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The map label for this gene is uvrD [H]

Identifier: 158312789

GI number: 158312789

Start: 1091885

End: 1094164

Strand: Direct

Name: uvrD [H]

Synonym: Franean1_0935

Alternate gene names: 158312789

Gene position: 1091885-1094164 (Clockwise)

Preceding gene: 158312786

Following gene: 158312790

Centisome position: 12.16

GC content: 76.23

Gene sequence:

>2280_bases
ATGTCCGGACCCAGCGCCTCCGAGGCCCATCGCGCGGCGTCGCCGCCCGATCGTCGATCGTCACCCGATCCGGTCCCGGC
CGGCGCGGAGCAGGGGCTCGACCCCGAGCAGCTCGCCGCCGTGCTCGCCCCGGTCGGGCCGGTCTGCATCCTCGCGGGCG
CGGGCACCGGCAAGACCCGCACCATCACCCACCGGATAGCGCACATGGTCACGGAACGGGAGGTCGGGGCGGGGCAGATC
CTCGCCGTCACCTTCACCAACCGGGCCGCCGGCGAGCTGCGCGGCCGGCTGCGGGTGATGGGTGTGGACGGCGTCCAGGC
CCGCACCTTCCACGCGGCCGCGCTGCGTCAGCTCTCCTACTTCTGGCCCTCCGTCGCCGGGACGGCGCTGCCGAGGCTGG
AGAAGAGCCGGATCCCGCTGATGGCGAAGGCCGCGAACCGTGCCCGGCTGCGCCCGGACCGCGCCGAGCTGCGCGACCTC
ACCTCCGAGGTGGAATGGGCGAAGGCGACGATGGTGGCGCCCGCCGACTACGTCCGCCTCGCCGCCGCCCACGGCCGGGA
GACCTCCTTCGCGCCCGACGTCGTCGCCCGCCTCTACGAGGCCTACGAGGAGGTCAAGAGCGAGGCGGGGGTCCTCGACT
TCGACGACCTGCTGCTGCTGACCGCCGCCGTGGTCGAGGAGCACGGCTGGGTCGCCACCGAGCTCCGCGCCCGCTACCGC
CACTTCGTCGTCGACGAGTACCAGGACGTCAACCCGCTGCAGCAGCGCGTGCTCGACGCCTGGCTCGGTGACCGCGACAG
CCTGTGCGTCGTCGGGGACGCAAACCAGACCATCTACTCGTTCACCGGCGCCTCCGCGCGGCACCTGGTGGAGTTCCCGC
GTCGGTTCCCGGCCGCGACGGTCGTCCGCCTCGTCCGGGACTACCGCTCCACCCCTCAGGTGGTCGCGCTGGCGAACCGG
CTGCTCGACGGCGCCGCCCGGCCCGCGCCGGATACGCGGGGAGCATCGGCCGTCCAGGCCGGCCCGGGTGTTCCGGGTGT
TCCGGGCGGTGCGGAGGGGCGGTCCGCGGCGGGGCGGCTGGTCGCGATGCGCCCGTCCGGCCCGGAGCCCGTGTGGCTGG
AGTCCGACAGCGAGCCCGAGGAGGCCGCCGCCGTGGCCCGGCGGATCCGCGGCCTGCTCGGCACGGGCGTCCCGGCGAGC
GAGATCGCCGTGCTGTACCGGATCAACGCCCAGTCGGAGGCGTACGAGACGGCGCTGGGCCGGGCTGAGATCCCCTATCT
TGTGCGCGGCGGTGAGAAGTTCTTCGAGCGGCCCGAGGTGACCGGGGCGGTGCGGATGCTGCGCGCCGCGCTGCGCTCCG
CCGAGACCGACCGCCCCGGTGGGCTCGCCGACGTGGTCGCGGACGTCCTCAGCGCGCTCGGATGGCGGCCGGGGGCGCCG
CCGGCCGGGCCCGGAGCCGACCGTGAGCGCTGGGAGAACCTCGCCGCGTTGCACCGGCTCGCCGCCGACCTCGAGGCGCG
CGAGCCCGAGGCCGACCTCGCCGCCTTCGCCGCCGACCTCGCCGAGCGCGCGGCACACCAGCACACCCCGACGGTGCAGG
GCGTCACGCTCGCCTCGCTGCACGCGGCCAAGGGCCTCGAGTGGGACGCGGTGTTCCTGGTCGGCCTCGTCGACGGGACG
CTGCCCATCGTGCACGCCCAGACCGACGAGCAACTGGCCGAGGAGCGCCGTCTCCTCTATGTCGGGGTCACCCGGGCGCG
GGTGCACCTGACGCTGTCCTGGGCGCTGGCTCGGGCGGAGGGCGCGCGCCGCTCGCGGCGGCCGTCCCGGTTCCTGGACG
AGCCGCGCCGTGCGGCGGCGGCTTTCCGGCGCGGCTCGTCCGCGGCCCGCCCAGGCTCGGCGCGTGCGGAGCCCGGCACC
GCCGGCAACGGCCGCGCACGGAACCGGTCGAGCGTGCTCTGCCGGGTCTGCGGGCGCGCGCTGGCGGGCGCCGAGGCCCG
CGTCGGCCGGTGCGAGGCCTGCCCGGGGGGGCCGGTGGACGGCGAGCTGTTCGAGCGGCTGCGCGCCTGGCGCGCCCGCC
GGGCGAAGGAGCAGGGCGCGCCGGCCTTCGTGGTCCTCACCGACGCGACGCTGCGCCTGATCGCGGAACGGCGCCCGTCC
ACGGTCGCCGAGCTGGTGGCGCTGCCCGGCATCGGCCAGAGCAAGCTCGACCGCTACGGCGAGGACGTCCTCGCGCTGGT
CACGGGGCGTCCACCGGCTGGATCGCCGTCCACGGGCTGA

Upstream 100 bases:

>100_bases
GAGCGACGTCCGGTGGGCGGCGCTCTGCGCATGACGCACTGCATAACCAGGCCATGGTGACTTCGCTTCCCCGGGCCGCG
CACGGTTACCGTGTCCGGTG

Downstream 100 bases:

>100_bases
CGTCTGGTGCTCGGAATGTGACACGCCGGTGGTGGGCGAGTCGCGCTGTTGCAGAGGGTGTTTGTATGATCACATGGAAA
ATAAGTTGTCAGCGTGGGCG

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 759; Mature: 758

Protein sequence:

>759_residues
MSGPSASEAHRAASPPDRRSSPDPVPAGAEQGLDPEQLAAVLAPVGPVCILAGAGTGKTRTITHRIAHMVTEREVGAGQI
LAVTFTNRAAGELRGRLRVMGVDGVQARTFHAAALRQLSYFWPSVAGTALPRLEKSRIPLMAKAANRARLRPDRAELRDL
TSEVEWAKATMVAPADYVRLAAAHGRETSFAPDVVARLYEAYEEVKSEAGVLDFDDLLLLTAAVVEEHGWVATELRARYR
HFVVDEYQDVNPLQQRVLDAWLGDRDSLCVVGDANQTIYSFTGASARHLVEFPRRFPAATVVRLVRDYRSTPQVVALANR
LLDGAARPAPDTRGASAVQAGPGVPGVPGGAEGRSAAGRLVAMRPSGPEPVWLESDSEPEEAAAVARRIRGLLGTGVPAS
EIAVLYRINAQSEAYETALGRAEIPYLVRGGEKFFERPEVTGAVRMLRAALRSAETDRPGGLADVVADVLSALGWRPGAP
PAGPGADRERWENLAALHRLAADLEAREPEADLAAFAADLAERAAHQHTPTVQGVTLASLHAAKGLEWDAVFLVGLVDGT
LPIVHAQTDEQLAEERRLLYVGVTRARVHLTLSWALARAEGARRSRRPSRFLDEPRRAAAAFRRGSSAARPGSARAEPGT
AGNGRARNRSSVLCRVCGRALAGAEARVGRCEACPGGPVDGELFERLRAWRARRAKEQGAPAFVVLTDATLRLIAERRPS
TVAELVALPGIGQSKLDRYGEDVLALVTGRPPAGSPSTG

Sequences:

>Translated_759_residues
MSGPSASEAHRAASPPDRRSSPDPVPAGAEQGLDPEQLAAVLAPVGPVCILAGAGTGKTRTITHRIAHMVTEREVGAGQI
LAVTFTNRAAGELRGRLRVMGVDGVQARTFHAAALRQLSYFWPSVAGTALPRLEKSRIPLMAKAANRARLRPDRAELRDL
TSEVEWAKATMVAPADYVRLAAAHGRETSFAPDVVARLYEAYEEVKSEAGVLDFDDLLLLTAAVVEEHGWVATELRARYR
HFVVDEYQDVNPLQQRVLDAWLGDRDSLCVVGDANQTIYSFTGASARHLVEFPRRFPAATVVRLVRDYRSTPQVVALANR
LLDGAARPAPDTRGASAVQAGPGVPGVPGGAEGRSAAGRLVAMRPSGPEPVWLESDSEPEEAAAVARRIRGLLGTGVPAS
EIAVLYRINAQSEAYETALGRAEIPYLVRGGEKFFERPEVTGAVRMLRAALRSAETDRPGGLADVVADVLSALGWRPGAP
PAGPGADRERWENLAALHRLAADLEAREPEADLAAFAADLAERAAHQHTPTVQGVTLASLHAAKGLEWDAVFLVGLVDGT
LPIVHAQTDEQLAEERRLLYVGVTRARVHLTLSWALARAEGARRSRRPSRFLDEPRRAAAAFRRGSSAARPGSARAEPGT
AGNGRARNRSSVLCRVCGRALAGAEARVGRCEACPGGPVDGELFERLRAWRARRAKEQGAPAFVVLTDATLRLIAERRPS
TVAELVALPGIGQSKLDRYGEDVLALVTGRPPAGSPSTG
>Mature_758_residues
SGPSASEAHRAASPPDRRSSPDPVPAGAEQGLDPEQLAAVLAPVGPVCILAGAGTGKTRTITHRIAHMVTEREVGAGQIL
AVTFTNRAAGELRGRLRVMGVDGVQARTFHAAALRQLSYFWPSVAGTALPRLEKSRIPLMAKAANRARLRPDRAELRDLT
SEVEWAKATMVAPADYVRLAAAHGRETSFAPDVVARLYEAYEEVKSEAGVLDFDDLLLLTAAVVEEHGWVATELRARYRH
FVVDEYQDVNPLQQRVLDAWLGDRDSLCVVGDANQTIYSFTGASARHLVEFPRRFPAATVVRLVRDYRSTPQVVALANRL
LDGAARPAPDTRGASAVQAGPGVPGVPGGAEGRSAAGRLVAMRPSGPEPVWLESDSEPEEAAAVARRIRGLLGTGVPASE
IAVLYRINAQSEAYETALGRAEIPYLVRGGEKFFERPEVTGAVRMLRAALRSAETDRPGGLADVVADVLSALGWRPGAPP
AGPGADRERWENLAALHRLAADLEAREPEADLAAFAADLAERAAHQHTPTVQGVTLASLHAAKGLEWDAVFLVGLVDGTL
PIVHAQTDEQLAEERRLLYVGVTRARVHLTLSWALARAEGARRSRRPSRFLDEPRRAAAAFRRGSSAARPGSARAEPGTA
GNGRARNRSSVLCRVCGRALAGAEARVGRCEACPGGPVDGELFERLRAWRARRAKEQGAPAFVVLTDATLRLIAERRPST
VAELVALPGIGQSKLDRYGEDVLALVTGRPPAGSPSTG

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=424, Percent_Identity=31.1320754716981, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI48994965, Length=423, Percent_Identity=31.2056737588652, Blast_Score=166, Evalue=7e-42,
Organism=Escherichia coli, GI1787196, Length=339, Percent_Identity=25.9587020648968, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1789183, Length=285, Percent_Identity=27.719298245614, Blast_Score=63, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322369, Length=527, Percent_Identity=23.9089184060721, Blast_Score=117, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324477, Length=412, Percent_Identity=23.0582524271845, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR002121
- InterPro:   IPR014016
- InterPro:   IPR010997 [H]

Pfam domain/function: PF00570 HRDC; PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 81059; Mature: 80927

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPSASEAHRAASPPDRRSSPDPVPAGAEQGLDPEQLAAVLAPVGPVCILAGAGTGKTR
CCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCH
TITHRIAHMVTEREVGAGQILAVTFTNRAAGELRGRLRVMGVDGVQARTFHAAALRQLSY
HHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHH
FWPSVAGTALPRLEKSRIPLMAKAANRARLRPDRAELRDLTSEVEWAKATMVAPADYVRL
HHHHHHHHHHCCHHHHCCCHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
AAAHGRETSFAPDVVARLYEAYEEVKSEAGVLDFDDLLLLTAAVVEEHGWVATELRARYR
HHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
HFVVDEYQDVNPLQQRVLDAWLGDRDSLCVVGDANQTIYSFTGASARHLVEFPRRFPAAT
HHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHCCHHH
VVRLVRDYRSTPQVVALANRLLDGAARPAPDTRGASAVQAGPGVPGVPGGAEGRSAAGRL
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
VAMRPSGPEPVWLESDSEPEEAAAVARRIRGLLGTGVPASEIAVLYRINAQSEAYETALG
EEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCCHHHHHHHCC
RAEIPYLVRGGEKFFERPEVTGAVRMLRAALRSAETDRPGGLADVVADVLSALGWRPGAP
CCCCCCEEECCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCC
PAGPGADRERWENLAALHRLAADLEAREPEADLAAFAADLAERAAHQHTPTVQGVTLASL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HAAKGLEWDAVFLVGLVDGTLPIVHAQTDEQLAEERRLLYVGVTRARVHLTLSWALARAE
HHHCCCCCHHEEEEEECCCCEEEEECCCHHHHHHCCCEEEEEEEEEEEEEEEHHHHHHHH
GARRSRRPSRFLDEPRRAAAAFRRGSSAARPGSARAEPGTAGNGRARNRSSVLCRVCGRA
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LAGAEARVGRCEACPGGPVDGELFERLRAWRARRAKEQGAPAFVVLTDATLRLIAERRPS
HCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHCCCH
TVAELVALPGIGQSKLDRYGEDVLALVTGRPPAGSPSTG
HHHHHHHCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SGPSASEAHRAASPPDRRSSPDPVPAGAEQGLDPEQLAAVLAPVGPVCILAGAGTGKTR
CCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCH
TITHRIAHMVTEREVGAGQILAVTFTNRAAGELRGRLRVMGVDGVQARTFHAAALRQLSY
HHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHH
FWPSVAGTALPRLEKSRIPLMAKAANRARLRPDRAELRDLTSEVEWAKATMVAPADYVRL
HHHHHHHHHHCCHHHHCCCHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
AAAHGRETSFAPDVVARLYEAYEEVKSEAGVLDFDDLLLLTAAVVEEHGWVATELRARYR
HHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
HFVVDEYQDVNPLQQRVLDAWLGDRDSLCVVGDANQTIYSFTGASARHLVEFPRRFPAAT
HHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHCCHHH
VVRLVRDYRSTPQVVALANRLLDGAARPAPDTRGASAVQAGPGVPGVPGGAEGRSAAGRL
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
VAMRPSGPEPVWLESDSEPEEAAAVARRIRGLLGTGVPASEIAVLYRINAQSEAYETALG
EEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCCHHHHHHHCC
RAEIPYLVRGGEKFFERPEVTGAVRMLRAALRSAETDRPGGLADVVADVLSALGWRPGAP
CCCCCCEEECCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCC
PAGPGADRERWENLAALHRLAADLEAREPEADLAAFAADLAERAAHQHTPTVQGVTLASL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HAAKGLEWDAVFLVGLVDGTLPIVHAQTDEQLAEERRLLYVGVTRARVHLTLSWALARAE
HHHCCCCCHHEEEEEECCCCEEEEECCCHHHHHHCCCEEEEEEEEEEEEEEEHHHHHHHH
GARRSRRPSRFLDEPRRAAAAFRRGSSAARPGSARAEPGTAGNGRARNRSSVLCRVCGRA
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LAGAEARVGRCEACPGGPVDGELFERLRAWRARRAKEQGAPAFVVLTDATLRLIAERRPS
HCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHCCCH
TVAELVALPGIGQSKLDRYGEDVLALVTGRPPAGSPSTG
HHHHHHHCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]