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The map label for this gene is vmrA [H]

Identifier: 157963864

GI number: 157963864

Start: 4924017

End: 4925414

Strand: Direct

Name: vmrA [H]

Synonym: Spea_4053

Alternate gene names: 157963864

Gene position: 4924017-4925414 (Clockwise)

Preceding gene: 157963861

Following gene: 157963868

Centisome position: 95.16

GC content: 45.99

Gene sequence:

>1398_bases
ATGTTAGATCCAAGCATAGAAAACACACAGACTCAGTCAATTAGCCGTACCTTTTGGCGTTACACTCTGCCTGCCATTGC
CGCCATGTTAGTTAACGGTTTATACCAAATCGTTGACGGTATTTTTATTGGCCATTACATCGGCTTTGAAGGACTCGCAG
CTATCAATATGGCCTGGCCTGTGATCTACTTTATGGTTGGTTTTGGCATCATGGTCGGCATGGGTAGTGGCAGCTTGCTA
TCGATTCAACGGGGTAAAGGCGATACTCGCGCGGCACCGACGATATTGACCAGCAGCTTAGTACTCATGCTTAGTCTAGC
CATAATCTCTACCTCGATTTTAGTCATCTGCAGCGACTTTTTTCTTGAGGCTCAGGGCGGTGCGGGCAACACCTTGGTGA
TGGCGCAAGAGTATATTAGCGTATTCACTTGGGGAACTGCGATCACTGTGATTGCTTCAGCCTTGCCGTTGCTCATTCGT
AACGATGAGAGCCCCAATATCGCTACCGGTTTAATGGTATTAGGCGCCTTTATCAATATTGCACTCGACTATCTATTGAT
AGGCGTATTTGACTTCGGCTTGCTTGGCGCTTCGATTGCCACCATTAGTGCACAGGCGACTGTCTGTGTTTTAGGTCTTA
TCTACTTTTGCTCTCGATTTAGCAGCATTAACTGGTCGGCAAAATTTAGTTGGTTTAACGCCTCTTTTGCTCAACAAATC
ACGCTGTTAGGCTCATCAAGCCTATTTATGTATCTGTATACCAGCTTTGTTTTTGCACTGCATAACCGACTCTTTACAGA
GTATGGTACACCGCTAACCGTAGGCGCCTTCGCCATTGTTGGCTACCTGATGGTGCTATATTACTTAGTCGCCGAAGGTG
TGGCCGAGGGTATGCAGCCTCCTGTTAGTTATTACTACGGCGCCGAGCAACATGAAAACATCAACAAGATGCTTAAGCTG
TCGGTAAAGGTGACTCTGATTGCGGGTACCAGCTGGGTATTACTGCTAAACCTAATGCCAGAGACCATGGTTGGACTATT
CAACAATGATGATCCCTTGCTAATTGCAACCGCAATTGATGGTATCAAAATGCATCTGTTTGCTATGCCGTTAGATGGCT
TTATTGCACTTTCGTCTGTGTACTTTATGGCGACTAACCAAGGCGTTAAAGCGTTAGTCATCGCCTGTGGCAATATGCTA
ATCCAGCTGCCATTCCTATATTTCTTACCTAAGGTTATGGGAGTCGAAGGTGTGTGGATGGCGATGCCGCTCTCCAACAT
AGCACTGTGCCTTATTGTGGCGCCTATGGTTTGGTTTGATGTTAAGTCGAGAAAGAAGCAATCAAGAGCGCAGCAAGATA
ATCCGTTAACTATCGATACAGCGGCAATCGTAAGTTAA

Upstream 100 bases:

>100_bases
CATGTCCAAACCTTATCTCAAAAACAGATAGTAACTAACTTTATTCAATCTCAAATACAGAGTAACTTGCCAAGCTTTAT
TGTTCAATATTGATATCCCC

Downstream 100 bases:

>100_bases
GCCTTGCAGCTAAGTCTTTAAGCCTTGCGATAACGTTTGAGCAAGATCTGCACCCGCTCAACATAGGCTTGGGTCTCTGT
GAGTACTAATGGAGTGCGGA

Product: multidrug efflux pump VmrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MLDPSIENTQTQSISRTFWRYTLPAIAAMLVNGLYQIVDGIFIGHYIGFEGLAAINMAWPVIYFMVGFGIMVGMGSGSLL
SIQRGKGDTRAAPTILTSSLVLMLSLAIISTSILVICSDFFLEAQGGAGNTLVMAQEYISVFTWGTAITVIASALPLLIR
NDESPNIATGLMVLGAFINIALDYLLIGVFDFGLLGASIATISAQATVCVLGLIYFCSRFSSINWSAKFSWFNASFAQQI
TLLGSSSLFMYLYTSFVFALHNRLFTEYGTPLTVGAFAIVGYLMVLYYLVAEGVAEGMQPPVSYYYGAEQHENINKMLKL
SVKVTLIAGTSWVLLLNLMPETMVGLFNNDDPLLIATAIDGIKMHLFAMPLDGFIALSSVYFMATNQGVKALVIACGNML
IQLPFLYFLPKVMGVEGVWMAMPLSNIALCLIVAPMVWFDVKSRKKQSRAQQDNPLTIDTAAIVS

Sequences:

>Translated_465_residues
MLDPSIENTQTQSISRTFWRYTLPAIAAMLVNGLYQIVDGIFIGHYIGFEGLAAINMAWPVIYFMVGFGIMVGMGSGSLL
SIQRGKGDTRAAPTILTSSLVLMLSLAIISTSILVICSDFFLEAQGGAGNTLVMAQEYISVFTWGTAITVIASALPLLIR
NDESPNIATGLMVLGAFINIALDYLLIGVFDFGLLGASIATISAQATVCVLGLIYFCSRFSSINWSAKFSWFNASFAQQI
TLLGSSSLFMYLYTSFVFALHNRLFTEYGTPLTVGAFAIVGYLMVLYYLVAEGVAEGMQPPVSYYYGAEQHENINKMLKL
SVKVTLIAGTSWVLLLNLMPETMVGLFNNDDPLLIATAIDGIKMHLFAMPLDGFIALSSVYFMATNQGVKALVIACGNML
IQLPFLYFLPKVMGVEGVWMAMPLSNIALCLIVAPMVWFDVKSRKKQSRAQQDNPLTIDTAAIVS
>Mature_465_residues
MLDPSIENTQTQSISRTFWRYTLPAIAAMLVNGLYQIVDGIFIGHYIGFEGLAAINMAWPVIYFMVGFGIMVGMGSGSLL
SIQRGKGDTRAAPTILTSSLVLMLSLAIISTSILVICSDFFLEAQGGAGNTLVMAQEYISVFTWGTAITVIASALPLLIR
NDESPNIATGLMVLGAFINIALDYLLIGVFDFGLLGASIATISAQATVCVLGLIYFCSRFSSINWSAKFSWFNASFAQQI
TLLGSSSLFMYLYTSFVFALHNRLFTEYGTPLTVGAFAIVGYLMVLYYLVAEGVAEGMQPPVSYYYGAEQHENINKMLKL
SVKVTLIAGTSWVLLLNLMPETMVGLFNNDDPLLIATAIDGIKMHLFAMPLDGFIALSSVYFMATNQGVKALVIACGNML
IQLPFLYFLPKVMGVEGVWMAMPLSNIALCLIVAPMVWFDVKSRKKQSRAQQDNPLTIDTAAIVS

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 50566; Mature: 50566

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPSIENTQTQSISRTFWRYTLPAIAAMLVNGLYQIVDGIFIGHYIGFEGLAAINMAWP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
VIYFMVGFGIMVGMGSGSLLSIQRGKGDTRAAPTILTSSLVLMLSLAIISTSILVICSDF
HHHHHHHHHHHEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLEAQGGAGNTLVMAQEYISVFTWGTAITVIASALPLLIRNDESPNIATGLMVLGAFINI
HEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHH
ALDYLLIGVFDFGLLGASIATISAQATVCVLGLIYFCSRFSSINWSAKFSWFNASFAQQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHH
TLLGSSSLFMYLYTSFVFALHNRLFTEYGTPLTVGAFAIVGYLMVLYYLVAEGVAEGMQP
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PVSYYYGAEQHENINKMLKLSVKVTLIAGTSWVLLLNLMPETMVGLFNNDDPLLIATAID
CHHHHCCCHHHHHHHHHHEEEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
GIKMHLFAMPLDGFIALSSVYFMATNQGVKALVIACGNMLIQLPFLYFLPKVMGVEGVWM
CCEEEEEEECCHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
AMPLSNIALCLIVAPMVWFDVKSRKKQSRAQQDNPLTIDTAAIVS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCC
>Mature Secondary Structure
MLDPSIENTQTQSISRTFWRYTLPAIAAMLVNGLYQIVDGIFIGHYIGFEGLAAINMAWP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
VIYFMVGFGIMVGMGSGSLLSIQRGKGDTRAAPTILTSSLVLMLSLAIISTSILVICSDF
HHHHHHHHHHHEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLEAQGGAGNTLVMAQEYISVFTWGTAITVIASALPLLIRNDESPNIATGLMVLGAFINI
HEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHH
ALDYLLIGVFDFGLLGASIATISAQATVCVLGLIYFCSRFSSINWSAKFSWFNASFAQQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHH
TLLGSSSLFMYLYTSFVFALHNRLFTEYGTPLTVGAFAIVGYLMVLYYLVAEGVAEGMQP
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PVSYYYGAEQHENINKMLKLSVKVTLIAGTSWVLLLNLMPETMVGLFNNDDPLLIATAID
CHHHHCCCHHHHHHHHHHEEEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
GIKMHLFAMPLDGFIALSSVYFMATNQGVKALVIACGNMLIQLPFLYFLPKVMGVEGVWM
CCEEEEEEECCHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
AMPLSNIALCLIVAPMVWFDVKSRKKQSRAQQDNPLTIDTAAIVS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA