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The map label for this gene is hipA [H]

Identifier: 157963657

GI number: 157963657

Start: 4673505

End: 4674824

Strand: Reverse

Name: hipA [H]

Synonym: Spea_3846

Alternate gene names: 157963657

Gene position: 4674824-4673505 (Counterclockwise)

Preceding gene: 157963658

Following gene: 157963655

Centisome position: 90.34

GC content: 42.95

Gene sequence:

>1320_bases
ATGGCAGTTCTGGATGTTTATATGAATGGCTATTTGGTCGGTGAGTTTACTAAATCGACCACAGGCTCTCATCTGTTTAA
GTATGCAGCCCAATGGCTAGATACGCCTGGCAGTCGTCCTATTTCACTGTCTATGCCATTGCGTTCGCAAGCGTATAAAG
GCGATGAGGTTTATAACTTCTTTGATAATTTACTGCCAGATAACATGGAGGTGAGAAACAGGATTGTTGCTCGTCACAAT
GCGCAATCGACACAAGCGTTCGATCTACTCGCTAAAGTCGGTCAAGACAGTGTTGGTGCACTGCAGTTAGTACCCCATGA
GCAGCAACCCTTTGAGGTTAAAAAGATTGAAGCTAAACCTTTATCTGATGAGGCATTGGAAAAAGTGCTCAAAGGTTATC
AGTCAGATATTCCATTAGGCATGCTAAGCGATGAAGATGATTTTCGAATATCGATTGCAGGTGCCCAAGAGAAGACCGCC
TTACTTAATTTAGATGGCCGATGGCAGCTTCCAATTAAAGCTACACCGACTACACATATCATTAAGTTGCCTATCGGTGA
GATACAGAGTCATTCATACACTATTGATATGTCTGACAGCGTTGAAAACGAATATCTGTGTATGATGATAGTAAGGGAGT
TTGGCTTAGATGTACCAGATTGCTCAATAATTAAAGTTGGTGATAATAAGGCGCTGGCAGTAGCACGTTTTGATCGTAAA
TTATCTAGCGATGGCCAATGGATTATGCGATTGCCACAAGAGGATTTCTGCCAAACATTAAATATTCCATCGGCTAAAAA
ATATGAAAGTCACGGCGGGCCGGGTGTTGAGCATATCATACCTTATTTACTGGGCTCTATGAACTCAGAGCAAGATAGGT
ATAACTTTATGAAGTCGCAAGTGCTGTTCTGGCTTTTAGCGGCAACAGACGGCCATGCTAAAAACTTCTCGCTATTTATT
GAGGTTGGCGGCGGGTATCGATTAACTCCCTTTTACGACATTATATCCATGTATCCAGTAATTGGTGGCAAGGGCCTAAA
TATCCGTGATGCCAAGCTTGCTATGGGGCTCAAAGCTACCAAAGGTAAGAAGTATCAGATAGTAAAGATTTTCCCTAAAC
ACTTTATCGAAACTGCGAAAGCGGTTGGCTTTGATCTCGCTACTATGGCAGCCATTTTGCGAGAGGTTGCTGATTCAGTA
GATAACGTGATTATGAAGGTTAAGACTCAGTTGCCCGAAGACTTTCCTGTACATATACGAGATTCGATTTTGGATGGTTT
GCAGGATAGAGCAAAGCGCCTGATGGCGGGGGCGTACTGA

Upstream 100 bases:

>100_bases
ACCTTGAGCTGGATATAAAGGTTAGGAATTCAGAACTAGCGGAACGGCTGAATGATGATAAAAGCACCGCCTCCGAGCAA
GAGTGGAAGGAGGAGTGGTA

Downstream 100 bases:

>100_bases
GGCTAACTTTGTAGCTAAAGAATAAGGTTAACTCCAAAAGGCAAACAAAAGCCCAGTGATAAACTGGGCTTGGACAGGCT
AATTCAAATCGATAAAAATC

Product: HipA domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MAVLDVYMNGYLVGEFTKSTTGSHLFKYAAQWLDTPGSRPISLSMPLRSQAYKGDEVYNFFDNLLPDNMEVRNRIVARHN
AQSTQAFDLLAKVGQDSVGALQLVPHEQQPFEVKKIEAKPLSDEALEKVLKGYQSDIPLGMLSDEDDFRISIAGAQEKTA
LLNLDGRWQLPIKATPTTHIIKLPIGEIQSHSYTIDMSDSVENEYLCMMIVREFGLDVPDCSIIKVGDNKALAVARFDRK
LSSDGQWIMRLPQEDFCQTLNIPSAKKYESHGGPGVEHIIPYLLGSMNSEQDRYNFMKSQVLFWLLAATDGHAKNFSLFI
EVGGGYRLTPFYDIISMYPVIGGKGLNIRDAKLAMGLKATKGKKYQIVKIFPKHFIETAKAVGFDLATMAAILREVADSV
DNVIMKVKTQLPEDFPVHIRDSILDGLQDRAKRLMAGAY

Sequences:

>Translated_439_residues
MAVLDVYMNGYLVGEFTKSTTGSHLFKYAAQWLDTPGSRPISLSMPLRSQAYKGDEVYNFFDNLLPDNMEVRNRIVARHN
AQSTQAFDLLAKVGQDSVGALQLVPHEQQPFEVKKIEAKPLSDEALEKVLKGYQSDIPLGMLSDEDDFRISIAGAQEKTA
LLNLDGRWQLPIKATPTTHIIKLPIGEIQSHSYTIDMSDSVENEYLCMMIVREFGLDVPDCSIIKVGDNKALAVARFDRK
LSSDGQWIMRLPQEDFCQTLNIPSAKKYESHGGPGVEHIIPYLLGSMNSEQDRYNFMKSQVLFWLLAATDGHAKNFSLFI
EVGGGYRLTPFYDIISMYPVIGGKGLNIRDAKLAMGLKATKGKKYQIVKIFPKHFIETAKAVGFDLATMAAILREVADSV
DNVIMKVKTQLPEDFPVHIRDSILDGLQDRAKRLMAGAY
>Mature_438_residues
AVLDVYMNGYLVGEFTKSTTGSHLFKYAAQWLDTPGSRPISLSMPLRSQAYKGDEVYNFFDNLLPDNMEVRNRIVARHNA
QSTQAFDLLAKVGQDSVGALQLVPHEQQPFEVKKIEAKPLSDEALEKVLKGYQSDIPLGMLSDEDDFRISIAGAQEKTAL
LNLDGRWQLPIKATPTTHIIKLPIGEIQSHSYTIDMSDSVENEYLCMMIVREFGLDVPDCSIIKVGDNKALAVARFDRKL
SSDGQWIMRLPQEDFCQTLNIPSAKKYESHGGPGVEHIIPYLLGSMNSEQDRYNFMKSQVLFWLLAATDGHAKNFSLFIE
VGGGYRLTPFYDIISMYPVIGGKGLNIRDAKLAMGLKATKGKKYQIVKIFPKHFIETAKAVGFDLATMAAILREVADSVD
NVIMKVKTQLPEDFPVHIRDSILDGLQDRAKRLMAGAY

Specific function: Unbalanced or excessive expression of hipA is toxic to the cell [H]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae HI_0665 [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=423, Percent_Identity=53.4278959810875, Blast_Score=473, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 49078; Mature: 48947

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLDVYMNGYLVGEFTKSTTGSHLFKYAAQWLDTPGSRPISLSMPLRSQAYKGDEVYNF
CEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHHCCCCCHHHHH
FDNLLPDNMEVRNRIVARHNAQSTQAFDLLAKVGQDSVGALQLVPHEQQPFEVKKIEAKP
HHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEECCCC
LSDEALEKVLKGYQSDIPLGMLSDEDDFRISIAGAQEKTALLNLDGRWQLPIKATPTTHI
CCHHHHHHHHHHHCCCCCEEECCCCCCCEEEEECCCCCEEEEECCCCEEEEEECCCCCEE
IKLPIGEIQSHSYTIDMSDSVENEYLCMMIVREFGLDVPDCSIIKVGDNKALAVARFDRK
EEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEHHHH
LSSDGQWIMRLPQEDFCQTLNIPSAKKYESHGGPGVEHIIPYLLGSMNSEQDRYNFMKSQ
HCCCCCEEEECCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
VLFWLLAATDGHAKNFSLFIEVGGGYRLTPFYDIISMYPVIGGKGLNIRDAKLAMGLKAT
HHHEEEECCCCCCCCEEEEEEECCCEEECHHHHHHHHHHCCCCCCCCEEHHHHHCCEECC
KGKKYQIVKIFPKHFIETAKAVGFDLATMAAILREVADSVDNVIMKVKTQLPEDFPVHIR
CCCCEEEEEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
DSILDGLQDRAKRLMAGAY
HHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVLDVYMNGYLVGEFTKSTTGSHLFKYAAQWLDTPGSRPISLSMPLRSQAYKGDEVYNF
EEEEEEECCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHHCCCCCHHHHH
FDNLLPDNMEVRNRIVARHNAQSTQAFDLLAKVGQDSVGALQLVPHEQQPFEVKKIEAKP
HHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEECCCC
LSDEALEKVLKGYQSDIPLGMLSDEDDFRISIAGAQEKTALLNLDGRWQLPIKATPTTHI
CCHHHHHHHHHHHCCCCCEEECCCCCCCEEEEECCCCCEEEEECCCCEEEEEECCCCCEE
IKLPIGEIQSHSYTIDMSDSVENEYLCMMIVREFGLDVPDCSIIKVGDNKALAVARFDRK
EEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEHHHH
LSSDGQWIMRLPQEDFCQTLNIPSAKKYESHGGPGVEHIIPYLLGSMNSEQDRYNFMKSQ
HCCCCCEEEECCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
VLFWLLAATDGHAKNFSLFIEVGGGYRLTPFYDIISMYPVIGGKGLNIRDAKLAMGLKAT
HHHEEEECCCCCCCCEEEEEEECCCEEECHHHHHHHHHHCCCCCCCCEEHHHHHCCEECC
KGKKYQIVKIFPKHFIETAKAVGFDLATMAAILREVADSVDNVIMKVKTQLPEDFPVHIR
CCCCEEEEEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
DSILDGLQDRAKRLMAGAY
HHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1715862; 9278503; 8021189 [H]