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The map label for this gene is 158312839

Identifier: 158312839

GI number: 158312839

Start: 1151733

End: 1153913

Strand: Direct

Name: 158312839

Synonym: Franean1_0985

Alternate gene names: NA

Gene position: 1151733-1153913 (Clockwise)

Preceding gene: 158312836

Following gene: 158312841

Centisome position: 12.82

GC content: 76.71

Gene sequence:

>2181_bases
GTGGAAAGCCGAGTGGTCGATCACGAGGAGTCATCCGCCGGCCGGGTCCGTCCAAGCGGCAAGATCCGCCTCGGGGTGGA
CGTCGGCGGTACCTTCACCGACCTGGTCGCCGTCGACCCGGACGGCGCGGTGCGGTTCGCCAAGGTTCCCTCGGTGCCCG
CCGACCCGTCCGACGGAGTGCTCGCCGCCCTCACCGCCGCGGGGCTGGACGGACCACTCGTGGGCACGTTCGCCCACGGC
ACCACCGTCGCCACGAACGCGCTGCTGGAGCGGGCCGGTGCCCGCACGGCCCTGGTGACCACCCGCGGGTTCCGGGACGT
GATCGAGATCGGCCGGCAGAACCGGCCGTCGCTCTACGACCTGACCCTCGACCGGCCGCCCGCCCTCGTCCCGCGCGAGC
TGCGCTTCACCGTGGCGGAACGGTGCGGCCCGCACGGGGTGCTCGAGCCGCTGCGGGCCGCCGAGGTGGACCGGGTCGTC
GAGGAGGTCGCGGCCGTCCCCGGCCTCGACGCGGTCGCCGTGTGCCTGCTGTTCTCCTTCGCCCACCCCGACCACGAACG
CACCGTCGCGGCCGCCCTGCGCGCCCGGCTGCCCGGGGTCACGGTGGTGGCCTCCAGCGAGGTCCTGCCGGTCTTCCGCG
AGTACGAACGGTTCACCACGGCCGTCGCCGACGCCTACCTGACCCCGCGGCTGTCGTCCTATCTGCGGGCGCTCGAGCGG
CGCTGCGCCGCCCGGGACGTCACCGTCCCGATGATCATGCAGTCCTCGGGCGGGGTCACCGAGCTGGCAGAGGCGGCCGG
CCACGCCGCCCGCTGCGTGCTCTCCGGGCCGGCCGGGGGAGTGGTCGGCGCCGCGTACGTGGCCGGCCTGTCCGGCGTGC
GCGACCTGCTGACCTTCGACATGGGCGGCACCTCCACCGACGTGGCGCCGGTCCTCGACGGCCGCGCGCTGACCACCTCC
GAGTCGGTGCTCGCCGGGGTACCGATCGTGCTGCCCACTGTGGACGTCCACTCGGTCAGCGCCGGCGGCGGGTCGATCGC
CTGGGTCGACGCCGGCGGCGCGCTGCGCGTCGGCCCGCGCTCCGCCGGCGCGGACCCGGGACCGGCCTGCTACGGCCGCG
GCGGCACGCGGCCCACGGTGACCGACGCCGACCTCTGCCTCGGCTACCTCGCCGACGGCGCCGGGCTCGGCGGCGAGGTC
ACCCTCTCGCGGACGGCGGCCGAGGCCGCGCTGGGCGCGCTGGGCGCCCCCCTCGGGCTCTCACCGGTCGAGGCCGCCGC
CGGGGTGGTGGCGGTCGCGGACGCCGAGATGACCCGTGCCCTGCGCGTCGTCTCCGTTGAGCGCGGGCTCGACCCGCGCG
AGCTCGTGCTGGTCGCCTTCGGTGGAGCCGGCGGGACGCATGCCTGCGCGCTCGCCGAGGAGCTCGGGATGACCCGGGTC
CTCGTCCCGCTCGCGGCCGGCGTCCTCTCCGCACTGGGCCTGGCGATCGGCGACGTCCGGCGCGACTACGCCCGCCCGCT
GATCGGCCGTCTGGGCGAGGTCGACCTGACGGCCGCGTTCGCCGGCCTCGTCGCGAGCGCCGGCCTCGTCGCGAGCGCCG
GCCTCGCTGCAAGCGCCGGCCTGGCCGGGGGCCACGATTCCGCGGGCGCGGTCGTGCTCCAACACCGGCTGGACTGCCGC
TACGTGGGGCAGTCCCACGAGCTGACCATCGACGTGGCGGAGCCCGGGGGCGGCGGCAGCGAGGCCGCGGGCGGCAGCGG
TGCGGCAAACAGCAGCGGTGCGGCGGGCGGCTGGGCGGCGGGGGCCGGCGGGCTCGTTGACGCCGTCCGTGCTGCCTTCG
AGGCCGAGCACCTGCGCCGCTACGGGCACATCGCGGCGGGCCGCGAGATCGAGACGGTGGCCGTCCGCCTGGTGGTGACC
GTGCCCGGGCCCAGACCGAGACCGGTCGCCCCGCGCCCCGATCCCACGGCGCGCCGCGGCCGGCGCCGGGCCTGGACGGA
CAGCGCGTGGCACGAGATCGACGTGATCCCCCGGGCAGCCCTCGGACCGGGAGACACGGTGACCGGCCCGGCCGTCGTGG
AGTTCGCCGAGGCGACCTGCCTGCTCCGCCGTGGTTGGACCGGCGTCGTGGACGACATCGGGACGATCGTCCTCACCCAC
ACGACGCCGTCCGCCGTCTGA

Upstream 100 bases:

>100_bases
TCACCGGCCGATCGGGAGGCCCGGCGCCGTCGCTCTGGGTGACTACCTGCCGGAGGGTGGCGGGCGCGGGAGTGAGCACG
TCAGGGGAGCCGTCAGAGGG

Downstream 100 bases:

>100_bases
ACCCGTCTGGCCGTCTGGCCATCCGCCGTCTGACGGAGTCGGGTGGGCGGCGCTGGATTGTTTGACGGGTATCCAGCGAA
CGGGAACAGGGCCGGGGTGT

Product: 5-oxoprolinase

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 726; Mature: 726

Protein sequence:

>726_residues
MESRVVDHEESSAGRVRPSGKIRLGVDVGGTFTDLVAVDPDGAVRFAKVPSVPADPSDGVLAALTAAGLDGPLVGTFAHG
TTVATNALLERAGARTALVTTRGFRDVIEIGRQNRPSLYDLTLDRPPALVPRELRFTVAERCGPHGVLEPLRAAEVDRVV
EEVAAVPGLDAVAVCLLFSFAHPDHERTVAAALRARLPGVTVVASSEVLPVFREYERFTTAVADAYLTPRLSSYLRALER
RCAARDVTVPMIMQSSGGVTELAEAAGHAARCVLSGPAGGVVGAAYVAGLSGVRDLLTFDMGGTSTDVAPVLDGRALTTS
ESVLAGVPIVLPTVDVHSVSAGGGSIAWVDAGGALRVGPRSAGADPGPACYGRGGTRPTVTDADLCLGYLADGAGLGGEV
TLSRTAAEAALGALGAPLGLSPVEAAAGVVAVADAEMTRALRVVSVERGLDPRELVLVAFGGAGGTHACALAEELGMTRV
LVPLAAGVLSALGLAIGDVRRDYARPLIGRLGEVDLTAAFAGLVASAGLVASAGLAASAGLAGGHDSAGAVVLQHRLDCR
YVGQSHELTIDVAEPGGGGSEAAGGSGAANSSGAAGGWAAGAGGLVDAVRAAFEAEHLRRYGHIAAGREIETVAVRLVVT
VPGPRPRPVAPRPDPTARRGRRRAWTDSAWHEIDVIPRAALGPGDTVTGPAVVEFAEATCLLRRGWTGVVDDIGTIVLTH
TTPSAV

Sequences:

>Translated_726_residues
MESRVVDHEESSAGRVRPSGKIRLGVDVGGTFTDLVAVDPDGAVRFAKVPSVPADPSDGVLAALTAAGLDGPLVGTFAHG
TTVATNALLERAGARTALVTTRGFRDVIEIGRQNRPSLYDLTLDRPPALVPRELRFTVAERCGPHGVLEPLRAAEVDRVV
EEVAAVPGLDAVAVCLLFSFAHPDHERTVAAALRARLPGVTVVASSEVLPVFREYERFTTAVADAYLTPRLSSYLRALER
RCAARDVTVPMIMQSSGGVTELAEAAGHAARCVLSGPAGGVVGAAYVAGLSGVRDLLTFDMGGTSTDVAPVLDGRALTTS
ESVLAGVPIVLPTVDVHSVSAGGGSIAWVDAGGALRVGPRSAGADPGPACYGRGGTRPTVTDADLCLGYLADGAGLGGEV
TLSRTAAEAALGALGAPLGLSPVEAAAGVVAVADAEMTRALRVVSVERGLDPRELVLVAFGGAGGTHACALAEELGMTRV
LVPLAAGVLSALGLAIGDVRRDYARPLIGRLGEVDLTAAFAGLVASAGLVASAGLAASAGLAGGHDSAGAVVLQHRLDCR
YVGQSHELTIDVAEPGGGGSEAAGGSGAANSSGAAGGWAAGAGGLVDAVRAAFEAEHLRRYGHIAAGREIETVAVRLVVT
VPGPRPRPVAPRPDPTARRGRRRAWTDSAWHEIDVIPRAALGPGDTVTGPAVVEFAEATCLLRRGWTGVVDDIGTIVLTH
TTPSAV
>Mature_726_residues
MESRVVDHEESSAGRVRPSGKIRLGVDVGGTFTDLVAVDPDGAVRFAKVPSVPADPSDGVLAALTAAGLDGPLVGTFAHG
TTVATNALLERAGARTALVTTRGFRDVIEIGRQNRPSLYDLTLDRPPALVPRELRFTVAERCGPHGVLEPLRAAEVDRVV
EEVAAVPGLDAVAVCLLFSFAHPDHERTVAAALRARLPGVTVVASSEVLPVFREYERFTTAVADAYLTPRLSSYLRALER
RCAARDVTVPMIMQSSGGVTELAEAAGHAARCVLSGPAGGVVGAAYVAGLSGVRDLLTFDMGGTSTDVAPVLDGRALTTS
ESVLAGVPIVLPTVDVHSVSAGGGSIAWVDAGGALRVGPRSAGADPGPACYGRGGTRPTVTDADLCLGYLADGAGLGGEV
TLSRTAAEAALGALGAPLGLSPVEAAAGVVAVADAEMTRALRVVSVERGLDPRELVLVAFGGAGGTHACALAEELGMTRV
LVPLAAGVLSALGLAIGDVRRDYARPLIGRLGEVDLTAAFAGLVASAGLVASAGLAASAGLAGGHDSAGAVVLQHRLDCR
YVGQSHELTIDVAEPGGGGSEAAGGSGAANSSGAAGGWAAGAGGLVDAVRAAFEAEHLRRYGHIAAGREIETVAVRLVVT
VPGPRPRPVAPRPDPTARRGRRRAWTDSAWHEIDVIPRAALGPGDTVTGPAVVEFAEATCLLRRGWTGVVDDIGTIVLTH
TTPSAV

Specific function: Unknown

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=517, Percent_Identity=40.4255319148936, Blast_Score=250, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI133901900, Length=523, Percent_Identity=32.887189292543, Blast_Score=226, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6322634, Length=609, Percent_Identity=33.4975369458128, Blast_Score=258, Evalue=2e-69,
Organism=Drosophila melanogaster, GI45550492, Length=549, Percent_Identity=38.4335154826958, Blast_Score=272, Evalue=6e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.14

Molecular weight: Translated: 73588; Mature: 73588

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESRVVDHEESSAGRVRPSGKIRLGVDVGGTFTDLVAVDPDGAVRFAKVPSVPADPSDGV
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCEEEEECCCCCCCCCCCH
LAALTAAGLDGPLVGTFAHGTTVATNALLERAGARTALVTTRGFRDVIEIGRQNRPSLYD
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCCCEEE
LTLDRPPALVPRELRFTVAERCGPHGVLEPLRAAEVDRVVEEVAAVPGLDAVAVCLLFSF
EECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AHPDHERTVAAALRARLPGVTVVASSEVLPVFREYERFTTAVADAYLTPRLSSYLRALER
CCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RCAARDVTVPMIMQSSGGVTELAEAAGHAARCVLSGPAGGVVGAAYVAGLSGVRDLLTFD
HHHHCCCCEEEEEECCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
MGGTSTDVAPVLDGRALTTSESVLAGVPIVLPTVDVHSVSAGGGSIAWVDAGGALRVGPR
CCCCCCCCHHHCCCCEEECCCHHHHCCCEEEECCEEEEECCCCCEEEEEECCCEEEECCC
SAGADPGPACYGRGGTRPTVTDADLCLGYLADGAGLGGEVTLSRTAAEAALGALGAPLGL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCCCCC
SPVEAAAGVVAVADAEMTRALRVVSVERGLDPRELVLVAFGGAGGTHACALAEELGMTRV
CHHHHHCCEEEEECHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCHHH
LVPLAAGVLSALGLAIGDVRRDYARPLIGRLGEVDLTAAFAGLVASAGLVASAGLAASAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHCC
LAGGHDSAGAVVLQHRLDCRYVGQSHELTIDVAEPGGGGSEAAGGSGAANSSGAAGGWAA
CCCCCCCCCCEEEEECCCEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
GAGGLVDAVRAAFEAEHLRRYGHIAAGREIETVAVRLVVTVPGPRPRPVAPRPDPTARRG
CCCHHHHHHHHHHHHHHHHHHCCHHCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHC
RRRAWTDSAWHEIDVIPRAALGPGDTVTGPAVVEFAEATCLLRRGWTGVVDDIGTIVLTH
CCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEE
TTPSAV
CCCCCC
>Mature Secondary Structure
MESRVVDHEESSAGRVRPSGKIRLGVDVGGTFTDLVAVDPDGAVRFAKVPSVPADPSDGV
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCEEEEECCCCCCCCCCCH
LAALTAAGLDGPLVGTFAHGTTVATNALLERAGARTALVTTRGFRDVIEIGRQNRPSLYD
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCCCEEE
LTLDRPPALVPRELRFTVAERCGPHGVLEPLRAAEVDRVVEEVAAVPGLDAVAVCLLFSF
EECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AHPDHERTVAAALRARLPGVTVVASSEVLPVFREYERFTTAVADAYLTPRLSSYLRALER
CCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RCAARDVTVPMIMQSSGGVTELAEAAGHAARCVLSGPAGGVVGAAYVAGLSGVRDLLTFD
HHHHCCCCEEEEEECCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
MGGTSTDVAPVLDGRALTTSESVLAGVPIVLPTVDVHSVSAGGGSIAWVDAGGALRVGPR
CCCCCCCCHHHCCCCEEECCCHHHHCCCEEEECCEEEEECCCCCEEEEEECCCEEEECCC
SAGADPGPACYGRGGTRPTVTDADLCLGYLADGAGLGGEVTLSRTAAEAALGALGAPLGL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCCCCC
SPVEAAAGVVAVADAEMTRALRVVSVERGLDPRELVLVAFGGAGGTHACALAEELGMTRV
CHHHHHCCEEEEECHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCHHH
LVPLAAGVLSALGLAIGDVRRDYARPLIGRLGEVDLTAAFAGLVASAGLVASAGLAASAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHCC
LAGGHDSAGAVVLQHRLDCRYVGQSHELTIDVAEPGGGGSEAAGGSGAANSSGAAGGWAA
CCCCCCCCCCEEEEECCCEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
GAGGLVDAVRAAFEAEHLRRYGHIAAGREIETVAVRLVVTVPGPRPRPVAPRPDPTARRG
CCCHHHHHHHHHHHHHHHHHHCCHHCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHC
RRRAWTDSAWHEIDVIPRAALGPGDTVTGPAVVEFAEATCLLRRGWTGVVDDIGTIVLTH
CCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEE
TTPSAV
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]