAAA
PAPTTGAPR
>Mature_169_residues
MVTWRPAGRGGQNGRVTARASDLDPAIARQLKRDGSGLFPAVAQQYDSGEVLMVGWMDDEALHRTLTTGRATYWSRSRAE
YWVKGDTSGHVQWVRSVALDCDGDTVLVQVDQVGPACHTGTRTCFTARELQVGGARPLQPPAVNPTPTPTSTPMSMPAAA
PAPTTGAPR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=89, Percent_Identity=50.561797752809, Blast_Score=103, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 18056; Mature: 18056

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTWRPAGRGGQNGRVTARASDLDPAIARQLKRDGSGLFPAVAQQYDSGEVLMVGWMDDE
CCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEECCCH
ALHRTLTTGRATYWSRSRAEYWVKGDTSGHVQWVRSVALDCDGDTVLVQVDQVGPACHTG
HHHHHHHCCCCEECCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
TRTCFTARELQVGGARPLQPPAVNPTPTPTSTPMSMPAAAPAPTTGAPR
CCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVTWRPAGRGGQNGRVTARASDLDPAIARQLKRDGSGLFPAVAQQYDSGEVLMVGWMDDE
CCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEECCCH
ALHRTLTTGRATYWSRSRAEYWVKGDTSGHVQWVRSVALDCDGDTVLVQVDQVGPACHTG
HHHHHHHCCCCEECCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
TRTCFTARELQVGGARPLQPPAVNPTPTPTSTPMSMPAAAPAPTTGAPR
CCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA