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The map label for this gene is fmt

Identifier: 158313555

GI number: 158313555

Start: 2055536

End: 2056471

Strand: Direct

Name: fmt

Synonym: Franean1_1719

Alternate gene names: 158313555

Gene position: 2055536-2056471 (Clockwise)

Preceding gene: 158313554

Following gene: 158313556

Centisome position: 22.88

GC content: 76.6

Gene sequence:

>936_bases
ATGCGTCTTGTCTTCGCCGGCACGCCGGCGGTCGCGCTGCCCAGCCTGCGCGCGCTGCTCGACAGTCCCCGCCACCAGGT
GGTCGCGGTGGTGACCCGTCCCGACCGGCCCGCCGGCCGGGGCCGGCACCAGCGGTCCTCGCCGGTGCGGGAGCTGGCGG
ACGAGCGTGGTCTTGAGGTGCTAGCCCCGGCCCGCGCCAGCGACCCCGACTTCCTCGCCCGGCTCGGTGAGATCGCCCCC
GACTGCTGCCCGGTGGTCGCCTACGGCGCGCTGCTGCCCCGGCCGGCCCTGGACATCCCGAAGCACGGCTGGGTCAACCT
GCACTTCTCGCTGCTGCCGGCCTACCGGGGCGCGGCGCCCGTGCAGCGTGCCGTCCTCGCCGGGGAGGACATGACCGGCG
CCAGCGTGTTCGAGATCGAGCCCGCCCTGGACTCCGGCCCGGTCTACGGGGTCCTCACCGAGCGGATCCGTCCCACGGAC
ACGTCCGGAGATCTCCTCGACCGCCTCGCCGTCGCCGGCGCGCGGCTGCTGGAGGCCGTCATGGACGGCATCGAGGACGG
CACTCTGCAGGCCCGCCCGCAGCCGTCCGACGGTGTCTCGCTGGCCCCGAAGCTCACCGTCGAGGACGTCCGCGTCGACT
GGTCGGCCCCGGCCGCCGCGGTTGACCGGCTGGTGCGGGCCGCCACCCCGGCGCCGGGCGCCTGGACGACCTTCCGTGAC
CGGCGCGTCAAGCTCGGTCCCGTGCGGCCGGCGCCCGCGGGCCACCCGCCGCTGCCCTCCGGGCGGCTCGCGGCGCCCGA
GCGCGGGCTCGTACTGGTGGGGACGGCGACCACGCCGGTGGTCCTTGACGAGGTCCGTCCCGAGGGAAAGGCGCCGATGC
CGGCGGCCGACTGGATCCGCGGCCTGCGGCCCGGCACGGACGAGGCGTTCGCGTGA

Upstream 100 bases:

>100_bases
ATCGGGTCCGCCGCCGGGTCGATGATCGTGATGATAGCCGGGACGATCGGATCCGCGGCCGGGGATCCGGCCCGGGATCG
GCGCTGAGGGAGCTGTGGTC

Downstream 100 bases:

>100_bases
GCGTCTCCGCGCCCCGCCGGGGCGGCACGACAGACCCGGCGCGCCTGCTCGCCTGGGAGGTGCTGCGCGCTGTCGACGAG
CGCGGCGCCTACGCCAACCT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MRLVFAGTPAVALPSLRALLDSPRHQVVAVVTRPDRPAGRGRHQRSSPVRELADERGLEVLAPARASDPDFLARLGEIAP
DCCPVVAYGALLPRPALDIPKHGWVNLHFSLLPAYRGAAPVQRAVLAGEDMTGASVFEIEPALDSGPVYGVLTERIRPTD
TSGDLLDRLAVAGARLLEAVMDGIEDGTLQARPQPSDGVSLAPKLTVEDVRVDWSAPAAAVDRLVRAATPAPGAWTTFRD
RRVKLGPVRPAPAGHPPLPSGRLAAPERGLVLVGTATTPVVLDEVRPEGKAPMPAADWIRGLRPGTDEAFA

Sequences:

>Translated_311_residues
MRLVFAGTPAVALPSLRALLDSPRHQVVAVVTRPDRPAGRGRHQRSSPVRELADERGLEVLAPARASDPDFLARLGEIAP
DCCPVVAYGALLPRPALDIPKHGWVNLHFSLLPAYRGAAPVQRAVLAGEDMTGASVFEIEPALDSGPVYGVLTERIRPTD
TSGDLLDRLAVAGARLLEAVMDGIEDGTLQARPQPSDGVSLAPKLTVEDVRVDWSAPAAAVDRLVRAATPAPGAWTTFRD
RRVKLGPVRPAPAGHPPLPSGRLAAPERGLVLVGTATTPVVLDEVRPEGKAPMPAADWIRGLRPGTDEAFA
>Mature_311_residues
MRLVFAGTPAVALPSLRALLDSPRHQVVAVVTRPDRPAGRGRHQRSSPVRELADERGLEVLAPARASDPDFLARLGEIAP
DCCPVVAYGALLPRPALDIPKHGWVNLHFSLLPAYRGAAPVQRAVLAGEDMTGASVFEIEPALDSGPVYGVLTERIRPTD
TSGDLLDRLAVAGARLLEAVMDGIEDGTLQARPQPSDGVSLAPKLTVEDVRVDWSAPAAAVDRLVRAATPAPGAWTTFRD
RRVKLGPVRPAPAGHPPLPSGRLAAPERGLVLVGTATTPVVLDEVRPEGKAPMPAADWIRGLRPGTDEAFA

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=296, Percent_Identity=23.3108108108108, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI238814322, Length=292, Percent_Identity=25.6849315068493, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI164663775, Length=234, Percent_Identity=29.9145299145299, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1789683, Length=303, Percent_Identity=38.2838283828383, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1788589, Length=253, Percent_Identity=28.4584980237154, Blast_Score=104, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI133930964, Length=329, Percent_Identity=24.9240121580547, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45550868, Length=311, Percent_Identity=29.2604501607717, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI28571984, Length=235, Percent_Identity=31.063829787234, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24585660, Length=322, Percent_Identity=22.6708074534161, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_FRASN (A8LE22)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001506063.1
- ProteinModelPortal:   A8LE22
- SMR:   A8LE22
- GeneID:   5670121
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_1719
- HOGENOM:   HBG571560
- OMA:   VVAYGAI
- ProtClustDB:   PRK00005
- BioCyc:   FSP1855:FRANEAN1_1719-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 32897; Mature: 32897

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVFAGTPAVALPSLRALLDSPRHQVVAVVTRPDRPAGRGRHQRSSPVRELADERGLEV
CEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCEE
LAPARASDPDFLARLGEIAPDCCPVVAYGALLPRPALDIPKHGWVNLHFSLLPAYRGAAP
EECCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCHH
VQRAVLAGEDMTGASVFEIEPALDSGPVYGVLTERIRPTDTSGDLLDRLAVAGARLLEAV
HHHHHHCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
MDGIEDGTLQARPQPSDGVSLAPKLTVEDVRVDWSAPAAAVDRLVRAATPAPGAWTTFRD
HHCCCCCCEECCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCC
RRVKLGPVRPAPAGHPPLPSGRLAAPERGLVLVGTATTPVVLDEVRPEGKAPMPAADWIR
CEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCCHHHHHH
GLRPGTDEAFA
CCCCCCCCCCC
>Mature Secondary Structure
MRLVFAGTPAVALPSLRALLDSPRHQVVAVVTRPDRPAGRGRHQRSSPVRELADERGLEV
CEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCEE
LAPARASDPDFLARLGEIAPDCCPVVAYGALLPRPALDIPKHGWVNLHFSLLPAYRGAAP
EECCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCHH
VQRAVLAGEDMTGASVFEIEPALDSGPVYGVLTERIRPTDTSGDLLDRLAVAGARLLEAV
HHHHHHCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
MDGIEDGTLQARPQPSDGVSLAPKLTVEDVRVDWSAPAAAVDRLVRAATPAPGAWTTFRD
HHCCCCCCEECCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCC
RRVKLGPVRPAPAGHPPLPSGRLAAPERGLVLVGTATTPVVLDEVRPEGKAPMPAADWIR
CEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCCHHHHHH
GLRPGTDEAFA
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA