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The map label for this gene is serA [H]

Identifier: 158312947

GI number: 158312947

Start: 1304976

End: 1306565

Strand: Direct

Name: serA [H]

Synonym: Franean1_1093

Alternate gene names: 158312947

Gene position: 1304976-1306565 (Clockwise)

Preceding gene: 158312946

Following gene: 158312948

Centisome position: 14.53

GC content: 71.95

Gene sequence:

>1590_bases
GTGCCCGTCGTACTCGTCGCCGAGGAACTCTCACCGGCCGGGCTGGAGGTCCTGTCCGGGGACTTCGAGATCCGCCATGT
GGACGGGGCCGACCGGTCCGCCCTGCTGCCGGCGCTGGCGGACGTCGACGCGGTCCTCATCCGCTCGGCGACGAAGATCG
ACGCCGAGGCGCTCGCGGCCGCCCCGCGGCTGAAGGTCGTGGCCCGCGCCGGGATCGGGCTCGACAACGTCGACGTCCCC
GCCGCCACCAACCGCGGCGTCATGGTGGTGAACGCGCCGCAGTCGAACATCGTCAGTGCCGCCGAGCACGCCATCGCACT
GCTGCTCGCGGTCGCCCGCCGGGTCCCGGCCGCCCATGAGTCGCTCGTCGGCGGTGAGTGGAAGCGCTCGAAGTACGTCG
GCGTGGAGCTGACGGAGAAGACCGCGGGCGTCGTCGGCCTCGGCCGCATCGGTGTCCTGGTCGCGCAGCGGCTGGCGGCC
TTCGGCATGAAGGTCCTGGCCTACGACCCCTATGTCTCCGTCGCCCGCGCCTCGCAGCTCGGTGTGCGCCTGGTGGACCT
CGACGAGCTGCTCACGTCCAGCGACGTCATCACGATCCACCTGCCGAAGACACCCGAGACGCTGGGGCTCATCGGGGCCG
ACGAGCTGGCCCGGGTGAAGCCGGGCGTGATCATCGTCAACGCGGCGCGCGGCGGCCTGGTCGACGAGGGCGCCCTGGCC
GACGCGGTCCGGTCCGGCCGGGTCGGCGGTGTCGGGCTCGACGTGTACGTCAAGGAGCCGACCACCTCCTCGCCGCTGTT
CGGGCTGGAGAACGTCGTCGTCACCCCGCACCTGGGCGCCTCGACGCAGGAGGCGCAGGACAAGGCCGGTCTGGCCGTGG
CCCGTTCGGTGCGCCTCGCGCTCAGCGGCGAGTTCGTCCCGGACGCGGTGAACGTGCAGGCCGGCGGGGTCGTGGCCGAG
GACGTGCGGCCCGGTCTGCCGCTGGCGGAGAAGCTGGGCCAGCTCTTCTCCGGGCTGGCCGCGGGCGTGGCCGCCGCGAT
CACCGTCGAGGTGCGCGGCGAGATCGCCGCGCACGACGTGTCGGTGCTGCAGCTCGCCGTCCTCAAGGGTGTCTTCATCG
ACATCGTCGAGGAGCAGGTCACCTACGTGAACGCGCCGCTGATCGCCAAGGAGCGCGGCGTCGACGTGGCGCTGGAGACC
TCCGAGGAGAGCCCCGACTACCGCAACCTCGTCACGGTGCGCGGTGTCCTGCCCGACGGGACGGCGGTGTCGGTCAGCGG
GACGCTCGTCGGCTCCCGCCAGGTCGAGAAGATCACCGCGATCGACGGGTTCGAGGTCGACCTGCGTCCCGAGGACCACC
TGGCGTTCTTCCGTTACGAGGATCGTCCCGGCATCGTCGGGGCCGTCGGCGCGCTGCTGGGCGAGGCCCACATCAACATC
GCCAACGCTCAGGTCAGCCGGCTCAGCGCCGGTGGCGAGGCCCTCATGTCGCTGTCCCTGGACGACGCGGTGGCGCCCGA
CATCCTGGCCGAGATCGCCAAGATCATCGGTGCGTCGTACGCCCGCGCGGTGAGCATCTCCGCGGGCTGA

Upstream 100 bases:

>100_bases
ATTCGACATCGTCGTCGTCCGCCCGGGCCGCGGCGCAGCGCGTCCATGCCGCTGCGTCCTCCCCAGCGGTGGCCGGCGAC
GAGCGTGCTAGGAGCAGACC

Downstream 100 bases:

>100_bases
GCGCGCCCCGGTGCAGGTAGGGCGCCTGTGCGGCGGGATTCTCCGTACTTGACCGGGGTCGTGACGTCTCGGCCCGGTGT
GGGTGATCTTTAGCGGGAAG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MPVVLVAEELSPAGLEVLSGDFEIRHVDGADRSALLPALADVDAVLIRSATKIDAEALAAAPRLKVVARAGIGLDNVDVP
AATNRGVMVVNAPQSNIVSAAEHAIALLLAVARRVPAAHESLVGGEWKRSKYVGVELTEKTAGVVGLGRIGVLVAQRLAA
FGMKVLAYDPYVSVARASQLGVRLVDLDELLTSSDVITIHLPKTPETLGLIGADELARVKPGVIIVNAARGGLVDEGALA
DAVRSGRVGGVGLDVYVKEPTTSSPLFGLENVVVTPHLGASTQEAQDKAGLAVARSVRLALSGEFVPDAVNVQAGGVVAE
DVRPGLPLAEKLGQLFSGLAAGVAAAITVEVRGEIAAHDVSVLQLAVLKGVFIDIVEEQVTYVNAPLIAKERGVDVALET
SEESPDYRNLVTVRGVLPDGTAVSVSGTLVGSRQVEKITAIDGFEVDLRPEDHLAFFRYEDRPGIVGAVGALLGEAHINI
ANAQVSRLSAGGEALMSLSLDDAVAPDILAEIAKIIGASYARAVSISAG

Sequences:

>Translated_529_residues
MPVVLVAEELSPAGLEVLSGDFEIRHVDGADRSALLPALADVDAVLIRSATKIDAEALAAAPRLKVVARAGIGLDNVDVP
AATNRGVMVVNAPQSNIVSAAEHAIALLLAVARRVPAAHESLVGGEWKRSKYVGVELTEKTAGVVGLGRIGVLVAQRLAA
FGMKVLAYDPYVSVARASQLGVRLVDLDELLTSSDVITIHLPKTPETLGLIGADELARVKPGVIIVNAARGGLVDEGALA
DAVRSGRVGGVGLDVYVKEPTTSSPLFGLENVVVTPHLGASTQEAQDKAGLAVARSVRLALSGEFVPDAVNVQAGGVVAE
DVRPGLPLAEKLGQLFSGLAAGVAAAITVEVRGEIAAHDVSVLQLAVLKGVFIDIVEEQVTYVNAPLIAKERGVDVALET
SEESPDYRNLVTVRGVLPDGTAVSVSGTLVGSRQVEKITAIDGFEVDLRPEDHLAFFRYEDRPGIVGAVGALLGEAHINI
ANAQVSRLSAGGEALMSLSLDDAVAPDILAEIAKIIGASYARAVSISAG
>Mature_528_residues
PVVLVAEELSPAGLEVLSGDFEIRHVDGADRSALLPALADVDAVLIRSATKIDAEALAAAPRLKVVARAGIGLDNVDVPA
ATNRGVMVVNAPQSNIVSAAEHAIALLLAVARRVPAAHESLVGGEWKRSKYVGVELTEKTAGVVGLGRIGVLVAQRLAAF
GMKVLAYDPYVSVARASQLGVRLVDLDELLTSSDVITIHLPKTPETLGLIGADELARVKPGVIIVNAARGGLVDEGALAD
AVRSGRVGGVGLDVYVKEPTTSSPLFGLENVVVTPHLGASTQEAQDKAGLAVARSVRLALSGEFVPDAVNVQAGGVVAED
VRPGLPLAEKLGQLFSGLAAGVAAAITVEVRGEIAAHDVSVLQLAVLKGVFIDIVEEQVTYVNAPLIAKERGVDVALETS
EESPDYRNLVTVRGVLPDGTAVSVSGTLVGSRQVEKITAIDGFEVDLRPEDHLAFFRYEDRPGIVGAVGALLGEAHINIA
NAQVSRLSAGGEALMSLSLDDAVAPDILAEIAKIIGASYARAVSISAG

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=405, Percent_Identity=38.7654320987654, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI61743967, Length=271, Percent_Identity=35.4243542435424, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI4557497, Length=317, Percent_Identity=32.4921135646688, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI145580578, Length=270, Percent_Identity=35.1851851851852, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI4557499, Length=270, Percent_Identity=35.1851851851852, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI6912396, Length=259, Percent_Identity=33.2046332046332, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI145580575, Length=270, Percent_Identity=35.1851851851852, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI87082289, Length=272, Percent_Identity=36.0294117647059, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1789279, Length=276, Percent_Identity=36.9565217391304, Blast_Score=165, Evalue=8e-42,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=39.7959183673469, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1788660, Length=288, Percent_Identity=31.9444444444444, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI87081824, Length=190, Percent_Identity=32.1052631578947, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=296, Percent_Identity=41.8918918918919, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI25147481, Length=331, Percent_Identity=31.7220543806647, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6320925, Length=275, Percent_Identity=36.3636363636364, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322116, Length=308, Percent_Identity=32.4675324675325, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324055, Length=275, Percent_Identity=31.6363636363636, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324964, Length=291, Percent_Identity=31.6151202749141, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324980, Length=212, Percent_Identity=29.7169811320755, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=176, Percent_Identity=32.9545454545455, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=165, Percent_Identity=31.5151515151515, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19921140, Length=273, Percent_Identity=46.1538461538462, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI28574286, Length=313, Percent_Identity=33.8658146964856, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=33.7620578778135, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=30.6709265175719, Blast_Score=145, Evalue=9e-35,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=30.6709265175719, Blast_Score=145, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=30.6709265175719, Blast_Score=145, Evalue=9e-35,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=30.6709265175719, Blast_Score=145, Evalue=9e-35,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=30.6709265175719, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646446, Length=323, Percent_Identity=31.2693498452012, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24646448, Length=323, Percent_Identity=31.2693498452012, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24646452, Length=323, Percent_Identity=31.2693498452012, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24646450, Length=323, Percent_Identity=31.2693498452012, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI62472511, Length=310, Percent_Identity=32.258064516129, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24585516, Length=278, Percent_Identity=28.7769784172662, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 54562; Mature: 54431

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVVLVAEELSPAGLEVLSGDFEIRHVDGADRSALLPALADVDAVLIRSATKIDAEALAA
CCEEEEECCCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHC
APRLKVVARAGIGLDNVDVPAATNRGVMVVNAPQSNIVSAAEHAIALLLAVARRVPAAHE
CCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHH
SLVGGEWKRSKYVGVELTEKTAGVVGLGRIGVLVAQRLAAFGMKVLAYDPYVSVARASQL
HHCCCCCCCCEEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHC
GVRLVDLDELLTSSDVITIHLPKTPETLGLIGADELARVKPGVIIVNAARGGLVDEGALA
CEEEEEHHHHHCCCCEEEEECCCCCCCEEECCCHHHHHCCCCEEEEECCCCCCCCCCHHH
DAVRSGRVGGVGLDVYVKEPTTSSPLFGLENVVVTPHLGASTQEAQDKAGLAVARSVRLA
HHHHCCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHEEEEE
LSGEFVPDAVNVQAGGVVAEDVRPGLPLAEKLGQLFSGLAAGVAAAITVEVRGEIAAHDV
ECCCCCCCCCCEEECCEEHHCCCCCCCHHHHHHHHHHHHHHHHEEEEEEEECCCEEHHHH
SVLQLAVLKGVFIDIVEEQVTYVNAPLIAKERGVDVALETSEESPDYRNLVTVRGVLPDG
HHHHHHHHHHHHHHHHHHHHHEECCCEEECCCCCEEEEECCCCCCCHHCEEEEEEECCCC
TAVSVSGTLVGSRQVEKITAIDGFEVDLRPEDHLAFFRYEDRPGIVGAVGALLGEAHINI
CEEEEEEEEECCCCEEEEEEECCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHCEEEE
ANAQVSRLSAGGEALMSLSLDDAVAPDILAEIAKIIGASYARAVSISAG
ECCHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHEEEEECCC
>Mature Secondary Structure 
PVVLVAEELSPAGLEVLSGDFEIRHVDGADRSALLPALADVDAVLIRSATKIDAEALAA
CEEEEECCCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHC
APRLKVVARAGIGLDNVDVPAATNRGVMVVNAPQSNIVSAAEHAIALLLAVARRVPAAHE
CCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHH
SLVGGEWKRSKYVGVELTEKTAGVVGLGRIGVLVAQRLAAFGMKVLAYDPYVSVARASQL
HHCCCCCCCCEEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHC
GVRLVDLDELLTSSDVITIHLPKTPETLGLIGADELARVKPGVIIVNAARGGLVDEGALA
CEEEEEHHHHHCCCCEEEEECCCCCCCEEECCCHHHHHCCCCEEEEECCCCCCCCCCHHH
DAVRSGRVGGVGLDVYVKEPTTSSPLFGLENVVVTPHLGASTQEAQDKAGLAVARSVRLA
HHHHCCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHEEEEE
LSGEFVPDAVNVQAGGVVAEDVRPGLPLAEKLGQLFSGLAAGVAAAITVEVRGEIAAHDV
ECCCCCCCCCCEEECCEEHHCCCCCCCHHHHHHHHHHHHHHHHEEEEEEEECCCEEHHHH
SVLQLAVLKGVFIDIVEEQVTYVNAPLIAKERGVDVALETSEESPDYRNLVTVRGVLPDG
HHHHHHHHHHHHHHHHHHHHHEECCCEEECCCCCEEEEECCCCCCCHHCEEEEEEECCCC
TAVSVSGTLVGSRQVEKITAIDGFEVDLRPEDHLAFFRYEDRPGIVGAVGALLGEAHINI
CEEEEEEEEECCCCEEEEEEECCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHCEEEE
ANAQVSRLSAGGEALMSLSLDDAVAPDILAEIAKIIGASYARAVSISAG
ECCHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]