Click here to switch to the map view.

The map label for this gene is argH [H]

Identifier: 158313580

GI number: 158313580

Start: 2083956

End: 2085491

Strand: Direct

Name: argH [H]

Synonym: Franean1_1744

Alternate gene names: 158313580

Gene position: 2083956-2085491 (Clockwise)

Preceding gene: 158313579

Following gene: 158313581

Centisome position: 23.2

GC content: 74.74

Gene sequence:

>1536_bases
ATGGATCCCGAACGGGCACAGGGCGACGTCGCGCGCACGGACGCGGCGCGCACGGACACCGCCGACGACACCGACGGAGA
GGACACCGGGGGGCACGCCGGCGCGGGTGGGCAGGCGGACGCCCCCGCGTCGACGCCGCCGCTGCGGCTGTGGGGCGGGC
GGTTCGCGGGCGGGCCGGCCGAGGCGCTGGCGCGGCTGTCGGTCAGCGTGCAGTTCGACTGGCGCCTGGCGCCGTACGAC
CTGCTCGCCTCCCGCTCACACGCCCGCGTCCTGCACCGCGCCGGCCTGCTGGACGACGCCGAGCTGACGGCGATGCTCGG
CGCACTCGACGACCTGTCGGACGCGGTCGCCCACGGCCGCTTCCGCCCGACCATCGAGGACGAGGACGTCCACACCGCGC
TCGAGCGGGGGCTGCTCGAGCGCCTCGGCGCGCTCGGGGGCAAGCTCCGGGCCGGCCGGAGCCGCAACGACCAGGTCGCG
ACCGACCTGCGCCTGTACCTGCGCGATCACGCGCGTCAGGTCGCCGCGCGGGTCACCGAGCTCTCCACCGCCCTCGTCGG
GCTGGCCGAGCAGCACGTCGAGACCCCGGCACCGGGGATGACCCACCTGCAGCACGCCCAGCCGATCTCGTTCGGGCACC
AGCTGCTGGCGCACGTCCACGCGTTCGCCCGGGACACCGACCGGCTGCGGGACTGGGACCGGCGTGCCTCGGTGAGCGCG
CTCGGCGCCGGCGCGCTCGCCGGCTCCTCACTGCCGCTGGACCCGGCGGGGGTGGCCGCCGAGCTCGGCTTCGACCGGGC
CTTCGCCAACTCGCTCGACGCGGTGTCCGACCGGGACTTCGCCGCCGAGTTCCTCTTCATCGCCGCGCTGATCGGGGTGC
ACCTGTCCCGGCTCGGTGAGGAGATCGTCCTGTGGACGACCCGGGAGTTCGGCTGGGTCGAGCTTGACGACGCCTTCGCC
ACCGGCAGCTCGATCATGCCGCAGAAGAAGAATCCGGACGTGGCCGAGCTGGCCCGCGGCAAGTCGGGCCGGCTCATCGG
CGCGCTCACCGGGCTGCTGACCACCCTCAAGGGCCTGCCGCTCGCCTACGACCGCGACCTGCAGGAGGACAAGGAGCCGG
TGTTCGACGCGGTCGACACCCTCCTCGTTGTGCTGCCGGCGGTGACCGGCATGGTCGCGACGATGCGGGTGCGCCGGGAA
CGGCTCGCGGCCGCCGCGCCGGACGGGTTCGCGCTGGCGACGGACGTGGCGGAGTACCTCGTCCGCAACGGGGTCGCCTT
CCGGGAGGCACACGAGGCCGTCGGGCAGCTCGTGGCCTGGTGTGTGGCCCACGACGCCGACATGGACGAGGTCTCCGAGG
ACGATCTCGCGGTCATCAGCCCACTGCTCACCGCCGACGTCCGATCGGTGCTCTCGGTGCGTGGTGCGCTCGAGGCACGC
TCGGCACCGGGCGGGACGGCTCCCGCGCGCGTCCGGGAGCAGATCGAGGCGCTCGGGCCGGTGCTCGACCGGGACCGGGC
GTGGGCCGGGAGCTGA

Upstream 100 bases:

>100_bases
CCAAGGTCTGGGCGGCCCGCGAACAGCGGCTCAACCCGTGACGTCGATCCGGTCGGTGGCGACTGGGAGTCACCCAGCGG
CCGACGAGGAGCAGGAACGG

Downstream 100 bases:

>100_bases
CCGGCGTTCCGAGTCGCGACTTCTACGACCGGCCCGTGCTGGCCGTCGCCCGAGATCTCCTCGGGACGACGGTCCGGCAC
GGGCCGGTCGCGTTGCGGGT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MDPERAQGDVARTDAARTDTADDTDGEDTGGHAGAGGQADAPASTPPLRLWGGRFAGGPAEALARLSVSVQFDWRLAPYD
LLASRSHARVLHRAGLLDDAELTAMLGALDDLSDAVAHGRFRPTIEDEDVHTALERGLLERLGALGGKLRAGRSRNDQVA
TDLRLYLRDHARQVAARVTELSTALVGLAEQHVETPAPGMTHLQHAQPISFGHQLLAHVHAFARDTDRLRDWDRRASVSA
LGAGALAGSSLPLDPAGVAAELGFDRAFANSLDAVSDRDFAAEFLFIAALIGVHLSRLGEEIVLWTTREFGWVELDDAFA
TGSSIMPQKKNPDVAELARGKSGRLIGALTGLLTTLKGLPLAYDRDLQEDKEPVFDAVDTLLVVLPAVTGMVATMRVRRE
RLAAAAPDGFALATDVAEYLVRNGVAFREAHEAVGQLVAWCVAHDADMDEVSEDDLAVISPLLTADVRSVLSVRGALEAR
SAPGGTAPARVREQIEALGPVLDRDRAWAGS

Sequences:

>Translated_511_residues
MDPERAQGDVARTDAARTDTADDTDGEDTGGHAGAGGQADAPASTPPLRLWGGRFAGGPAEALARLSVSVQFDWRLAPYD
LLASRSHARVLHRAGLLDDAELTAMLGALDDLSDAVAHGRFRPTIEDEDVHTALERGLLERLGALGGKLRAGRSRNDQVA
TDLRLYLRDHARQVAARVTELSTALVGLAEQHVETPAPGMTHLQHAQPISFGHQLLAHVHAFARDTDRLRDWDRRASVSA
LGAGALAGSSLPLDPAGVAAELGFDRAFANSLDAVSDRDFAAEFLFIAALIGVHLSRLGEEIVLWTTREFGWVELDDAFA
TGSSIMPQKKNPDVAELARGKSGRLIGALTGLLTTLKGLPLAYDRDLQEDKEPVFDAVDTLLVVLPAVTGMVATMRVRRE
RLAAAAPDGFALATDVAEYLVRNGVAFREAHEAVGQLVAWCVAHDADMDEVSEDDLAVISPLLTADVRSVLSVRGALEAR
SAPGGTAPARVREQIEALGPVLDRDRAWAGS
>Mature_511_residues
MDPERAQGDVARTDAARTDTADDTDGEDTGGHAGAGGQADAPASTPPLRLWGGRFAGGPAEALARLSVSVQFDWRLAPYD
LLASRSHARVLHRAGLLDDAELTAMLGALDDLSDAVAHGRFRPTIEDEDVHTALERGLLERLGALGGKLRAGRSRNDQVA
TDLRLYLRDHARQVAARVTELSTALVGLAEQHVETPAPGMTHLQHAQPISFGHQLLAHVHAFARDTDRLRDWDRRASVSA
LGAGALAGSSLPLDPAGVAAELGFDRAFANSLDAVSDRDFAAEFLFIAALIGVHLSRLGEEIVLWTTREFGWVELDDAFA
TGSSIMPQKKNPDVAELARGKSGRLIGALTGLLTTLKGLPLAYDRDLQEDKEPVFDAVDTLLVVLPAVTGMVATMRVRRE
RLAAAAPDGFALATDVAEYLVRNGVAFREAHEAVGQLVAWCVAHDADMDEVSEDDLAVISPLLTADVRSVLSVRGALEAR
SAPGGTAPARVREQIEALGPVLDRDRAWAGS

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=460, Percent_Identity=45, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI68303542, Length=460, Percent_Identity=45, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI68303549, Length=460, Percent_Identity=42.8260869565217, Blast_Score=358, Evalue=8e-99,
Organism=Homo sapiens, GI68303547, Length=460, Percent_Identity=42.1739130434783, Blast_Score=350, Evalue=2e-96,
Organism=Escherichia coli, GI1790398, Length=448, Percent_Identity=43.9732142857143, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6321806, Length=462, Percent_Identity=40.2597402597403, Blast_Score=328, Evalue=1e-90,
Organism=Drosophila melanogaster, GI221473854, Length=450, Percent_Identity=42, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI78706858, Length=450, Percent_Identity=42, Blast_Score=355, Evalue=4e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 54427; Mature: 54427

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPERAQGDVARTDAARTDTADDTDGEDTGGHAGAGGQADAPASTPPLRLWGGRFAGGPA
CCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHH
EALARLSVSVQFDWRLAPYDLLASRSHARVLHRAGLLDDAELTAMLGALDDLSDAVAHGR
HHHHHHHEEEEEECEECHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
FRPTIEDEDVHTALERGLLERLGALGGKLRAGRSRNDQVATDLRLYLRDHARQVAARVTE
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSTALVGLAEQHVETPAPGMTHLQHAQPISFGHQLLAHVHAFARDTDRLRDWDRRASVSA
HHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGAGALAGSSLPLDPAGVAAELGFDRAFANSLDAVSDRDFAAEFLFIAALIGVHLSRLGE
HCCHHHCCCCCCCCCCCHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
EIVLWTTREFGWVELDDAFATGSSIMPQKKNPDVAELARGKSGRLIGALTGLLTTLKGLP
EEEEEEECCCCCEEECHHHHCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCC
LAYDRDLQEDKEPVFDAVDTLLVVLPAVTGMVATMRVRRERLAAAAPDGFALATDVAEYL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VRNGVAFREAHEAVGQLVAWCVAHDADMDEVSEDDLAVISPLLTADVRSVLSVRGALEAR
HHCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
SAPGGTAPARVREQIEALGPVLDRDRAWAGS
CCCCCCCHHHHHHHHHHHCCHHHCCCCCCCC
>Mature Secondary Structure
MDPERAQGDVARTDAARTDTADDTDGEDTGGHAGAGGQADAPASTPPLRLWGGRFAGGPA
CCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHH
EALARLSVSVQFDWRLAPYDLLASRSHARVLHRAGLLDDAELTAMLGALDDLSDAVAHGR
HHHHHHHEEEEEECEECHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
FRPTIEDEDVHTALERGLLERLGALGGKLRAGRSRNDQVATDLRLYLRDHARQVAARVTE
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSTALVGLAEQHVETPAPGMTHLQHAQPISFGHQLLAHVHAFARDTDRLRDWDRRASVSA
HHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGAGALAGSSLPLDPAGVAAELGFDRAFANSLDAVSDRDFAAEFLFIAALIGVHLSRLGE
HCCHHHCCCCCCCCCCCHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
EIVLWTTREFGWVELDDAFATGSSIMPQKKNPDVAELARGKSGRLIGALTGLLTTLKGLP
EEEEEEECCCCCEEECHHHHCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCC
LAYDRDLQEDKEPVFDAVDTLLVVLPAVTGMVATMRVRRERLAAAAPDGFALATDVAEYL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VRNGVAFREAHEAVGQLVAWCVAHDADMDEVSEDDLAVISPLLTADVRSVLSVRGALEAR
HHCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
SAPGGTAPARVREQIEALGPVLDRDRAWAGS
CCCCCCCHHHHHHHHHHHCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA