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The map label for this gene is prlC [H]

Identifier: 157963876

GI number: 157963876

Start: 4941228

End: 4943267

Strand: Reverse

Name: prlC [H]

Synonym: Spea_4065

Alternate gene names: 157963876

Gene position: 4943267-4941228 (Counterclockwise)

Preceding gene: 157963882

Following gene: 157963875

Centisome position: 95.53

GC content: 50.34

Gene sequence:

>2040_bases
ATGAGCAATCCTTTGCTAAGCAGTGCCACGCTTCCCCCTTTTTCAAGTATCAAGCCTGAACATATTCAGCCCGCTGTTGA
GCAAGGTATCGCCAATTGTCGCCACAAGATCGAAGAGGTGCTTAAGCATCAAGGTGAGTTCACTTGGGATAATCTTGTGG
CGCCGCTAGAGGAAGTGGACGACCAACTCGGCAAGATGTGGTCACCTATCTCGCACATGAATTCGGTTGTGAGTAGCGAA
GAGTGGCGCAAGGCTCATGATGCCTGTTTACCTTTACTATCTGAGTACGGCACCTTTGTCGGACAGCATCAGGGACTGTA
TGAGGCCTACAAATCATTAGCGGCATCGGTTGAATTTGCCACTTACTCGCAAGCACAGAAGAAACTGATTGAGAATAGCC
TGCGAGACTTCGAACTTTCGGGGATTGGCCTGAGCGATAGCGATAAGTTGCGCTACGGCGAGCTGGTTAAGCGCTTGTCT
GAACTCACCAGTAACTTCTCTAATCAGCTATTAGATGCGACTCAGGCCTGGAGCAAGTTAATCACTGATGAAGCAGAGCT
TGCAGGTCTACCAGAGTCTGCGGTTGCTGCTGCTAAGGCGATGGCCGAGGCTAAAGAGCTCGACGGTTGGTTATTCACCT
TAGACATTCCGTCTTACCTGCCAGTTATGATGTATAGCGAAAACCGCGAGCTGCGCGAAGAGTGCTACCGCGCCTTTATC
ACTCGTGCATCGGATCAAGGTCCGAATGCCGGAGAGTTCGATAACGGTCCCTTGATGGATGAGATTTTGGCATTGCGTCA
TGAGCTGGCCAATCTATTGGGTTTCGAAAGCTTTGCCGATAAGTCGTTAGCCACCAAGATGGCAGAATCTCCTGCGCAGG
TGCTGGAGTTCCTAACTGAGCTGGCTGCGCGTTCTAAGTCGCAAGGCGAAGCCGAGCTGGCAGAACTTAAAGAATTTGCT
GAAAAAGAGTGTGGCGTGACGGAGCTTGAGCCTTGGGATTTGAGTTTCTACGCCGAAAAGTTAAAGCATCATAGATATGA
GATCTCGCAAGAGATCTTGCGTCCGTACTTCCCTGAAGACAAGGTGTTATCGGGTCTGTTTTACACCGTCTCTCGCCTAT
TTGGCCTCAAGGTTGAAGAGCAGAAAGAGTTCGATAGCTACCATAAAGACGTACGTTTCTTCCATATTACTGACAGCAGC
GGTGAGCATCGCGGTAGCTTCTATCTGGATCTGTATGCACGTGAAGGTAAGCGTGGCGGCGCTTGGATGGATGACTGTCG
TGCCCGCCGTAAGACACTCGGCGGTATGCAAGATCCTGTGGCTTACCTAACTTGTAACTTCAATGCGCCGGTGGCGGGCA
AGCCTGCACTGTTTACCCATGATGAAGTGACCACACTGTTCCATGAGTTTGGCCATGGTATTCACCATATGTTGACTAAA
ATCGATGTGGGTGGAGTATCTGGGATCAGCGGTGTACCTTGGGATGCGGTAGAGCTACCGAGCCAGTTTATGGAAAACTG
GTGTTATGAAGAAGAGGCGTTAGCCGAGATCTCAGGCCACTACGAAACTGGCGAGCCGTTACCAAAAGCCATGTTAGACA
AGATGCTAGCGGCGAAAAACTTCCAGTCTGGCATGATGATGTTGCGCCAACTTGAATTTTCACTGTTTGATTTCAAAATG
CACTTAGAGTTTGACCCAGCTAAGGGCGCCGAGATCCAGCAAAAACTTGATGAGGTGCGTGAGCAAGTGGCGGTGATTAA
GGCGGCGGAGTTTAACCGTTTCCAACATAGCTTTGCTCACATCTTTGCTGGCGGCTACGCGGCGGGTTACTACAGCTATA
AGTGGGCAGAGGTGTTGTCGGCCGATGCCTTCTCCTTGTTTGAGGAGCAGGGGATCTTCAATGCCGATACCGGCCAAAGC
TTCCTTGAGAATATCCTAGAAATGGGTGGCAGCGAGGAGCCGATGGAATTGTTTAAACGTTTCCGTGGCCGTGAGCCACA
AACCGATGCGCTATTGAGACACAGCGGGATTAACGGCTAA

Upstream 100 bases:

>100_bases
GACGCATTTAGTTTATAAACAATTATGCTGTATAGATTGAATATTGTGGCATTAGCCCTTATCTCTTTACTTATCAACAT
AGAATGTTAAGGAATCATCG

Downstream 100 bases:

>100_bases
AATTAGCTTGTAAACCCAATAAAAAAGGCGCGTTAAGCGCCTTTTTTGTTGTTCTCGTTCAAGCTTGTTATCTGGTATGA
CCTTTGTTAGCCTTTGCGAT

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MSNPLLSSATLPPFSSIKPEHIQPAVEQGIANCRHKIEEVLKHQGEFTWDNLVAPLEEVDDQLGKMWSPISHMNSVVSSE
EWRKAHDACLPLLSEYGTFVGQHQGLYEAYKSLAASVEFATYSQAQKKLIENSLRDFELSGIGLSDSDKLRYGELVKRLS
ELTSNFSNQLLDATQAWSKLITDEAELAGLPESAVAAAKAMAEAKELDGWLFTLDIPSYLPVMMYSENRELREECYRAFI
TRASDQGPNAGEFDNGPLMDEILALRHELANLLGFESFADKSLATKMAESPAQVLEFLTELAARSKSQGEAELAELKEFA
EKECGVTELEPWDLSFYAEKLKHHRYEISQEILRPYFPEDKVLSGLFYTVSRLFGLKVEEQKEFDSYHKDVRFFHITDSS
GEHRGSFYLDLYAREGKRGGAWMDDCRARRKTLGGMQDPVAYLTCNFNAPVAGKPALFTHDEVTTLFHEFGHGIHHMLTK
IDVGGVSGISGVPWDAVELPSQFMENWCYEEEALAEISGHYETGEPLPKAMLDKMLAAKNFQSGMMMLRQLEFSLFDFKM
HLEFDPAKGAEIQQKLDEVREQVAVIKAAEFNRFQHSFAHIFAGGYAAGYYSYKWAEVLSADAFSLFEEQGIFNADTGQS
FLENILEMGGSEEPMELFKRFRGREPQTDALLRHSGING

Sequences:

>Translated_679_residues
MSNPLLSSATLPPFSSIKPEHIQPAVEQGIANCRHKIEEVLKHQGEFTWDNLVAPLEEVDDQLGKMWSPISHMNSVVSSE
EWRKAHDACLPLLSEYGTFVGQHQGLYEAYKSLAASVEFATYSQAQKKLIENSLRDFELSGIGLSDSDKLRYGELVKRLS
ELTSNFSNQLLDATQAWSKLITDEAELAGLPESAVAAAKAMAEAKELDGWLFTLDIPSYLPVMMYSENRELREECYRAFI
TRASDQGPNAGEFDNGPLMDEILALRHELANLLGFESFADKSLATKMAESPAQVLEFLTELAARSKSQGEAELAELKEFA
EKECGVTELEPWDLSFYAEKLKHHRYEISQEILRPYFPEDKVLSGLFYTVSRLFGLKVEEQKEFDSYHKDVRFFHITDSS
GEHRGSFYLDLYAREGKRGGAWMDDCRARRKTLGGMQDPVAYLTCNFNAPVAGKPALFTHDEVTTLFHEFGHGIHHMLTK
IDVGGVSGISGVPWDAVELPSQFMENWCYEEEALAEISGHYETGEPLPKAMLDKMLAAKNFQSGMMMLRQLEFSLFDFKM
HLEFDPAKGAEIQQKLDEVREQVAVIKAAEFNRFQHSFAHIFAGGYAAGYYSYKWAEVLSADAFSLFEEQGIFNADTGQS
FLENILEMGGSEEPMELFKRFRGREPQTDALLRHSGING
>Mature_678_residues
SNPLLSSATLPPFSSIKPEHIQPAVEQGIANCRHKIEEVLKHQGEFTWDNLVAPLEEVDDQLGKMWSPISHMNSVVSSEE
WRKAHDACLPLLSEYGTFVGQHQGLYEAYKSLAASVEFATYSQAQKKLIENSLRDFELSGIGLSDSDKLRYGELVKRLSE
LTSNFSNQLLDATQAWSKLITDEAELAGLPESAVAAAKAMAEAKELDGWLFTLDIPSYLPVMMYSENRELREECYRAFIT
RASDQGPNAGEFDNGPLMDEILALRHELANLLGFESFADKSLATKMAESPAQVLEFLTELAARSKSQGEAELAELKEFAE
KECGVTELEPWDLSFYAEKLKHHRYEISQEILRPYFPEDKVLSGLFYTVSRLFGLKVEEQKEFDSYHKDVRFFHITDSSG
EHRGSFYLDLYAREGKRGGAWMDDCRARRKTLGGMQDPVAYLTCNFNAPVAGKPALFTHDEVTTLFHEFGHGIHHMLTKI
DVGGVSGISGVPWDAVELPSQFMENWCYEEEALAEISGHYETGEPLPKAMLDKMLAAKNFQSGMMMLRQLEFSLFDFKMH
LEFDPAKGAEIQQKLDEVREQVAVIKAAEFNRFQHSFAHIFAGGYAAGYYSYKWAEVLSADAFSLFEEQGIFNADTGQSF
LENILEMGGSEEPMELFKRFRGREPQTDALLRHSGING

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=615, Percent_Identity=31.3821138211382, Blast_Score=293, Evalue=4e-79,
Organism=Homo sapiens, GI14149738, Length=681, Percent_Identity=30.1027900146843, Blast_Score=286, Evalue=5e-77,
Organism=Homo sapiens, GI156105687, Length=601, Percent_Identity=25.6239600665557, Blast_Score=174, Evalue=3e-43,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=66.0294117647059, Blast_Score=934, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=687, Percent_Identity=31.7321688500728, Blast_Score=328, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI71999758, Length=582, Percent_Identity=26.1168384879725, Blast_Score=152, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI32565901, Length=649, Percent_Identity=22.1879815100154, Blast_Score=102, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6319793, Length=697, Percent_Identity=28.8378766140603, Blast_Score=280, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6322715, Length=701, Percent_Identity=25.1069900142653, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21356111, Length=691, Percent_Identity=27.7858176555716, Blast_Score=242, Evalue=5e-64,
Organism=Drosophila melanogaster, GI20129717, Length=628, Percent_Identity=23.5668789808917, Blast_Score=158, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76522; Mature: 76391

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLLSSATLPPFSSIKPEHIQPAVEQGIANCRHKIEEVLKHQGEFTWDNLVAPLEEVD
CCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHH
DQLGKMWSPISHMNSVVSSEEWRKAHDACLPLLSEYGTFVGQHQGLYEAYKSLAASVEFA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
TYSQAQKKLIENSLRDFELSGIGLSDSDKLRYGELVKRLSELTSNFSNQLLDATQAWSKL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITDEAELAGLPESAVAAAKAMAEAKELDGWLFTLDIPSYLPVMMYSENRELREECYRAFI
HCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHH
TRASDQGPNAGEFDNGPLMDEILALRHELANLLGFESFADKSLATKMAESPAQVLEFLTE
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LAARSKSQGEAELAELKEFAEKECGVTELEPWDLSFYAEKLKHHRYEISQEILRPYFPED
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
KVLSGLFYTVSRLFGLKVEEQKEFDSYHKDVRFFHITDSSGEHRGSFYLDLYAREGKRGG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCCCCC
AWMDDCRARRKTLGGMQDPVAYLTCNFNAPVAGKPALFTHDEVTTLFHEFGHGIHHMLTK
CCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
IDVGGVSGISGVPWDAVELPSQFMENWCYEEEALAEISGHYETGEPLPKAMLDKMLAAKN
HCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
FQSGMMMLRQLEFSLFDFKMHLEFDPAKGAEIQQKLDEVREQVAVIKAAEFNRFQHSFAH
HHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFAGGYAAGYYSYKWAEVLSADAFSLFEEQGIFNADTGQSFLENILEMGGSEEPMELFKR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHH
FRGREPQTDALLRHSGING
HCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure 
SNPLLSSATLPPFSSIKPEHIQPAVEQGIANCRHKIEEVLKHQGEFTWDNLVAPLEEVD
CCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHH
DQLGKMWSPISHMNSVVSSEEWRKAHDACLPLLSEYGTFVGQHQGLYEAYKSLAASVEFA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
TYSQAQKKLIENSLRDFELSGIGLSDSDKLRYGELVKRLSELTSNFSNQLLDATQAWSKL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITDEAELAGLPESAVAAAKAMAEAKELDGWLFTLDIPSYLPVMMYSENRELREECYRAFI
HCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHH
TRASDQGPNAGEFDNGPLMDEILALRHELANLLGFESFADKSLATKMAESPAQVLEFLTE
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LAARSKSQGEAELAELKEFAEKECGVTELEPWDLSFYAEKLKHHRYEISQEILRPYFPED
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
KVLSGLFYTVSRLFGLKVEEQKEFDSYHKDVRFFHITDSSGEHRGSFYLDLYAREGKRGG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCCCCC
AWMDDCRARRKTLGGMQDPVAYLTCNFNAPVAGKPALFTHDEVTTLFHEFGHGIHHMLTK
CCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
IDVGGVSGISGVPWDAVELPSQFMENWCYEEEALAEISGHYETGEPLPKAMLDKMLAAKN
HCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
FQSGMMMLRQLEFSLFDFKMHLEFDPAKGAEIQQKLDEVREQVAVIKAAEFNRFQHSFAH
HHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFAGGYAAGYYSYKWAEVLSADAFSLFEEQGIFNADTGQSFLENILEMGGSEEPMELFKR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHH
FRGREPQTDALLRHSGING
HCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]