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The map label for this gene is lysA [H]

Identifier: 158312520

GI number: 158312520

Start: 778608

End: 779969

Strand: Direct

Name: lysA [H]

Synonym: Franean1_0663

Alternate gene names: 158312520

Gene position: 778608-779969 (Clockwise)

Preceding gene: 158312513

Following gene: 158312523

Centisome position: 8.67

GC content: 76.14

Gene sequence:

>1362_bases
GTGCTGGATCTCCCCATCTCCGCCGCGCCGCTGCGCGCGCTCGGCCCGGATCGGCTGCCGGCGGCGGTGCTCGCGTGCCT
GCGGGAGTGGCCCGCGCGGCGCGGAGAGATCGGCGGCTACCTCTACTCGCCGGCGGTGGCCGCGGCACGGGCCGCCGAGC
TGCGCCGACACCTGCCCGACTGGGCGGAGCTGCTCTTCGCGGTCAAGGCGAACGCCTTCCCCCCGATCCTCGACGCCCTG
CTCGCCGGAACCGCGAGCACCGACGCCGGGACCGCCGCGGGTGCCGGGGCCGGCATCGATGGGTTCGAGGTCTCGTCGGC
GCACGAGCTCGTCCTGGCCGCCGCGGCCGTGGAGCGCGCCCGGCAGCGGGGCGCGGTGCGGGCGGCCGGGCAACACCCGT
CCGGCGGGGCGCGGCTGGTGGCGTCCGGGCCGGGCAAGTCGGTGAGCCTGCTGCGTGCGCTCCTTGGCGCGGTGCCGGTG
GAGGGCGCGGTGCCGGCGGTCGACGTCGTCAACGCCGAGAGCCCGCTGGAGCTGCGGCGGATCGACGCCGTGGCGGCGGA
GACGGGGCGGCGGGCCGCCGTCGCGCTGCGGGTGAACCCGGCCCGCGTCGGCCTCTCCGGCTCGCTGCGGATGGGCGGGC
GCCCGACCGCTTTCGGAATCCAGGAGCGGGACGTGCCCGCGGCGGTCGAGCTGGCCCGCTCGCTGCCGTGGATCGACCTG
GTCGGCTTCCACGTCCACGCGGTGTCGGGGAACCTCGATGCCACCGCCCACCTGGACTATGTGCGGTGGTGCCTGGACTT
CGCCGTCCGTCAGGCCCGCCTGGGCGATGTCGACCTGCGGGTGGTGGATGTAGGCGGCGGCCTCGGGGTGCCCTTCGAGC
CCGACCGGCTCGGCGAGCGCCCCTTCGACCTGGACGTCTTCGGCGCCGGCCTGGACCAGTTGCGCCCCCCGACCGGGGTC
CGGGTGGTCTTCGAGCCCGGCCGGGCCCTGGTGGCCGACTGCGGCTGGTACGCGGCCGAGGTGACCGACGTCAAGCTGGT
CCACGGCGGTGCCTTCGCGGTCCTGCGCGGCGGCATCCACCACTTCCAGCTGCCGACGTCCTGGGAGATCGTCCACAACT
TCGCCGTCGTCCCGCGGGACGACTGGCTGCCCGGCTGGCCCCGGCCGGAGGTGGCTGCGGGCCCGGTGACCGTGGTGGGG
GAGCTGTGCACCCCCGAGGACACCCTCGCCCGCGACGTGACCGTCGACCGGCTGCGCGCCGGGGATGTCGTCGTCTTCCC
GATGGCCGGCGCCTACGGCTACGAGTTCGCGATGCACGAGTTCCTCGGCCACCCGCGCGCCCACCGCGTCGTCGTGGACT
AG

Upstream 100 bases:

>100_bases
CCCGTCATCGTCACATGTCGGGACGTCGGACGTCGCGCGGGAACCGGGCCGAGCGGGTGCGGTCCTGGTCACGGGCGCAC
GGGCGCCGGAAGGGTGCGCC

Downstream 100 bases:

>100_bases
CCGGGCACGGGAACGGGACTCAACTCCGGGGTCCCCAGTCGGCGCGGTACCTAGGGCGTCCGGATGACCGGGAGGTCGAA
CCAGAGGTACTTGCCGGACT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MLDLPISAAPLRALGPDRLPAAVLACLREWPARRGEIGGYLYSPAVAAARAAELRRHLPDWAELLFAVKANAFPPILDAL
LAGTASTDAGTAAGAGAGIDGFEVSSAHELVLAAAAVERARQRGAVRAAGQHPSGGARLVASGPGKSVSLLRALLGAVPV
EGAVPAVDVVNAESPLELRRIDAVAAETGRRAAVALRVNPARVGLSGSLRMGGRPTAFGIQERDVPAAVELARSLPWIDL
VGFHVHAVSGNLDATAHLDYVRWCLDFAVRQARLGDVDLRVVDVGGGLGVPFEPDRLGERPFDLDVFGAGLDQLRPPTGV
RVVFEPGRALVADCGWYAAEVTDVKLVHGGAFAVLRGGIHHFQLPTSWEIVHNFAVVPRDDWLPGWPRPEVAAGPVTVVG
ELCTPEDTLARDVTVDRLRAGDVVVFPMAGAYGYEFAMHEFLGHPRAHRVVVD

Sequences:

>Translated_453_residues
MLDLPISAAPLRALGPDRLPAAVLACLREWPARRGEIGGYLYSPAVAAARAAELRRHLPDWAELLFAVKANAFPPILDAL
LAGTASTDAGTAAGAGAGIDGFEVSSAHELVLAAAAVERARQRGAVRAAGQHPSGGARLVASGPGKSVSLLRALLGAVPV
EGAVPAVDVVNAESPLELRRIDAVAAETGRRAAVALRVNPARVGLSGSLRMGGRPTAFGIQERDVPAAVELARSLPWIDL
VGFHVHAVSGNLDATAHLDYVRWCLDFAVRQARLGDVDLRVVDVGGGLGVPFEPDRLGERPFDLDVFGAGLDQLRPPTGV
RVVFEPGRALVADCGWYAAEVTDVKLVHGGAFAVLRGGIHHFQLPTSWEIVHNFAVVPRDDWLPGWPRPEVAAGPVTVVG
ELCTPEDTLARDVTVDRLRAGDVVVFPMAGAYGYEFAMHEFLGHPRAHRVVVD
>Mature_453_residues
MLDLPISAAPLRALGPDRLPAAVLACLREWPARRGEIGGYLYSPAVAAARAAELRRHLPDWAELLFAVKANAFPPILDAL
LAGTASTDAGTAAGAGAGIDGFEVSSAHELVLAAAAVERARQRGAVRAAGQHPSGGARLVASGPGKSVSLLRALLGAVPV
EGAVPAVDVVNAESPLELRRIDAVAAETGRRAAVALRVNPARVGLSGSLRMGGRPTAFGIQERDVPAAVELARSLPWIDL
VGFHVHAVSGNLDATAHLDYVRWCLDFAVRQARLGDVDLRVVDVGGGLGVPFEPDRLGERPFDLDVFGAGLDQLRPPTGV
RVVFEPGRALVADCGWYAAEVTDVKLVHGGAFAVLRGGIHHFQLPTSWEIVHNFAVVPRDDWLPGWPRPEVAAGPVTVVG
ELCTPEDTLARDVTVDRLRAGDVVVFPMAGAYGYEFAMHEFLGHPRAHRVVVD

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=250, Percent_Identity=31.6, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47765; Mature: 47765

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLPISAAPLRALGPDRLPAAVLACLREWPARRGEIGGYLYSPAVAAARAAELRRHLPD
CCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHHCCH
WAELLFAVKANAFPPILDALLAGTASTDAGTAAGAGAGIDGFEVSSAHELVLAAAAVERA
HHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RQRGAVRAAGQHPSGGARLVASGPGKSVSLLRALLGAVPVEGAVPAVDVVNAESPLELRR
HHCCCEEECCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHH
IDAVAAETGRRAAVALRVNPARVGLSGSLRMGGRPTAFGIQERDVPAAVELARSLPWIDL
HHHHHHCCCCEEEEEEEECHHEECCCCCEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEE
VGFHVHAVSGNLDATAHLDYVRWCLDFAVRQARLGDVDLRVVDVGGGLGVPFEPDRLGER
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHCCCC
PFDLDVFGAGLDQLRPPTGVRVVFEPGRALVADCGWYAAEVTDVKLVHGGAFAVLRGGIH
CCCEEEECCCHHHCCCCCCEEEEECCCCEEEECCCCEEEEEEEEEEEECCEEEEHHCCCE
HFQLPTSWEIVHNFAVVPRDDWLPGWPRPEVAAGPVTVVGELCTPEDTLARDVTVDRLRA
EEECCCCHHHHHCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCHHHHCC
GDVVVFPMAGAYGYEFAMHEFLGHPRAHRVVVD
CCEEEEECCCCCHHHHHHHHHHCCCCCCEEECC
>Mature Secondary Structure
MLDLPISAAPLRALGPDRLPAAVLACLREWPARRGEIGGYLYSPAVAAARAAELRRHLPD
CCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHHCCH
WAELLFAVKANAFPPILDALLAGTASTDAGTAAGAGAGIDGFEVSSAHELVLAAAAVERA
HHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RQRGAVRAAGQHPSGGARLVASGPGKSVSLLRALLGAVPVEGAVPAVDVVNAESPLELRR
HHCCCEEECCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHH
IDAVAAETGRRAAVALRVNPARVGLSGSLRMGGRPTAFGIQERDVPAAVELARSLPWIDL
HHHHHHCCCCEEEEEEEECHHEECCCCCEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEE
VGFHVHAVSGNLDATAHLDYVRWCLDFAVRQARLGDVDLRVVDVGGGLGVPFEPDRLGER
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHCCCC
PFDLDVFGAGLDQLRPPTGVRVVFEPGRALVADCGWYAAEVTDVKLVHGGAFAVLRGGIH
CCCEEEECCCHHHCCCCCCEEEEECCCCEEEECCCCEEEEEEEEEEEECCEEEEHHCCCE
HFQLPTSWEIVHNFAVVPRDDWLPGWPRPEVAAGPVTVVGELCTPEDTLARDVTVDRLRA
EEECCCCHHHHHCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCHHHHCC
GDVVVFPMAGAYGYEFAMHEFLGHPRAHRVVVD
CCEEEEECCCCCHHHHHHHHHHCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]