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The map label for this gene is bioI [H]

Identifier: 158312479

GI number: 158312479

Start: 722500

End: 723747

Strand: Direct

Name: bioI [H]

Synonym: Franean1_0622

Alternate gene names: 158312479

Gene position: 722500-723747 (Clockwise)

Preceding gene: 158312478

Following gene: 158312480

Centisome position: 8.04

GC content: 71.31

Gene sequence:

>1248_bases
ATGAGCACCACCGCCACCCTCGACCGCGAACGGGTCCGGCAGCTGTTCGACCTGCGCAGCAGCTACAACGTGCACATGGG
CGGCGGCTACCGGCAGGACCCGTACCCGGTCTGGCACCGGCTGCGCGAGCAGGCCCCGGTGCACCCGGGGATCGTCCACG
AGCTGACCGGCTTCGACGGCCCGGCGATGTTCTCCGGTCTGCCGTACCCCGACCGCCCGCACTTCTCGGCCTTCAGCTAC
GCCGCGTGCGACGCCGCCTACCGCGATCCCGAGGTGTTCGCGTCGGCGGCCGGGCCGGTGGATCCCAACAACGGCCCGTA
CGGCGCGACGAACAGCATGCTGTCGATGGGCGGGAGGCAGCACCGCCGGTACCGCGGGCTCGTACAGCCCTCGTTCGTGC
CGGGCAAGGCGAAATGGTGGATCAGCAACTGGATCGAGGAGACCGTCGACCTGCTCATCGACGGGTTCGTCGACGCGGGG
CGGGCCGAGCTGAACGTGGACTTCTGCGCGGCCATCCCGGTGCTCACGATCACCAGCAGCTTCGGCGTGCCCGTCGACCG
GGCGCTCGACATCCGTGCCGCGCTGACCAGGCCCGACGAGATCGTGCGGATGCTCGAGCCGATCGTCGCCGCCCGGCGTG
CGGACCCGCAGGACGACCTGATCAGCATCCTCGTGCAGGCCGAGATGACCGACGAGAACGGGGTCACCCACCGGCTCACC
GACGCCGAGATCTACTCCTTCTCGGTGCTGCTGCTGACCGCCGGCTCCGGCACCACCTGGAAGCAGATGGGCATCACGCT
CACCGCGCTGCTGCAGCACCCCGAGGCGCTGGCCGCGGTACGCGCCGACCGCTCGCTGCTCCGGCTGGCGATCGAGGAGT
CGCTGCGGTGGTCACCCACCGACCCGATGTTCTCCCGCTGGGTGACCGAGGACGTCGACTTCTTCGGCGTGCACATGCCG
GCCGGGTCGGTGCTGCACCTGTGCATCGGCGCGGCCAACCGCGACCCGGCCCGCTGGGACCGCCCGGACGAGTACGACAT
CACCCGCGCCCTGCGGCCGTCCTTCGCCTTCGGCGGGGGCGCCCACGTCTGCCTGGGCATGCACGTGGCCCGCGCCGAGA
TGCGGGTCGGGATCGGGGCGCTGCTCGACCGGCTCCCCGACCTGCGCCTCGACCCCGACCGCGAGGCACCCCGCTTCATC
GGCATGTACGAGCGAGGCGCGACCGAGATCCCCGTCGTCTTCGGGTGA

Upstream 100 bases:

>100_bases
GACTGCGCCGAGGCCGCCGTCTACCTGGTCTCCGACCGCGCGCTCAACATCACCGGTGTGCTGCTGCCGGTCGACGGCGG
ATACGTGGCGAGGTGACCCG

Downstream 100 bases:

>100_bases
CCCCGAGACCTCGGGGGTGAGGAGACATCCCATGAGCGAGACCGGCTACACCGCCCCGGACCTGAGTCTGCGCGGGGCCG
AGCACATCGCGCGTTACCGG

Product: cytochrome P450

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSTTATLDRERVRQLFDLRSSYNVHMGGGYRQDPYPVWHRLREQAPVHPGIVHELTGFDGPAMFSGLPYPDRPHFSAFSY
AACDAAYRDPEVFASAAGPVDPNNGPYGATNSMLSMGGRQHRRYRGLVQPSFVPGKAKWWISNWIEETVDLLIDGFVDAG
RAELNVDFCAAIPVLTITSSFGVPVDRALDIRAALTRPDEIVRMLEPIVAARRADPQDDLISILVQAEMTDENGVTHRLT
DAEIYSFSVLLLTAGSGTTWKQMGITLTALLQHPEALAAVRADRSLLRLAIEESLRWSPTDPMFSRWVTEDVDFFGVHMP
AGSVLHLCIGAANRDPARWDRPDEYDITRALRPSFAFGGGAHVCLGMHVARAEMRVGIGALLDRLPDLRLDPDREAPRFI
GMYERGATEIPVVFG

Sequences:

>Translated_415_residues
MSTTATLDRERVRQLFDLRSSYNVHMGGGYRQDPYPVWHRLREQAPVHPGIVHELTGFDGPAMFSGLPYPDRPHFSAFSY
AACDAAYRDPEVFASAAGPVDPNNGPYGATNSMLSMGGRQHRRYRGLVQPSFVPGKAKWWISNWIEETVDLLIDGFVDAG
RAELNVDFCAAIPVLTITSSFGVPVDRALDIRAALTRPDEIVRMLEPIVAARRADPQDDLISILVQAEMTDENGVTHRLT
DAEIYSFSVLLLTAGSGTTWKQMGITLTALLQHPEALAAVRADRSLLRLAIEESLRWSPTDPMFSRWVTEDVDFFGVHMP
AGSVLHLCIGAANRDPARWDRPDEYDITRALRPSFAFGGGAHVCLGMHVARAEMRVGIGALLDRLPDLRLDPDREAPRFI
GMYERGATEIPVVFG
>Mature_414_residues
STTATLDRERVRQLFDLRSSYNVHMGGGYRQDPYPVWHRLREQAPVHPGIVHELTGFDGPAMFSGLPYPDRPHFSAFSYA
ACDAAYRDPEVFASAAGPVDPNNGPYGATNSMLSMGGRQHRRYRGLVQPSFVPGKAKWWISNWIEETVDLLIDGFVDAGR
AELNVDFCAAIPVLTITSSFGVPVDRALDIRAALTRPDEIVRMLEPIVAARRADPQDDLISILVQAEMTDENGVTHRLTD
AEIYSFSVLLLTAGSGTTWKQMGITLTALLQHPEALAAVRADRSLLRLAIEESLRWSPTDPMFSRWVTEDVDFFGVHMPA
GSVLHLCIGAANRDPARWDRPDEYDITRALRPSFAFGGGAHVCLGMHVARAEMRVGIGALLDRLPDLRLDPDREAPRFIG
MYERGATEIPVVFG

Specific function: Catalyzes the C-C bond cleavage of fatty acid linked to acyl carrier protein (ACP) to generate pimelic acid for biotin biosynthesis. It has high affinity for long-chain fatty acids with the greatest affinity for myristic acid [H]

COG id: COG2124

COG function: function code Q; Cytochrome P450

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family [H]

Homologues:

Organism=Homo sapiens, GI4503231, Length=276, Percent_Identity=23.5507246376812, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI310125130, Length=225, Percent_Identity=28.4444444444444, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI190570174, Length=225, Percent_Identity=28.4444444444444, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI310125128, Length=225, Percent_Identity=28.4444444444444, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI14550409, Length=225, Percent_Identity=28.4444444444444, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001128
- InterPro:   IPR002397
- InterPro:   IPR017972 [H]

Pfam domain/function: PF00067 p450 [H]

EC number: NA

Molecular weight: Translated: 45970; Mature: 45839

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00086 CYTOCHROME_P450

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTATLDRERVRQLFDLRSSYNVHMGGGYRQDPYPVWHRLREQAPVHPGIVHELTGFDG
CCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHCCCCC
PAMFSGLPYPDRPHFSAFSYAACDAAYRDPEVFASAAGPVDPNNGPYGATNSMLSMGGRQ
HHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHH
HRRYRGLVQPSFVPGKAKWWISNWIEETVDLLIDGFVDAGRAELNVDFCAAIPVLTITSS
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHEECC
FGVPVDRALDIRAALTRPDEIVRMLEPIVAARRADPQDDLISILVQAEMTDENGVTHRLT
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEC
DAEIYSFSVLLLTAGSGTTWKQMGITLTALLQHPEALAAVRADRSLLRLAIEESLRWSPT
CCHHEEEEEEEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCC
DPMFSRWVTEDVDFFGVHMPAGSVLHLCIGAANRDPARWDRPDEYDITRALRPSFAFGGG
CHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
AHVCLGMHVARAEMRVGIGALLDRLPDLRLDPDREAPRFIGMYERGATEIPVVFG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEC
>Mature Secondary Structure 
STTATLDRERVRQLFDLRSSYNVHMGGGYRQDPYPVWHRLREQAPVHPGIVHELTGFDG
CCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHCCCCC
PAMFSGLPYPDRPHFSAFSYAACDAAYRDPEVFASAAGPVDPNNGPYGATNSMLSMGGRQ
HHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHH
HRRYRGLVQPSFVPGKAKWWISNWIEETVDLLIDGFVDAGRAELNVDFCAAIPVLTITSS
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHEECC
FGVPVDRALDIRAALTRPDEIVRMLEPIVAARRADPQDDLISILVQAEMTDENGVTHRLT
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEC
DAEIYSFSVLLLTAGSGTTWKQMGITLTALLQHPEALAAVRADRSLLRLAIEESLRWSPT
CCHHEEEEEEEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCC
DPMFSRWVTEDVDFFGVHMPAGSVLHLCIGAANRDPARWDRPDEYDITRALRPSFAFGGG
CHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
AHVCLGMHVARAEMRVGIGALLDRLPDLRLDPDREAPRFIGMYERGATEIPVVFG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8763940; 9387221; 9384377 [H]