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The map label for this gene is hutH [H]

Identifier: 157963705

GI number: 157963705

Start: 4740218

End: 4741780

Strand: Direct

Name: hutH [H]

Synonym: Spea_3894

Alternate gene names: 157963705

Gene position: 4740218-4741780 (Clockwise)

Preceding gene: 157963704

Following gene: 157963706

Centisome position: 91.61

GC content: 50.8

Gene sequence:

>1563_bases
ATGACCCAAGATAATACCTATAACCTTAGCCAGCAAACCGTTGAATTTGGCTATAACAGCCTATCGCTTGAAGATGTGGT
GGCTATCGCCAAAGGCGCAACAGCCAAGCTGAATCAAACGACCGAATACCGCAGCTATATTCAAAAAGGCGCGCTGTTTA
TCGATAGCCTGCTTAAAGAAGAGGGCGTGGTTTACGGCGTCACTACAGGTTATGGTGATTCTTGTACTGTCACTGTGGGT
CTTGACTTGGTTCATGAGCTACCGCTGCACCTGACTCGTTTTCATGGCTGTGGTATGGGTGAGATCCTGTCGCCGATGCA
AGCTCGCGCCGTGATGGCATGCCGACTTAGCTCGCTAGCTGTCGGTAAATCTGGGGTCACTTTCGAGCTACTTGAGCGTA
TCGAAACCCTGCTTAATCTTAATATTACTCCGGTGATCCCCGAAGAGGGCTCAGTTGGCGCCAGTGGCGACTTAACGCCA
CTATCTTATCTAGCAGCGGTATTGATCGGCGAGCGCGATGTGATTTACCAAGGTGAACGACGCCCAACTAGCCAAGTGTA
CCAAGAGCTTAATATCGTACCGCTAAAACTTCGTCCGAAAGAAGGCCTAGCGCTAATGAACGGCACTGCGGTCATGACGG
CGCTAGCTTGTTTAGCCTATGACAGAGCCCAGTACATGGCGCGTCTTGCCAGCCGTATCACCGCCATGGCATCACTGACC
CTTAAAGGTAACTCGAATCACTTCGACGACATCTTATTTGCCGCTAAGCCGCACCCGGGCCAGAACCAAATCGCTGCTTG
GATCCGTGAAGACTTGAATCATCATATTCATCCACGTAACTCCGACAGACTGCAAGACAGATACTCTATCCGCTGTGCAC
CCCATGTGATTGGTGTGCTACAAGACGCGCTGCCGTTTATGCGTCAGTTTATTGAAACTGAACTCAACAGCGCCAACGAC
AACCCAATTGTTGATGGTGAAGGCGAGCATATTCTACATGGCGGTCACTTCTATGGCGGCCACATCGCCTTTGCCATGGA
TGCGATGAAAAATGCGGTAGCCAATATTGCCGATCTTATCGATCGCCAGATGGCATTAGTCATGGATCAGAAATTCAATA
ACGGTTTACCGGCCAACTTATCGGGCGCTCAAGGCAGACGTAAGGCGATTAACCACGGCTTTAAAGCGGTGCAGATTGGC
GTATCCGCGTGGACGGCTGAAGCCCTGAAAAACACCATGCCAGCCAGCGTGTTCTCACGCTCTACCGAGTGCCATAACCA
AGATAAGGTCAGCATGGGCACCATCTCGGCTCGTGATTGTATGCGCGTATTACAACTGACCGAGCAAGTCGCTGCGGCGG
CGTTACTGGCCATGTCGCAAGGTATTCGCCTGCGCATTGCTCAAGAGGAGCTCGTCGAAAGCTCGATTACACCTTCTTTA
GCCAATACCCTTGCTCAAGTTGAAGCCGACTTTGAATTATTAACTGAAGATAGACCGCTAGAGCAGACCCTACGCTCTAC
CGTCGATAAGATCCAAAATGGCTACTGGGAAGTGTGCGGTTAA

Upstream 100 bases:

>100_bases
TTTATGATTTCTGGCGCAAGGACGAAGAGTTCCAACGTGCAGATGTGCAAAGCAGTGAACGCTGTAGCAGTAGTAGCAAT
ACTAAAGGACAAGCAAGTAA

Downstream 100 bases:

>100_bases
TGAAAGGTATCTTATTCGCAGAGATGGAAGTTGAAATTCCATTTCATGATGTCGATTCGATGGGGATCACTTGGCATGGC
AATTATCTACGCTATTTTGA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MTQDNTYNLSQQTVEFGYNSLSLEDVVAIAKGATAKLNQTTEYRSYIQKGALFIDSLLKEEGVVYGVTTGYGDSCTVTVG
LDLVHELPLHLTRFHGCGMGEILSPMQARAVMACRLSSLAVGKSGVTFELLERIETLLNLNITPVIPEEGSVGASGDLTP
LSYLAAVLIGERDVIYQGERRPTSQVYQELNIVPLKLRPKEGLALMNGTAVMTALACLAYDRAQYMARLASRITAMASLT
LKGNSNHFDDILFAAKPHPGQNQIAAWIREDLNHHIHPRNSDRLQDRYSIRCAPHVIGVLQDALPFMRQFIETELNSAND
NPIVDGEGEHILHGGHFYGGHIAFAMDAMKNAVANIADLIDRQMALVMDQKFNNGLPANLSGAQGRRKAINHGFKAVQIG
VSAWTAEALKNTMPASVFSRSTECHNQDKVSMGTISARDCMRVLQLTEQVAAAALLAMSQGIRLRIAQEELVESSITPSL
ANTLAQVEADFELLTEDRPLEQTLRSTVDKIQNGYWEVCG

Sequences:

>Translated_520_residues
MTQDNTYNLSQQTVEFGYNSLSLEDVVAIAKGATAKLNQTTEYRSYIQKGALFIDSLLKEEGVVYGVTTGYGDSCTVTVG
LDLVHELPLHLTRFHGCGMGEILSPMQARAVMACRLSSLAVGKSGVTFELLERIETLLNLNITPVIPEEGSVGASGDLTP
LSYLAAVLIGERDVIYQGERRPTSQVYQELNIVPLKLRPKEGLALMNGTAVMTALACLAYDRAQYMARLASRITAMASLT
LKGNSNHFDDILFAAKPHPGQNQIAAWIREDLNHHIHPRNSDRLQDRYSIRCAPHVIGVLQDALPFMRQFIETELNSAND
NPIVDGEGEHILHGGHFYGGHIAFAMDAMKNAVANIADLIDRQMALVMDQKFNNGLPANLSGAQGRRKAINHGFKAVQIG
VSAWTAEALKNTMPASVFSRSTECHNQDKVSMGTISARDCMRVLQLTEQVAAAALLAMSQGIRLRIAQEELVESSITPSL
ANTLAQVEADFELLTEDRPLEQTLRSTVDKIQNGYWEVCG
>Mature_519_residues
TQDNTYNLSQQTVEFGYNSLSLEDVVAIAKGATAKLNQTTEYRSYIQKGALFIDSLLKEEGVVYGVTTGYGDSCTVTVGL
DLVHELPLHLTRFHGCGMGEILSPMQARAVMACRLSSLAVGKSGVTFELLERIETLLNLNITPVIPEEGSVGASGDLTPL
SYLAAVLIGERDVIYQGERRPTSQVYQELNIVPLKLRPKEGLALMNGTAVMTALACLAYDRAQYMARLASRITAMASLTL
KGNSNHFDDILFAAKPHPGQNQIAAWIREDLNHHIHPRNSDRLQDRYSIRCAPHVIGVLQDALPFMRQFIETELNSANDN
PIVDGEGEHILHGGHFYGGHIAFAMDAMKNAVANIADLIDRQMALVMDQKFNNGLPANLSGAQGRRKAINHGFKAVQIGV
SAWTAEALKNTMPASVFSRSTECHNQDKVSMGTISARDCMRVLQLTEQVAAAALLAMSQGIRLRIAQEELVESSITPSLA
NTLAQVEADFELLTEDRPLEQTLRSTVDKIQNGYWEVCG

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=517, Percent_Identity=36.1702127659575, Blast_Score=296, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17567831, Length=509, Percent_Identity=35.9528487229862, Blast_Score=274, Evalue=7e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 56898; Mature: 56766

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQDNTYNLSQQTVEFGYNSLSLEDVVAIAKGATAKLNQTTEYRSYIQKGALFIDSLLKE
CCCCCCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EGVVYGVTTGYGDSCTVTVGLDLVHELPLHLTRFHGCGMGEILSPMQARAVMACRLSSLA
CCEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VGKSGVTFELLERIETLLNLNITPVIPEEGSVGASGDLTPLSYLAAVLIGERDVIYQGER
CCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCC
RPTSQVYQELNIVPLKLRPKEGLALMNGTAVMTALACLAYDRAQYMARLASRITAMASLT
CCHHHHHHHCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LKGNSNHFDDILFAAKPHPGQNQIAAWIREDLNHHIHPRNSDRLQDRYSIRCAPHVIGVL
EECCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEHHHHHHHH
QDALPFMRQFIETELNSANDNPIVDGEGEHILHGGHFYGGHIAFAMDAMKNAVANIADLI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCEEECCHHHHHHHHHHHHHHHHHHHH
DRQMALVMDQKFNNGLPANLSGAQGRRKAINHGFKAVQIGVSAWTAEALKNTMPASVFSR
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCHHHHHC
STECHNQDKVSMGTISARDCMRVLQLTEQVAAAALLAMSQGIRLRIAQEELVESSITPSL
CHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHCCCHHH
ANTLAQVEADFELLTEDRPLEQTLRSTVDKIQNGYWEVCG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEECCC
>Mature Secondary Structure 
TQDNTYNLSQQTVEFGYNSLSLEDVVAIAKGATAKLNQTTEYRSYIQKGALFIDSLLKE
CCCCCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EGVVYGVTTGYGDSCTVTVGLDLVHELPLHLTRFHGCGMGEILSPMQARAVMACRLSSLA
CCEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VGKSGVTFELLERIETLLNLNITPVIPEEGSVGASGDLTPLSYLAAVLIGERDVIYQGER
CCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCC
RPTSQVYQELNIVPLKLRPKEGLALMNGTAVMTALACLAYDRAQYMARLASRITAMASLT
CCHHHHHHHCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LKGNSNHFDDILFAAKPHPGQNQIAAWIREDLNHHIHPRNSDRLQDRYSIRCAPHVIGVL
EECCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEHHHHHHHH
QDALPFMRQFIETELNSANDNPIVDGEGEHILHGGHFYGGHIAFAMDAMKNAVANIADLI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCEEECCHHHHHHHHHHHHHHHHHHHH
DRQMALVMDQKFNNGLPANLSGAQGRRKAINHGFKAVQIGVSAWTAEALKNTMPASVFSR
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCHHHHHC
STECHNQDKVSMGTISARDCMRVLQLTEQVAAAALLAMSQGIRLRIAQEELVESSITPSL
CHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHCCCHHH
ANTLAQVEADFELLTEDRPLEQTLRSTVDKIQNGYWEVCG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA