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The map label for this gene is ilvC

Identifier: 158312946

GI number: 158312946

Start: 1303736

End: 1304731

Strand: Direct

Name: ilvC

Synonym: Franean1_1092

Alternate gene names: 158312946

Gene position: 1303736-1304731 (Clockwise)

Preceding gene: 158312945

Following gene: 158312947

Centisome position: 14.51

GC content: 70.08

Gene sequence:

>996_bases
ATGGTCGAGATCTACTACGACGACGACGCCAACCTCGACAACCTGGCCGACCGCAAGGTCGCCGTGATCGGCTTCGGCAG
CCAGGGGCACGCGCACGCGCTGAACCTGCGCGACAGCGGGGTCGACGTCCGCGTCGGGCTGCCGGAGACGAGCACCAGCC
GGGCCAAGGCCGAGGAGCAGGGCCTGCGGGTGGTGACCCCGGCGGAGGCGTCCGCCGAGGCCGACATCATCATGATCCTC
ACGCCGGACACGACCCACCGCAAGATCTACGCCGAGTCGATCGCGCCGCACCTCACCCCCGGCAAGGCGCTGGCGTTCGG
GCACGGGTTCAACATCCGGTACGGCCTCATCGAGCCGCCGGCCGGCGTCGACGTCTTCATGGTCGCCCCCAAGGGCCCTG
GTCACCTCGTCCGCCGGGTGTTCGTCGAGGGCAAGGGCGTACCGGTGCTCGTCGCCGTCGAGGCCGACGCCACCGGCAAG
GCGCTCGACATCGCGCTCGCCTACGCGAAGGGCATCGGCGGCACCCGGGCCGGCGCGCTGCGCACGACCTTCACCGAGGA
GACCGAGACCGACCTGTTCGGCGAGCAGGCGGTGCTCTGCGGCGGCGCCAGCGCGCTGGTCCAGGCCGGCTTCGAGACGC
TGGTCGAGGCGGGCTACACCCCCGAGGTCGCGTACTTCGAGTGCCTGCACGAGCTGAAGCTGATCGTCGACCTCATGTAC
GAGGGCGGCATCTCGCAGATGCGCTACTCCATCTCGGACACCGCCGAGTACGGCGACGTCACTCGCGGCCCGCGGGTGAT
CACCCCGGCGGTCAAGGCCGAGATGCGCAAGATCCTCGACGAGATCCAGGACGGGACGTTCGCCCGCGAGTGGGTCGCCG
AGGACGACGCGGGCCGGGCCACCTTCACCAAGCTCGTCGAGGAGGGCAAGCAGCACCCGATCGAGCAGGTCGGTGGCAAG
CTCCGCCCGATGATGTCCTGGATCGCGAAGGACTGA

Upstream 100 bases:

>100_bases
TCGCGGTCGATCACCGATCGCAGTCTGCGCGCCGTCGAGCGCTCGGCCTGACTCCCATCCCTCATTCACCCCTCATTTCC
CTCGAGGAGATTCACCGAAG

Downstream 100 bases:

>100_bases
GGCGAGCCGGGCCGGGCGGCACGTGCCGCCCGGCCCGTCGACGTGCGCCCGCGCCCGCCGCAGGTGAGAGCGGGCACACC
CGTCGCGGCGCCCGAACGTG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MVEIYYDDDANLDNLADRKVAVIGFGSQGHAHALNLRDSGVDVRVGLPETSTSRAKAEEQGLRVVTPAEASAEADIIMIL
TPDTTHRKIYAESIAPHLTPGKALAFGHGFNIRYGLIEPPAGVDVFMVAPKGPGHLVRRVFVEGKGVPVLVAVEADATGK
ALDIALAYAKGIGGTRAGALRTTFTEETETDLFGEQAVLCGGASALVQAGFETLVEAGYTPEVAYFECLHELKLIVDLMY
EGGISQMRYSISDTAEYGDVTRGPRVITPAVKAEMRKILDEIQDGTFAREWVAEDDAGRATFTKLVEEGKQHPIEQVGGK
LRPMMSWIAKD

Sequences:

>Translated_331_residues
MVEIYYDDDANLDNLADRKVAVIGFGSQGHAHALNLRDSGVDVRVGLPETSTSRAKAEEQGLRVVTPAEASAEADIIMIL
TPDTTHRKIYAESIAPHLTPGKALAFGHGFNIRYGLIEPPAGVDVFMVAPKGPGHLVRRVFVEGKGVPVLVAVEADATGK
ALDIALAYAKGIGGTRAGALRTTFTEETETDLFGEQAVLCGGASALVQAGFETLVEAGYTPEVAYFECLHELKLIVDLMY
EGGISQMRYSISDTAEYGDVTRGPRVITPAVKAEMRKILDEIQDGTFAREWVAEDDAGRATFTKLVEEGKQHPIEQVGGK
LRPMMSWIAKD
>Mature_331_residues
MVEIYYDDDANLDNLADRKVAVIGFGSQGHAHALNLRDSGVDVRVGLPETSTSRAKAEEQGLRVVTPAEASAEADIIMIL
TPDTTHRKIYAESIAPHLTPGKALAFGHGFNIRYGLIEPPAGVDVFMVAPKGPGHLVRRVFVEGKGVPVLVAVEADATGK
ALDIALAYAKGIGGTRAGALRTTFTEETETDLFGEQAVLCGGASALVQAGFETLVEAGYTPEVAYFECLHELKLIVDLMY
EGGISQMRYSISDTAEYGDVTRGPRVITPAVKAEMRKILDEIQDGTFAREWVAEDDAGRATFTKLVEEGKQHPIEQVGGK
LRPMMSWIAKD

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=294, Percent_Identity=36.3945578231293, Blast_Score=150, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323387, Length=326, Percent_Identity=33.1288343558282, Blast_Score=132, Evalue=9e-32,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_FRASN (A8L548)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001505454.1
- ProteinModelPortal:   A8L548
- SMR:   A8L548
- GeneID:   5669506
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_1092
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   FSP1855:FRANEAN1_1092-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 35631; Mature: 35631

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEIYYDDDANLDNLADRKVAVIGFGSQGHAHALNLRDSGVDVRVGLPETSTSRAKAEEQ
CEEEEECCCCCCCHHCCCEEEEEEECCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHC
GLRVVTPAEASAEADIIMILTPDTTHRKIYAESIAPHLTPGKALAFGHGFNIRYGLIEPP
CCEEEECCCCCCCCCEEEEECCCCCCCEEEHHHCCCCCCCCCEEEEECCCEEEEEEECCC
AGVDVFMVAPKGPGHLVRRVFVEGKGVPVLVAVEADATGKALDIALAYAKGIGGTRAGAL
CCCEEEEECCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHEEEHHHHCCCCCCCCCE
RTTFTEETETDLFGEQAVLCGGASALVQAGFETLVEAGYTPEVAYFECLHELKLIVDLMY
EEEECCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGISQMRYSISDTAEYGDVTRGPRVITPAVKAEMRKILDEIQDGTFAREWVAEDDAGRA
HCCHHHHEECCCCCHHCCCCCCCCEEECHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHH
TFTKLVEEGKQHPIEQVGGKLRPMMSWIAKD
HHHHHHHHHHCCCHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MVEIYYDDDANLDNLADRKVAVIGFGSQGHAHALNLRDSGVDVRVGLPETSTSRAKAEEQ
CEEEEECCCCCCCHHCCCEEEEEEECCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHC
GLRVVTPAEASAEADIIMILTPDTTHRKIYAESIAPHLTPGKALAFGHGFNIRYGLIEPP
CCEEEECCCCCCCCCEEEEECCCCCCCEEEHHHCCCCCCCCCEEEEECCCEEEEEEECCC
AGVDVFMVAPKGPGHLVRRVFVEGKGVPVLVAVEADATGKALDIALAYAKGIGGTRAGAL
CCCEEEEECCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHEEEHHHHCCCCCCCCCE
RTTFTEETETDLFGEQAVLCGGASALVQAGFETLVEAGYTPEVAYFECLHELKLIVDLMY
EEEECCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGISQMRYSISDTAEYGDVTRGPRVITPAVKAEMRKILDEIQDGTFAREWVAEDDAGRA
HCCHHHHEECCCCCHHCCCCCCCCEEECHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHH
TFTKLVEEGKQHPIEQVGGKLRPMMSWIAKD
HHHHHHHHHHCCCHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA