Click here to switch to the map view.

The map label for this gene is meaA [H]

Identifier: 158312888

GI number: 158312888

Start: 1213234

End: 1215234

Strand: Direct

Name: meaA [H]

Synonym: Franean1_1034

Alternate gene names: 158312888

Gene position: 1213234-1215234 (Clockwise)

Preceding gene: 158312887

Following gene: 158312889

Centisome position: 13.51

GC content: 66.67

Gene sequence:

>2001_bases
ATGACGGATGTGGCCAGGTCGGAGCGTGACCGGCCGTGGATCGTGCGGACCTACGCGGGTCATTCGAGTCCGGCGGAGAG
TAACGCTCTGTACCGGCGGAATCTGGCGAAGGGGCAGACGGGTCTGTCGGTGGCTTTCGATCTGCCGACGCAGACCGGGT
ACGACCCGGATCATGTGCTGGCGCGTGGTGAGGTCGGGAAGGTGGGTGTGCCGGTCGCGCATCTGGGTGACATGCGGGCG
TTGTTCGAGCAGATCCCGTTGGGTCGGATGAACACGTCGATGACCATCAACGCGACGGCGATGTGGTTGCTGGCGTTGTA
CCAGGTGGTGGCGGAGGAGCAGGGTGTCGCGGCCGAGGAGCTGACCGGCACGACCCAGAACGACATCATCAAGGAGTACC
TGTCGCGGGGGACGTATGTGTTCCCGCCGGGGCCGTCGCTGCGGCTGATCACGGACATCGTCGCGTACACGGTGACGGAG
ATCCCGCGCTGGAACCCGATCAACATCTGTAGTTATCACCTGCAGGAGGCGGGTGCGACGCCGGTGCAGGAGTTGGCGTA
CTCGTTGTGCACGGTGATCGCGGTGCTCGACGCGGTGGTCGCTTCCGGTCAGGTGCCGGTGGAGCGGATGGGCGAGGTGT
GTGCCCGGATGTCGTTCTTCGTGAACGCCGGGGTGCGTTTCGTGGAGGAGATGTGCAAGATGCGGGCGTTCGTCGCCCTG
TGGGATGATCTGCTGCGGACTCGTTACGGGGTGACGGATCCGCGTCACCGCCGGTTCCGTTACGGGGTGCAGGTCAACTC
GTTGGGGTTGACCGAGGCGCAGCCGGAGAACAACGTGATCCGGATCGTGTTGGAGGCGCTCGGGGTCACGTTGTCGAAGG
ACGCGCGGTGTCGGGCGTTGCAGTTGCCTGCGTGGAACGAGGCCCTGGGTTTGCCGCGTCCGTGGGATCAGCAGTGGTCG
CTGCGTATCCAGCAGATCCTGGCCTATGAGACGGATCTGTTGGAGTACCCGGATCTGTTCGAGGGCTCGGTGGTGGTGGC
CCGGCGGGTCGAGGAGCTGGTTGCGGCCGCGACCGAGGAGATCGACCGGGTGCAGGCGATGGGTGGGGCTGTCGCCGCTG
TGGAGAGCGGGTATATGAAGTCCCAGTTGGTGGCTTCGCAGGCGATGCGGCGGGCGCGGATCGAGTCTGGTGAGGATGTT
GTTGTCGGGGTGAACCGGTTCACTGAGACCGAGCCGAATCCGCTGCTGGCCGATCTGGATGCGGCGGTGCAGACGGTGGA
TCCGGCGGGTGAGGAGGCGGCCCGGGTTCAGGTCGCTGCGTGGCGGGCCGCCCGTGATGCCTCCGTTGTCGACGAGGCGC
TGCTCGGGTTGCGTGAGGCGGCGAAGACGGATGCGAACCTGGTGCCGGCGACGTTGGCGTGTGCTCGTGCCGGGGTGACG
ACGGGGGAGTGGGCGGGTGTGTTGCGTGAGGTGTTCGGTGAGTACCGGGCGCCGACCGGGGTGTCTGCCGCGCCGTCGGC
CGCTGCTGCGGGTGCTGGGCTGGGGGAGGTGCGTGACCTGGTGACCGTGACCGCTGGTGAGTTGGGTCGCCGGCCGCGGC
TGCTGGTGGGTAAGCCCGGGTTGGACGGGCATTCCAACGGTGCCGAGCAGATCGCGGTCCGGGCTCGTGATGTGGGCTTT
GAGGTGGTCTATCAGGGGATCCGTCTCACCCCGGCGCAGATCGTCGCTGCGGCTGTGGAGGAGGACGTTCATGTGGTGGG
GCTGTCGGTGCTCTCCGGTTCGCATATGAACCTGGTGCCCGAGGTGCTGGACGGGCTGCGTGCGGCTGGTCTCGGGGATG
TTCCGGTCGTGGTCGGGGGGATCATTCCGCCCGCGGACGCGGAACGCCTGGCGACGCTCGGTGTTGCGGCGGTCTTCACA
CCGAAGGACTACGGGCTGACCGACATCATGCGTGGCATCGTGAACATCGTGCGCACCTCAAACGGCCTGGCGAGTGCCTG
A

Upstream 100 bases:

>100_bases
CCGAGGTCCGTGCGCACGGCCCGTGCCTGTGGCTCTGCGCGCGGGGGCGTCCGTCCGGCTGCCGGTTCTTGGGCGTCGCA
CGGAGCGCTAGGAGGCGGCG

Downstream 100 bases:

>100_bases
ACCGGCGGCCGCCCCCACTCCCCAGCCGCAGCCTCCGCCGCGGCCGTCGCTGGAGGACGCGGTGGCGCTGGCGGCCCGGG
CCCACACCGGCCAGCTCGAC

Product: methylmalonyl-CoA mutase, large subunit

Products: succinyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MTDVARSERDRPWIVRTYAGHSSPAESNALYRRNLAKGQTGLSVAFDLPTQTGYDPDHVLARGEVGKVGVPVAHLGDMRA
LFEQIPLGRMNTSMTINATAMWLLALYQVVAEEQGVAAEELTGTTQNDIIKEYLSRGTYVFPPGPSLRLITDIVAYTVTE
IPRWNPINICSYHLQEAGATPVQELAYSLCTVIAVLDAVVASGQVPVERMGEVCARMSFFVNAGVRFVEEMCKMRAFVAL
WDDLLRTRYGVTDPRHRRFRYGVQVNSLGLTEAQPENNVIRIVLEALGVTLSKDARCRALQLPAWNEALGLPRPWDQQWS
LRIQQILAYETDLLEYPDLFEGSVVVARRVEELVAAATEEIDRVQAMGGAVAAVESGYMKSQLVASQAMRRARIESGEDV
VVGVNRFTETEPNPLLADLDAAVQTVDPAGEEAARVQVAAWRAARDASVVDEALLGLREAAKTDANLVPATLACARAGVT
TGEWAGVLREVFGEYRAPTGVSAAPSAAAAGAGLGEVRDLVTVTAGELGRRPRLLVGKPGLDGHSNGAEQIAVRARDVGF
EVVYQGIRLTPAQIVAAAVEEDVHVVGLSVLSGSHMNLVPEVLDGLRAAGLGDVPVVVGGIIPPADAERLATLGVAAVFT
PKDYGLTDIMRGIVNIVRTSNGLASA

Sequences:

>Translated_666_residues
MTDVARSERDRPWIVRTYAGHSSPAESNALYRRNLAKGQTGLSVAFDLPTQTGYDPDHVLARGEVGKVGVPVAHLGDMRA
LFEQIPLGRMNTSMTINATAMWLLALYQVVAEEQGVAAEELTGTTQNDIIKEYLSRGTYVFPPGPSLRLITDIVAYTVTE
IPRWNPINICSYHLQEAGATPVQELAYSLCTVIAVLDAVVASGQVPVERMGEVCARMSFFVNAGVRFVEEMCKMRAFVAL
WDDLLRTRYGVTDPRHRRFRYGVQVNSLGLTEAQPENNVIRIVLEALGVTLSKDARCRALQLPAWNEALGLPRPWDQQWS
LRIQQILAYETDLLEYPDLFEGSVVVARRVEELVAAATEEIDRVQAMGGAVAAVESGYMKSQLVASQAMRRARIESGEDV
VVGVNRFTETEPNPLLADLDAAVQTVDPAGEEAARVQVAAWRAARDASVVDEALLGLREAAKTDANLVPATLACARAGVT
TGEWAGVLREVFGEYRAPTGVSAAPSAAAAGAGLGEVRDLVTVTAGELGRRPRLLVGKPGLDGHSNGAEQIAVRARDVGF
EVVYQGIRLTPAQIVAAAVEEDVHVVGLSVLSGSHMNLVPEVLDGLRAAGLGDVPVVVGGIIPPADAERLATLGVAAVFT
PKDYGLTDIMRGIVNIVRTSNGLASA
>Mature_665_residues
TDVARSERDRPWIVRTYAGHSSPAESNALYRRNLAKGQTGLSVAFDLPTQTGYDPDHVLARGEVGKVGVPVAHLGDMRAL
FEQIPLGRMNTSMTINATAMWLLALYQVVAEEQGVAAEELTGTTQNDIIKEYLSRGTYVFPPGPSLRLITDIVAYTVTEI
PRWNPINICSYHLQEAGATPVQELAYSLCTVIAVLDAVVASGQVPVERMGEVCARMSFFVNAGVRFVEEMCKMRAFVALW
DDLLRTRYGVTDPRHRRFRYGVQVNSLGLTEAQPENNVIRIVLEALGVTLSKDARCRALQLPAWNEALGLPRPWDQQWSL
RIQQILAYETDLLEYPDLFEGSVVVARRVEELVAAATEEIDRVQAMGGAVAAVESGYMKSQLVASQAMRRARIESGEDVV
VGVNRFTETEPNPLLADLDAAVQTVDPAGEEAARVQVAAWRAARDASVVDEALLGLREAAKTDANLVPATLACARAGVTT
GEWAGVLREVFGEYRAPTGVSAAPSAAAAGAGLGEVRDLVTVTAGELGRRPRLLVGKPGLDGHSNGAEQIAVRARDVGFE
VVYQGIRLTPAQIVAAAVEEDVHVVGLSVLSGSHMNLVPEVLDGLRAAGLGDVPVVVGGIIPPADAERLATLGVAAVFTP
KDYGLTDIMRGIVNIVRTSNGLASA

Specific function: Required for the assimilation of methanol and ethanol [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=640, Percent_Identity=37.03125, Blast_Score=405, Evalue=1e-113,
Organism=Escherichia coli, GI1789284, Length=657, Percent_Identity=39.2694063926941, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI25144500, Length=634, Percent_Identity=36.9085173501577, Blast_Score=407, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: 5.4.99.2

Molecular weight: Translated: 71471; Mature: 71340

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVARSERDRPWIVRTYAGHSSPAESNALYRRNLAKGQTGLSVAFDLPTQTGYDPDHVL
CCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCHHHEE
ARGEVGKVGVPVAHLGDMRALFEQIPLGRMNTSMTINATAMWLLALYQVVAEEQGVAAEE
ECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHH
LTGTTQNDIIKEYLSRGTYVFPPGPSLRLITDIVAYTVTEIPRWNPINICSYHLQEAGAT
HCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
PVQELAYSLCTVIAVLDAVVASGQVPVERMGEVCARMSFFVNAGVRFVEEMCKMRAFVAL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WDDLLRTRYGVTDPRHRRFRYGVQVNSLGLTEAQPENNVIRIVLEALGVTLSKDARCRAL
HHHHHHHHCCCCCCHHHHEEECEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEE
QLPAWNEALGLPRPWDQQWSLRIQQILAYETDLLEYPDLFEGSVVVARRVEELVAAATEE
ECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
IDRVQAMGGAVAAVESGYMKSQLVASQAMRRARIESGEDVVVGVNRFTETEPNPLLADLD
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHCCCCCCCCHHHHH
AAVQTVDPAGEEAARVQVAAWRAARDASVVDEALLGLREAAKTDANLVPATLACARAGVT
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
TGEWAGVLREVFGEYRAPTGVSAAPSAAAAGAGLGEVRDLVTVTAGELGRRPRLLVGKPG
CHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEECCC
LDGHSNGAEQIAVRARDVGFEVVYQGIRLTPAQIVAAAVEEDVHVVGLSVLSGSHMNLVP
CCCCCCCHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHCCHHEEEEHHHCCCCCHHHH
EVLDGLRAAGLGDVPVVVGGIIPPADAERLATLGVAAVFTPKDYGLTDIMRGIVNIVRTS
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCC
NGLASA
CCCCCC
>Mature Secondary Structure 
TDVARSERDRPWIVRTYAGHSSPAESNALYRRNLAKGQTGLSVAFDLPTQTGYDPDHVL
CCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCHHHEE
ARGEVGKVGVPVAHLGDMRALFEQIPLGRMNTSMTINATAMWLLALYQVVAEEQGVAAEE
ECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHH
LTGTTQNDIIKEYLSRGTYVFPPGPSLRLITDIVAYTVTEIPRWNPINICSYHLQEAGAT
HCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
PVQELAYSLCTVIAVLDAVVASGQVPVERMGEVCARMSFFVNAGVRFVEEMCKMRAFVAL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WDDLLRTRYGVTDPRHRRFRYGVQVNSLGLTEAQPENNVIRIVLEALGVTLSKDARCRAL
HHHHHHHHCCCCCCHHHHEEECEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEE
QLPAWNEALGLPRPWDQQWSLRIQQILAYETDLLEYPDLFEGSVVVARRVEELVAAATEE
ECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
IDRVQAMGGAVAAVESGYMKSQLVASQAMRRARIESGEDVVVGVNRFTETEPNPLLADLD
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHCCCCCCCCHHHHH
AAVQTVDPAGEEAARVQVAAWRAARDASVVDEALLGLREAAKTDANLVPATLACARAGVT
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
TGEWAGVLREVFGEYRAPTGVSAAPSAAAAGAGLGEVRDLVTVTAGELGRRPRLLVGKPG
CHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEECCC
LDGHSNGAEQIAVRARDVGFEVVYQGIRLTPAQIVAAAVEEDVHVVGLSVLSGSHMNLVP
CCCCCCCHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHCCHHEEEEHHHCCCCCHHHH
EVLDGLRAAGLGDVPVVVGGIIPPADAERLATLGVAAVFTPKDYGLTDIMRGIVNIVRTS
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCC
NGLASA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-methylmalonyl-CoA

Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]