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The map label for this gene is hbd [H]

Identifier: 158312891

GI number: 158312891

Start: 1216811

End: 1218598

Strand: Direct

Name: hbd [H]

Synonym: Franean1_1037

Alternate gene names: 158312891

Gene position: 1216811-1218598 (Clockwise)

Preceding gene: 158312890

Following gene: 158312892

Centisome position: 13.55

GC content: 70.64

Gene sequence:

>1788_bases
ATGGGCCAGGAGAGCACCCTCGGTGAGCTGACGAGGATCGGGGTCATCGGGCTCGGCACCATGGGCGCCGGCATCGCGGA
GGTGCTGGCCCGTGCTGGTATCGACGTGGTGGGCGTCGAACGGGACGAGGCCGGGCTGGCCCGCGGTCGGGGCCATCTGG
AGCACTCCACGCATCGGGCGGTCGAGCGCGGCAAGCTGACCCCGGCCGAGCGCGAGGAGCTGCTCGGCCGCATCAGCAGT
GGCGTCGACCTGACGGCCGTCGCGGACTGTCCGCTGATCATCGAGGCCATCCACGAGCGGCTGGACGCCAAGCAGGAGCT
CATCGCCCGTCTCGACGAGATCTGTCCCGCCGAGACGATCATCGCCAGCAACACCAGCTCACTGTCGGTCACCGAGCTTG
CCGCCGGCACCCACCGGCCGTCCAGGGTGCTCGGCACGCACTGGTTCAACCCGGCGCCGGTGATGGAACTTGTTGAGGTG
GTCGGGACGGTCGTCACGGATCCTGTCGTCCTTGACGACGTCCGCGACCTGGTCGGTCGCGTCGGGAAGATTGCGGTCAG
GGCAGGCGACCGGGCCGGTTTCATCGCCAACGCGCTGCTGTTCGGCTACCTGAACAACGCGGTGCGGATGCTGGAGGCGC
ACTACGCGACCCGGGAGGACATCGACGCGGCGATGCGCCTCGGCTGCGGTCACCCGATGGGGCCGCTGGCCCTGCTCGAC
CTGATCGGGCTCGACTCCGCGTACGAGATCCTCGACTCGATGTACCACCAGTCCCGCGATCACCTGCATGCTCCCGCGCC
GCTGCTCAAGCAGCTCGTCACGGCCGGAATGCTGGGCCGCAAGACCGGTCGGGGCTTCTACACCTACGCCGAGGCCGACT
CGCCGCACGTCGTCGACGACGCCGCCCCGAGCGTGGTCGCCGGGGTCGAACCCAGGCCGGTGCGCTCCGTCGGCGTCGTG
GGCACCGGGACGATGGCCTGCGGCATCGTCGAGGTCCTGGCCCGCTCCGGTTTCGACGTGGTGTTCCGCGCGCGGTCCGA
CGACAAGGTGTCGGCCGTCCGCAAGAGACTGGTGGAGTCGCTGGAGCGAGGCGTCCAGCGTGGACGGCTGTCCGCCGAGG
AGCGTGACGCCGCGCTCGCCCGGGTGACGGGGACGACCGACCTCGACGCGCTCGCCGGCTGCGATCTCGTCGTCGAGGCG
GTCGTCGAGGAGCTTTCGGTGAAGCGGGCGCTGTTCGCCGCGCTCGACGAGGTGATGAAGCCGGGGGCGGTGCTCGCGAC
CACGACGTCATCCCTGCCGGTGGTCGAGTGCGCCACGGCGACGACCCGTCCGCGGGACGTCGTCGGGATGCACTGGTTCA
ACCCGGCGCCCGCGATGCGCCTGATCGAGGTCGTGCCTACGGTGCTGACCGCTCCCGATGTCACCGCGACGGTGCTCGCG
GTCAGCCGGGCCGCCGGCAAGCACCCGGTGGTCTGCGCGGACCGCGCCGGGTTCATCGTGAACGCGCTGCTCTTCCCGTA
CCTCAACGACGCCGTGCGGATGCTGGAGGCGCACTACGCCAGCGTCGACGACATCGACACCGCGATGACGGTGGGCTGCG
GGCATCCGATGGGCCCGTTCGCGCTGGCGGACGTGGTCGGTCTCGACGTCACACTGGCGATCCAGCGGACGTTGTACCTG
GAGTTCCGGGAGCCGGGCTATGCCCCGGCCCCCCTGCTCGAGCACCTCGTGAAGGCGGGCTACCTGGGGCGCAAGACCGG
CCGGGGCTTCCGCGACCACTCGCGCTGA

Upstream 100 bases:

>100_bases
CACACCGGTGCCCGGGACGTCGCACGCCGCAGGCCGCGTACTCGGCGGTGACAGGCGGCTAGACCACGGGAAAGACCACC
CGGAGGAAGGAGCGCTGGGC

Downstream 100 bases:

>100_bases
GGCGGCGGGGGTCCGGTCGGAGGGGGTTCGTGGCCCCTCCGGGGGGTACCTGACGGGCAGCCGACGTTGATCACCCTTCG
GGGCGGGTCGGCGGTCGTGT

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MGQESTLGELTRIGVIGLGTMGAGIAEVLARAGIDVVGVERDEAGLARGRGHLEHSTHRAVERGKLTPAEREELLGRISS
GVDLTAVADCPLIIEAIHERLDAKQELIARLDEICPAETIIASNTSSLSVTELAAGTHRPSRVLGTHWFNPAPVMELVEV
VGTVVTDPVVLDDVRDLVGRVGKIAVRAGDRAGFIANALLFGYLNNAVRMLEAHYATREDIDAAMRLGCGHPMGPLALLD
LIGLDSAYEILDSMYHQSRDHLHAPAPLLKQLVTAGMLGRKTGRGFYTYAEADSPHVVDDAAPSVVAGVEPRPVRSVGVV
GTGTMACGIVEVLARSGFDVVFRARSDDKVSAVRKRLVESLERGVQRGRLSAEERDAALARVTGTTDLDALAGCDLVVEA
VVEELSVKRALFAALDEVMKPGAVLATTTSSLPVVECATATTRPRDVVGMHWFNPAPAMRLIEVVPTVLTAPDVTATVLA
VSRAAGKHPVVCADRAGFIVNALLFPYLNDAVRMLEAHYASVDDIDTAMTVGCGHPMGPFALADVVGLDVTLAIQRTLYL
EFREPGYAPAPLLEHLVKAGYLGRKTGRGFRDHSR

Sequences:

>Translated_595_residues
MGQESTLGELTRIGVIGLGTMGAGIAEVLARAGIDVVGVERDEAGLARGRGHLEHSTHRAVERGKLTPAEREELLGRISS
GVDLTAVADCPLIIEAIHERLDAKQELIARLDEICPAETIIASNTSSLSVTELAAGTHRPSRVLGTHWFNPAPVMELVEV
VGTVVTDPVVLDDVRDLVGRVGKIAVRAGDRAGFIANALLFGYLNNAVRMLEAHYATREDIDAAMRLGCGHPMGPLALLD
LIGLDSAYEILDSMYHQSRDHLHAPAPLLKQLVTAGMLGRKTGRGFYTYAEADSPHVVDDAAPSVVAGVEPRPVRSVGVV
GTGTMACGIVEVLARSGFDVVFRARSDDKVSAVRKRLVESLERGVQRGRLSAEERDAALARVTGTTDLDALAGCDLVVEA
VVEELSVKRALFAALDEVMKPGAVLATTTSSLPVVECATATTRPRDVVGMHWFNPAPAMRLIEVVPTVLTAPDVTATVLA
VSRAAGKHPVVCADRAGFIVNALLFPYLNDAVRMLEAHYASVDDIDTAMTVGCGHPMGPFALADVVGLDVTLAIQRTLYL
EFREPGYAPAPLLEHLVKAGYLGRKTGRGFRDHSR
>Mature_594_residues
GQESTLGELTRIGVIGLGTMGAGIAEVLARAGIDVVGVERDEAGLARGRGHLEHSTHRAVERGKLTPAEREELLGRISSG
VDLTAVADCPLIIEAIHERLDAKQELIARLDEICPAETIIASNTSSLSVTELAAGTHRPSRVLGTHWFNPAPVMELVEVV
GTVVTDPVVLDDVRDLVGRVGKIAVRAGDRAGFIANALLFGYLNNAVRMLEAHYATREDIDAAMRLGCGHPMGPLALLDL
IGLDSAYEILDSMYHQSRDHLHAPAPLLKQLVTAGMLGRKTGRGFYTYAEADSPHVVDDAAPSVVAGVEPRPVRSVGVVG
TGTMACGIVEVLARSGFDVVFRARSDDKVSAVRKRLVESLERGVQRGRLSAEERDAALARVTGTTDLDALAGCDLVVEAV
VEELSVKRALFAALDEVMKPGAVLATTTSSLPVVECATATTRPRDVVGMHWFNPAPAMRLIEVVPTVLTAPDVTATVLAV
SRAAGKHPVVCADRAGFIVNALLFPYLNDAVRMLEAHYASVDDIDTAMTVGCGHPMGPFALADVVGLDVTLAIQRTLYLE
FREPGYAPAPLLEHLVKAGYLGRKTGRGFRDHSR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=285, Percent_Identity=42.8070175438597, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI296179427, Length=302, Percent_Identity=40.3973509933775, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI261878539, Length=296, Percent_Identity=36.1486486486487, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI68989263, Length=296, Percent_Identity=36.1486486486487, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI20127408, Length=286, Percent_Identity=31.4685314685315, Blast_Score=156, Evalue=7e-38,
Organism=Homo sapiens, GI115430219, Length=224, Percent_Identity=27.2321428571429, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1787661, Length=280, Percent_Identity=40.3571428571429, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1788682, Length=256, Percent_Identity=37.109375, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1790281, Length=260, Percent_Identity=32.6923076923077, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17563036, Length=291, Percent_Identity=38.1443298969072, Blast_Score=195, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17553560, Length=290, Percent_Identity=35.5172413793103, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17549919, Length=295, Percent_Identity=37.2881355932203, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI71985923, Length=281, Percent_Identity=31.3167259786477, Blast_Score=158, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17558304, Length=310, Percent_Identity=31.2903225806452, Blast_Score=149, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI25144276, Length=282, Percent_Identity=32.9787234042553, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71985930, Length=284, Percent_Identity=28.5211267605634, Blast_Score=146, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17508953, Length=282, Percent_Identity=32.9787234042553, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17508951, Length=282, Percent_Identity=32.9787234042553, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI193203623, Length=184, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115533614, Length=184, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583077, Length=287, Percent_Identity=36.2369337979094, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24583079, Length=287, Percent_Identity=36.2369337979094, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI19921000, Length=287, Percent_Identity=36.2369337979094, Blast_Score=163, Evalue=4e-40,
Organism=Drosophila melanogaster, GI45549573, Length=226, Percent_Identity=31.858407079646, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI20129993, Length=224, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 63347; Mature: 63215

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQESTLGELTRIGVIGLGTMGAGIAEVLARAGIDVVGVERDEAGLARGRGHLEHSTHRA
CCCCCHHHHHHHHHEEEECHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCHHHHHHH
VERGKLTPAEREELLGRISSGVDLTAVADCPLIIEAIHERLDAKQELIARLDEICPAETI
HHHCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHCCCHHE
IASNTSSLSVTELAAGTHRPSRVLGTHWFNPAPVMELVEVVGTVVTDPVVLDDVRDLVGR
EECCCCCCCHHHHHCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
VGKIAVRAGDRAGFIANALLFGYLNNAVRMLEAHYATREDIDAAMRLGCGHPMGPLALLD
HHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LIGLDSAYEILDSMYHQSRDHLHAPAPLLKQLVTAGMLGRKTGRGFYTYAEADSPHVVDD
HHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCC
AAPSVVAGVEPRPVRSVGVVGTGTMACGIVEVLARSGFDVVFRARSDDKVSAVRKRLVES
CCCCCEECCCCCCCCEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
LERGVQRGRLSAEERDAALARVTGTTDLDALAGCDLVVEAVVEELSVKRALFAALDEVMK
HHHHHHHCCCCCHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PGAVLATTTSSLPVVECATATTRPRDVVGMHWFNPAPAMRLIEVVPTVLTAPDVTATVLA
CCCEEEECCCCCCEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
VSRAAGKHPVVCADRAGFIVNALLFPYLNDAVRMLEAHYASVDDIDTAMTVGCGHPMGPF
HHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEECCCCCCCHH
ALADVVGLDVTLAIQRTLYLEFREPGYAPAPLLEHLVKAGYLGRKTGRGFRDHSR
HHHHHHHCCHHEEEEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GQESTLGELTRIGVIGLGTMGAGIAEVLARAGIDVVGVERDEAGLARGRGHLEHSTHRA
CCCCHHHHHHHHHEEEECHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCHHHHHHH
VERGKLTPAEREELLGRISSGVDLTAVADCPLIIEAIHERLDAKQELIARLDEICPAETI
HHHCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHCCCHHE
IASNTSSLSVTELAAGTHRPSRVLGTHWFNPAPVMELVEVVGTVVTDPVVLDDVRDLVGR
EECCCCCCCHHHHHCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
VGKIAVRAGDRAGFIANALLFGYLNNAVRMLEAHYATREDIDAAMRLGCGHPMGPLALLD
HHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LIGLDSAYEILDSMYHQSRDHLHAPAPLLKQLVTAGMLGRKTGRGFYTYAEADSPHVVDD
HHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCC
AAPSVVAGVEPRPVRSVGVVGTGTMACGIVEVLARSGFDVVFRARSDDKVSAVRKRLVES
CCCCCEECCCCCCCCEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
LERGVQRGRLSAEERDAALARVTGTTDLDALAGCDLVVEAVVEELSVKRALFAALDEVMK
HHHHHHHCCCCCHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PGAVLATTTSSLPVVECATATTRPRDVVGMHWFNPAPAMRLIEVVPTVLTAPDVTATVLA
CCCEEEECCCCCCEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
VSRAAGKHPVVCADRAGFIVNALLFPYLNDAVRMLEAHYASVDDIDTAMTVGCGHPMGPF
HHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEECCCCCCCHH
ALADVVGLDVTLAIQRTLYLEFREPGYAPAPLLEHLVKAGYLGRKTGRGFRDHSR
HHHHHHHCCHHEEEEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]