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The map label for this gene is guaC [H]

Identifier: 157964044

GI number: 157964044

Start: 5144832

End: 5145875

Strand: Direct

Name: guaC [H]

Synonym: Spea_4233

Alternate gene names: 157964044

Gene position: 5144832-5145875 (Clockwise)

Preceding gene: 157964043

Following gene: 157964064

Centisome position: 99.43

GC content: 48.08

Gene sequence:

>1044_bases
ATGCGTATTGAACAAGATTTAAAGTTAGGTTTCAAAGATGTTCTTATCCGACCTAAGCGTTCAACGTTAAAGAGTCGTTC
TCAAGTAGACTTAAATCGTCAATTTACTTTTAAGCATAGTGGCAAGACCTGGTCTGGTGTGCCTATTATTGCCGCTAACA
TGGATTCTGTCGCTAGCTTCGAAATGGCAGCTAGCCTAGCCCAGCACAACGTGATGACTGCAGTGCACAAACACTACAGC
GTCGAGCAGTGGGGCGAGTTTGTTGCTAGCCAAACGGCTGAAGTACTGCAGCACGTTATGGTTTCAAGCGGTACCTCTGA
CACAGACTTTATCAAGCTGAGTGAAATCCTAGCTAAGTCTGAAGATCTGAACTTCATCTGTATCGACATCGCTAACGGTT
ACTCAGAACACCTAGTTGATTACGTACGTAAAGTAAGACAAGCCCACCCACAAGCCGTGATCAGTGCCGGTAACGTAGTC
ACTGGTGACATGGTTGAAGAGCTTATCATTGCTGGTGCCGATATCGTTAAAGTCGGTATTGGTCCAGGTTCTGTGTGTAC
CACTCGCGTTAAGACGGGTGTTGGCTATCCACAGCTTTCAGCCATTATCGAGTGTGCCGATGCTGCACACGGCCTAGGCG
GTCAAATCATTGGTGACGGCGGCTGTAGCTGTGCTGGTGACGTAGCAAAAGCCTTTGGCGGCGGCGCTGATTTCGTCATG
CTTGGCGGTATGCTAGCGGGTCACGAACAGAGTGGCGGAGAAGTCGTTGAGCAAGATGGCAAGATGATGGTGAAGTTCTA
CGGCATGTCTTCACAGTCTGCCATGGATAAGCACTCTGGCGGTGTTGCTAAGTACCGCGCCGCAGAAGGTAAGACGGTAT
TACTGCCATTTAAAGGCAGCGTCGATAACACGATTAACGACATTATGGGTGGCGTACGTTCAACTTGTACCTATGTTGGT
GCAGCGTCTCTAAAAGAGCTAACTAAGCGTACCACCTTTATCCGTGTTCAAGAGCAAGAAAACAACGTTTACGGTAAAGA
GTAA

Upstream 100 bases:

>100_bases
TTTGTGCCTGAAATAAACTCAGGAATTAACTTAATATCCGATGAAATTTAATTTTTATCGGCGGTTTTGCTGCGCGCAAA
ATCCATGTGAGGAATAAACT

Downstream 100 bases:

>100_bases
GCAATAATATAGCGCTAACGACTATATAACTGGTTAGCGTTTATATTGATTACATTTTAATAGTAAGGTTTTTATTTAAT
AAGCTTTAAATAAGTATCAC

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRIEQDLKLGFKDVLIRPKRSTLKSRSQVDLNRQFTFKHSGKTWSGVPIIAANMDSVASFEMAASLAQHNVMTAVHKHYS
VEQWGEFVASQTAEVLQHVMVSSGTSDTDFIKLSEILAKSEDLNFICIDIANGYSEHLVDYVRKVRQAHPQAVISAGNVV
TGDMVEELIIAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGQIIGDGGCSCAGDVAKAFGGGADFVM
LGGMLAGHEQSGGEVVEQDGKMMVKFYGMSSQSAMDKHSGGVAKYRAAEGKTVLLPFKGSVDNTINDIMGGVRSTCTYVG
AASLKELTKRTTFIRVQEQENNVYGKE

Sequences:

>Translated_347_residues
MRIEQDLKLGFKDVLIRPKRSTLKSRSQVDLNRQFTFKHSGKTWSGVPIIAANMDSVASFEMAASLAQHNVMTAVHKHYS
VEQWGEFVASQTAEVLQHVMVSSGTSDTDFIKLSEILAKSEDLNFICIDIANGYSEHLVDYVRKVRQAHPQAVISAGNVV
TGDMVEELIIAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGQIIGDGGCSCAGDVAKAFGGGADFVM
LGGMLAGHEQSGGEVVEQDGKMMVKFYGMSSQSAMDKHSGGVAKYRAAEGKTVLLPFKGSVDNTINDIMGGVRSTCTYVG
AASLKELTKRTTFIRVQEQENNVYGKE
>Mature_347_residues
MRIEQDLKLGFKDVLIRPKRSTLKSRSQVDLNRQFTFKHSGKTWSGVPIIAANMDSVASFEMAASLAQHNVMTAVHKHYS
VEQWGEFVASQTAEVLQHVMVSSGTSDTDFIKLSEILAKSEDLNFICIDIANGYSEHLVDYVRKVRQAHPQAVISAGNVV
TGDMVEELIIAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGQIIGDGGCSCAGDVAKAFGGGADFVM
LGGMLAGHEQSGGEVVEQDGKMMVKFYGMSSQSAMDKHSGGVAKYRAAEGKTVLLPFKGSVDNTINDIMGGVRSTCTYVG
AASLKELTKRTTFIRVQEQENNVYGKE

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541956, Length=344, Percent_Identity=67.1511627906977, Blast_Score=495, Evalue=1e-140,
Organism=Homo sapiens, GI50541954, Length=342, Percent_Identity=67.5438596491228, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI50541952, Length=342, Percent_Identity=67.5438596491228, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI50541948, Length=342, Percent_Identity=67.5438596491228, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI156104880, Length=343, Percent_Identity=65.0145772594752, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI66933016, Length=231, Percent_Identity=31.6017316017316, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI217035152, Length=231, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI217035150, Length=231, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI156616279, Length=231, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI217035146, Length=231, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI34328930, Length=231, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI34328928, Length=231, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI217035148, Length=231, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786293, Length=344, Percent_Identity=73.2558139534884, Blast_Score=544, Evalue=1e-156,
Organism=Escherichia coli, GI1788855, Length=232, Percent_Identity=37.9310344827586, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17560440, Length=343, Percent_Identity=60.932944606414, Blast_Score=475, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71994385, Length=217, Percent_Identity=32.258064516129, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71994389, Length=167, Percent_Identity=36.5269461077844, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322012, Length=252, Percent_Identity=32.9365079365079, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323464, Length=252, Percent_Identity=31.7460317460317, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323585, Length=216, Percent_Identity=32.8703703703704, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6319352, Length=135, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24641071, Length=235, Percent_Identity=31.063829787234, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24641073, Length=235, Percent_Identity=31.063829787234, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28571163, Length=235, Percent_Identity=31.063829787234, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005993
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 37062; Mature: 37062

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEQDLKLGFKDVLIRPKRSTLKSRSQVDLNRQFTFKHSGKTWSGVPIIAANMDSVASF
CCCCHHHHCCHHHHEECCCHHHHHCHHHCCCCCEEEEEECCCCCCCCEEEEECCHHHHHH
EMAASLAQHNVMTAVHKHYSVEQWGEFVASQTAEVLQHVMVSSGTSDTDFIKLSEILAKS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
EDLNFICIDIANGYSEHLVDYVRKVRQAHPQAVISAGNVVTGDMVEELIIAGADIVKVGI
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHEECCCCEEEHHHHHHHHHCCCCEEEECC
GPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGQIIGDGGCSCAGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCCCHHH
LGGMLAGHEQSGGEVVEQDGKMMVKFYGMSSQSAMDKHSGGVAKYRAAEGKTVLLPFKGS
HCCCCCCCCCCCCHHHHCCCCEEEEEECCCCHHHHHHHCCCCEEEEECCCCEEEEECCCC
VDNTINDIMGGVRSTCTYVGAASLKELTKRTTFIRVQEQENNVYGKE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCC
>Mature Secondary Structure
MRIEQDLKLGFKDVLIRPKRSTLKSRSQVDLNRQFTFKHSGKTWSGVPIIAANMDSVASF
CCCCHHHHCCHHHHEECCCHHHHHCHHHCCCCCEEEEEECCCCCCCCEEEEECCHHHHHH
EMAASLAQHNVMTAVHKHYSVEQWGEFVASQTAEVLQHVMVSSGTSDTDFIKLSEILAKS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
EDLNFICIDIANGYSEHLVDYVRKVRQAHPQAVISAGNVVTGDMVEELIIAGADIVKVGI
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHEECCCCEEEHHHHHHHHHCCCCEEEECC
GPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGQIIGDGGCSCAGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCCCHHH
LGGMLAGHEQSGGEVVEQDGKMMVKFYGMSSQSAMDKHSGGVAKYRAAEGKTVLLPFKGS
HCCCCCCCCCCCCHHHHCCCCEEEEEECCCCHHHHHHHCCCCEEEEECCCCEEEEECCCC
VDNTINDIMGGVRSTCTYVGAASLKELTKRTTFIRVQEQENNVYGKE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA