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The map label for this gene is glmU

Identifier: 157964048

GI number: 157964048

Start: 5151269

End: 5152633

Strand: Reverse

Name: glmU

Synonym: Spea_4237

Alternate gene names: 157964048

Gene position: 5152633-5151269 (Counterclockwise)

Preceding gene: 157964049

Following gene: 157964047

Centisome position: 99.58

GC content: 47.47

Gene sequence:

>1365_bases
ATGGCACTGAATGTAGTGATTTTGGCCGCAGGCAAGGGAACCCGCATGCGCTCAGATCTTCCAAAAGTTCTTCACCCAAT
TGCACACAAGAGCATGGTTCAGCATGTAATCGATACTGCGTATCAAGTCGGTAGCGATGCTATTCAGCTGGTTTACGGCT
ATGGCGCCGATAAGTTGCAAGCAAGATTGGGTGAGCAGCAACTAAACTGGGTGCTACAAGCCGAGCAATTGGGCACGGGC
CATGCGGTAGCGCAGGCGAGTGCAAATATCGCTGATGATGATACTGTACTGATCCTTTATGGCGATGTACCGCTTATCCA
AGCATCTACGCTTGAAGCTTTACTTGCTGCTAGAGAAGAGAATGGTTTAGCTATCTTAACCGTTAACTTACCAAATCCGA
CGGGTTATGGGCGCATAGTTAGAGAAGGTGGAAGTGTAGTTGGCATTATTGAGCAAAAAGATGCCAATACTGAGCAGCTT
GCTATTAATGAGATCAACACTGGCATAATGGCTGCACCGGGTAAGCAACTTAAAGCTTGGCTTGGTCAGTTGTCATCTGA
TAACGCCCAAGGTGAATACTACCTTACCGATATCGTGGCTATGGCGCACAGAGATGGCGTGGCTATTACCACTGCCCAGC
CTGAGTCCGCGGTAGAAGTTGAAGGCGCGAATAACCGCGTGCAGCTGGCTCAGTTAGAGCGTGCTTACCAGGCTCGCGCA
GCTGAAAAGCTAATGCTTGAAGGGGCTAATCTGCGTGATCCTGCTCGCATCGATATTCGTGGTGATGTTACTGTGGGTAT
GGACGTGATGATCGACGTTAACGTGGTTATCGAAGGCAAGGTGACTATTGGTAATAACGTGACTATTGGCGCGGGTGTGA
TCCTTATCGATTGCGATATTAGCGACAATGCCGTAATCAAACCTTACTCTATTATCGAGAGTGCCAAAGTCGGTGTCGAT
GCCAGTGCAGGACCTTTTGCACGTTTACGTCCAGGTGCCGAGCTTAAAGAAGATGCCCACATTGGTAACTTCGTAGAGAT
GAAAAAAGCGGTATTAGGTAAAGGCTCTAAAGCGGGTCACTTAGCCTATATTGGCGATGCGACAATTGGTAGCGGTGTAA
ACATAGGTGCAGGCACCATTACTTGTAACTATGACGGTGCTAACAAGTTCCAAACCATTATCGAAGACAATGTGTTTGTT
GGTAGTGATACTCAGCTAGTTGCCCCTGTGACTATTGGAAAAGGTGCGACGTTAGGAGCGGGTTCGACTATCACTAAAGA
TGTGGCGGAAAACGAGTTAGTGATTACTCGTGTTAAACAACGTCATTTAACAGGTTGGCCACGACCAGTTAAGCTGAAAA
AATAA

Upstream 100 bases:

>100_bases
AGTCGAGTCGCTTTTAATACCCGTATCGCTTAAAATCAAAACTCAAATATAGCTCTCATTTTTCTAATATTAGATAAAGC
ACTAGCTCAAGGATATATCC

Downstream 100 bases:

>100_bases
GCGTGATTTTGATTTTAAAGGCGACCAATTGGTCGCCTTTTTTGTTTTAAATTTAAGCAGTAAAGTAAGGGTATATTGAT
AATTACACTGCGAAAATTCT

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MALNVVILAAGKGTRMRSDLPKVLHPIAHKSMVQHVIDTAYQVGSDAIQLVYGYGADKLQARLGEQQLNWVLQAEQLGTG
HAVAQASANIADDDTVLILYGDVPLIQASTLEALLAAREENGLAILTVNLPNPTGYGRIVREGGSVVGIIEQKDANTEQL
AINEINTGIMAAPGKQLKAWLGQLSSDNAQGEYYLTDIVAMAHRDGVAITTAQPESAVEVEGANNRVQLAQLERAYQARA
AEKLMLEGANLRDPARIDIRGDVTVGMDVMIDVNVVIEGKVTIGNNVTIGAGVILIDCDISDNAVIKPYSIIESAKVGVD
ASAGPFARLRPGAELKEDAHIGNFVEMKKAVLGKGSKAGHLAYIGDATIGSGVNIGAGTITCNYDGANKFQTIIEDNVFV
GSDTQLVAPVTIGKGATLGAGSTITKDVAENELVITRVKQRHLTGWPRPVKLKK

Sequences:

>Translated_454_residues
MALNVVILAAGKGTRMRSDLPKVLHPIAHKSMVQHVIDTAYQVGSDAIQLVYGYGADKLQARLGEQQLNWVLQAEQLGTG
HAVAQASANIADDDTVLILYGDVPLIQASTLEALLAAREENGLAILTVNLPNPTGYGRIVREGGSVVGIIEQKDANTEQL
AINEINTGIMAAPGKQLKAWLGQLSSDNAQGEYYLTDIVAMAHRDGVAITTAQPESAVEVEGANNRVQLAQLERAYQARA
AEKLMLEGANLRDPARIDIRGDVTVGMDVMIDVNVVIEGKVTIGNNVTIGAGVILIDCDISDNAVIKPYSIIESAKVGVD
ASAGPFARLRPGAELKEDAHIGNFVEMKKAVLGKGSKAGHLAYIGDATIGSGVNIGAGTITCNYDGANKFQTIIEDNVFV
GSDTQLVAPVTIGKGATLGAGSTITKDVAENELVITRVKQRHLTGWPRPVKLKK
>Mature_453_residues
ALNVVILAAGKGTRMRSDLPKVLHPIAHKSMVQHVIDTAYQVGSDAIQLVYGYGADKLQARLGEQQLNWVLQAEQLGTGH
AVAQASANIADDDTVLILYGDVPLIQASTLEALLAAREENGLAILTVNLPNPTGYGRIVREGGSVVGIIEQKDANTEQLA
INEINTGIMAAPGKQLKAWLGQLSSDNAQGEYYLTDIVAMAHRDGVAITTAQPESAVEVEGANNRVQLAQLERAYQARAA
EKLMLEGANLRDPARIDIRGDVTVGMDVMIDVNVVIEGKVTIGNNVTIGAGVILIDCDISDNAVIKPYSIIESAKVGVDA
SAGPFARLRPGAELKEDAHIGNFVEMKKAVLGKGSKAGHLAYIGDATIGSGVNIGAGTITCNYDGANKFQTIIEDNVFVG
SDTQLVAPVTIGKGATLGAGSTITKDVAENELVITRVKQRHLTGWPRPVKLKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=452, Percent_Identity=61.7256637168142, Blast_Score=575, Evalue=1e-165,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_SHEPA (A8HAG0)

Other databases:

- EMBL:   CP000851
- RefSeq:   YP_001504082.1
- ProteinModelPortal:   A8HAG0
- SMR:   A8HAG0
- STRING:   A8HAG0
- GeneID:   5664621
- GenomeReviews:   CP000851_GR
- KEGG:   spl:Spea_4237
- NMPDR:   fig|398579.3.peg.3678
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   CLSK907802
- BioCyc:   SPEA398579:SPEA_4237-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 47960; Mature: 47829

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 360-360 BINDING 73-73 BINDING 137-137 BINDING 151-151 BINDING 166-166 BINDING 384-384 BINDING 402-402 BINDING 420-420 BINDING 437-437

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALNVVILAAGKGTRMRSDLPKVLHPIAHKSMVQHVIDTAYQVGSDAIQLVYGYGADKLQ
CCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHH
ARLGEQQLNWVLQAEQLGTGHAVAQASANIADDDTVLILYGDVPLIQASTLEALLAAREE
HHHCHHHHHEEEEHHHCCCCCEEHHCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHCC
NGLAILTVNLPNPTGYGRIVREGGSVVGIIEQKDANTEQLAINEINTGIMAAPGKQLKAW
CCEEEEEEECCCCCCCCCEEECCCCEEEEEECCCCCCCEEEEEECCCCEEECCCHHHHHH
LGQLSSDNAQGEYYLTDIVAMAHRDGVAITTAQPESAVEVEGANNRVQLAQLERAYQARA
HHCCCCCCCCCCEEHHHHHHHHCCCCEEEEECCCCCEEEEECCCCEEEHHHHHHHHHHHH
AEKLMLEGANLRDPARIDIRGDVTVGMDVMIDVNVVIEGKVTIGNNVTIGAGVILIDCDI
HHHHHHCCCCCCCCEEEEEECCEEECEEEEEEEEEEEEEEEEECCCEEEECEEEEEEECC
SDNAVIKPYSIIESAKVGVDASAGPFARLRPGAELKEDAHIGNFVEMKKAVLGKGSKAGH
CCCCEECCHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCE
LAYIGDATIGSGVNIGAGTITCNYDGANKFQTIIEDNVFVGSDTQLVAPVTIGKGATLGA
EEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHCCCEEECCCCEEEEEEEECCCCCCCC
GSTITKDVAENELVITRVKQRHLTGWPRPVKLKK
CCCHHHHHCCCCEEEEEEHHHHCCCCCCCEECCC
>Mature Secondary Structure 
ALNVVILAAGKGTRMRSDLPKVLHPIAHKSMVQHVIDTAYQVGSDAIQLVYGYGADKLQ
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHH
ARLGEQQLNWVLQAEQLGTGHAVAQASANIADDDTVLILYGDVPLIQASTLEALLAAREE
HHHCHHHHHEEEEHHHCCCCCEEHHCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHCC
NGLAILTVNLPNPTGYGRIVREGGSVVGIIEQKDANTEQLAINEINTGIMAAPGKQLKAW
CCEEEEEEECCCCCCCCCEEECCCCEEEEEECCCCCCCEEEEEECCCCEEECCCHHHHHH
LGQLSSDNAQGEYYLTDIVAMAHRDGVAITTAQPESAVEVEGANNRVQLAQLERAYQARA
HHCCCCCCCCCCEEHHHHHHHHCCCCEEEEECCCCCEEEEECCCCEEEHHHHHHHHHHHH
AEKLMLEGANLRDPARIDIRGDVTVGMDVMIDVNVVIEGKVTIGNNVTIGAGVILIDCDI
HHHHHHCCCCCCCCEEEEEECCEEECEEEEEEEEEEEEEEEEECCCEEEECEEEEEEECC
SDNAVIKPYSIIESAKVGVDASAGPFARLRPGAELKEDAHIGNFVEMKKAVLGKGSKAGH
CCCCEECCHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCE
LAYIGDATIGSGVNIGAGTITCNYDGANKFQTIIEDNVFVGSDTQLVAPVTIGKGATLGA
EEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHCCCEEECCCCEEEEEEEECCCCCCCC
GSTITKDVAENELVITRVKQRHLTGWPRPVKLKK
CCCHHHHHCCCCEEEEEEHHHHCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA